The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Oxytocin and Reduction of Social Threat Hypersensitivity in Women With Borderline Personality Disorder
Abstract
OBJECTIVE: Patients with borderline personality disorder are characterized by emotional hyperarousal with increased stress levels, anger proneness, and hostile, impulsive behaviors. They tend to ascribe anger to ambiguous facial expressions and exhibit enhanced and prolonged reactions in response to threatening social cues, associated with enhanced and prolonged amygdala responses. Because the intranasal administration of the neuropeptide oxytocin has been shown to improve facial recognition and to shift attention away from negative social information, the authors investigated whether borderline patients would benefit from oxytocin administration. METHOD: In a randomized placebo-controlled double-blind group design, 40 nonmedicated, adult female patients with a current DSM-IV diagnosis of borderline personality disorder (two patients were excluded based on hormonal analyses) and 41 healthy women, matched on age, education, and IQ, took part in an emotion classification task 45 minutes after intranasal administration of 26 IU of oxytocin or placebo. Dependent variables were latencies and number or initial reflexive eye movements measured by eye tracking, manual response latencies, and blood-oxygen-level-dependent responses of the amygdala to angry and fearful compared with happy facial expressions. RESULTS: Borderline patients exhibited more and faster initial fixation changes to the eyes of angry faces combined with increased amygdala activation in response to angry faces compared with the control group. These abnormal behavioral and neural patterns were normalized after oxytocin administration. CONCLUSIONS: Borderline patients exhibit a hypersensitivity to social threat in early, reflexive stages of information processing. Oxytocin may decrease social threat hypersensitivity and thus reduce anger and aggressive behavior in borderline personality disorder or other psychiatric disorders with enhanced threat-driven reactive aggression.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition, functional MRI (fMRI) studies have shown that OT administration dampened amygdala reactivity toward emotional stimuli in healthy males (Kirsch et al, 2005), males with generalized social anxiety disorder (GSAD; Labuschagne et al, 2010) and females with borderline personality disorder (BPD; Bertsch et al, 2013), although findings for females have been mixed (Domes et al, 2010).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Bertsch et al, 2013
In the citing paper
“We cannot exclude the possibility that this may have influenced our results, although similar effects of OT on amygdala reactivity previously were found in females tested in the follicular phase (Domes et al, 2010) and luteal phase (Bertsch et al, 2013).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Bertsch et al, 2013
Citations
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
Self-citationOxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,581
Jeurgen, K., Assheuer, J., & Paxinos, G. (1997) · Medical Entomology and Zoology · Cited by 1,403
Borderline personality disorder
Lieb, K., Zanarini, M. C., Schmahl, C., Linehan, M. M., & Bohus, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16770-6 · Cited by 1,369
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298
Self-citationLoranger, A. W. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030051005 · Cited by 1,069
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941
What does the amygdala contribute to social cognition
Adolphs, R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05445.x · Cited by 836
Transmitting and Decoding Facial Expressions
Smith, M. L., Cottrell, G. W., Gosselin, F., & Schyns, P. G. (2005) · Psychological Science · doi:10.1111/j.0956-7976.2005.00801.x · Cited by 776
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774
Self-citationZanarini, M. C., Frankenburg, F. R., Hennen, J. A., Reich, D. B., & Silk, K. R. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2108 · Cited by 545
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521
Self-citationEvidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study
Herpertz, S. C., Dietrich, T., Wenning, B., Krings, T., Erberich, S. G., Willmes, K., Thron, A. K., & Saß, H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01075-7 · Cited by 503
Self-citationDifferent amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487
Self-citationOxytocin can hinder trust and cooperation in borderline personality disorder
Bartz, J., Simeon, D., Hamilton, H., Kim, S., Crystal, S., Braun, A., Vicens, V., & Hollander, E. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq085 · Cited by 452
Psychometric Properties of the Borderline Symptom List (BSL)
Bohus, M., Limberger, M. F., Frank, U., Chapman, A. L., Kühler, T., & Stieglitz, R. (2007) · Psychopathology · doi:10.1159/000098493 · Cited by 320
Minzenberg, M., Fan, J., New, A. S., Tang, C. Y., & Siever, L. J. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.03.006 · Cited by 314
Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder
Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., & Herpertz, S. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.007 · Cited by 255
Self-citationRecognition of Facial Affect in Borderline Personality Disorder
Domes, G., Czieschnek, D., Weidler, F., Berger, C., Fast, K., & Herpertz, S. C. (2008) · Journal of Personality Disorders · doi:10.1521/pedi.2008.22.2.135 · Cited by 254
Self-citationFacial emotion recognition in borderline personality disorder
Daros, A. R., Zakzanis, K. K., & Ruocco, A. C. (2012) · Psychological Medicine · doi:10.1017/s0033291712002607 · Cited by 251
Lischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.015 · Cited by 221
