Microbiota Modulating Nutritional Approaches to Countering the Effects of Viral Respiratory Infections Including SARS-CoV-2 through Promoting Metabolic and Immune Fitness with Probiotics and Plant Bioactives.
Open accessAbstract
Viral respiratory infections (VRIs) can spread quickly and cause enormous morbidity and mortality worldwide. These events pose serious threats to public health due to time lags in developing vaccines to activate the acquired immune system. The high variability of people’s symptomatic responses to viral infections, as illustrated in the current COVID-19 pandemic, indicates the potential to moderate the severity of morbidity from VRIs. Growing evidence supports roles for probiotic bacteria (PB) and prebiotic dietary fiber (DF) and other plant nutritional bioactives in modulating immune functions. While human studies help to understand the epidemiology and immunopathology of VRIs, the chaotic nature of viral transmissions makes it difficult to undertake mechanistic study where the pre-conditioning of the metabolic and immune system could be beneficial. However, recent experimental studies have significantly enhanced our understanding of how PB and DF, along with plant bioactives, can significantly modulate innate and acquired immunity responses to VRIs. Synbiotic combinations of PB and DF potentiate increased benefits primarily through augmenting the production of short-chain fatty acids (SCFAs) such as butyrate. These and specific plant polyphenolics help to regulate immune responses to both restrain VRIs and temper the neutrophil response that can lead to acute respiratory distress syndrome (ARDS). This review highlights the current understanding of the potential impact of targeted nutritional strategies in setting a balanced immune tone for viral clearance and reinforcing homeostasis. This knowledge may guide the development of public health tactics and the application of functional foods with PB and DF components as a nutritional approach to support countering VRI morbidity.
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Butyrate inhibits histone deacetylase 3 to confer macrophages with non-inflammatory enhanced antimicrobial activity.
“Butyrate also inhibits histone deacetylase 3 to confer macrophages with non-inflammatory enhanced antimicrobial activity (Shinde et al., 2020).”
From Insect Derived Lauric Acid as Promising Alternative Strategy to Antibiotics in the Antimicrobial Resistance Scenario (2021) · cites this paper as Shinde et al., 2020
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Health Benefits of Plant-Based Nutrition: Focus on Beans in Cardiometabolic Diseases
Mullins, A. P., & Arjmandi, B. H. (2021) · Nutrients · doi:10.3390/nu13020519 · Cited by 208 · see citing works
Wang, B., Zhang, L., Wang, Y., Dai, T., Qin, Z., Zhou, F., & Zhang, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00986-0 · Cited by 185 · see citing works
Borrelli, L., Varriale, L., Dipineto, L., Pace, A., Menna, L. F., & Fioretti, A. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.620798 · Cited by 159 · see citing works
SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role
Din, A. U., Mazhar, M., Waseem, M., Ahmad, W., Bibi, A., Hassan, A., Ali, N., Wang, G., Gao, Q., Ullah, R., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110947 · Cited by 119 · see citing works
Short-Chain Fatty Acids as a Potential Treatment for Infections: a Closer Look at the Lungs
Machado, M., Sencio, V., & Trottein, F. (2021) · Infection and Immunity · doi:10.1128/iai.00188-21 · Cited by 113 · see citing works
Probiotics in Treatment of Viral Respiratory Infections and Neuroinflammatory Disorders
Shahbazi, R., Yasavoli‐Sharahi, H., Alsadi, N., Ismail, N., & Matar, C. (2020) · Molecules · doi:10.3390/molecules25214891 · Cited by 101 · see citing works
Vallianou, N. G., Dalamaga, Μ., Stratigou, T., Karampela, Ι., & Tsigalou, C. (2021) · Current Obesity Reports · doi:10.1007/s13679-021-00438-w · Cited by 99 · see citing works
Reflections on treatment of COVID-19 with traditional Chinese medicine
Luo, H., Gao, Y., Zou, J. P., Zhang, S., Chen, H., Liu, Q., Tan, D., Han, Y., Zhao, Y., & Wang, S. (2020) · Chinese Medicine · doi:10.1186/s13020-020-00375-1 · Cited by 97 · see citing works
Sencio, V., Machelart, A., Robil, C., Benech, N., Hoffmann, E., Galbert, C., Deryuter, L., Heumel, S., Hantute-Ghesquier, A., Flourens, A., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.2018900 · Cited by 87 · see citing works
Gut‐lung axis and asthma: A historical review on mechanism and future perspective
Song, X., Liang, J., Lin, S., Xie, Y., Ke, C., Ao, D., Lü, J., Chen, X., He, Y., Liu, X., et al. (2024) · Clinical and Translational Allergy · doi:10.1002/clt2.12356 · Cited by 71 · see citing works
Augusti, P. R., Conterato, G. M. M., Denardin, C. C., Prazeres, I. D., Serra, T., Bronze, M. R., & Emanuelli, T. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108787 · Cited by 69 · see citing works
COVID-19: Is there a role for immunonutrition in obese patient?
