Effect of psychotherapy for depression on quality of life: meta-analysis

Kolovos, Spyros; Kleiboer, Annet; Cuijpers, Pim

doi:10.1192/bjp.bp.115.175059

Cited by 153Psychotherapy Techniques and ApplicationsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health Treatment and Access

Effect of psychotherapy for depression on quality of life: meta-analysis

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Kolovos, Spyros, Kleiboer, Annet, Cuijpers, Pim·2016·British Journal of Psychiatry

DOI 10.1192/bjp.bp.115.175059

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Abstract

Background: Several meta-analyses have shown that psychotherapy is effective for reducing depressive symptom severity. However, the impact on quality of life (QoL) is as yet unknown. Aims: To investigate the effectiveness of psychotherapy for depression on global QoL and on the mental health and physical health components of QoL. Method: We conducted a meta-analysis of 44 randomised clinical trials comparing psychotherapy for adults experiencing clinical depression or elevated depressive symptoms with a control group. We used subgroup analyses to explore the influence of various study characteristics on the effectiveness of treatment. Results: We detected a small to moderate effect size (Hedges' g = 0.33, 95% CI 0.24–0.42) for global QoL, a moderate effect size for the mental health component ( g = 0.42, 95% CI 0.33–0.51) and, after removing an outlier, a small but statistically significant effect size for the physical health component ( g = 0.16, 95% CI 0.05–0.27). Multivariate meta-regression analyses showed that the effect size of depressive symptoms was significantly related to the effect size of the mental health component of QoL. The effect size of depressive symptoms was not related to global QoL or the physical health component. Conclusions: Psychotherapy for depression has a positive impact on the QoL of patients with depression. Improvements in QoL are not fully explained by improvements in depressive symptom severity.

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Withdrawal symptoms have been reported to occur typically within a few days and persist for a few weeks; but many variations are possible including later onset and longer duration.
“Withdrawal symptoms have been reported to occur typically within a few days and persist for a few weeks; but many variations are possible including later onset and longer duration. 526”
From Time for united action on depression: a Lancet–World Psychiatric Association Commission (2022) · cites this paper as [526]

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Zilcha‐Mano, S., Dinger, U., McCarthy, K. S., Barrett, M. S., & Barber, J. P. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.015 · Cited by 40 · see citing works
Treating depression and substance use: A randomized controlled trial
Hunter, S. B., Watkins, K. E., Hepner, K. A., Paddock, S. M., Ewing, B. A., Osilla, K. C., & Perry, S. (2012) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2011.12.004 · Cited by 37 · see citing works