Atypical Reflexive Gaze Patterns on Emotional Faces in Autism Spectrum Disorders
Kliemann, D., Dziobek, I., Hatri, A., Steimke, R., & Heekeren, H. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0688-10.2010 · Cited by 212
Interpersonal evaluation bias in borderline personality disorder
Barnow, S., Stopsack, M., Grabe, H. J., Meinke, C., Spitzer, C., Kronmüller, K., & Sieswerda, S. (2009) · Behaviour Research and Therapy · doi:10.1016/j.brat.2009.02.003 · Cited by 203
Amygdala Activation Predicts Gaze toward Fearful Eyes
Gamer, M., & Buchel, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1883-09.2009 · Cited by 203
Self-citationOxytocin increases amygdala reactivity to threatening scenes in females
Lischke, A., Gamer, M., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.011 · Cited by 194
Self-citationReduced plasma oxytocin levels in female patients with borderline personality disorder
Bertsch, K., Schmidinger, I., Neumann, I. D., & Herpertz, S. C. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.11.013 · Cited by 189
Self-citationPotentiated amygdala response to repeated emotional pictures in borderline personality disorder
Hazlett, E. A., Zhang, J., New, A. S., Zelmanova, Y., Goldstein, K. E., Haznedar, M. M., Meyerson, D., Goodman, M., Siever, L. J., & Chu, K.-W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.027 · Cited by 186
The role of the amygdala in atypical gaze on emotional faces in autism spectrum disorders
Kliemann, D., Dziobek, I., Hatri, A., Baudewig, J., & Heekeren, H. R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5294-11.2012 · Cited by 183
Oxytocin increases recognition of masked emotional faces
Schulze, L., Lischke, A., Greif, J., Herpertz, S. C., Heinrichs, M., & Domes, G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.011 · Cited by 180
Self-citationSimeon, D., Bartz, J. A., Hamilton, H., Crystal, S., Braun, A. R., Ketay, S., & Hollander, E. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.013 · Cited by 167
Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions
Leknes, S., Wessberg, J., Ellingsen, D.-M., Chelnokova, O., Olausson, H., & Laeng, B. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss062 · Cited by 151
Intranasal oxytocin increases covert attention to positive social cues
Domes, G., Sibold, M., Schulze, L., Lischke, A., Herpertz, S. C., & Heinrichs, M. (2013) · Psychological Medicine · doi:10.1017/s0033291712002565 · Cited by 130
Self-citationEvaluations of Others by Borderline Patients
Arntz, A. R., & Veen, G. C. D.-D. (2001) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200108000-00004 · Cited by 116
Ellenbogen, M. A., Linnen, A., Grumet, R., Cardoso, C., & Joober, R. (2012) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01278.x · Cited by 82
von Ceumern-Lindenstjerna, I.-A., Brunner, R. M., Parzer, P., Mundt, C., Fiedler, P. A., & Resch, F. (2009) · Psychopathology · doi:10.1159/000255960 · Cited by 54
Initial Orienting to Emotional Faces in Female Adolescents with Borderline Personality Disorder
von Ceumern-Lindenstjerna, I.-A., Brunner, R. M., Parzer, P., Mundt, C., Fiedler, P. A., & Resch, F. (2010) · Psychopathology · doi:10.1159/000274176 · Cited by 54
Hirosawa, T., Kikuchi, M., Higashida, H., Okumura, E., Ueno, S., Shitamichi, K., Yoshimura, Y., Munesue, T., Tsubokawa, T., Haruta, Y., et al. (2012) · Scientific Reports · doi:10.1038/srep00384 · Cited by 25
Flagged first, then by citations
Research works printed but not linked: 4
- Leknes S, Soc Cogn Affect Neurosci
- Domes G, 2012, Psychol Med, 12, 1
- Bartz JA, 2011, Trends Cogn Sci, 15, 301
- Daros AR, 2012, Psychol Med, 13, 1
Cited by
Sorted by citations
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
Psychological therapies for people with borderline personality disorder.
Stoffers-Winterling, J. M., Völlm, B. A., Rücker, G., Timmer, A., Huband, N., & Lieb, K. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005652.pub2 · Cited by 895
Borderline personality disorder
Gunderson, J. G., Herpertz, S. C., Skodol, A. E., Torgersen, S. O., & Zanarini, M. C. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.29 · Cited by 511
Self-citationPsychological therapies for people with borderline personality disorder
Storebø, O. J., Stoffers-Winterling, J. M., Völlm, B. A., Kongerslev, M. T., Mattivi, J. T., Jørgensen, M. S., Faltinsen, E., Todorovac, A., Sales, C. P., Callesen, H. E., et al. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012955.pub2 · Cited by 450
Treatment of personality disorder.
Bateman, A., Gunderson, J., & Mulder, R. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61394-5 · Cited by 257
Metadata
- Authors
- Bertsch, K., Gamer, M., Schmidt, B., Schmidinger, I., Walther, S., Kästel, T., Schnell, K., Büchel, C., Domes, G., & Herpertz, S. C.
- Affiliations
- University of Freiburg (DE)
- Venue
- American Journal of Psychiatry
- Published
- 2013-10
- Volume
- 170
- Issue
- 10
- Pages
- 1169-1177
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2128455436
- Semantic Scholar
- 4aecba81946119f855d958c33ed5143911d98810
- Cited by
- 214
- References
- 42
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 11 · 2021: 18 · 2020: 18 · 2019: 19 · 2018: 29 · 2017: 25 · 2016: 12 · 2015: 26 · 2014: 17 · 2013: 5
- FWCI
- 29.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- oxytocin, borderline personality disorder, amygdala activation, angry facial expressions, emotion classification, eye movements, intranasal administration, reactive aggression, women, facial expression recognition
- MeSH terms
- Administration, Intranasal, Adolescent, Adult, Aggression, Amygdala, Anger, Arousal, Borderline Personality Disorder, Double-Blind Method, Emotions, Facial Expression, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Oxytocin, Pattern Recognition, Visual, Reaction Time, Social Perception, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
