The acute effects of intranasal oxytocin on automatic and effortful attentional shifting to emotional faces
Abstract
Oxytocin is known to promote social affiliation. The mechanism by which this occurs is unknown, but it may involve changes in social information processing. In a placebo‐controlled study, we examined the influence of intranasal oxytocin on effortful and automatic attentional shifting in 57 participants using a spatial cueing task with emotional and neutral faces. For effortful processing, oxytocin decreased the speed of shifting attention to sad faces presented for 750 ms and facilitated disengagement from right hemifield sad and angry faces presented for 200 ms. For automatic processing, symptoms of depression moderated the relationship between drug and disengagement. Oxytocin attenuated an attentional bias to masked angry faces on disengagement trials in persons with high depression scores. Oxytocin's influence on social behavior may occur, in part, by eliciting flexible attentional shifting in the early stages of information processing.
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IN-OXT has been shown in an increasing number of studies to change social visual attention in non-clinical populations of humans.
“IN-OXT has also been shown in an increasing number of studies to change social visual attention in non-clinical populations of humans77–81.”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [81]
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Oxytocin modulates amygdala reactivity to masked fearful eyes
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How does oxytocin modulate human behavior?
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Oxytocin and Facial Emotion Recognition
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Motivated Attention and Reward in Parenting
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Oral Administration of Oxytocin, Like Intranasal Administration, Decreases Top-Down Social Attention
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Oxytocin modulates hemodynamic responses to monetary incentives in humans
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Eye-Tracking Reveals a Role of Oxytocin in Attention Allocation Towards Familiar Faces
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Depressive symptoms and social context modulate oxytocin’s effect on negative memory recall
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Oxytocin and psychotherapy: Keeping context and person in mind
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Memory response to oxytocin predicts relationship dissolution over 18 months
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Oxytocin reduces interoceptive influences on empathy-for-pain in the anterior insulaPreprint
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Collectivity as a Basic Instinct for Survival
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- Authors
- Ellenbogen, M. A., Linnen, A., Grumet, R., Cardoso, C., & Joober, R.
- Affiliations
- Concordia University (CA)
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Ellenbogen, Mark A.
- Venue
- Psychophysiology
- Publisher
- Wiley
- Published
- 2011-09-08
- Volume
- 49
- Issue
- 1
- Pages
- 128-137
- ISSN
- 0048-5772 (ISSN-L)
- 1469-8986
- OpenAlex
- W2101839115
- Cited by
- 82
- References
- 90
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 8 · 2016: 5 · 2015: 6 · 2014: 15 · 2013: 10 · 2012: 9
- FWCI
- 15.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- intranasal oxytocin, attentional shift, emotional facial expressions, automatic attention, attentional bias, disengagement, spatial cueing, depressive symptoms, social affiliation, sad faces, angry faces, social information processing
- MeSH terms
- Administration, Intranasal, Adult, Attention, Cues, Double-Blind Method, Emotions, Face, Facial Expression, Female, Humans, Male, Oxytocin, Pattern Recognition, Visual, Reaction Time
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