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Sorted by citations

Time for united action on depression: a Lancet–World Psychiatric Association Commission
Herrman, H., Patel, V., Kieling, C., Berk, M., Buchweitz, C., Cuijpers, P., Furukawa, T. A., Kessler, R. C., Kohrt, B. A., Maj, M., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(21)02141-3 · Cited by 1,104 · see citing works
Self-citation
Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications
Li, Z., Ruan, M., Chen, J., & Fang, Y. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00638-3 · Cited by 352 · see citing works
“2017 [143] 2,148 MDD patients and 7,957 healthy controls sMRI Cortical thickness and surface region Metaanalysis Gray matter of orbital prefrontal lobe, anterior cingulate gyrus, posterior cingulate gyrus, insular lobe, and temporal lobe in adult MDD patients was thinner than that in the control group.”
Background
Four decades of outcome research on psychotherapies for adult depression: an overview of a series of meta-analyses.
Cuijpers, P. (2017) · Canadian Psychology / Psychologie canadienne · doi:10.1037/cap0000096 · Cited by 231 · see citing works
Self-citation
Targets and Outcomes of Psychotherapies for Mental Disorders: An Overview
Cuijpers, P. (2019) · World Psychiatry · doi:10.1002/wps.20661 · Cited by 206 · see citing works
Effect of treatments for depression on quality of life: a meta-analysis
Hofmann, S. G., Curtiss, J., Carpenter, J. K., & Kind, S. (2017) · Cognitive Behaviour Therapy · doi:10.1080/16506073.2017.1304445 · Cited by 189 · see citing works
“A recent meta-analysis by Kolovos et al. (2016), for instance, found no difference between the effect of CBT and other forms of psychotherapy on QOL in depression, further underscoring the need for more comparative studies.”
Result
Major depressive disorder: Validated treatments and future challenges
Karrouri, R., Hammani, Z., Benjelloun, R., & Otheman, Y. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i31.9350 · Cited by 201 · see citing works
Psychological treatment of depression: A systematic overview of a 'Meta-Analytic Research Domain'
Cuijpers, P., Miguel, C., Harrer, M., Plessen, C. Y., Ciharova, M., Papola, D., Ebert, D., & Karyotaki, E. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.05.011 · Cited by 136 · see citing works
Self-citation
The effects of art therapy on anxiety, depression, and quality of life in adults with cancer: a systematic literature review
Bosman, J., Bood, Z., Scherer-Rath, M., Dörr, H., Christophe, N., Sprangers, M., & van Laarhoven, H. V. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05869-0 · Cited by 104 · see citing works
Psychological treatment of perinatal depression: a meta-analysis
Cuijpers, P., Franco, P., Ciharova, M., Miguel, C., Segre, L., Quero, S., & Karyotaki, E. (2023) · Psychological Medicine · doi:10.1017/s0033291721004529 · Cited by 103 · see citing works
Self-citation
Quality of life in patients with severe mental illness: a cross-sectional survey in an integrated outpatient health care model
Berghöfer, A., Martin, L., Hense, S., Weinmann, S., & Roll, S. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02470-0 · Cited by 87 · see citing works
The effect of treatment as usual on major depressive disorder: A meta-analysis
Kolovos, S., van Tulder, M. W., Cuijpers, P., Prigent, A., Chevreul, K., Riper, H., & Bosmans, J. E. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.12.013 · Cited by 79 · see citing works
“Previous studies have already established the effectiveness of treatments for depression in decreasing the depressive symptoms and improving the QoL of the patients (Cuijpers et al., 2008a; Kolovos et al., 2016).”
ResultSelf-citation
Cost effectiveness of guided internet-based interventions for depression in comparison with control conditions: an individual–participant data meta-analysis
Kolovos, S., van Dongen, J. M., Riper, H., Buntrock, C., Cuijpers, P., Ebert, D. D., Geraedts, A. S., Kenter, R. M., Nobis, S., Smith, A., et al. (2018) · Depression and Anxiety · doi:10.1002/da.22714 · Cited by 63 · see citing works
“We did not detect any inconsistencies in the data we received as compared to those reported in the primary studies (Buntrock et al., 2017; Geraedts et al., 2015; Kolovos et al., 2016; Nobis et al., 2013;Warmerdam et al., 2010).”
BackgroundResultInfluentialSelf-citation
Functioning and quality of life in patients with somatic symptom disorder: The association with comorbid depression
