Association of frontal and posterior cortical gray matter volume with time to alcohol relapse: a prospective study
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OBJECTIVE: Alcoholism is associated with gray matter volume deficits in frontal and other brain regions. Whether persistent brain volume deficits in abstinence are predictive of subsequent time to alcohol relapse has not been established. The authors measured gray matter volumes in healthy volunteers and in a sample of treatment-engaged, alcohol-dependent patients after 1 month of abstinence and assessed whether smaller frontal gray matter volume was predictive of subsequent alcohol relapse outcomes. METHOD: Forty-five abstinent alcohol-dependent patients in treatment and 50 healthy comparison subjects were scanned once using high-resolution (T(1)-weighted) structural MRI, and voxel-based morphometry was used to assess regional brain volume differences between the groups. A prospective study design was used to assess alcohol relapse in the alcohol-dependent group for 90 days after discharge from 6 weeks of inpatient treatment. RESULTS: Significantly smaller gray matter volume in alcohol-dependent patients relative to comparison subjects was seen in three regions: the medial frontal cortex, the right lateral prefrontal cortex, and a posterior region surrounding the parietal-occipital sulcus. Smaller medial frontal and parietal-occipital gray matter volumes were each predictive of shorter time to any alcohol use and to heavy drinking relapse. CONCLUSIONS: These findings are the first to demonstrate that gray matter volume deficits in specific medial frontal and posterior parietal-occipital brain regions are predictive of an earlier return to alcohol use and relapse risk, suggesting a significant role for gray matter atrophy in poor clinical outcomes in alcoholism. Extent of gray matter volume deficits in these regions could serve as useful neural markers of relapse risk and alcoholism treatment outcome.
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Frontal cortex-derived executive function disorders in addiction have been linked to deficits in behavioural treatments' ability to effect recovery.
“Such frontal cortex-derived executive function disorders in addiction have been linked to deficits in the ability of behavioural treatments to effect recovery.110”
From Neurobiology of addiction: a neurocircuitry analysis (2016) · cites this paper as [110]
The Discussion (page unavailable) reports that smaller medial frontal gray matter volume predicted shorter time to relapse in alcohol-dependent patients and suggests that impaired cognitive control could contribute. It explicitly says the study did not establish a link with functional impairment; it does not assess whether executive-function deficits reduce the effectiveness of behavioural treatments. (LLM, conf=0.88)
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Regression Models and Life-Tables
Cox, D. R. (1972) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1972.tb00899.x · Cited by 39,793 · see citing works
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · see citing works
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676 · see citing works
A fast diffeomorphic image registration algorithm
Ashburner, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.007 · Cited by 8,122 · see citing works
Ashburner, J., & Friston, K. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.018 · Cited by 7,507 · see citing works
Measuring the thickness of the human cerebral cortex from magnetic resonance images
Fischl, B. R., & Dale, A. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200033797 · Cited by 5,789 · see citing works
Maldjian, J., Laurienti, P., Kraft, R., & Burdette, J. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,453 · see citing works
Sobell, L. C., & Sobell, M. B. (1992) · Measuring Alcohol Consumption · doi:10.1007/978-1-4612-0357-5_3 · Cited by 4,110 · see citing works
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377 · see citing works
Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration
Klein, A., Andersson, J., Ardekani, B. A., Ashburner, J., Avants, B., Chiang, M.-C., Christensen, G. E., Collins, D. L., Gee, J., Hellier, P., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.037 · Cited by 2,227 · see citing works
Evenden, J. L. (1999) · Psychopharmacology · doi:10.1007/pl00005481 · Cited by 2,044 · see citing works
Anton, R. F., O’Malley, S. S., Ciraulo, D. A., Cisler, R. A., Couper, D., Donovan, D. M., Gastfriend, D. R., Hosking, J. D., Johnson, B. A., LoCastro, J. S., et al. (2006) · JAMA · doi:10.1001/jama.295.17.2003 · Cited by 1,930 · see citing works
Structured Clinical Interview for DSM-III-R Personality Disorders
First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2012) · PsycTESTS Dataset · doi:10.1037/t07827-000 · Cited by 1,403 · see citing works
Detecting activations in PET and fMRI: levels of inference and power