Renzo, L. D., Gualtieri, P., Pivari, F., Soldati, L., Attinà, A., Leggeri, C., Cinelli, G., Tarsitano, M. G., Caparello, G., Carrano, E., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02594-4 · Cited by 69 · see citing works
The Role of Oat Nutrients in the Immune System: A Narrative Review
Chen, O., Mah, E., Dioum, E. M., Marwaha, A., Shanmugam, S., Malleshi, N. G., Sudha, V., Gayathri, R., Ranjit Unnikrishnan, I., Anjana, R. M., et al. (2021) · Nutrients · doi:10.3390/nu13041048 · Cited by 68 · see citing works
Ferreira, C., Viana, S., & Reis, F. (2020) · Microorganisms · doi:10.3390/microorganisms8101514 · Cited by 66 · see citing works
Awareness, Knowledge, and Interest about Prebiotics—A Study among Romanian Consumers
Precup, G., Pocol, C. B., Teleky, B., & Vodnar, D. C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031208 · Cited by 63 · see citing works
Heumel, S., Rodovalho, V. D. R., Urien, C., Specque, F., Rodrigues, P. B., Robil, C., Delval, L., Sencio, V., Descat, A., Deruyter, L., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2325067 · Cited by 63 · see citing works
Cámara, M., Sánchez‐Mata, M. D. C., Fernández‐Ruiz, V., Cámara, R. M., Cebadera, E., & Díaz, L. D. (2021) · Foods · doi:10.3390/foods10051088 · Cited by 57 · see citing works
Batista, K. S., de Albuquerque, J. G., de Vasconcelos, M. H. A., Bezerra, M. L. R., Barbalho, M. B. D. S., Pinheiro, R. O., & Aquino, J. D. S. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000317 · Cited by 54 · see citing works
Fedullo, A. L., Schiattarella, A., Morlando, M., Raguzzini, A., Toti, E., FRANCISCIS, P. D., & Peluso, I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031213 · Cited by 53 · see citing works
Kezer, G., Paramithiotis, S., Khwaldia, K., Harahap, I. A., Čagalj, M., Šimat, V., Smaoui, S., Elfalleh, W., Özoğul, F., & Esatbeyoglu, T. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1651965 · Cited by 61 · see citing works
Microbiota-derived short chain fatty acids: Their role and mechanisms in viral infections
Feng, C., Jin, C., Liu, K., & Yang, Z. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114414 · Cited by 48 · see citing works
Probiotic-Based Bacteriocin: Immunity Supplementation Against Viruses. An Updated Review
Umair, M., Jabbar, S., Zhaoxin, L., Zhang, J., Abid, M., Khan, K.-U.-R., Korma, S. A., Alghamdi, M. A., El‐Saadony, M. T., El-Hack, M. E. A., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.876058 · Cited by 41 · see citing works
Liu, H., Lu, H., Wang, Y., yu, C., He, Z., & Dong, H. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1449030 · Cited by 41 · see citing works
McKay, S., Oranje, P., Helin, J., Koek, J. H., Kreijveld, E., den Abbeele, P. V., Pohl, U., Bothe, G., Tzoumaki, M. V., Aparicio-Vergara, M., et al. (2021) · Nutrients · doi:10.3390/nu13030963 · Cited by 38 · see citing works
Capozzi, V., Fragasso, M., & Bimbo, F. (2021) · Fermentation · doi:10.3390/fermentation7020054 · Cited by 39 · see citing works
Faecalibacterium duncaniae as a novel next generation probiotic against influenza
Chollet, L., Heumel, S., Deruyter, L., Bouilloux, F., Delval, L., Robert, V., Gevaert, M.-H., Pichavant, M., Sencio, V., Robil, C., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1347676 · Cited by 36 · see citing works
Is butyrate a natural alternative to dexamethasone in the management of CoVID-19?
