Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder
Abstract
Background Autism spectrum disorder (ASD) is associated with altered face processing and decreased activity in brain regions involved in face processing. The neuropeptide oxytocin has been shown to promote face processing and modulate brain activity in healthy adults. The present study examined the effects of oxytocin on the neural basis of face processing in adults with Asperger syndrome (AS).Methods A group of 14 individuals with AS and a group of 14 neurotypical control participants performed a face-matching and a house-matching task during functional magnetic resonance imaging. The effects of a single dose of 24 IU intranasally administered oxytocin were tested in a randomized, placebo-controlled, within-subject, cross-over design.Results Under placebo, the AS group showed decreased activity in the right amygdala, fusiform gyrus, and inferior occipital gyrus compared with the control group during face processing. After oxytocin treatment, right amygdala activity to facial stimuli increased in the AS group.Conclusions These findings indicate that oxytocin increases the saliency of social stimuli and in ASD and suggest that oxytocin might promote face processing and eye contact in individuals with ASD as prerequisites for neurotypical social interaction.
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The intranasal route of administration has been validated for both oxytocin and naloxone in previous human studies.
“This route of administration has been validated for both OT (6, 71) and NAL (72–74) in previous human studies”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [71]
Oxytocin administration has been shown to increase amygdala activation during face processing specifically in adults with ASD, accompanied by improvements in emotion recognition.
“Similarly, oxytocin administration has been shown to increase amygdala activation during face processing specifically in adults with ASD, accompanied by improvements in emotion recognition51,52.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [51]
Previous studies showing oxytocin effects on emotion recognition, empathy, or face processing in adults with ASD had an average sample size of 21.5 participants.
“Moreover, previous studies showing oxytocin effects on emotion recognition, empathy, or face processing in adults with ASD had an average sample size of 21.5 participants48,50,51,86–88.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [51]
Most randomized clinical trials have found some oxytocin effects on ASD symptoms and brain function, but not all trials have reported effects.
“While most randomized clinical trials have found some oxytocin effects on ASD symptoms33,50–52 and brain function50–52,80,81, not all trials have reported effects82.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [51]
Oxytocin administration leads to an increase in amygdala activation during the processing of faces in men with ASD.
“While this finding fits with previous reports that oxytocin administration leads to an increase in amygdala activation during the processing of faces in men with ASD51,52, these findings are not consistent with studies that examine neural responses to aversive stimuli in men without an ASD diagnosis.”
From Randomized clinical trial shows no substantial modulation of empathy-related neural activation by intranasal oxytocin in autism (2021) · cites this paper as [51]
Cites
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065 · see citing works
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520 · see citing works
Wechsler Abbreviated Scale of Intelligence
Dumont, R., Willis, J. O., Veizel, K., & Zibulsky, J. (2014) · Wiley eBooks · doi:10.1002/9781118660584.ese2519 · Cited by 5,547 · see citing works
Wechsler Abbreviated Scale of Intelligence
Wechsler, D. (1999) · PsycTESTS Dataset · doi:10.1037/t15170-000 · Cited by 4,681 · see citing works
Baron‐Cohen, S., Wheelwright, S., Hill, J., Raste, Y., & Plumb, I. (2001) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00715 · Cited by 4,555 · cited 1× · see citing works
“Studies with adults have demonstrated diminished eye gaze (8–10) and impaired facial emotion recognition (11,12) in persons with ASD.”
BackgroundBaron‐Cohen, S., Wheelwright, S. J., Hill, J., Raste, Y., & Plumb, I. (2001) · PubMed · Cited by 4,313 · see citing works
Oxytocin increases trust in humans
Kosfeld, M., Heinrichs, M., Zak, P. J., Fischbacher, U., & Fehr, E. (2005) · Nature · doi:10.1038/nature03701 · Cited by 3,690 · see citing works
Self-citationPragmatics of measuring recognition memory: Applications to dementia and amnesia.
Snodgrass, J. G., & Corwin, J. (1988) · Journal of Experimental Psychology General · doi:10.1037//0096-3445.117.1.34 · Cited by 3,093 · see citing works
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · see citing works
Pragmatics of measuring recognition memory: Applications to dementia and amnesia.