Friston, K. J., Holmes, A., Poline, J.-B., Price, C. J., & Frith, C. D. (1996) · NeuroImage · doi:10.1006/nimg.1996.0074 · Cited by 1,148 · see citing works
Action sets and decisions in the medial frontal cortex
RUSHWORTH, M., WALTON, M., KENNERLEY, S., & BANNERMAN, D. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.009 · Cited by 1,004 · see citing works
Bush, G., Frazier, J. A., Rauch, S. L., Seidman, L. J., Whalen, P. J., Jenike, M. A., Rosen, B. R., & Biederman, J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00083-9 · Cited by 866 · see citing works
Impulsivity, frontal lobes and risk for addiction
Crews, F. T., & Boettiger, C. A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.018 · Cited by 679 · see citing works
Combining spatial extent and peak intensity to test for activations in functional imaging
Poline, J.-B., Worsley, K. J., Evans, A. C., & Friston, K. J. (1997) · NeuroImage · doi:10.1006/nimg.1996.0248 · Cited by 670 · see citing works
Fals-Stewart, W., O'Farrell, T., Freitas, T. T., McFarlin, S., & Rutigliano, P. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.68.1.134 · Cited by 644 · see citing works
Drug addiction: the neurobiology of behaviour gone awry
Volkow, N. D., & Li, T. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1539 · Cited by 620 · see citing works
Mechanisms of Neurodegeneration and Regeneration in Alcoholism
Crews, F. T., & Nixon, K. (2008) · Alcohol and Alcoholism · doi:10.1093/alcalc/agn079 · Cited by 579 · see citing works
Pfefferbaum, A., Lim, K. O., Zipursky, R. B., Mathalon, D. H., Rosenbloom, M. J., Lane, B., Ha, C. N., & Sullivan, E. V. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb00702.x · Cited by 566 · see citing works
Fals-Stewart, W. S., O’Farrell, T. J., Freitas, T. T., et al. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.1.134 · Cited by 538 · see citing works
Frontal Lobe Volume Loss Observed with Magnetic Resonance Imaging in Older Chronic Alcoholics
Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H., & Lim, K. O. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03798.x · Cited by 492 · see citing works
Validating cluster size inference: random field and permutation methods
Hayasaka, S. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.08.003 · Cited by 491 · see citing works
False discovery rate revisited: FDR and topological inference using Gaussian random fields
Chumbley, J. R., & Friston, K. J. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.05.021 · Cited by 458 · see citing works
Measurement of drinking behavior using the Form 90 family of instruments.
Miller, W. R., & Boca, F. K. D. (1994) · Journal of Studies on Alcohol Supplement · doi:10.15288/jsas.1994.s12.112 · Cited by 450 · see citing works
The role of stress in addiction relapse
Sinha, R. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0050-6 · Cited by 423 · see citing works
Self-citationPfefferbaum, A., Sullivan, E. V., Mathalon, D. H., Shear, P. K., Rosenbloom, M. J., & Lim, K. O. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01598.x · Cited by 420 · see citing works
Chanraud, S., Martelli, C., Delain, F., Kostogianni, N., Douaud, G., Aubin, H., Reynaud, M., & Martinot, J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301219 · Cited by 419 · see citing works
Pfefferbaum, A., Sullivan, E. V., Rosenbloom, M. J., Mathalon, D. H., & Lim, K. O. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.10.905 · Cited by 396 · see citing works
Relapse and Relapse Prevention
Brandon, T. H., Vidrine, J. I., & Litvin, E. B. (2007) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.3.022806.091455 · Cited by 385 · see citing works
More accurate Talairach coordinates for neuroimaging using non-linear registration
Lacadie, C., Fulbright, R. K., Rajeevan, N., Constable, R. T., & Papademetris, X. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.240 · Cited by 351 · see citing works
Evidence for a Gender-Related Effect of Alcoholism on Brain Volumes
Hommer, D. W., Momenan, R., Kaiser, E., & Rawlings, R. R. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.2.198 · Cited by 350 · see citing works
Reduced Cerebral Grey Matter Observed in Alcoholics Using Magnetic Resonance Imaging
Jernigan, T. L., Butters, N., Ditraglia, G. M., Schafer, K. A., Smith, T., Irwin, M. R., Grant, I., Schuckit, M. A., & Cermak, L. S. (1991) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1991.tb00540.x · Cited by 349 · see citing works
Li, C.-S. R., & Sinha, R. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.003 · Cited by 345 · see citing works
Self-citationProbabilistic segmentation of white matter lesions in MR imaging
Anbeek, P., Vincken, K. L., van Osch, M. J. P., Bisschops, R. H. C., & van der Grond, J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.10.012 · Cited by 323 · see citing works
Cerebellar volume decline in normal aging, alcoholism, and Korsakoff's syndrome: Relation to ataxia.