Kuriakose, N., Patil, P., Bhandary, S. K., Haridas, V. M., Kumari, S., Edachery, S., & Shetty, P. K. (2021) · F1000Research · doi:10.12688/f1000research.51786.1 · Cited by 30 · see citing works
Wang, F., Pan, B., Xu, S., Xu, Z., Zhang, T., Zhang, Q., Bao, Y., Wang, Y., Zhang, J., Xu, C., et al. (2021) · Bioscience Reports · doi:10.1042/bsr20203638 · Cited by 21 · see citing works
Idowu, P. A., Mbambalala, L., Akinmoladun, O. F., & Idowu, A. P. (2025) · Applied Microbiology · doi:10.3390/applmicrobiol5040149 · Cited by 19 · see citing works
A comprehensive perspective on the interaction between gut microbiota and COVID-19 vaccines
Hong, M., Lan, T., Li, Q., Li, B., Yuan, Y., Xu, F., & Wang, W. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2233146 · Cited by 19 · see citing works
Mediterranean Diet a Potential Strategy against SARS-CoV-2 Infection: A Narrative Review
Ferro, Y., Pujia, R., Maurotti, S., Boragina, G., Mirarchi, A., Gnagnarella, P., & Mazza, E. (2021) · Medicina · doi:10.3390/medicina57121389 · Cited by 18 · see citing works
Clinical features and mechanistic insights into drug repurposing for combating COVID-19
Asrani, P., Tiwari, K., Eapen, M. S., McAlinden, K. D., Haug, G., Johansen, M. D., Hansbro, P. M., Flanagan, K. L., Hassan, M. I., & Sohal, S. S. (2021) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2021.106114 · Cited by 16 · see citing works
Self-citationA comprehensive review of the analysis and integration of omics data for SARS-CoV-2 and COVID-19
Zhu, Z., Zhang, S., Wang, P., Chen, X., Bi, J., Cheng, L., & Zhang, X. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab446 · Cited by 14 · see citing works
Zoonotic evolution and implications of microbiome in viral transmission and infection
Rajeev, R., Prathiviraj, R., Kiran, G. S., & Selvin, J. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198175 · Cited by 14 · see citing works
Respiratory syndrome coronavirus‐2 response: Microbiota as lactobacilli could make the difference
Zrelli, S., Amairia, S., & Zrelli, M. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26746 · Cited by 13 · see citing works
A naturopathic treatment approach for mild and moderate COVID-19: A retrospective chart review
Barber, M. S., Barrett, R., Bradley, R. D., & Walker, E. (2021) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2021.102788 · Cited by 11 · see citing works
Immunopathological mechanisms in sepsis of viral etiology in COVID-19
Зиганшин, А. М., & Рамильевич, М. А. (2021) · Siberian medical review · doi:10.20333/25000136-2021-6-35-43 · Cited by 11 · see citing works
Medoro, C., Cianciabella, M., Magli, M., Daniele, G. M., Lippi, N., Gatti, E., Volpe, R., Longo, V. G., Nazzaro, F., Mattoni, S., et al. (2022) · Nutrients · doi:10.3390/nu14071490 · Cited by 11 · see citing works
Chen, J. Y., Huang, T. R., Hsu, S. Y., Huang, C. C., Wang, H. S., & Chang, J. (2024) · Phytotherapy Research · doi:10.1002/ptr.8175 · Cited by 10 · see citing works
El-Khoury, G., Hajjar, C., Geitani, R., Sarkis, D. K., Butel, M., Barbut, F., Abifadel, M., & Kapel, N. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1605143 · Cited by 9 · see citing works
Immunomodulatory effects of probiotics
Plotnikova, E. Y., & Zakharova, Y. V. (2020) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2020-15-135-144 · Cited by 7 · see citing works
Grot, M., Krupa-Kotara, K. H., Wypych-Ślusarska, A., Grajek, M. K., & Białek-Dratwa, A. (2022) · Nutrients · doi:10.3390/nu14091702 · Cited by 6 · see citing works
Lu, W., Eapen, M. S., Singhera, G. K., Markos, J., Haug, G., Chia, C., Larby, J., Brake, S. J., Westall, G. P., Jaffar, J., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030777 · Cited by 6 · see citing works
