Cognitive-Behavioral Therapy for Depression in Parkinson's Disease: A Randomized, Controlled Trial
Open accessAbstract
OBJECTIVE: Despite the negative effects of depression in Parkinson's disease, there is currently no evidence-based standard of care. The purpose of this study was to examine the efficacy of individually administered cognitive-behavioral therapy (CBT), relative to clinical monitoring (with no new treatment), for depression in this medical population. METHOD: Eighty depressed (based on DSM-IV criteria) patients with Parkinson's disease participated in a randomized, controlled trial of CBT relative to clinical monitoring (1:1 ratio) in an academic medical center from April 2007 to July 2010. All patients continued to maintain stable medication regimens under the care of their personal physicians. The 17-item Hamilton Depression Rating Scale (HAM-D) total score was the primary outcome. CBT was modified to meet the unique needs of the Parkinson's disease population and provided for 10 weeks. Assessments were completed by blind raters at baseline and 5 (midpoint), 10 (end of treatment), and 14 weeks (follow-up evaluation) postrandomization. RESULTS: The CBT group reported greater reductions in depression (change in HAM-D score) than the clinical monitoring group. At week 10, the mean HAM-D score change was 7.35 for CBT relative to 0.05 for clinical monitoring. CBT was also superior to clinical monitoring on several secondary outcomes (i.e., Beck Depression Inventory scores, anxiety, quality of life, coping, Parkinson's disease symptom ratings). There were more treatment responders in the CBT group than the clinical monitoring group (56% versus 8%, respectively). CONCLUSIONS: CBT may be a viable approach for the treatment of depression in Parkinson's disease. Further research is needed to replicate and extend these findings.
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There is very little research into the effectiveness of psychological interventions in Parkinson's disease, with only a small number of studies investigating the feasibility and effectiveness of cognitive behavioural therapy in the treatment of depression and anxiety.
“To date, there is very little research into the effectiveness of psychological interventions in PD, with only a small number of studies [10–12] investigating the feasibility and effectiveness of cognitive behavioural therapy (CBT) in the treatment of depression and anxiety.”
From Distant delivery of a mindfulness-based intervention for people with Parkinson's disease: The study protocol of a randomised pilot trial (2017) · cites this paper as [10]
Cognitive behavioural therapy reduces symptoms of depressive disorders in adults with chronic somatic conditions.
“CBT has also been found to reduce symptoms of depressive disorders in adults with chronic somatic conditions [18–20]”
From Effectiveness and cost-effectiveness of guided Internet- and mobile-based CBT for adolescents and young adults with chronic somatic conditions and comorbid depression and anxiety symptoms (youthCOACHCD): study protocol for a multicentre randomized controlled trial (2020) · cites this paper as [18]
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- Authors
- Dobkin, R. D., Menza, M., Allen, L. A., Gara, M. A., Mark, M. H., Tiu, J., Bienfait, K. L., & Friedman, J.
- Affiliations
- University of Medicine and Dentistry of New Jersey (US)
- ORCID
- Dobkin, Roseanne D.
- Venue
- American Journal of Psychiatry
- Published
- 2011-10
- Volume
- 168
- Issue
- 10
- Pages
- 1066-1074
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC3186855
- OpenAlex
- W1969355958
- Cited by
- 310
- References
- 49
- Citations by year
- 2026: 16 · 2025: 15 · 2024: 18 · 2023: 17 · 2022: 25 · 2021: 17 · 2020: 18 · 2019: 21 · 2018: 15 · 2017: 24 · 2016: 23 · 2015: 29 · 2014: 24 · 2013: 30 · 2012: 12
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (K23NS052155)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- cognitive behavioral therapy, depression, Parkinson's disease, treatment efficacy, patient monitoring, Hamilton Depression Rating Scale, anxiety, quality of life, coping
- MeSH terms
- Adult, Aged, Aged, 80 and over, Depressive Disorder, Female, Humans, Male, Middle Aged, Parkinson Disease, Cognitive Behavioral Therapy, Single-Blind Method, Treatment Outcome
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