Sullivan, E. V., Deshmukh, A., Desmond, J. E., Lim, K. O., & Pfefferbaum, A. (2000) · Neuropsychology · doi:10.1037/0894-4105.14.3.341 · Cited by 286 · see citing works
Update on neuropharmacological treatments for alcoholism: Scientific basis and clinical findings
Johnson, B. A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.005 · Cited by 265 · see citing works
Cortical Gray Matter Loss in Treatment‐Naïve Alcohol Dependent Individuals
Fein, G., Sclafani, V. D., Cardenas, V. A., Goldmann, H., Tolou‐Shams, M., & Meyerhoff, D. J. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02574.x · Cited by 258 · see citing works
Altered Impulse Control in Alcohol Dependence: Neural Measures of Stop Signal Performance
Li, C.-S. R., Luo, X., Yan, P., Bergquist, K. L., & Sinha, R. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00891.x · Cited by 254 · see citing works
Self-citationMechtcheriakov, S., Brenneis, C., Egger, K. E., Koppelstaetter, F., Schocke, M., & Marksteiner, J. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.095869 · Cited by 245 · see citing works
DEVELOPING A PROTOTYPE FOR EVALUATING ALCOHOL TREATMENT EFFECTIVENESS
Sobell, M. B., COOPER, A. M., Maisto, S. A., Cooper, T., Sobell, L. C., & Sanders, B. (1980) · Elsevier eBooks · doi:10.1016/b978-0-08-022997-3.50013-2 · Cited by 244 · see citing works
Amygdala Volume Associated With Alcohol Abuse Relapse and Craving
Wrase, J., Makris, N., Braus, D. F., Mann, K. F., Smolka, M. N., Kennedy, D. N., Caviness, V. S., Hodge, S. M., Tang, L., Albaugh, M. D., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07121877 · Cited by 241 · see citing works
Medial orbitofrontal cortex gray matter is reduced in abstinent substance dependent individuals
Tanabe, J., Tregellas, J., Dalwani, M., Thompson, L., Owens, E., Crowley, T., & Banich, M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.030 · Cited by 238 · see citing works
Deformation-based morphometry of brain changes in alcohol dependence and abstinence
Cardenas, V. A., Studholme, C., Gazdzinski, S. P., Durazzo, T. C., & Meyerhoff, D. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.015 · Cited by 237 · see citing works
The Neural Mechanisms for Minimizing Cross-Modal Distraction
Weissman, D. H., Warner, L. M., & Woldorff, M. G. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3669-04.2004 · Cited by 174 · see citing works
Gazdzinski, S. P., Durazzo, T. C., & Meyerhoff, D. J. (2005) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2004.11.004 · Cited by 129 · see citing works
Reduced Frontal Lobe Activity in Subjects With High Impulsivity and Alcoholism
Chen, A. C. H., Bernice Porjesz, A., Rangaswamy, M., Kamarajan, C., Tang, Y., Jones, K. A., Chorlian, D. B., Stimus, A. T., & Begleiter, H. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00277.x · Cited by 129 · see citing works
Cerebellar Atrophy in Essential Tremor Using an Automated Segmentation Method
Cerasa, A., Messina, D. N., Nicoletti, G., Novellino, F., Lanza, P. L., Condino, F., Arabia, G., Salsone, M., & Quattrone, A. (2009) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1544 · Cited by 128 · see citing works
Sýkora, P., Kharbanda, K. K., Crumm, S. E., & Cahill, A. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00803.x · Cited by 126 · see citing works
Fama, R., Pfefferbaum, A., & Sullivan, E. V. (2004) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000145690.48510.da · Cited by 114 · see citing works
Davies, R., Scahill, V. L., Graham, A., Williams, G. B., Graham, K. S., & Hodges, J. R. (2009) · Neuroradiology · doi:10.1007/s00234-009-0521-z · Cited by 109 · see citing works
On evaluating brain tissue classifiers without a ground truth
Sylvain Bouix, A., Martín‐Fernández, M., Ungar, L., Nakamura, M., Koo, M., McCarley, R. W., & Shenton, M. E. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.031 · Cited by 98 · see citing works
Prefrontal cortex and cognitive control: motivating functional hierarchies
Egner, T. (2009) · Nature Neuroscience · doi:10.1038/nn0709-821 · Cited by 68 · see citing works
Fein, G., Shimotsu, R., Chu, R., & Barakos, J. A. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01019.x · Cited by 65 · see citing works
Gazdzinski, S. P., Durazzo, T. C., Weiner, M. W., & Meyerhoff, D. J. (2008) · Alcohol · doi:10.1016/j.alcohol.2008.01.002 · Cited by 40 · see citing works
Hermann, D., Smolka, M. N., Vollstädt‐Klein, S., Heinz, A., Mann, K. F., & Braus, D. F. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00039.x · Cited by 27 · see citing works
