Cited by 250Neural and Behavioral Psychology StudiesChild and Adolescent Psychosocial and Emotional DevelopmentAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

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Blunted Neural Response to Rewards as a Prospective Predictor of the Development of Depression in Adolescent Girls

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Nelson, Brady D., Perlman, Greg, Klein, Daniel N., Kotov, Roman, Hajcak, Greg·2016·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2016.15121524

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Abstract

OBJECTIVE: A blunted neural response to rewards has recently emerged as a potential mechanistic biomarker of adolescent depression. The reward positivity, an event-related potential elicited by feedback indicating monetary gain relative to loss, has been associated with risk for depression. The authors examined whether the reward positivity prospectively predicted the development of depression 18 months later in a large community sample of adolescent girls. METHOD: The sample included 444 girls 13.5-15.5 years old with no lifetime history of a depressive disorder, along with a biological parent for each girl. At baseline, the adolescents' reward positivity was measured using a monetary guessing task, their current depressive symptoms were assessed using a self-report questionnaire, and the adolescents' and parents' lifetime psychiatric histories were evaluated with diagnostic interviews. The same interview and questionnaire were administered to the adolescents again approximately 18 months later. RESULTS: A blunted reward positivity at baseline predicted first-onset depressive disorder and greater depressive symptom scores 18 months later. The reward positivity was also a significant predictor independent of other prominent risk factors, including baseline depressive symptoms and adolescent and parental lifetime psychiatric history. The combination of a blunted reward positivity and greater depressive symptom scores at baseline provided the greatest positive predictive value for first-onset depressive disorder. CONCLUSIONS: This study provides strong converging evidence that a blunted neural response to rewards precedes adolescent-onset depression and symptom emergence. Blunted neural response may therefore constitute an important target for screening and prevention.

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Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148
Lifetime prevalence of mental disorders in U.S. adolescents: results from the National Comorbidity Survey Replication - Adolescent Supplement (NCS-A)
Merikangas, K. R., He, J.-P., Burstein, M., Swanson, S. A., Avenevoli, S., Cui, L., Benjet, C., Georgiades, K., & Swendsen, J. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.05.017 · Cited by 6,278
A new method for off-line removal of ocular artifact
Gratton, G., Coles, M. G. H., & Donchin, E. (1983) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(83)90135-9 · Cited by 5,055 · cited 1×
“1 to 30 Hz), and corrected for eye movement artifacts (31).”
Background
The neural basis of human error processing: Reinforcement learning, dopamine, and the error-related negativity.
Holroyd, C. B., & Coles, M. G. H. (2002) · Psychological Review · doi:10.1037/0033-295x.109.4.679 · Cited by 4,027
Maternal Depression and Child Psychopathology: A Meta-Analytic Review
Goodman, S. H., Rouse, M. H., Connell, A. M., Broth, M. R., Hall, C. M., & Heyward, D. (2011) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-010-0080-1 · Cited by 2,621 · cited 3×
“, anxiety and behavioral disorders) (5), and a family history of psychiatric disorders (6).”
Background
Understanding adolescence as a period of social–affective engagement and goal flexibility
Crone, E. A., & Dahl, R. E. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3313 · Cited by 2,507
Development of depression from preadolescence to young adulthood: Emerging gender differences in a 10-year longitudinal study
Hankin, B. L., Abramson, L. Y., Moffitt, T. E., Silva, P. A., McGee, R., & Angell, K. E. (1998) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.107.1.128 · Cited by 2,333
The Medial Frontal Cortex and the Rapid Processing of Monetary Gains and Losses
Gehring, W. J., & Willoughby, A. R. (2002) · Science · doi:10.1126/science.1066893 · Cited by 1,884
The brain reward circuitry in mood disorders
Russo, S. J., & Nestler, E. J. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3381 · Cited by 1,870
Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., & Fava, M. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.08081201 · Cited by 1,232

Show all 38 references

Research works printed but not linked: 1

First MB, 1997, Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-CV), Clinician Version