Snodgrass, J. G., & Corwin, J. (1988) · Journal of Experimental Psychology General · doi:10.1037/0096-3445.117.1.34 · Cited by 2,527 · see citing works
Klin, A., Jones, W., Schultz, R., Volkmar, F., & Cohen, D. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.9.809 · Cited by 2,120 · see citing works
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Self-citationPessoa, L., & Adolphs, R. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2920 · Cited by 1,794 · see citing works
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Self-citationOxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
Gaze fixation and the neural circuitry of face processing in autism
Dalton, K. M., Nacewicz, B. M., Johnstone, T., Schaefer, H. S., Gernsbacher, M. A., Goldsmith, H. H., Alexander, A. L., & Davidson, R. J. (2005) · Nature Neuroscience · doi:10.1038/nn1421 · Cited by 1,543 · see citing works
Newborns' preferential tracking of face-like stimuli and its subsequent decline
Johnson, M. H., Dziurawiec, S., Ellis, H. D., & Morton, J. (1991) · Cognition · doi:10.1016/0010-0277(91)90045-6 · Cited by 1,463 · see citing works
Eye contact detection in humans from birth
Farroni, T., Csibra, G., Simion, F., & Johnson, M. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152159999 · Cited by 1,442 · see citing works
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · see citing works
Social intelligence in the normal and autistic brain: An fMRI study
Baron‐Cohen, S., Ring, H. A., Wheelwright, S., Bullmore, E. T., Brammer, M. J., Simmons, A., & Williams, S. C. R. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00621.x · Cited by 1,320 · see citing works
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
Self-citationOxytocin shapes the neural circuitry of trust and trust adaptation in humans
Baumgartner, T., Heinrichs, M., Vonlanthen, A., Fischbacher, U., & Fehr, E. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.009 · Cited by 1,258 · see citing works
Self-citationVisual scanning of faces in autism
Pelphrey, K. A., Sasson, N. J., Reznick, J. S., Paul, G., Goldman, B. D., & Piven, J. (2002) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1016374617369 · Cited by 1,187 · see citing works
Visual Following and Pattern Discrimination of Face-like Stimuli by Newborn Infants
Goren, C. C., Sarty, M., & Wu, P. Y. K. (1975) · Pediatrics · doi:10.1542/peds.56.4.544 · Cited by 1,158 · see citing works
Schultz, R. T. (2005) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.12.012 · Cited by 1,071 · see citing works
Social Intelligence in the Normal and Autistic Brain: An fMRI Study
Baron‐Cohen, S., RING, H. A., Wheelwright, S. J., Bullmore, E. T., Brammer, M. J., Simmons, A., & Williams, S. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0028 · Cited by 1,044 · see citing works
A Prospective Study of the Emergence of Early Behavioral Signs of Autism
Ozonoff, S., Iosif, A.-M., Baguio, F., Cook, I. C., Hill, M. M., Hutman, T., Rogers, S. J., Rozga, A., Sangha, S., Sigman, M., et al. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2009.11.009 · Cited by 1,011 · see citing works
Schultz, R. T., Gauthier, I., Klin, A., Fulbright, R. K., Anderson, A. W., Volkmar, F., Skudlarski, P., Lacadie, C., Cohen, D. J., & Gore, J. C. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.4.331 · Cited by 1,000 · see citing works
Johnson, M. H. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1766 · Cited by 969 · see citing works
Intranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.
Guastella, A. J., Einfeld, S. L., Gray, K. M., Rinehart, N. J., Tonge, B. J., Lambert, T. J., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.020 · Cited by 962 · see citing works
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941 · see citing works
Face processing occurs outside the fusiform ‘face area’ in autism: evidence from functional MRI
Pierce, K. (2001) · Brain · doi:10.1093/brain/124.10.2059 · Cited by 898 · see citing works
What does the amygdala contribute to social cognition
Adolphs, R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05445.x · Cited by 836 · see citing works
Oxytocin increases gaze to the eye region of human faces
Guastella, A. J., Mitchell, P. B., & Dadds, M. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.06.026 · Cited by 798 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · cited 1× · see citing works
“After oxytocin treatment, NT controls showed decreased activity in the right anterior amygdala, which replicates the results of previous studies in healthy men, which showed attenuated amygdala activity after oxytocin treatment in response to emotional facial expressions (32,33,61).”