FIFTEEN RELAPSE AMONG COCAINE ABUSERS: THEORETICAL, METHODOLOGICAL, AND TREATMENT CONSIDERATIONS
Rohsenow, D. J., & Monti, P. M. (2017) · Yale University Press eBooks · doi:10.12987/9780300143485-016 · Cited by 1 · see citing works
Lurito (2000) · doi:10.1002/1097-0193(200007)10:3
Flagged first, then by citations
Research works printed but not linked: 2
- [19]First MB Spitzer RL Williams JBW Gibbon M Structured Clinical Interview for DSM-IV-Patient Edition (SCID-P) 1995 American Psychiatric Press Washington, DC
- [30]Sobell LC Sobell MB Litten RZ Allen JP Timeline followback: a technique for assessing self-reported alcohol consumption, in Measuring Alcohol Consumption: Pyschosocial and Biochemical Methods 1992 Humana Press Totowa, NJ
Cited by
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Neurobiology of addiction: a neurocircuitry analysis
Koob, G. F., & Volkow, N. D. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)00104-8 · Cited by 3,698 · see citing works
Mander, B. A., Winer, J. R., & Walker, M. P. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.004 · Cited by 1,214 · see citing works
Prediction as a Humanitarian and Pragmatic Contribution from Human Cognitive Neuroscience
Gabrieli, J. D. E., Ghosh, S., & Whitfield, S. (2015) · Neuron · doi:10.1016/j.neuron.2014.10.047 · Cited by 526 · see citing works
New findings on biological factors predicting addiction relapse vulnerability
Sinha, R. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0224-0 · Cited by 401 · see citing works
Self-citationAlcohol use disorder relapse factors: A systematic review.
Sliedrecht, W., de Waart, R., Witkiewitz, K., & Roozen, H. G. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.05.038 · Cited by 358 · see citing works
Ansell, E. B., Rando, K., Tuit, K., Guarnaccia, J., & Sinha, R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.022 · Cited by 354 · see citing works
Self-citationDisrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Seo, D., Lacadie, C., Tuit, K. L., Hong, K., Constable, R. T., & Sinha, R. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.762 · Cited by 302 · see citing works
Self-citationBeck, A., Wüstenberg, T., Genauck, A., Wrase, J., Schlagenhauf, F., Smolka, M. N., Mann, K. F., & Heinz, A. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2026 · Cited by 269 · see citing works
Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders
Blaine, S. K., & Sinha, R. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.037 · Cited by 257 · see citing works
Self-citationAssociations between alcohol consumption and gray and white matter volumes in the UK Biobank
Daviet, R., Aydogan, G., Jagannathan, K., Spilka, N. H., Koellinger, P., Kranzler, H. R., Nave, G., & Wetherill, R. R. (2022) · Nature Communications · doi:10.1038/s41467-022-28735-5 · Cited by 241 · see citing works
Alcohol's Effects on the Brain: Neuroimaging Results in Humans and Animal Models
Zahr, N. M. (2017) · Alcohol research · doi:10.35946/arcr.v38.2.04 · Cited by 228 · see citing works
Chapter 1. Neurocircuitry of Addiction
Koob, G. F., & Volkow, N. D. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615373970.kb01 · Cited by 236 · see citing works
Witkiewitz, K., Lustyk, M. K. B., & Bowen, S. (2013) · Psychology of Addictive Behaviors · doi:10.1037/a0029258 · Cited by 207 · see citing works
Cognitive impairment in substance use disorders
Ramey, T., & Regier, P. S. (2018) · CNS Spectrums · doi:10.1017/s1092852918001426 · Cited by 211 · see citing works
When Optimism Hurts: Inflated Predictions in Psychiatric Neuroimaging
Whelan, R., & Garavan, H. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.014 · Cited by 209 · see citing works
Noninvasive brain stimulation treatments for addiction and major depression
Dunlop, K., Hanlon, C. A., & Downar, J. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12985 · Cited by 171 · see citing works
Van Dam, N. T., Rando, K., Potenza, M. N., Tuit, K., & Sinha, R. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.680 · Cited by 172 · see citing works
Self-citationA voxel-based morphometry study comparing problem gamblers, alcohol abusers, and healthy controls
van Holst, R. J., de Ruiter, M. B., van den Brink, W., Veltman, D. J., & Goudriaan, A. E. (2012) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.12.025 · Cited by 150 · see citing works
Ceceli, A. O., Bradberry, C. W., & Goldstein, R. Z. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01153-9 · Cited by 150 · see citing works
How does stress lead to risk of alcohol relapse?
