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Identification of Common Neural Circuit Disruptions in Cognitive Control Across Psychiatric Disorders
Open accessAbstract
OBJECTIVE: Cognitive deficits are a common feature of psychiatric disorders. The authors investigated the nature of disruptions in neural circuitry underlying cognitive control capacities across psychiatric disorders through a transdiagnostic neuroimaging meta-analysis. METHOD: A PubMed search was conducted for whole-brain functional neuroimaging articles published through June 2015 that compared activation in patients with axis I disorders and matched healthy control participants during cognitive control tasks. Tasks that probed performance or conflict monitoring, response inhibition or selection, set shifting, verbal fluency, and recognition or working memory were included. Activation likelihood estimation meta-analyses were conducted on peak voxel coordinates. RESULTS: The 283 experiments submitted to meta-analysis included 5,728 control participants and 5,493 patients with various disorders (schizophrenia, bipolar or unipolar depression, anxiety disorders, and substance use disorders). Transdiagnostically abnormal activation was evident in the left prefrontal cortex as well as the anterior insula, the right ventrolateral prefrontal cortex, the right intraparietal sulcus, and the midcingulate/presupplementary motor area. Disruption was also observed in a more anterior cluster in the dorsal cingulate cortex, which overlapped with a network of structural perturbation that the authors previously reported in a transdiagnostic meta-analysis of gray matter volume. CONCLUSIONS: These findings demonstrate a common pattern of disruption across major psychiatric disorders that parallels the "multiple-demand network" observed in intact cognition. This network interfaces with the anterior-cingulo-insular or "salience network" demonstrated to be transdiagnostically vulnerable to gray matter reduction. Thus, networks intrinsic to adaptive, flexible cognition are vulnerable to broad-spectrum psychopathology. Dysfunction in these networks may reflect an intermediate transdiagnostic phenotype, which could be leveraged to advance therapeutics.
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“many of these findings are unlikely to be specific to PTSD, and may instead represent common neural abnormalities across psychiatric disorders [9,10].”
From Trauma, PTSD, and the Developing Brain (2017) · cites this paper as [10]
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“Further, meta-analyses across psychiatric disorders have found evidence of more similarities in functional and structural neuroimaging abnormalities across disorders than differences, despite variance in symptoms (Goodkind et al., 2015; McTeague et al., 2017).”
From Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety (2018) · cites this paper as McTeague et al., 2017
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A critical review of research on executive functions in sport and exercise
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“Without going into detail, EFs have been shown to depend primarily on the prefrontal cortex and interconnected brain regions like the anterior cingulate cortex and parietal cortex (Aron, 2007; Braver & Barch, 2002; McTeague et al., 2017; Petrides, 2005).”
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Psychedelic therapy's transdiagnostic effects: A research domain criteria (RDoC) perspective
Kelly, J. R., Gillan, C. M., Prenderville, J., Kelly, C., Harkin, A., Clarke, G., & O'Keane, V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.800072 · Cited by 69
Lasting connectivity increase and anxiety reduction via transcranial alternating current stimulation
Clancy, K. J., Baisley, S. K., Albizu, A., Kartvelishvili, N., Ding, M., & Li, W. (2018) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsy096 · Cited by 68
“Meanwhile, network views of psychopathology have gained rapid traction in recent years, advancing conceptualization of mental disorders from local neural aberrations to largescale circuit anomalies (Kaiser et al., 2015; Clancy et al., 2017; McTeague et al., 2017).”
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“In fact, meta-analyses across all DSM-IV axis I disorders suggest that gray matter volume in the insular cortex is the best differentiator of individuals with diagnosable psychopathology broadly and those without (50, 51).”
BackgroundIdentification of Common Thalamocortical Dysconnectivity in Four Major Psychiatric Disorders
Tu, P., Bai, Y. M., Li, C., Chen, M., Lin, W.-C., Chang, W.-C., & Su, T. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby166 · Cited by 71
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“Supporting this notion, emerging evidence from cognitive neuroscience suggests that the same brain regions implicated in EF are transdiagnostically associated with psychopathology, including the dorsal anterior cingulate cortex and anterior insula (Goodkind et al., 2015; McTeague et al., 2017).”
BackgroundFew-Shot Domain-Adaptive Anomaly Detection for Cross-Site Brain Images
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“This is an open access article psychopathological conditions [1,2], comprise the intentional selection of thoughts, emotions, and behaviours based on current task demands [3] involving functions of attention, memory, and emotional control [4], and are associated with altered patterns of brain activation [5,6].”
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“Moreover, evidence from recent brain imaging studies has suggested a common neurobiological substrate across psychopathological disorders (Goodkind et al., 2015; McTeague et al., 2017; Sha et al., 2017; Sprooten et al., 2017).”
Self-citationTransdiagnostic neuroimaging markers of psychiatric risk: A narrative review
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“evident in child and adolescent psychiatric samples, suggesting an important role for this region in cognitive dyscontrol throughout development (McTeague et al., 2017).”
Motor cortex inhibition and modulation in children with ADHD
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“40,41 Intriguingly, the insula and anterior cingulate have been identified as sites of common vulnerability across psychotic and affective disorders, 42 suggesting that a deeper understanding of their processing roles would have widespread clinical implications.”