Liao, S., Ma, H.-M., Lin, Y., & Huang, W. (2019) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2019.02.004 · Cited by 68 · see citing works
Major Depressive Disorder: Existing Hypotheses about Pathophysiological Mechanisms and New Genetic Findings
Kamran, M., Bibi, F., Rehman, A. U., & Morris, D. W. (2022) · Genes · doi:10.3390/genes13040646 · Cited by 62 · see citing works
“Psychotherapy (cognitive behavior therapy, interpersonal therapy and online psychological interventions) has been reported to have an impact on relieving symptoms [18] and on improving patients’ overall quality of life [19].”
Background
Effectiveness of Prompt Mental Health Care, the Norwegian Version of Improving Access to Psychological Therapies: A Randomized Controlled Trial
Knapstad, M., Lervik, L. V., Sæther, S. M. M., Aarø, L. E., & Smith, O. R. F. (2019) · Psychotherapy and Psychosomatics · doi:10.1159/000504453 · Cited by 61 · see citing works
THE LONG-TERM EFFICACY OF ACUTE-PHASE PSYCHOTHERAPY FOR DEPRESSION: A META-ANALYSIS OF RANDOMIZED TRIALS
Karyotaki, E., Smit, Y., Beurs, D. P. D., Henningsen, K. H., Robays, J., Huibers, M. J. H., Weitz, E. S., & Cuijpers, P. J. (2016) · Depression and Anxiety · doi:10.1002/da.22491 · Cited by 56 · see citing works
Self-citation
Antidepressants and health-related quality of life (HRQoL) for patients with depression: Analysis of the medical expenditure panel survey from the United States
Almohammed, O. A., Alsalem, A., Almangour, A., Alotaibi, L. H., Yami, M. S. A., & Lai, L. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265928 · Cited by 55 · see citing works
Digital Interventions for Common Mental Disorders in Low- and Middle-Income Countries: A Systematic Review and Meta-Analysis
Karyotaki, E., Miguel, C., Panagiotopoulou, O. M., Harrer, M., Seward, N., Sijbrandij, M., Araya, R., Patel, V., & Cuijpers, P. (2023) · Cambridge Prisms Global Mental Health · doi:10.1017/gmh.2023.50 · Cited by 56 · see citing works
“This finding is in line with previous meta-analyses on psy-chotherapies that have found almost identical effects on quality of life ( g = 0.33) (Kolovos et al., 2016).”
ResultInfluentialSelf-citation
Patient experiences of psychological therapy for depression: a qualitative metasynthesis
McPherson, S., Wicks, C., & Tercelli, I. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02682-1 · Cited by 52 · see citing works
Symptoms of internet gaming disorder and depression in Chinese adolescents: A network analysis
Sit, H. F., Chang, C. I., Yuan, G. F., Chen, C., Cui, L., Elhai, J. D., & Hall, B. J. (2023) · Psychiatry Research · doi:10.1016/j.psychres.2023.115097 · Cited by 54 · see citing works
Efficacy of psychotherapy for bulimia nervosa and binge‐eating disorder on self‐esteem improvement: Meta‐analysis
Linardon, J., Kothe, E. J., & Fuller‐Tyszkiewicz, M. (2019) · European Eating Disorders Review · doi:10.1002/erv.2662 · Cited by 48 · see citing works
Psychotherapy for bulimia nervosa on symptoms of depression: A meta‐analysis of randomized controlled trials
Linardon, J., Wade, T. D., Garcia, X. D. L. P., & Brennan, L. (2017) · International Journal of Eating Disorders · doi:10.1002/eat.22763 · Cited by 43 · see citing works
Utility scores for different health states related to depression: individual participant data analysis
Kolovos, S., Bosmans, J. E., van Dongen, J. M., van Esveld, B., Magai, D. N., van Straten, A., Feltz-Cornelis, C. M. V. D., van Steenbergen-Weijenburg, K. M., Huijbregts, K. M. L., van Marwijk, H., et al. (2017) · Quality of Life Research · doi:10.1007/s11136-017-1536-2 · Cited by 40 · see citing works
“Improvements in HRQoL may take longer to occur and should, therefore, be monitored after remission of depressive symptoms as well [31, 33].”
BackgroundSelf-citation
Music Therapy for Depression Enhanced With Listening Homework and Slow Paced Breathing: A Randomised Controlled Trial
Erkkilä, J., Brabant, O., Hartmann, M., Mavrolampados, A., Ala-Ruona, E., Snape, N., Saarikallio, S. H., & Gold, C. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.613821 · Cited by 38 · see citing works
Advancements Exploring Major Depressive Disorder: Insights on Oxidative Stress, Serotonin Metabolism, BDNF, HPA Axis Dysfunction, and Pharmacotherapy Advances
Correia, A. S., & Vale, N. (2024) · International Journal of Translational Medicine · doi:10.3390/ijtm4010010 · Cited by 41 · see citing works