Sinha, R. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.07 · Cited by 147 · see citing works
Self-citationDeep TMS on alcoholics: effects on cortisolemia and dopamine pathway modulation. A pilot study
Ceccanti, M., Inghilleri, M., Attilia, M. L., Raccah, R. N., Fiore, M., Zangen, A., & Ceccanti, M. (2015) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2014-0188 · Cited by 135 · see citing works
Trantham‐Davidson, H., Glover, E. J., Gass, J. T., Lopez, M. F., Mulholland, P. J., Centanni, S. W., Floresco, S., & Chandler, L. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0623-13.2014 · Cited by 128 · see citing works
Resting-State Synchrony During Early Alcohol Abstinence Can Predict Subsequent Relapse
Camchong, J., Stenger, A., & Fein, G. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs190 · Cited by 126 · see citing works
Stress and substance use disorders: risk, relapse, and treatment outcomes
Sinha, R. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172883 · Cited by 145 · see citing works
Self-citationXiao, P., Dai, Z., Zhong, J., Zhu, Y., Shi, H., & Pan, P. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.05.030 · Cited by 120 · see citing works
Moeller, S. J., & Paulus, M. P. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.03.003 · Cited by 118 · see citing works
Welch, K. A., Carson, A. J., & Lawrie, S. M. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt037 · Cited by 112 · see citing works
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Moorman, D. E. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.010 · Cited by 109 · see citing works
Error processing and gender-shared and -specific neural predictors of relapse in cocaine dependence
Luo, X., Zhang, S., Hu, S., Bednarski, S. R., Erdman, E., Farr, O. M., Hong, K., Sinha, R., Mazure, C. M., & Li, C.-S. R. (2013) · Brain · doi:10.1093/brain/awt040 · Cited by 105 · see citing works
Self-citationAlcohol Use Disorder: Neurobiology and Therapeutics
Yang, W., Singla, R., Maheshwari, O., Fontaine, C. J., & Gil‐Mohapel, J. (2022) · Biomedicines · doi:10.3390/biomedicines10051192 · Cited by 111 · see citing works
Disrupted Regulation of Social Exclusion in Alcohol-Dependence: An fMRI Study
Maurage, P., Joassin, F., Philippot, P., Heeren, A., Vermeulen, N., Mahau, P., delperdange, C., Corneille, O., Luminet, O., & de Timary, P. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.54 · Cited by 103 · see citing works
Dissociated Grey Matter Changes with Prolonged Addiction and Extended Abstinence in Cocaine Users
Connolly, C. G., Bell, R. P., Foxe, J. J., & Garavan, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059645 · Cited by 96 · see citing works
Verdejo‐García, A., Lorenzetti, V., Manning, V., Piercy, H., Bruno, R., Hester, R., Pennington, D., Tolomeo, S., Arunogiri, S., Bates, M. E., et al. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00877 · Cited by 95 · see citing works
The neurobiology of alcohol craving and relapse
Seo, D., & Sinha, R. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00021-5 · Cited by 94 · see citing works
Self-citationDurazzo, T. C., & Meyerhoff, D. J. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13267 · Cited by 93 · see citing works
O-37 - Disrupted regulation of social exclusion in alcohol dependence: an fmri study
Maurage, P., Joassin, F., Pesenti, M., Philippot, P., Vermeulen, N., Corneille, O., Luminet, O., & de Timary, P. (2012) · European Psychiatry · doi:10.1016/s0924-9338(12)74137-8 · Cited by 88 · see citing works
The Role of Aging, Drug Dependence, and Hepatitis C Comorbidity in Alcoholism Cortical Compromise
Sullivan, E. V., Zahr, N. M., Sassoon, S. A., Thompson, W. K., Kwon, D., Pohl, K. M., & Pfefferbaum, A. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.0021 · Cited by 85 · see citing works
Cannabidiol as a Novel Candidate Alcohol Use Disorder Pharmacotherapy: A Systematic Review
Turna, J., Syan, S. K., Frey, B. N., Rush, B. R., Costello, M. J., Weiss, M., & MacKillop, J. M. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13964 · Cited by 83 · see citing works
Age-Related Sex-Specific Changes in Brain Metabolism and Morphology
Kakimoto, A., Ito, S., Okada, H., Nishizawa, S., Minoshima, S., & Ouchi, Y. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.166439 · Cited by 81 · see citing works
Alcohol-induced alterations in dopamine modulation of prefrontal activity
Trantham‐Davidson, H., & Chandler, L. J. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.09.001 · Cited by 79 · see citing works
