Effects of prebiotics on the immune response to vaccination in the elderly

Bunout, D; Hirsch, S; de la Maza, MP; Munoz, C; Haschke, F; Steenhout, P; Klassen, P; Barrera, G; Gattas, V; Petermann, M

doi:10.1177/0148607102026006372

Cited by 107Microbial Metabolites in Food BiotechnologyProbiotics and Fermented FoodsImmune responses and vaccinations

Effects of prebiotics on the immune response to vaccination in the elderly

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Bunout, D, Hirsch, S, de la Maza, MP, Munoz, C, Haschke, F, Steenhout, P, Klassen, P, Barrera, G +2 more·2002·Journal of Parenteral and Enteral Nutrition

DOI 10.1177/0148607102026006372

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Abstract

BACKGROUND: Prebiotics stimulate the growth of bifidogenic bacteria in the gut. The aim of this work was to assess the effects of a prebiotic mixture on the immune response in healthy elderly people. METHODS: Healthy free-living elderly people (age, > or = 70 years), receiving a nutritional supplement that provided 1.6 MJ, 15 g of protein, and 50% of vitamin daily reference values per day, were randomly assigned to receive a prebiotic mixture (6 g/d of a 70% raftilose and 30% raftiline mixture) or placebo (6 g of maltodextrin powder) for 28 weeks. At week 2 of the study, all subjects were vaccinated with influenza and pneumococcal vaccines. At weeks 0, 2, and 8 of the study, serum total proteins, albumin, immunoglobulins, saliva secretory immunoglobulin A (IgA), and serum titers of influenza A and B and pneumococcal antibodies were measured. At week 8, cultured peripheral monocyte cell secretion of interleukin-4, interferon-gamma, and lymphocyte proliferation, stimulated with phytohemagglutinin and influenza antigen, were measured. RESULTS: Sixty-six subjects were considered eligible for the study, and 43 (20 receiving prebiotics and 23 receiving placebo) were considered for final analyses on a per protocol basis. No changes in serum proteins, albumin, immunoglobulins, and secretory IgA were observed. Antibodies against influenza B and pneumococcus increased significantly from weeks 0 to 8, with no significant differences between groups. Antibodies against influenza A did not increase. No effects of prebiotics on interleukin-4 and interferon-gamma secretion by cultured monocytes were observed. CONCLUSIONS: No immunological effects of prebiotics were observed in this study.

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Healthy status, including absence of disease and nutritional status, seems crucial for the action of pro- or prebiotics, as demonstrated by null results on immunomodulation after administration of prebiotics in older adults vaccinated with influenza or pneumococcal vaccines.
“Moreover, healthy status, including absence of disease and nutritional status, seems to be crucial for their action as demonstrated by null results on immunomodulation after administration of prebiotics in older adults vaccinated with influenza or pneumococcal vaccines (125).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [125]

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Self-citation
Effects of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486 with prebiotic on the B-cell response to influenza vaccination
Enani, S. M., Childs, C. E., Przemska-Kosicka, A., Maidens, C. M., Dong, H., Rowland, I. R., Tuohy, K. M., Todd, S., Gosney, M., & Yaqoob, P. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114000238 · Cited by 4 · see citing works

Authors: Bunout, D., Hirsch, S., de la Maza, M., Munoz, C., Haschke, F., Steenhout, P., Klassen, P., Barrera, G., Gattas, V, & Petermann, M.
Affiliations: University of Chile (CL)
National Agricultural Technology Institute (AR)
ORCID: Bunout, D
Klassen, P
Venue: Journal of Parenteral and Enteral Nutrition
Publisher: Wiley
Published: 2002-11
Volume: 26
Issue: 6
Pages: 372-376
ISSN: 0148-6071 (ISSN-L)
1941-2444
DOI: 10.1177/0148607102026006372
OpenAlex: W2030975061
Cited by: 107
References: 9
Citations by year: 2025: 1 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 4
FWCI: 2.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Parenteral and Enteral Nutrition (publishedVersion)
PubMed (publishedVersion)
Funders: Nestec
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: prebiotics, vaccine response, older adults, influenza vaccination, pneumococcal vaccine, secretory IgA, immunoglobulins, antibody response, IL-4, interferon-gamma, monocytes, lymphocyte proliferation, dietary supplements
MeSH terms: Aged, Analysis of Variance, Antibody Formation, Blood Proteins, Female, Humans, Immunoglobulins, Influenza Vaccines, Lymphocytes, Male, Reference Values, Time Factors, Vaccination, Cytokines, Dietary Supplements, Probiotics, Pneumococcal Vaccines

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Effects of prebiotics on the immune response to vaccination in the elderly

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