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Keren, H., O’Callaghan, G., Vidal-Ribas, P., Buzzell, G. A., Brotman, M. A., Leibenluft, E., Pan, P. M., Meffert, L., Kaiser, A., Wolke, S., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17101124 · Cited by 521
Validity and utility of Hierarchical Taxonomy of Psychopathology ( HiTOP ): III . Emotional dysfunction superspectrum
Watson, D., Levin‐Aspenson, H. F., Waszczuk, M. A., Conway, C. C., Dalgleish, T., Dretsch, M. N., Eaton, N. R., Forbes, M. K., Forbush, K. T., Hobbs, K. A., et al. (2022) · World Psychiatry · doi:10.1002/wps.20943 · Cited by 311
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Linking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience
Michelini, G., Palumbo, I. M., DeYoung, C. G., Latzman, R. D., & Kotov, R. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102025 · Cited by 304
Self-citation
The Utility of Event-Related Potentials in Clinical Psychology
Hajcak, G., Klawohn, J., & Meyer, A. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095457 · Cited by 205
Self-citation
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192
“For example, women with a history of both childhood sexual abuse and MDD (Pechtel and Pizzagalli, 2013), adolescents exposed to physical abuse (Hanson et al., 2017), and young adults who had high levels of various adversities in early life (Birn et al., 2017) demonstrate decreased reinforcement learning.”
BackgroundInfluential
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Holroyd, C. B., & Umemoto, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.021 · Cited by 187
Reliability of the electrocortical response to gains and losses in the doors task
Levinson, A. R., Speed, B. C., Infantolino, Z. P., & Hajcak, G. (2017) · Psychophysiology · doi:10.1111/psyp.12813 · Cited by 155
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Reduced neural response to reward and pleasant pictures independently relate to depression
Klawohn, J., Burani, K., Bruchnak, A., Santopetro, N. J., & Hajcak, G. (2020) · Psychological Medicine · doi:10.1017/s0033291719003659 · Cited by 148
Self-citation
Vulnerability to Depression in Youth: Advances From Affective Neuroscience
Kujawa, A., & Burkhouse, K. L. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.09.006 · Cited by 128
Selective kappa-opioid antagonism ameliorates anhedonic behavior: evidence from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS)
Pizzagalli, D. A., Smoski, M. J., Ang, Y., Whitton, A. E., Sanacora, G., Mathew, S. J., Nürnberger, J. I., Lisanby, S. H., Iosifescu, D. V., Murrough, J. W., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0738-4 · Cited by 104
Positive affect and reward processing in the treatment of depression, anxiety and trauma
Craske, M. G., Dunn, B. D., Meuret, A. E., Rizvi, S. J., & Taylor, C. T. (2024) · Nature Reviews Psychology · doi:10.1038/s44159-024-00355-4 · Cited by 110
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Toenders, Y. J., van Velzen, L. S., Heideman, I. Z., Harrison, B. J., Davey, C. G., & Schmaal, L. (2019) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2019.100700 · Cited by 93
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Rolle, C. E., Fonzo, G. A., Wu, W., Toll, R. T., Jha, M. K., Cooper, C. M., Fatt, C. C., Pizzagalli, D. A., Trombello, J. M., Deckersbach, T., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.3867 · Cited by 90
Using Multilevel Modeling to Examine Blunted Neural Responses to Reward in Major Depression
Brush, C. J., Ehmann, P. J., Hajcak, G., Selby, E. A., & Alderman, B. L. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.04.003 · Cited by 88
Self-citation
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Luby, J. L., Arpana Agrawal, A., Belden, A. C., Whalen, D. J., Tillman, R., & Barch, D. M. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17070777 · Cited by 86
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Self-citation
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Pegg, S. L., Ethridge, P., Shields, G. S., Slavich, G. M., Weinberg, A., & Kujawa, A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00178 · Cited by 82
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Zhang, D., Shen, J., Bi, R., Zhang, Y., Zhou, F., Feng, C., & Gu, R. (2020) · Psychological Medicine · doi:10.1017/s0033291720003967 · Cited by 82
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Self-citation
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Self-citation
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Nelson, B. D., & Jarcho, J. M. (2021) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsab055 · Cited by 59
Self-citation
Annual Research Review: Neuroimmune network model of depression: a developmental perspective
Nusslock, R., Alloy, L. B., Brody, G. H., & Miller, G. E. (2024) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13961 · Cited by 67
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Self-citation
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Self-citation
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Rappaport, B. I., Hennefield, L., Kujawa, A., Arfer, K. B., Kelly, D., Kappenman, E. S., Luby, J. L., & Barch, D. M. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00120 · Cited by 55
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Thompson, B., Santopetro, N. J., Brush, C. J., Foti, D., & Hajcak, G. (2023) · Psychophysiology · doi:10.1111/psyp.14257 · Cited by 48
Self-citation
Neural reactivity to reward and internalizing symptom dimensions
Burkhouse, K. L., Gorka, S. M., Afshar, K., & Phan, K. L. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.03.061 · Cited by 47
Experience-driven plasticity and the emergence of psychopathology: A mechanistic framework integrating development and the environment into the Research Domain Criteria (RDoC) model.
McLaughlin, K. A., & Gabard-Durnam, L. J. (2022) · Journal of Psychopathology and Clinical Science · doi:10.1037/abn0000598 · Cited by 48
Neural reward responsiveness in children who engage in nonsuicidal self‐injury: an ERP study
Tsypes, A., Owens, M., Hajcak, G., & Gibb, B. E. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12919 · Cited by 46
