Behavioral Health Symptoms Associated With Chronic Traumatic Encephalopathy: A Critical Review of the Literature and Recommendations for Treatment and Research
Abstract
Chronic traumatic encephalopathy (CTE) is a neurodegenerative syndrome that has been linked to serious psychiatric symptoms, including depression, aggression, and suicidal behavior. This review critically examines the extant research on the behavioral manifestations of CTE and concludes that the paucity of longitudinal prospective studies on CTE, combined with a lack of research-accepted diagnostic criteria for identifying individuals who are considered at risk for CTE, makes it difficult to reliably establish a causal relationship between CTE and the onset of behavioral health problems. Selection and reporting bias and inconsistency in data collection methods are other concerns. To advance the field, there is a critical need for more empirical research on the behavioral manifestations of CTE. Recommendations and intervention models are also discussed.
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CTE is described clinically by a set of non-specific but severe symptoms including depression, anxiety, motor dysfunction, aggression, irritability, memory loss, and suicidality.
“However, CTE is described clinically by a set of non-specific but yet severe symptoms including depression, anxiety, motor dysfunction, aggression, irritability, memory loss, and suicidality [4, 68, 94].”
From DNA repair deficiency and senescence in concussed professional athletes involved in contact sports (2019) · cites this paper as [4]
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- Authors
- Antonius, D., Mathew, N., Picano, J., Hinds, A., Cogswell, A., Olympia, J., Brooks, T., DiGiacomo, M., Baker, J., Willer, B., & Leddy, J.
- Affiliations
- New York University (US)
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2014-10
- Volume
- 26
- Issue
- 4
- Pages
- 313-322
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W2148658150
- Cited by
- 14
- References
- 57
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- chronic traumatic encephalopathy, depression, aggression, suicidal behavior, neurodegenerative diseases, diagnostic criteria, selection bias, reporting bias, prospective longitudinal study, treatment guidelines, sports-related brain injury
- MeSH terms
- Behavioral Symptoms, Brain Injuries, Humans, Guidelines as Topic, Disease Management, Biomedical Research
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