Durazzo, T. C., Mon, A., Gazdzinski, S. P., Yeh, P., & Meyerhoff, D. J. (2014) · Addiction Biology · doi:10.1111/adb.12180 · Cited by 74 · see citing works
Durazzo, T. C., Mon, A., Gazdzinski, S. P., & Meyerhoff, D. J. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00407.x · Cited by 72 · see citing works
The neurobiology of successful abstinence
Garavan, H., Brennan, K., Hester, R., & Whelan, R. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.029 · Cited by 74 · see citing works
Frontal White Matter Integrity Predictors of Adult Alcohol Treatment Outcome
Sorg, S. F., Taylor, M. J., Alhassoon, O. M., Gongvatana, A., Theilmann, R. J., Frank, L. R., & Grant, I. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.022 · Cited by 68 · see citing works
Resting state connectivity best predicts alcohol use severity in moderate to heavy alcohol users
Fede, S. J., Grodin, E. N., Dean, S., Diazgranados, N., & Momenan, R. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101782 · Cited by 66 · see citing works
Addictions NeuroImaging Assessment (ANIA): Towards an integrative framework for alcohol use disorder
Voon, V., Grodin, E. N., Mandali, A., Morris, L. S., Doñamayor, N., Weidacker, K., Kwako, L. E., Goldman, D. A., Koob, G. F., & Momenan, R. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.004 · Cited by 67 · see citing works
Parvaz, M. A., Rabin, R. A., Adams, F., & Goldstein, R. Z. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109319 · Cited by 71 · see citing works
Prefrontal correlates of approach preferences for alcohol stimuli in alcohol dependence
Ernst, L. H., Plichta, M. M., Dresler, T., Zesewitz, A. K., Tupak, S. V., Haeussinger, F. B., Fischer, M., Polak, T. T., Fallgatter, A. J., & Ehlis, A. (2012) · Addiction Biology · doi:10.1111/adb.12005 · Cited by 65 · see citing works
Liput, D. J., Hammell, D. C., Stinchcomb, A. L., & Nixon, K. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.08.013 · Cited by 65 · see citing works
Zou, X., Durazzo, T. C., & Meyerhoff, D. J. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13757 · Cited by 63 · see citing works
Morgenstern, J., Naqvi, N. H., Debellis, R., & Breiter, H. C. (2013) · Psychology of Addictive Behaviors · doi:10.1037/a0032435 · Cited by 61 · see citing works
D’Hondt, F., Billieux, J., & Maurage, P. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.005 · Cited by 64 · see citing works
Reinforcer Pathology: Implications for Substance Abuse Intervention
Bickel, W. K., Athamneh, L. N., Snider, S. E., Craft, W. H., DeHart, W. B., Kaplan, B. A., & Basso, J. C. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_145 · Cited by 61 · see citing works
Maurage, F., de Timary, P., Tecco, J. M., Lechantre, S., & Samson, D. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12717 · Cited by 60 · see citing works
Rando, K., Tuit, K. L., Hannestad, J. O., Guarnaccia, J. B., & Sinha, R. (2012) · Addiction Biology · doi:10.1111/adb.12008 · Cited by 60 · see citing works
Self-citationGrodin, E. N., Lin, H., Durkee, C. A., Hommer, D. W., & Momenan, R. (2013) · NeuroImage Clinical · doi:10.1016/j.nicl.2013.03.013 · Cited by 59 · see citing works
Czapla, M., Baeuchl, C., Simon, J. J., Richter, B., Kluge, M., Friederich, H., Mann, K. F., Herpertz, S. C., & Loeber, S. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4541-9 · Cited by 57 · see citing works
Le, T. M., Potvin, S., Zhornitsky, S., & Li, C.-S. R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.028 · Cited by 58 · see citing works
Self-citationPennington, D., Durazzo, T. C., Schmidt, T. P., Abé, C., Mon, A., & Meyerhoff, D. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122505 · Cited by 51 · see citing works
Wang, L., Zou, F., Zhai, T., Lei, Y., Shuwen, T., Jin, X., Ye, E., Shao, Y., Yang, Y., & Zheng, Y. (2015) · Addiction Biology · doi:10.1111/adb.12228 · Cited by 51 · see citing works
Neuroplasticity and Predictors of Alcohol Recovery
Seo, D. (2015) · Alcohol research · doi:10.35946/arcr.v37.1.10 · Cited by 48 · see citing works
Rando, K., Chaplin, T. M., Potenza, M. N., Mayes, L. C., & Sinha, R. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.030 · Cited by 49 · see citing works
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Logrip, M. L., & Zorrilla, E. P. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2012.00460.x · Cited by 48 · see citing works