Self-citationInsular subdivisions functional connectivity dysfunction within major depressive disorder
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Neural networks of aggression: ALE meta-analyses on trait and elicited aggression
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“Recent neuroimaging meta-analyses have identified domain-nonspecific neural disruptions across psychiatric disorders in the salience (or anteriorcingulo-insular) network (Goodkind et al. 2015; McTeague et al. 2017).”
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Exposure therapy for pediatric irritability: Theory and potential mechanisms
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“It refers to the capacity to deploy cognitive resources flexibly in response to changing environmental contingencies (McTeague et al., 2017).”
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“Since the ACC is a part of the salience network and plays an important role in attention shifting and control, more prominent abnormality of P300 novel amplitude may reflect deficits in salience processing of as supported by the right frontal cortex and ACC and leading to the conversion to psychosis (McTeague et al.,…”
BackgroundHuang, C., Luo, Q., Palaniyappan, L. K., Yang, A. C., Hung, C., Chou, K., Lo, C. Z., Liu, M., Tsai, S., Barch, D. M., et al. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.01.010 · Cited by 60
“We have achieved this in the current study and have not only confirmed the involvement of SVN and DMN in these disorders (10,11,31), but also provided new insights on the illnessspecific nature of the ECN, which has been previously considered as a transdiagnostic feature by the meta-analysis at a brain regional level…”
BackgroundResultInfluentialHurstak, E., Johnson, J. K., Tieu, L., Guzman, D., Ponath, C., Lee, C. T., Jamora, C. W., & Kushel, M. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.06.002 · Cited by 56
“Studies in the general population demonstrate that cognitive deficits are common in psychiatric disorders (McTeague et al., 2017).”
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Elbau, I., Brücklmeier, B., Uhr, M., Arloth, J., Czamara, D., Spoormaker, V. I., Czisch, M., Stephan, K. E., Binder, E. B., & Sämann, P. G. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1804340115 · Cited by 57
“, hippocampus (HC), anterior cingulate cortex, and ventromedial prefrontal cortex (9)] substantially overlap with regions functionally or structurally altered in major depression (10–16) and even across affective and psychotic disorders (17, 18).”
BackgroundNeural underpinnings of individual differences in emotion regulation: A systematic review
Morawetz, C., & Basten, U. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105727 · Cited by 62
“…emotion regulation with lateral PFC activity as an outcome measure holds promise for unravelling biomarkers, addressing trans-diagnostic features (McTeague et al., 2017; Phillips et al., 2008; Zil-verstand et al., 2017), and fostering resilience, thereby advancing our understanding and…”
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Caulfield, K. A., Indahlastari, A., Nissim, N. R., Lopez, J. W., Fleischmann, H. H., Woods, A. J., & George, M. S. (2020) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13342 · Cited by 51
Liu, R., Huang, Z.-A., Hu, Y. F., Zhu, Z., Wong, K., & Tan, K. C. (2022) · IEEE Transactions on Neural Networks and Learning Systems · doi:10.1109/tnnls.2022.3219551 · Cited by 53
“This observation is consistent with the theoretical evidence in previous studies [54] that the common disruption pattern across mental disorders in cortical areas could result in gray matter reduction, vulnerable to broad-spectrum psychopathology.”
ResultDecoding task engagement from distributed network electrophysiology in humans
Provenza, N. R., Paulk, A. C., Peled, N., Restrepo, M. I., Cash, S. S., Dougherty, D. D., Eskandar, E. N., Borton, D. A., & Widge, A. S. (2019) · Journal of Neural Engineering · doi:10.1088/1741-2552/ab2c58 · Cited by 51
Nakada, S., Ho, F. K. W., Celis-Morales, C. A., Jackson, C., & Pell, J. P. (2023) · European Psychiatry · doi:10.1192/j.eurpsy.2023.2425 · Cited by 50
Metadata
- Authors
- McTeague, L. M., Huemer, J., Carreon, D. M., Jiang, Y., Eickhoff, S. B., & Etkin, A.
- Affiliations
- Medical University of South Carolina (US)
- Venue
- American Journal of Psychiatry
- Published
- 2017-07-01
- Volume
- 174
- Issue
- 7
- Pages
- 676-685
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC5543416
- OpenAlex
- W2602886720
- Cited by
- 635
- References
- 48
- Citations by year
- 2026: 55 · 2025: 61 · 2024: 127 · 2023: 60 · 2022: 74 · 2021: 86 · 2020: 66 · 2019: 50 · 2018: 40 · 2017: 16
- FWCI
- 26.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Österreichischen Akademie der Wissenschaften
- National Institute of Mental Health (R01MH074457, K23MH104849)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- cognitive control, mental illness, multiple-demand network, salience network, prefrontal cortex, anterior insula, intraparietal sulcus, schizophrenia, bipolar disorder, depression, anxiety disorders, substance use disorders, cognitive impairment, activation likelihood estimation
- MeSH terms
- Mental Disorders, Brain, Brain Mapping, Dominance, Cerebral, Humans, Nerve Net, Neuropsychological Tests, Psychometrics, Reference Values, Cognitive Dysfunction
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