Healthy diet, depression and quality of life: A narrative review of biological mechanisms and primary prevention opportunities
Pano, O., Martínez‐Lapiscina, E. H., Sayón-Orea, C., Martínez‐González, M. Á., Martínez, J. A., & Sánchez‐Villegas, A. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i11.997 · Cited by 36 · see citing works
Psychological treatments are as effective as pharmacotherapies in the treatment of adult depression: a summary from Randomized Clinical Trials and neuroscience evidence
Cuijpers, P., & Gentili, C. (2017) · Research in Psychotherapy: Psychopathology, Process and Outcome · doi:10.4081/ripppo.2017.273 · Cited by 24 · see citing works
Self-citation
Efficacy of a Brief Blended Cognitive Behavioral Therapy Program for the Treatment of Depression and Anxiety in University Students: Uncontrolled Intervention Study
Atik, E., Stricker, J. H., Schückes, M., & Pittig, A. (2023) · JMIR Mental Health · doi:10.2196/44742 · Cited by 25 · see citing works
“This study comprised a broad set of outcome measures, covering symptoms of depression and anxiety, perceived functioning, well-being, satisfaction with the treatment program, and competencies [71-75].”
Background
When is it Effective to Focus on the Alliance? Analysis of a Within-Client Moderator
Zilcha‐Mano, S., Lipsitz‐Odess, I., & Errázuriz, P. (2017) · Cognitive Therapy and Research · doi:10.1007/s10608-017-9867-4 · Cited by 23 · see citing works
Quality of life and associated factors in patients with chronic Chagas disease
Santos‐Filho, J. C. L., Vieira, M. C., Xavier, I. G. G., Maciel, E. R., Rodrigues, L. F., Curvo, E. O., Pereira, I. M., Quintana, M. D. S. B., da Silva, G. M. S., Veloso, H. H., et al. (2018) · Tropical Medicine & International Health · doi:10.1111/tmi.13144 · Cited by 23 · see citing works
“an important confounding factor for QoL in the general population [38] and in individuals with CD [3].”
Background
Supported Internet-Delivered Cognitive Behavior Treatment for Adults with Severe Depressive Symptoms: A Secondary Analysis
Richards, D., Duffy, D. J., Burke, J., Anderson, M., Connell, S., & Timulák, L. (2018) · JMIR Mental Health · doi:10.2196/10204 · Cited by 23 · see citing works
“Increasingly in depression research, the need to include data points relevant to quality of life and functional impairment has been recognized [51,52].”
Breathing-focused Yoga as Augmentation for Unipolar and Bipolar Depression: A Randomized Controlled Trial: Le yoga axé sur la respiration comme traitement d’appoint pour la dépression unipolaire et bipolaire: Un essai randomisé contrôlé
Ravindran, A. V., McKay, M. S., Silva, T. D., Tindall, C., Garfinkel, T., Paric, A., & Ravindran, L. (2021) · The Canadian Journal of Psychiatry · doi:10.1177/0706743720940535 · Cited by 22 · see citing works
“, cognitive behavioral therapy and psychoeducation).(5,6) However, the limitations of these first-line treatments are wellrecognized as patients often discontinue medications due to adverse side effects.”
Background
Antidepressants and quality of life in patients with major depressive disorder – Systematic review and meta‐analysis of double‐blind, placebo‐controlled RCTs
Wiesinger, T., Kremer, S., Bschor, T., & Baethge, C. (2023) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13541 · Cited by 23 · see citing works
“Similar to our findings, however, Kolovos et al.79 reported stronger effects among patients with primary depression versus patients with comorbidity, and they also found better effects on depression than on QoL.”
Background
Effect of an Intervention for Obesity and Depression on Patient-Centered Outcomes: An RCT
Rosas, L. G., Azar, K. M. J., Lv, N., Xiao, L., Goldhaber‐Fiebert, J. D., Snowden, M. B., Venditti, E. M., Lewis, M. A., Goldstein‐Piekarski, A. N., & Ma, J. (2020) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2019.11.005 · Cited by 22 · see citing works
Mediation of depressive symptoms in the association between blood urea nitrogen to creatinine ratio and cognition among middle-aged and elderly adults: evidence from a national longitudinal cohort study
Feng, Q., Yang, S., Ye, S., Wan, C., Wang, H., & You, J. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05941-7 · Cited by 19 · see citing works
“The impact of depression on individuals extends to their quality of life and social engagement and can even lead to self-harm and suicidal tendencies [12, 13].”
Background