ResultSelf-citationOxytocin Increases Retention of Social Cognition in Autism
Hollander, E., Bartz, J., Chaplin, W., Phillips, A., Sumner, J., Soorya, L., Anagnostou, E., & Wasserman, S. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.030 · Cited by 693 · see citing works
Wilensky, A. E., Schafe, G. E., Kristensen, M. P., & LeDoux, J. E. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4316-06.2006 · Cited by 533 · see citing works
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521 · see citing works
Self-citationDifferent amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487 · cited 1× · see citing works
“Initial studies in healthy humans show that oxytocin, a nine– amino acid neuropeptide, reduces anxiety and endocrine responses to social stress (18,19), modulates social memory (20–22), promotes trust in social interactions (23), improves the ability to infer the emotional or mental states of others from subtle facial…”
BackgroundThe role of the fusiform face area in social cognition: implications for the pathobiology of autism
Schultz, R. T., Grelotti, D. J., Klin, A., Kleinman, J., Van der Gaag, C., Marois, R., & Skudlarski, P. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1208 · Cited by 469 · see citing works
Neural basis of eye gaze processing deficits in autism
Pelphrey, K. A., Morris, J. P., & McCarthy, G. (2005) · Brain · doi:10.1093/brain/awh404 · Cited by 446 · see citing works
The brain response to personally familiar faces in autism: Findings of fusiform activity and beyond
Pierce, K. (2004) · Brain · doi:10.1093/brain/awh289 · Cited by 432 · see citing works
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432 · see citing works
Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism
Jacob, S., Brune, C. W., Carter, C. S., Leventhal, B. L., Lord, C., & Cook, E. H. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.02.001 · Cited by 425 · see citing works
Is there an innate gaze module? Evidence from human neonates
Bátki, A., Baron‐Cohen, S., Wheelwright, S. J., Connellan, J., & Ahluwalia, J. S. (2000) · Infant Behavior and Development · doi:10.1016/s0163-6383(01)00037-6 · Cited by 420 · see citing works
A Prospective Study of the Emergence of Early Behavioral Signs of Autism
Ozonoff, S. J., Iosif, A., Baguio, F., et al. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-201003000-00009 · Cited by 406 · see citing works
Oxytocin and autistic disorder: alterations in peptide forms
Green, L., Fein, D., Modahl, C., Feinstein, C., Waterhouse, L., & Morris, M. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01139-8 · Cited by 404 · see citing works
Oxytocin Makes a Face in Memory Familiar
Rimmele, U., Hediger, K., Heinrichs, M., & Klaver, P. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4260-08.2009 · Cited by 402 · see citing works
Self-citationCan a nonspecific bias toward top-heavy patterns explain newborns’ face preference?
Viola Macchi, C., Turati, C., & Simion, F. (2004) · Psychological Science · doi:10.1111/j.0956-7976.2004.00688.x · Cited by 363 · see citing works
Oxytocin enhances the encoding of positive social memories in humans.
Guastella, A. J., Mitchell, P. B., & Mathews, F. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.008 · Cited by 352 · see citing works
Anagnostou, E., Soorya, L., Chaplin, W., Bartz, J., Halpern, D., Wasserman, S., Wang, A. T., Pepa, L., Tanel, N., Kushki, A., et al. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-16 · Cited by 350 · see citing works
Lerer, E., Levi, S., Salomon, S., Darvasi, A., Yirmiya, N., & Ebstein, R. P. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002087 · Cited by 349 · see citing works
Genetics of Human Social Behavior
Ebstein, R. P., Israel, S., Chew, S. H., Zhong, S., & Knafo, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.020 · Cited by 323 · see citing works
Visualization of Group Inference Data in Functional Neuroimaging
Gläscher, J. P. (2009) · Neuroinformatics · doi:10.1007/s12021-008-9042-x · Cited by 306 · see citing works
Corden, B., Chilvers, R., & Skuse, D. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.08.005 · Cited by 291 · see citing works
Rossion, B., Hanseeuw, B. J., & Dricot, L. (2012) · Brain and Cognition · doi:10.1016/j.bandc.2012.01.001 · Cited by 270 · see citing works
Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system
Kumsta, R., & Heinrichs, M. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.09.004 · Cited by 265 · see citing works
Self-citationGrelotti, D. J., Klin, A. J., Gauthier, I., Skudlarski, P., Cohen, D. J., Gore, J. C., Volkmar, F. R., & Schultz, R. T. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.06.015 · Cited by 254 · see citing works
Oxytocin facilitates protective responses to aversive social stimuli in males
Striepens, N., Scheele, D., Kendrick, K. M., Becker, B., Schäfer, L., Schwalba, K., Reul, J., Maier, W., & Hurlemann, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208852109 · Cited by 242 · see citing works
Oxytocin, vasopressin, and autism: Is there a connection?
Insel, T. R., O’Brien, D. J., & Leckman, J. F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00142-5 · Cited by 226 · see citing works
Lischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.015 · Cited by 221 · see citing works
Self-citationOxytocin, Vasopressin, and Autism: Is There a Connection?