Nahum-Shani, I. B., Ertefaie, A., Lu, X., Lynch, K. G., McKay, J. R., Oslin, D. W., & Almirall, D. (2016) · Addiction · doi:10.1111/add.13743 · Cited by 47 · see citing works
Fernandez, G. M., Stewart, W. N., & Savage, L. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0149987 · Cited by 47 · see citing works
Kaag, A. M., Schulte, M. H. J., Jansen, J. M., van Wingen, G. A., Homberg, J. R., van den Brink, W., Wiers, R. W. H. J., Schmaal, L., Goudriaan, A. E., & Reneman, L. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.03.010 · Cited by 48 · see citing works
Zois, E., Kiefer, F., Leménager, T., Vollstädt‐Klein, S., Mann, K. F., & Fauth‐Bühler, M. (2016) · Addiction Biology · doi:10.1111/adb.12368 · Cited by 46 · see citing works
Dupuy, M., & Chanraud, S. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.04.003 · Cited by 46 · see citing works
Tapia‐Rojas, C., Mira, R. G., Torres, A. K., Jara, C., Maria Jose Perez, J., Vergara, E. H., Cerpa, W. F., & Quintanilla, R. A. (2017) · Birth Defects Research · doi:10.1002/bdr2.1172 · Cited by 44 · see citing works
Smith, K., Lacadie, C., Milivojevic, V., Fogelman, N., & Sinha, R. (2023) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2023.109794 · Cited by 42 · see citing works
Self-citationTRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration
Qin, L., Zou, J., Barnett, A., Vetreno, R. P., Crews, F. T., & Coleman, L. G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052547 · Cited by 42 · see citing works
Spindler, C., Trautmann, S., Alexander, N., Bröning, S., Bartscher, S., Stuppe, M., & Muehlhan, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-84804-7 · Cited by 34 · see citing works
Reduced limbic metabolism and fronto-cortical volume in rats vulnerable to alcohol addiction
Gozzi, A., Agosta, F., Massi, M., Ciccocioppo, R., & Bifone, A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.12.015 · Cited by 40 · see citing works
Alcohol�s Negative Emotional Side: The Role of Stress Neurobiology in Alcohol Use Disorder
Sinha, R. (2022) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v42.1.12 · Cited by 39 · see citing works
Self-citationGröpper, S., Spengler, S., Stuke, H., Gawron, C. K., Parnack, J., Gutwinski, S., Wiers, C. E., & Bermpohl, F. (2016) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.08.006 · Cited by 39 · see citing works
West, R. K., Maynard, M. E., & Leasure, J. L. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2018.01.027 · Cited by 39 · see citing works
Naqvi, N. H. (2015) · Alcohol research · doi:10.35946/arcr.v37.1.03 · Cited by 38 · see citing works
Borruto, A. M., Stopponi, S., Li, H., Weiss, F., Roberto, M., & Ciccocioppo, R. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108446 · Cited by 38 · see citing works
Wang, J., Fan, Y., Dong, Y., Ma, M., Dong, Y., Niu, Y., Jiang, Y., Wang, H., Wang, Z., Wu, L., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196860 · Cited by 37 · see citing works
Schacht, J. P., Anton, R. F., Randall, P. K., Li, X., Henderson, S., & Myrick, H. (2013) · Psychopharmacology · doi:10.1007/s00213-013-2996-x · Cited by 35 · see citing works
Schier, C. J., Dilly, G. A., & Gonzales, R. A. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12042 · Cited by 35 · see citing works
Nippert, K. E., Rowland, C. P., Vazey, E. M., & Moorman, D. E. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110114 · Cited by 34 · see citing works
Binge drinking differentially affects cortical and subcortical microstructure
Morris, L. S., Dowell, N. G., Cercignani, M., Harrison, N. A., & Voon, V. (2018) · Addiction Biology · doi:10.1111/adb.12493 · Cited by 34 · see citing works
Staples, M. C., & Mandyam, C. D. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00162 · Cited by 33 · see citing works
Determination of Mo CA Cutoff Score in Patients with Alcohol Use Disorders
Ewert, V., Pelletier, S., Alarcon, R., Nalpas, B., Donnadieu‐Rigole, H., Trouillet, R., & Perney, P. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13547 · Cited by 34 · see citing works
White matter integrity is associated with alcohol cue reactivity in heavy drinkers
Monnig, M. A., Thayer, R. E., Caprihan, A., Claus, E. D., Yeo, R. A., Calhoun, V. D., & Hutchison, K. E. (2013) · Brain and Behavior · doi:10.1002/brb3.204 · Cited by 33 · see citing works
Draps, M., Sescousse, G., Potenza, M. N., Marchewka, A., Duda, A., Lew-Starowicz, M., Kopera, M., Jakubczyk, A., Wojnar, M., & Gola, M. (2020) · The Journal of Sexual Medicine · doi:10.1016/j.jsxm.2020.05.007 · Cited by 34 · see citing works