Transcranial focused ultrasound targeting the default mode network for the treatment of depression
Schachtner, J. N., Dahill-Fuchel, J. F., Ehrmann, K., Bawiec, C. R., Hollender, P. J., Ornellas, S. B., Konecky, S. D., Achrol, A. S., & Allen, J. J. B. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1451828 · Cited by 20 · see citing works
Psychotherapy for comorbid depression and somatic disorders: a systematic review and meta-analysis
Miguel, C., Karyotaki, E., Čihařová, M., Cristea, I. A., Penninx, B. W. J. H., & Cuijpers, P. J. (2021) · Psychological Medicine · doi:10.1017/s0033291721004414 · Cited by 23 · see citing works
“Following procedures from comparable research (Kolovos et al., 2016), we estimated the effects for Overall QoL , and also separately for Physical and Mental QoL subcomponents.”
InfluentialSelf-citation
Psychological Status, Compliance, Serum Brain-Derived Neurotrophic Factor, and Nerve Growth Factor Levels of Patients with Depression after Augmented Mindfulness-Based Cognitive Therapy
Guo, H., Ren, Y., Huang, B., Wang, J., Yang, X., & Wang, Y. (2022) · Genetics Research · doi:10.1155/2022/1097982 · Cited by 19 · see citing works
“Patients with depression will show a series of psychosocial function impairments (such as work, life, and interpersonal communication), accompanied by a significant decline in the quality of life [21].”
Background
Quality of life among people living with mental illness and predictors in Africa: a systematic review and meta-analysis
Alemu, W. G., Due, C., Muir‐Cochrane, E., Mwanri, L., Azale, T., & Ziersch, A. M. (2023) · Quality of Life Research · doi:10.1007/s11136-023-03525-8 · Cited by 20 · see citing works
Venlafaxine protects against chronic stress-related behaviors in mice by activating the mTORC1 signaling cascade
Wang, J., Wang, Y., Gao, T., Liu, L., Wang, Y., Guan, W., Chen, T., Zhao, J., Zhang, Y., & Jiang, B. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.096 · Cited by 17 · see citing works
Challenging the promotion of antidepressants for nonsevere depression
Braillon, A., Lexchin, J., Noble, J. H., Menkes, D., M'sahli, L., Fierlbeck, K., Blumsohn, A., & Naudet, F. (2019) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13010 · Cited by 16 · see citing works
“These treatments, robustly evidence-based in the real-life setting and over the long term (19, 20), are often preferred by patients(21) and known to improve self-esteem, agency, and social functioning (22).”
Background
Health-related quality of life is impaired in people with autoimmune hepatitis: Results of a multicentre cross-sectional study within the European Reference Network
Snijders, R. J. A. L. M., Janik, M. K., Mund, M., Uhlenbusch, N., Raszeja‐Wyszomirska, J., Gerussi, A., Bolis, F., Cristoferi, L., Invernizzi, P., Kovats, P. J., et al. (2025) · Hepatology · doi:10.1097/hep.0000000000001271 · Cited by 16 · see citing works
A Narrative Review on REM Sleep Deprivation: A Promising Non-Pharmaceutical Alternative for Treating Endogenous Depression
Crișan, C. A., Milhem, Z., Stretea, R., Țața, I.-M., Cherecheș, R. M., & Micluția, I. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13020306 · Cited by 17 · see citing works
Measuring success in the treatment of depression: what is most important to patients?
Cuijpers, P. J. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1712807 · Cited by 16 · see citing works
Self-citation
Effectiveness of a structured intervention to make routine clinical meetings therapeutically effective (DIALOG+) for patients with depressive and anxiety disorders in Bosnia and Herzegovina: A cluster randomised controlled trial
Murga, S. S., Janković, S., Muhić, M., Sikira, H., Burn, E., Priebe, S., & Kulenović, A. D. (2021) · Psychiatry Research Communications · doi:10.1016/j.psycom.2021.100010 · Cited by 15 · see citing works
Psychological interventions for preventing relapse in individuals with partial remission of depression: a systematic review and individual participant data meta-analysis
Gülpen, J., Breedvelt, J., van Dis, E. A. M., Geurtsen, G. J., Warren, F. C., Heeringen, C. V., Hitchcock, C., Holländare, F., Huijbers, M. J., Jarrett, R. B., et al. (2025) · Psychological Medicine · doi:10.1017/s0033291725000157 · Cited by 15 · see citing works
“No differences were observed for quality of life, contrasting positive results previously reported (Kolovos et al., 2016; Segal et al., 2020).”