Insel, T. R., O’Brien, D. J., & Leckman, J. F. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0049 · Cited by 211 · see citing works
Selective amnesic effects of oxytocin on human memory
Heinrichs, M., Meinlschmidt, G., Wippich, W., Ehlert, U., & Hellhammer, D. H. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.020 · Cited by 205 · see citing works
Self-citationOxytocin increases amygdala reactivity to threatening scenes in females
Lischke, A., Gamer, M., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.011 · Cited by 194 · see citing works
Self-citationOxytocin increases recognition of masked emotional faces
Schulze, L., Lischke, A., Greif, J., Herpertz, S. C., Heinrichs, M., & Domes, G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.011 · Cited by 180 · see citing works
Self-citationOxytocin differentially modulates eye gaze to naturalistic social signals of happiness and anger
Domes, G., Steiner, A., Porges, S. W., & Heinrichs, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.10.002 · Cited by 139 · see citing works
Self-citationEvidence for a general face salience signal in human amygdala
Santos, A., Mier, D. U., Kirsch, P., & Meyer‐Lindenberg, A. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.024 · Cited by 120 · see citing works
Ditzen, B., Nater, U. M., Schaer, M., La Marca, R., Bodenmann, G., Ehlert, U., & Heinrichs, M. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss083 · Cited by 111 · cited 1× · see citing works
“Initial studies in healthy humans show that oxytocin, a nine– amino acid neuropeptide, reduces anxiety and endocrine responses to social stress (18,19), modulates social memory (20–22), promotes trust in social interactions (23), improves the ability to infer the emotional or mental states of others from subtle facial…”
BackgroundSelf-citationNeutral faces activate the amygdala during identity matching
Wright, P. K., & Liu, Y. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.047 · Cited by 89 · see citing works
Why Faces Are Not Special to Newborns
Turati, C. (2004) · Current Directions in Psychological Science · doi:10.1111/j.0963-7214.2004.01301002.x · Cited by 86 · see citing works
Examining Autism Spectrum Disorders by Biomarkers: Example From the Oxytocin and Serotonin Systems
Hammock, E. A. D., Veenstra-VanderWeele, J. M., Yan, Z., Kerr, T. M., Morris, M., Anderson, G. M., Carter, C. S., Cook, E. H., & Jacob, S. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.04.010 · Cited by 79 · see citing works
The role of the amygdala in face perception and evaluation
Todorov, A. T. (2011) · Motivation and Emotion · doi:10.1007/s11031-011-9238-5 · Cited by 78 · see citing works
Klumpp, H., Angstadt, M., & Phan, K. L. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.003 · Cited by 21 · see citing works
Flagged first, then by citations
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Sorted by citations
Autism Spectrum Disorder: Classification, diagnosis and therapy
Sharma, S., Gonda, X., & Tarazi, F. I. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.05.007 · Cited by 695 · see citing works
Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
Autism, oxytocin and interoception
Quattrocki, E., & Friston, K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.09.012 · Cited by 393 · see citing works
Oxytocin enhances social recognition by modulating cortical control of early olfactory processing
Oettl, L.-L., Ravi, N., Schneider, M., Scheller, M. F., Schneider, P., Mitre, M., da Silva Gouveia, M., Froemke, R. C., Chao, M. V., Young, W. S., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.033 · Cited by 359 · see citing works
Oxytocin enhances brain function in children with autism
Gordon, I., Vander Wyk, B. C., Bennett, R. H., Cordeaux, C., Lucas, M. V., Eilbott, J. A., Zagoory-Sharon, O., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1312857110 · Cited by 336 · see citing works
Quintana, D. S., Lischke, A., Grace, S., Scheele, D., Ma, Y., & Becker, B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00864-7 · Cited by 263 · see citing works
Auyeung, B., Lombardo, M. V., Heinrichs, M., Chakrabarti, B., Sule, A., Deakin, J. B., Bethlehem, R. A. I., Dickens, L., Mooney, N., Sipple, J. A. N., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.146 · Cited by 234 · see citing works
Self-citationBaribeau, D. A., & Anagnostou, E. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00335 · Cited by 229 · see citing works
Guastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223 · see citing works
Bertsch, K., Gamer, M., Schmidt, B., Schmidinger, I., Walther, S., Kästel, T., Schnell, K., Büchel, C., Domes, G., & Herpertz, S. C. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13020263 · Cited by 214 · see citing works
Self-citationPaloyelis, Y., Doyle, O. M., Zelaya, F. O., Maltezos, S., Williams, S. C., Fotopoulou, A., & Howard, M. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.10.005 · Cited by 187 · see citing works
Oxytocin improves behavioural and neural deficits in inferring others’ social emotions in autism
Aoki, Y., Yahata, N., Watanabe, T., Takano, Y., Kawakubo, Y., Kuwabara, H., Iwashiro, N., Natsubori, T., Inoue, H., Suga, M., et al. (2014) · Brain · doi:10.1093/brain/awu231 · Cited by 187 · see citing works
Freeman, S. M., Inoue, K., Smith, A. L., Goodman, M. M., & Young, L. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.023 · Cited by 185 · see citing works
“The OT system is a potential target for enhancing social cognition in psychiatric disorders (Modi and Young, 2012), and several studies have now shown that IN-OT improves some aspects of social functioning in autism spectrum disorder (Andari et al., 2010; Domes et al., 2013; Hollander et al., 2007).”