Eva, L., Brehar, F.-M., Florian, I. A., Covache-Busuioc, R.-A., Costin, H. P., Dumitrascu, D.-I., Bratu, B.-G., Glavan, L.-A., & Ciurea, A. V. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12186101 · Cited by 31 · see citing works
Lange, E. H., Nerland, S., Jørgensen, K. N., Mørch-Johnsen, L. E., Nesvåg, R., Hartberg, C. B., Haukvik, U. K., Osnes, K., Melle, I. S., Andreassen, O. A., et al. (2016) · Psychological Medicine · doi:10.1017/s0033291716002920 · Cited by 30 · see citing works
Zhornitsky, S., Ide, J. S., Wang, W., Chao, H. H., Zhang, S., Hu, S., Krystal, J. H., & Li, C.-S. R. (2018) · Brain Connectivity · doi:10.1089/brain.2018.0633 · Cited by 29 · see citing works
Self-citationGhin, F., Beste, C., & Stock, A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.031 · Cited by 29 · see citing works
Lamb, R. L., Cavagnetto, A. R., & Akmal, T. T. (2014) · International Journal of Science and Mathematics Education · doi:10.1007/s10763-014-9593-2 · Cited by 28 · see citing works
Pelição, R., dos Santos, M. C., Freitas‐Lima, L. C., Meyrelles, S. S., Vasquez, E. C., Nakamura-Palacios, E. M., & Rodrigues, L. C. M. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.068 · Cited by 28 · see citing works
Durazzo, T. C., Mon, A., Gazdzinski, S. P., & Meyerhoff, D. J. (2016) · Addiction Biology · doi:10.1111/adb.12420 · Cited by 28 · see citing works
Loss in connectivity among regions of the brain reward system in alcohol dependence
Kuceyeski, A. F., Meyerhoff, D. J., Durazzo, T. C., & Raj, A. (2012) · Human Brain Mapping · doi:10.1002/hbm.22132 · Cited by 26 · see citing works
Le, T. M., Zhornitsky, S., Wang, W., Ide, J. S., Zhang, S., & Li, C.-S. R. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0508-19.2019 · Cited by 27 · see citing works
Self-citationWhite matter microstructural correlates of relapse in alcohol dependence
Zou, Y., Murray, D. E., Durazzo, T. C., Schmidt, T. P., Murray, T. A., & Meyerhoff, D. J. (2018) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.09.004 · Cited by 25 · see citing works
Aberrant prefrontal–parietal–cerebellar circuits in alcohol dependence
Liu, R., Liu, B., Ma, M., Kong, D., Li, G., Yang, J., Wu, X., Zheng, J., & Dong, Y. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s178257 · Cited by 23 · see citing works
Genetic imaging consortium for addiction medicine
Mackey, S., Kan, K., Chaarani, B., Nelly Alia-klein, A., Batalla, A., Brooks, S. J., Cousijn, J., Dagher, A., de Ruiter, M. B., Desrivières, S., et al. (2015) · Progress in brain research · doi:10.1016/bs.pbr.2015.07.026 · Cited by 24 · see citing works
Self-citationKlaming, R., Harlé, K. M., Infante, M. A., Bomyea, J. A., Kim, C., & Spadoni, A. D. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.09.009 · Cited by 25 · see citing works
- Authors
- Rando, K., Hong, K.-I., Bhagwagar, Z., Li, C.-S. R., Bergquist, K., Guarnaccia, J., & Sinha, R.
- Affiliations
- Yale University (US)
- From the Departments of Psychiatry and Neurology, Yale University School of Medicine; and the Yale Child Study Center, New Haven.
- Venue
- American Journal of Psychiatry
- Published
- 2011-02
- Volume
- 168
- Issue
- 2
- Pages
- 183-192
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC3668974
- OpenAlex
- W2167579043
- Semantic Scholar
- fe22c1d89798d6093ae0492c55dc75298cb50196
- Cited by
- 189
- References
- 62
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 16 · 2020: 15 · 2019: 13 · 2018: 16 · 2017: 16 · 2016: 20 · 2015: 16 · 2014: 9 · 2013: 15 · 2012: 15
- FWCI
- 7.94
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5k23mh077914-02)
- National Institute on Alcohol Abuse and Alcoholism (R01AA013892)
- National Institute of Mental Health (K23-MH077914)
- National Institute on Drug Abuse (K02DA026990)
- National Institute of Dental and Craniofacial Research (UL1DE019586)
- National Center for Research Resources (UL1RR024139)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Keywords
- alcohol relapse, gray matter volume, alcoholism, abstinence, medial frontal cortex, prefrontal cortex, gray matter atrophy, relapse risk prediction, neural markers, treatment outcomes
- MeSH terms
- Adolescent, Adult, Alcoholism, Brain Mapping, Female, Frontal Lobe, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Occipital Lobe, Organ Size, Parietal Lobe, Prospective Studies, Recurrence, Reference Values, Temperance, Young Adult
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