One-year follow-up of the effectiveness and mediators of cognitive behavioural therapy among adults with attention-deficit/hyperactivity disorder: secondary outcomes of a randomised controlled trial
Pan, M., Dong, M., Zhang, S., Liu, L., Li, H., Wang, Y., & Qian, Q. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05673-8 · Cited by 16 · see citing works
“The decrease in depression was related to increases in QoL [65], and changes in mental health-related QoL over the course of treatment were accounted for by changes in depression [63].”
Background
Relationship between treatment and period of absence among employees on sick leave due to mental disease
Muramatsu, K., Fujino, Y., Kubo, T., Otani, M., & Matsuda, S. (2018) · Industrial Health · doi:10.2486/indhealth.2018-0055 · Cited by 13 · see citing works
Facilitating access to iCBT: a randomized controlled trial assessing a translated version of an empirically validated program using a minimally monitored delivery model
Robichaud, M., Talbot, F., Titov, N., Dear, B. F., Hadjistavropoulos, H. D., Hadjistavropoulos, T., & Jbilou, J. (2019) · Behavioural and Cognitive Psychotherapy · doi:10.1017/s135246581900047x · Cited by 13 · see citing works
“Recent findings suggest that higherorder constructs such as quality of life or life satisfaction may take more time to change with iCBT than with face-to-face CBT (Enrique et al., 2018; Hofmann et al., 2014; Kolovos et al., 2016).”
Background
Quality of life after response to acute-phase cognitive therapy for recurrent depression
Vittengl, J. R., Jha, M. K., Minhajuddin, A., Thase, M. E., & Jarrett, R. B. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.09.059 · Cited by 12 · see citing works
“Other reviews have reached broadly similar conclusions (IsHak, Ha, Kapitanski, et al., 2011; Kolovos et al., 2016; Sheehan et al., 2017).”
Result
Tratamiento psicológico de los trastornos emocionales en atención primaria: fundamentos teóricos y empíricos del estudio PsicAP
Cordero‐Andrés, P., González‐Blanch, C., Umaran‐Alfageme, O., Muñoz‐Navarro, R., Ruiz‐Rodríguez, P., Medrano, L. A., Hernández-de-Hita, F., Pérez-Poo, T., & Vindel, A. C. (2017) · Ansiedad y Estrés · doi:10.1016/j.anyes.2017.10.004 · Cited by 12 · see citing works
Psychotherapie depressiver Störungen
Meister, R., Jansen, A., Berger, T., Baumeister, H., Bschor, T., Harfst, T., Hautzinger, M., Kriston, L., Kühner, C., Schauenburg, H., et al. (2018) · Der Nervenarzt · doi:10.1007/s00115-018-0484-6 · Cited by 12 · see citing works
“Die Veränderungen in der Lebensqualität konnten dabei nicht gänzlich durch die Reduktion depressiver Symptome erklärt werden [8].”
Background
The nature of the relation between mental well-being and ill-being
Tamnes, C. K., Bekkhus, M., Eilertsen, M., Nes, R. B., Prydz, M. B., Ystrøm, E., Aksnes, E. R., Andersen, S. N., Ask, H., Ayorech, Z., et al. (2025) · Nature Human Behaviour · doi:10.1038/s41562-025-02319-x · Cited by 12 · see citing works
“A meta-analysis on psychotherapy for depression showed positive effects on different outcomes, with larger reductions in depressive symptoms ( g = 0.60) than increases in indicators of well-being such as quality of life ( g = 0.33) 85 .”
Influential
Evaluation of the internet-based intervention “Selfapy” in participants with unipolar depression and the impact on quality of life: a randomized, parallel group study
Schefft, C., Krämer, R., Haaf, R., Jedeck, D., Schumacher, A., & Köhler, S. (2024) · Quality of Life Research · doi:10.1007/s11136-024-03606-2 · Cited by 11 · see citing works
Quality of Life Impacts of Bright Light Treatment, Fluoxetine, and the Combination in Patients with Nonseasonal Major Depressive Disorder: A Randomized Clinical Trial
Morton, E. E., Michalak, E. E., LEVITT, A. J., Levitan, R. D., Cheung, A., Morehouse, R. L., Ramasubbu, R., Yatham, L. N., Tam, E. M., & Lam, R. W. M. (2020) · The Canadian Journal of Psychiatry · doi:10.1177/0706743720936470 · Cited by 11 · see citing works
“Further, a meta-analysis of the impact of psychotherapy showing that across studies, improvements in QoL were not fully explained by reduction in depressive symptom severity.(34) It is therefore important for trials of light therapy in nonseasonal MDD to explore additional predictors of change in QoL to better target…”
Background
Determinants of quality of life improvements in anxiety and depressive disorders—A longitudinal study of inpatient psychotherapy