BackgroundDomes, G., Kumbier, E., Heinrichs, M., & Herpertz, S. C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.254 · Cited by 160 · see citing works
Self-citationFace processing in autism spectrum disorders: From brain regions to brain networks
Nomi, J. S., & Uddin, L. Q. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.03.029 · Cited by 155 · see citing works
Frye, R. E. (2018) · CNS Drugs · doi:10.1007/s40263-018-0556-y · Cited by 157 · see citing works
A quarter century of progress on the early detection and treatment of autism spectrum disorder
Dawson, G., & Bernier, R. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000710 · Cited by 152 · see citing works
Intranasal oxytocin, social cognition and neurodevelopmental disorders: A meta-analysis
Keech, B., Crowe, S., & Hocking, D. R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.09.022 · Cited by 145 · see citing works
Oxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Neural Circuits for Social Cognition: Implications for Autism
Fernández, M. C., Mollinedo-Gajate, I., & Peñagarikano, O. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.013 · Cited by 137 · see citing works
Fan, Y., Herrera-Meléndez, A. L., Pestke, K., Feeser, M., Aust, S., Otte, C., Pruessner, J. C., Böker, H., Bajbouj, M., & Grimm, S. (2014) · Human Brain Mapping · doi:10.1002/hbm.22553 · Cited by 134 · see citing works
Ma, Y., Shamay-Tsoory, S., Han, S., & Zink, C. F. (2016) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2015.10.009 · Cited by 131 · see citing works
Long-term exposure to intranasal oxytocin in a mouse autism model
Bales, K. L., Solomon, M., Jacob, S., Crawley, J. N., Silverman, J. L., Larke, R. H., Sahagún, E., Puhger, K. R., Pride, M. C., & Mendoza, S. P. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.117 · Cited by 131 · see citing works
Oxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129 · see citing works
Plasma and CSF oxytocin levels after intranasal and intravenous oxytocin in awake macaques
Freeman, S. M., Samineni, S., Allen, P. C., Stockinger, D., Bales, K. L., Hwa, G. G. C., & Roberts, J. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.01.014 · Cited by 128 · see citing works
Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects
Müller, F., Lenz, C., Dolder, P. C., Harder, S., Schmid, Y., Lang, U. E., Liechti, M. E., & Borgwardt, S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.54 · Cited by 128 · see citing works
Schmidt, A., Borgwardt, S., Gerber, H., Wiesbeck, G. A., Schmid, O., Riecher‐Rössler, A., Smieskova, R., Lang, U. E., & Walter, M. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.019 · Cited by 126 · see citing works
Oxytocin and the social brain: Neural mechanisms and perspectives in human research
Kanat, M., Heinrichs, M., & Domes, G. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.003 · Cited by 122 · see citing works
Self-citationOverview of human oxytocin research
Kendrick, K. M., Guastella, A. J., & Becker, B. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_19 · Cited by 121 · see citing works
Bethlehem, R. A. I., Baron-Cohen, S., van Honk, J., Auyeung, B., & Bos, P. A. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00048 · Cited by 120 · see citing works
Grace, S. A., Rossell, S. L., Heinrichs, M., Kordsachia, C., & Labuschagne, I. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.031 · Cited by 120 · see citing works
Self-citationIntranasal oxytocin in the treatment of autism spectrum disorders: A multilevel meta-analysis
Huang, Y., Huang, X., Ebstein, R. P., & Yu, R. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.12.028 · Cited by 119 · see citing works
Gordon, I., Jack, A., Pretzsch, C. M., Vander Wyk, B., Leckman, J. F., Feldman, R., & Pelphrey, K. A. (2016) · Scientific Reports · doi:10.1038/srep35054 · Cited by 114 · see citing works
Oxytocin and Autism: A Systematic Review of Randomized Controlled Trials
Preti, A., Melis, M., Siddi, S., Vellante, M., Doneddu, G., & Fadda, R. (2014) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2013.0040 · Cited by 114 · see citing works
Oxytocin and Autism Spectrum Disorders
Yamasue, H., & Domes, G. (2017) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2017_24 · Cited by 109 · see citing works
Self-citationJankowski, K. F., & Takahashi, H. (2014) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12182 · Cited by 110 · see citing works
Zürcher, N. R., Bhanot, A., McDougle, C. J., & Hooker, J. M. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.02.002 · Cited by 99 · see citing works
Koch, S. B., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.299 · Cited by 98 · see citing works
Visual Perception in Autism Spectrum Disorder: A Review of Neuroimaging Studies