Self-citation
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Self-citation
Blunted neural response to appetitive images prospectively predicts symptoms of depression, and not anxiety, during the transition to university
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Self-citation
Neural responses to gains and losses in children of suicide attempters.
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Self-citation
Reward processing and future life stress: Stress generation pathway to depression.
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Self-citation
Stress to inflammation and anhedonia: Mechanistic insights from preclinical and clinical models
Boyle, C. C., Bower, J. E., Eisenberger, N. I., & Irwin, M. R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105307 · Cited by 45
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Self-citation
Retracted
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Interfacing neural constructs with the Hierarchical Taxonomy of Psychopathology : ‘Why' and ‘how'
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Altered reward responsiveness and depressive symptoms: An examination of social and monetary reward domains and interactions with rejection sensitivity
Pegg, S. L., Arfer, K. B., & Kujawa, A. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.093 · Cited by 41
Stress-related psychopathology during the COVID-19 pandemic
McLaughlin, K. A., Rosen, M. L., Kasparek, S. W., & Rodman, A. M. (2022) · Behaviour Research and Therapy · doi:10.1016/j.brat.2022.104121 · Cited by 47
Abnormal self-schema in semantic memory in major depressive disorder: Evidence from event-related brain potentials
Kiang, M., Farzan, F., Blumberger, D. M., Marta Kutas, A., McKinnon, M. C., Kansal, V., Rajji, T. K., & Daskalakis, Z. J. (2017) · Biological Psychology · doi:10.1016/j.biopsycho.2017.04.003 · Cited by 38
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Self-citation
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Funkhouser, C. J., Auerbach, R. P., Kujawa, A., Morelli, S. A., Phan, K. L., & Shankman, S. A. (2019) · Journal of Psychophysiology · doi:10.1027/0269-8803/a000253 · Cited by 44
Valuation in major depression is intact and stable in a non-learning environment
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Putamen Volume Differences Among Older Adults: Depression Status, Melancholia, and Age
Sachs‐Ericsson, N., Hajcak, G., Sheffler, J., Stanley, I. H., Selby, E. A., Potter, G. G., & Steffens, D. C. (2017) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988717747049 · Cited by 36
Self-citation
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Brain function and clinical characterization in the Boston adolescent neuroimaging of depression and anxiety study
Hubbard, N. A., Siless, V., Frosch, I. R., Goncalves, M., Lo, N., Wang, J., Bauer, C. C. C., Conroy, K., Cosby, E. A., Hay, A. C., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102240 · Cited by 36
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Self-citation
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Moser, J. S., Fisher, M. E., Hicks, B. M., Zucker, R. A., & Durbin, C. E. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.08.015 · Cited by 25
Differentiating stages of reward responsiveness: Neurophysiological measures and associations with facets of the behavioral activation system
Pegg, S. L., Jeong, H. J., Foti, D., & Kujawa, A. (2021) · Psychophysiology · doi:10.1111/psyp.13764 · Cited by 27
Positive valence systems in youth anxiety development: A scoping review
Sequeira, S. L., Forbes, E. E., Hanson, J. L., & Silk, J. S. (2022) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2022.102588 · Cited by 23
Variation in reward- and error-related neural measures attributable to age, gender, race, and ethnicity
Hill, K. E., Oumeziane, B. A., Novak, K. D., Rollock, D., & Foti, D. (2017) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.12.009 · Cited by 23
Extraversion, neuroticism, and the electrocortical response to monetary rewards in adolescent girls
Speed, B. C., Nelson, B. D., Levinson, A. R., Perlman, G., Klein, D. N., Kotov, R., & Hajcak, G. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.05.017 · Cited by 28
Self-citation
Neuroimaging Advances for Depression.
Dunlop, B. W., & Mayberg, H. S. (2017) · Europe PMC (PubMed Central) · Cited by 23
Time-Frequency Delta Activity to Social Feedback Demonstrates Differential Associations With Depression and Social Anxiety Symptoms
Jin, J., Sabharwal, A., Infantolino, Z. P., Jarcho, J. M., & Nelson, B. D. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00189 · Cited by 24
Self-citation
Blunted neural effects of perceived control on reward feedback in major depressive disorder
Chang, Y., Wang, Y., Mei, S., Yi, W., & Zheng, Y. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.06.071 · Cited by 22

Authors: Nelson, B. D., Perlman, G., Klein, D. N., Kotov, R., & Hajcak, G.
Affiliations: Stony Brook University (US)
ORCID: Nelson, Brady D.
Perlman, Greg
Klein, Daniel N.
Kotov, Roman
Hajcak, Greg
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2016-12-01
Volume: 173
Issue: 12
Pages: 1223-1230
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2016.15121524
OpenAlex: W2475319108
Cited by: 250
References: 38
Citations by year: 2026: 14 · 2025: 22 · 2024: 22 · 2023: 24 · 2022: 31 · 2021: 30 · 2020: 31 · 2019: 29 · 2018: 27 · 2017: 15 · 2016: 5
FWCI: 16.12
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (R01MH093479)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords: reward positivity, adolescent depression, depressive symptoms, event-related potentials, biomarkers, depression risk prediction, adolescent girls
MeSH terms: Adolescent, Depressive Disorder, Evoked Potentials, Family Health, Female, Humans, Predictive Value of Tests, Prognosis, Prospective Studies, Reward, Risk Factors, Disease Progression

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Blunted Neural Response to Rewards as a Prospective Predictor of the Development of Depression in Adolescent Girls

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