Freidl, M., Wegerer, M., Litvan, Z., König, D., Alexandrowicz, R. W., Millinger, F. P., & Gruber, M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.937194 · Cited by 10 · see citing works
Psychological treatments for persistent depression: A systematic review and meta-analysis of quality of life and functioning outcomes.
McPherson, S., & Senra, H. (2022) · Psychotherapy · doi:10.1037/pst0000448 · Cited by 10 · see citing works
“A previous meta-analysis of 44 trials of psychotherapy for depression reporting quality-of-life data included waitlist or placebo control studies of psychotherapy but excluded studies likely to fall into the category of persistent depression (Kolovos et al., 2016).”
BackgroundMethod
Long-term effectiveness of two models of brief psychotherapy for depression: A three-year follow-up randomized clinical trial
dos Santos, É. N., Molina, M. L., Mondin, T. C., Cardoso, T. D. A., da Silva, R. A., Souza, L. D. D. M., & Jansen, K. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.112804 · Cited by 9 · see citing works
Ego-defense mechanisms and brief psychotherapies for the management of major depressive disorder in adults: A longitudinal and quasi-experimental study
Machado, R. D. S., Vieira, I. S., Scaini, C. R., Molina, M. L., Barbosa, L. P., da Silva, G. D. G., Ores, L. D. C., Souza, L. D. D. M., Jansen, K., & da Silva, R. A. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.02.141 · Cited by 9 · see citing works
What does “Staying well” After depression mean? Chronic low grade symptomatology after treatment for depression is common
Strege, M. V., Richey, J. A., & Siegle, G. J. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.08.075 · Cited by 8 · see citing works
The Long-Term and Mediating Effects of Mindfulness Integrated with Body-Mind-Spirit Group Therapy on Depressive Symptoms and Quality of Life Among Non-small Cell Lung Cancer Patients
Hsiao, F., Lin, Z., Huang, F., Lai, Y., Chen, Y., Shih, J.-Y., Ho, C., Yu, C., & Hsieh, C. (2021) · Mindfulness · doi:10.1007/s12671-021-01793-4 · Cited by 8 · see citing works
“A meta-analysis demonstrated psychotherapy for depression is related to further QOL improvements (Kolovos et al., 2016).”
Background
Efficacy of internet-based cognitive behavioral and interpersonal treatment for depression in Arabic speaking countries: A randomized controlled trial
El‐Haj‐Mohamad, R., Stein, J., Stammel, N., Nesterko, Y., Wagner, B., Böttche, M., & Knaevelsrud, C. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.080 · Cited by 8 · see citing works
Discrepancies between self- and observer-rated depression severities in patients with major depressive disorder associated with frequent emotion-oriented coping responses and hopelessness
Tsujimoto, E., Tsujii, N., Mikawa, W., Ono, H., & Shirakawa, O. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s175973 · Cited by 8 · see citing works
“37,38 Our results also confirmed that patients with MDD rarely use task-oriented coping and emphasized the frequent use of emotion-oriented coping, at least in patients with a rating discrepancy.”
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Authors: Kolovos, S., Kleiboer, A., & Cuijpers, P.
Affiliations: Leuphana University of Lüneburg (DE)
Utrecht University (NL)
Corresponding author: Kolovos, Spyros
ORCID: Kolovos, Spyros
Kleiboer, Annet
Cuijpers, Pim
Venue: British Journal of Psychiatry
Publisher: Royal College of Psychiatrists
Published: 2016-12
Volume: 209
Issue: 6
Pages: 460-468
ISSN: 0007-1250 (ISSN-L)
1472-1465
DOI: 10.1192/bjp.bp.115.175059
OpenAlex: W2510438371
Cited by: 153
References: 85
Citations by year: 2026: 9 · 2025: 21 · 2024: 19 · 2023: 25 · 2022: 19 · 2021: 15 · 2020: 12 · 2019: 11 · 2018: 10 · 2017: 10 · 2016: 2
FWCI: 1.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 397 d)
Locations: The British Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Multilingual Matters (Channel View Publications) (submittedVersion, other-oa)
VU Research Portal (submittedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords: psychotherapy, depression, quality of life, mental health, physical health, depression severity, treatment effectiveness
MeSH terms: Depression, Depressive Disorder, Humans, Psychotherapy, Quality of Life, Outcome Assessment, Health Care

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Effect of psychotherapy for depression on quality of life: meta-analysis

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