Chung, S., & Son, J.-W. (2020) · Journal of korean Academy of Child and Adolescent Psychiatry · doi:10.5765/jkacap.200018 · Cited by 106 · see citing works
Insular function in autism: Update and future directions in neuroimaging and interventions
Nomi, J. S., Molnar-Szakacs, I., & Uddin, L. Q. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.10.015 · Cited by 95 · see citing works
Aoki, Y., Watanabe, T., Abe, O., Kuwabara, H., Yahata, N., Takano, Y., Iwashiro, N., Natsubori, T., Takao, H., Kawakubo, Y., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.74 · Cited by 95 · see citing works
Alvares, G. A., Quintana, D. S., & Whitehouse, A. J. O. (2017) · Autism Research · doi:10.1002/aur.1692 · Cited by 91 · see citing works
The many faces of oxytocin: Implications for psychiatry
Zik, J. B., & Roberts, D. L. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.11.048 · Cited by 85 · see citing works
Parent–child interaction and oxytocin production in pre-schoolers with autism spectrum disorder
Feldman, R., Golan, O., Hirschler‐Guttenberg, Y., Ostfeld‐Etzion, S., & Zagoory‐Sharon, O. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.113.137513 · Cited by 86 · see citing works
The amygdala and the relevance detection theory of autism: an evolutionary perspective
Zalla, T., & Sperduti, M. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00894 · Cited by 85 · see citing works
Freeman, S. M., Palumbo, M. C., Lawrence, R. H., Smith, A. L., Goodman, M. M., & Bales, K. L. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0315-3 · Cited by 82 · see citing works
Inhaled oxytocin increases positive social behaviors in newborn macaques
Simpson, E. A., Sclafani, V., Paukner, A., Hamel, A. F., Novak, M. A., Meyer, J. S., Suomi, S. J., & Ferrari, P. F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1402471111 · Cited by 82 · see citing works
Oxytocin during Development: Possible Organizational Effects on Behavior
Miller, T. V., & Caldwell, H. K. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00076 · Cited by 79 · see citing works
Cai, Q., Feng, L., & Yap, K. Z. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12627 · Cited by 77 · see citing works
Oxytocin attenuates neural reactivity to masked threat cues from the eyes
Kanat, M., Heinrichs, M., Schwarzwald, R., & Domes, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.183 · Cited by 77 · see citing works
Self-citationHicks, C., Ramos, L., Reekie, T., Misagh, G. H., Narlawar, R., Kassiou, M., & McGregor, I. S. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12613 · Cited by 76 · see citing works
The role of oxytocin and vasopressin dysfunction in cognitive impairment and mental disorders
Abramova, O. V., Zorkina, Y., Ushakova, V. M., Zubkov, E. A., Morozova, A. Y., & Chekhonin, V. P. (2020) · Neuropeptides · doi:10.1016/j.npep.2020.102079 · Cited by 74 · see citing works
Peled‐Avron, L., Abu-Akel, A. M., & Shamay‐Tsoory, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.023 · Cited by 73 · see citing works
Schelinski, S., Borowiak, K., & von Kriegstein, K. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw089 · Cited by 77 · see citing works
Restoring effects of oxytocin on the attentional preference for faces in autism
Kanat, M., Spenthof, I., Riedel, A., van Elst, L. T., Heinrichs, M., & Domes, G. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.67 · Cited by 70 · see citing works
Self-citationKruppa, J. A., Gossen, A., Oberwelland Weiß, E., Kohls, G., Großheinrich, N., Cholemkery, H., Freitag, C. M., Karges, W., Wölfle, E., Sinzig, J., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0258-7 · Cited by 69 · see citing works
Effects of Oxytocin on Neural Response to Facial Expressions in Patients with Schizophrenia
Shin, N. Y., Park, H. Y., Jung, W. H., Park, J. W., Yun, J., Jang, J. H., Kim, S. N., Han, H. J., Kim, S.-Y., Kang, D., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.41 · Cited by 69 · see citing works
The effect of oxytocin on attention to angry and happy faces in chronic depression
Domes, G., Normann, C., & Heinrichs, M. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-0794-9 · Cited by 69 · see citing works
Self-citationOxytocin and Vasopressin Receptor Gene Polymorphisms: Role in Social and Psychiatric Traits
Aspé-Sánchez, M., Moreno, M., Rivera, M. I., Rossi, A., & Ewer, J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00510 · Cited by 68 · see citing works
Gillberg, C., Fernell, E., Kočovská, E., Minnis, H., Bourgeron, T., Thompson, L., & Allely, C. S. (2017) · Autism Research · doi:10.1002/aur.1777 · Cited by 65 · see citing works
Adaptive coding of the value of social cues with oxytocin, an fMRI study in autism spectrum disorder
