Toward a neurobiology of psychotherapy: basic science and clinical applications
Abstract
Psychotherapy is used commonly to treat a variety of mental illnesses, yet surprisingly little is known about its biological mechanisms especially in comparison with pharmacotherapy. In this review we survey the current knowledge about changes in brain function following psychotherapeutic intervention that are detectable with current neuroimaging techniques. We also consider the possible role for neuroimaging in refining clinical diagnoses and predicting treatment outcome, which would benefit both clinical decision-making and the cognitive neuroscience of psychotherapy.
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Psychotherapy research to date has only considered the patient's brain as the locus of therapeutic effects.
“This is a fundamentally new perspective because psychotherapy research to date has only considered the patient’s brain as the locus of therapeutic effects (Etkin et al., 2005; Beauregard, 2014; Weingarten and Strauman, 2015).”
From Synchrony in Psychotherapy: A Review and an Integrative Framework for the Therapeutic Alliance (2016) · cites this paper as Etkin et al., 2005
An equivalent model of psychological therapy action has been proposed for anxiety disorders.
“An equivalent model in anxiety disorders has been proposed (Etkin et al., 2005).”
From Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety (2018) · cites this paper as Etkin et al., 2005
Patients with affective disorders who remit show recovery in the imbalance between prefrontal and limbic systems.
“Patients with affective disorders who remit have been found to show recovery in the imbalance between these two systems (DeRubeis et al., 2008; Etkin et al., 2005; Siegle et al., 2007).”
From Meta-analyses of the neural mechanisms and predictors of response to psychotherapy in depression and anxiety (2018) · cites this paper as Etkin et al., 2005
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- Authors
- Etkin, A., Pittenger, C., Polan, H. J., & Kandel, E. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2005-05
- Volume
- 17
- Issue
- 2
- Pages
- 145-158
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- OpenAlex
- W1988088970
- Cited by
- 244
- References
- 63
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 10 · 2015: 27 · 2014: 12 · 2013: 13 · 2012: 15
- FWCI
- 13.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- psychotherapy, neurobiology of psychotherapy, brain function changes, neuroimaging, treatment outcome prediction, diagnosis, drug therapy comparison
- MeSH terms
- Mental Disorders, Consciousness, Diagnostic Imaging, Humans, Neurobiology, Psychotherapy, Treatment Outcome
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