Andari, E., Richard, N., Leboyer, M., & Sirigu, A. (2016) · Cortex · doi:10.1016/j.cortex.2015.12.010 · Cited by 62 · see citing works
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv116 · Cited by 62 · see citing works
Krol, K. M., Monakhov, M. V., Lai, P. S., Ebstein, R. P., & Großmann, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506352112 · Cited by 62 · see citing works
Oxytocin selectively modulates brain response to stimuli probing social synchrony
Lévy, J., Goldstein, A., Zagoory‐Sharon, O., Weisman, O., Schneiderman, I., Eidelman-Rothman, M., & Feldman, R. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.09.066 · Cited by 61 · see citing works
Neurochemistry of Visual Attention
Lockhofen, D. E. L., & Mulert, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.643597 · Cited by 62 · see citing works
Voice identity processing in autism spectrum disorder
Schelinski, S., Roswandowitz, C., & von Kriegstein, K. (2017) · Autism Research · doi:10.1002/aur.1639 · Cited by 60 · see citing works
Genetic modulation of oxytocin sensitivity: A pharmacogenetic approach
Chen, F. S., Kumsta, R., Dvorak, F., Domes, G., Yim, O. S., Ebstein, R. P., & Heinrichs, M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.163 · Cited by 59 · see citing works
Self-citationYamasue, H. (2016) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12364 · Cited by 58 · see citing works
Oxytocin sharpens self-other perceptual boundary
Colonnello, V., Chen, F. S., Panksepp, J., & Heinrichs, M. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.08.010 · Cited by 58 · see citing works
Self-citationHigashida, H., Munesue, T., Kosaka, H., Yamasue, H., Yokoyama, S., & Kikuchi, M. (2019) · Diseases · doi:10.3390/diseases7010024 · Cited by 64 · see citing works
Frantz, M., Pellissier, L. P., Pflimlin, E., Loison, S., Gandía, J., MARSOL, C., Durroux, T., Mouillac, B., Becker, J. A. J., Merrer, J. L., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00697 · Cited by 57 · see citing works
Oxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte, O., Piva, M., Anderson, K. M., Tringides, M., Holmes, A. J., & Chang, S. W. C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702725114 · Cited by 55 · see citing works
Domes, G., Ower, N., von Dawans, B., Spengler, F. B., Dziobek, I., Bohus, M., Matthies, S., Philipsen, A., & Heinrichs, M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0658-4 · Cited by 58 · see citing works
Self-citationNeurobiological correlates of social anxiety disorder: an update
Marazziti, D., Abelli, M., Baroni, S., Carpita, B., Ramacciotti, C., & Dell’Osso, L. (2014) · CNS Spectrums · doi:10.1017/s109285291400008x · Cited by 57 · see citing works
Bartholomeusz, C. F., Ganella, E. P., Labuschagne, I., Bousman, C., & Pantelis, C. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.06.007 · Cited by 54 · see citing works
Chang, W. H., Lee, I. H., Chen, K. C., Chi, M. H., Chiu, N.-T., Yao, W. J., Lu, R., Yang, Y. K., & Chen, P. S. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.020 · Cited by 54 · see citing works
Oxytocin in animal models of autism spectrum disorder
Peñagarikano, O. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22449 · Cited by 54 · see citing works
Scherf, K. S., Elbich, D., Minshew, N., & Behrmann, M. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.11.003 · Cited by 53 · see citing works
Bakker-Huvenaars, M. J., Greven, C. U., Herpers, P., Wiegers, E., Jansen, A., van der Steen, R., van Herwaarden, A. E., Baanders, A. N., Nijhof, K. S., Scheepers, F., et al. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.07.097 · Cited by 51 · see citing works
Lai, X., Wu, X., Hou, N., Liu, S., Li, Q., Yang, T., Miao, J., Dong, Z., Chen, J., & Li, T. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700754 · Cited by 51 · see citing works
Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial
Yamasue, H., Kojima, M., Kuwabara, H., Kuroda, M., Matsumoto, K., Kanai, C., Inada, N., Owada, K., Ochi, K., Ono, N., et al. (2021) · Brain · doi:10.1093/brain/awab291 · Cited by 51 · see citing works
Atypical frontoamygdala functional connectivity in youth with autism
Odriozola, P., Dajani, D. R., Burrows, C. A., Gabard-Durnam, L. J., Goodman, E. S., Baez, A. C., Tottenham, N., Uddin, L. Q., & Gee, D. G. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.12.001 · Cited by 49 · see citing works
Research Progress in Vitamin A and Autism Spectrum Disorder
Liu, Z., Wang, J., Xu, Q., Hong, Q., Zhu, J., & Chi, X. (2021) · Behavioural Neurology · doi:10.1155/2021/5417497 · Cited by 49 · see citing works
Ferreira, A. C., & Osório, F. D. L. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110561 · Cited by 47 · see citing works
Intranasal gene delivery for treating Parkinson’s disease: overcoming the blood–brain barrier
Aly, A. E.-E., & Waszczak, B. L. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1069815 · Cited by 45 · see citing works
Seeley, S. H., Chou, Y., & O'Connor, M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.011 · Cited by 42 · see citing works
Lischke, A., Herpertz, S. C., Berger, C., Domes, G., & Gamer, M. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx107 · Cited by 46 · see citing works
Self-citationAdditive effects of oxytocin receptor gene polymorphisms on reward circuitry in youth with autism
Hernandez, L. M., Krasileva, K., Green, S. A., Sherman, L. E., Ponting, C., McCarron, R., Lowe, J. K., Geschwind, D. H., Bookheimer, S. Y., & Dapretto, M. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.209 · Cited by 43 · see citing works
Audunsdottir, K., Sartorius, A. M., Kang, H., Glaser, B. D., Bøen, R., Nærland, T., Alaerts, K., Kildal, E. S.-M., Westlye, L. T., Andreassen, O. A., et al. (2024) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2024.107067 · Cited by 41 · see citing works
Intranasal delivery: circumventing the iron curtain to treat neurological disorders
Jiang, Y., Li, Y., & Liu, X. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1065812 · Cited by 43 · see citing works
Emerging role of astrocytes in oxytocin-mediated control of neural circuits and brain functions
Baudon, A., Creusot, E. C., Althammer, F., Schaaf, C. P., & Charlet, A. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102328 · Cited by 40 · see citing works
Neurochemical evidence for differential effects of acute and repeated oxytocin administration
Benner, S., Aoki, Y., Watanabe, T., Endo, N., Abe, O., Kuroda, M., Kuwabara, H., Kawakubo, Y., Takao, H., Kunimatsu, A., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-018-0249-4 · Cited by 40 · see citing works
Lin, I.-F., Kashino, M., Ohta, H., Yamada, T., Tani, M., Watanabe, H., Kanai, C., Ohno, T., Takayama, Y., Iwanami, A., et al. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-20 · Cited by 40 · see citing works
Dumais, K. M., Alonso, A. G., Bredewold, R., & Veenema, A. H. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.036 · Cited by 40 · see citing works
Bertelli, M. O., Azeem, M. W., Underwood, L., Scattoni, M. L., Persico, A. M., Ricciardello, A., Sappok, T., Bergmann, T. J., Keller, R., Bianco, A., et al. (2022) · Springer eBooks · doi:10.1007/978-3-319-95720-3_16 · Cited by 41 · see citing works
Associations between oxytocin-related genes and autistic-like traits
Hovey, D., Zettergren, A., Jonsson, L., Melke, J., Anckarsäter, H., Lichtenstein, P., & Westberg, L. (2014) · Social Neuroscience · doi:10.1080/17470919.2014.897995 · Cited by 37 · see citing works
Bernaerts, S., Boets, B., Steyaert, J. G., Wenderoth, N., & Alaerts, K. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01069-w · Cited by 35 · see citing works
Moerkerke, M., Bonte, M.-L., Daniëls, N., Chubar, V., Alaerts, K., Steyaert, J. G., & Boets, B. (2021) · Research in Autism · doi:10.1016/j.rasd.2021.101785 · Cited by 33 · see citing works
Althammer, F., Muscatelli, F., Grinevich, V., & Schaaf, C. P. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02054-1 · Cited by 34 · see citing works
Wang, Y., Wang, M.-J., Rong, Y., He, H.-Z., & Yang, C.-J. (2019) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2019.03.007 · Cited by 33 · see citing works
- Authors
- Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., & Herpertz, S. C.
- Affiliations
- University of Freiburg (DE)
- University of Rostock (DE)
- Heidelberg University (DE)
- Corresponding author
- Domes, Gregor
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 74
- Issue
- 3
- Pages
- 164-171
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2044266604
- Semantic Scholar
- 02b25bec70f500269e547014635b42f556d8e173
- Cited by
- 255
- References
- 72
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 8 · 2023: 17 · 2022: 23 · 2021: 23 · 2020: 23 · 2019: 11 · 2018: 15 · 2017: 20 · 2016: 21 · 2015: 32 · 2014: 35 · 2013: 13 · 2012: 1
- FWCI
- 50.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- oxytocin, autism spectrum disorder, Asperger syndrome, face processing, amygdala, fusiform gyrus, inferior occipital gyrus, social cognition, social salience, eye contact, neuroimaging
- MeSH terms
- Administration, Intranasal, Adolescent, Adult, Amygdala, Brain Mapping, Child, Child Development Disorders, Pervasive, Discrimination, Psychological, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Oxytocin, Pattern Recognition, Visual, Photic Stimulation, Time Factors, Cross-Over Studies, Young Adult
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