Self-citationRompies, R., Nurkolis, F., Natanael, H., Manoppo, J. I. C., Mayulu, N., Kawengian, S. E. S., & Assa, Y. A. (2021) · Proceedings of The Nutrition Society · doi:10.1017/s0029665121000835 · Cited by 4 · see citing works
The essential role of prebiotics in restoring gut health in long COVID
Rubio‐Casillas, A., Rodríguez-Quintero, C. M., Hromić-Jahjefendić, A., Uversky, V. N., Redwan, E. M. M. M., & Brogna, C. (2025) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2025.01.004 · Cited by 3 · see citing works
Kossumov, A., Mussabay, K., Pepoyan, A., Tsaturyan, V. V., Sidamonidze, K., Tsereteli, D., Supiyev, A., Kozhakhmetov, S., Chulenbayeva, L., Утеуович, Д. М., et al. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.7470 · Cited by 3 · see citing works
Stefanis, C., Tsigalou, C., Bezirtzoglou, I., Mitropoulou, G., Voidarou, C. C., & Stavropoulou, E. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1575130 · Cited by 2 · see citing works
Liang, M., Deng, Z., Wu, W., Dong, Q., & Fan, J. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156959 · Cited by 2 · see citing works
Ullah, H., Daglia, M., & Khan, H. Z. (2022) · doi:10.1002/9781119746843.ch5 · Cited by 2 · see citing works
Gaonkar, S. K., Nadaf, Z. I., Nayak, S., Gaokar, R. D., & Borkar, S. (2024) · Discover Food · doi:10.1007/s44187-024-00075-x · Cited by 1 · see citing works
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Self-citationModulating susceptibility and severity of COVID-19: Role of immuno-nutrition
Mehta, S., Mehta, A., & Mehta, V. (2020) · Panacea Journal of Medical Sciences · doi:10.18231/j.pjms.2020.038
Combatendo a COVID-19 através do fortalecimento do sistema imune com produtos naturais
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State-of-the-Art Clinical Microbiology in South Korea: Current Trends and Future Prospects
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Microbial, biocatalytic, and nanobiotechnology-based approaches for sustainable food bioprocessing
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Intervention Effect of Exercise and Diet on Immunity Under the Coronavirus Pandemic
Gao, L., & Zhao, Y. (2023) · International Journal of Healthcare Information Systems and Informatics · doi:10.4018/ijhisi.325237
Zhang, C., Zhang, Q., Zhang, L., Chen, Y., & Chen, D. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1925745
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- Authors
- Shinde, T., Hansbro, P. M., Sohal, S. S., Dingle, P., Eri, R., & Stanley, R.
- Affiliations
- University of Tasmania (AU)
- University of Technology Sydney (AU)
- Dingle Wellness, South Fremantle, WA 6162, Australia
- Corresponding author
- Shinde, Tanvi
- Stanley, Roger
- Venue
- Microorganisms
- Publisher
- MDPI AG
- Published
- 2020-06-18
- Volume
- 8
- Issue
- 6
- Pages
- 921
- ISSN
- 2076-2607 (ISSN-L)
- PMC
- PMC7355654
- OpenAlex
- W3036781191
- Cited by
- 61
- References
- 181
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 6 · 2023: 4 · 2022: 9 · 2021: 24 · 2020: 9
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Microorganisms (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UTAS Research Repository (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- RMIT Research Repository (RMIT University Library) (submittedVersion, cc-by)
- UTS ePRESS (University of Technology Sydney) (submittedVersion)
- Funders
- Clifford Craig Foundation
- Rebecca L. Cooper Medical Research Foundation
- Medical Research Council (1175134, 1138004)
- National Health and Medical Research Council (1175134, 1138004)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- respiratory viral infections, SARS-CoV-2, COVID-19 pandemic, gut microbiota, probiotics, synbiotics, phytochemicals, short-chain fatty acids, butyrate, plant polyphenols, innate immunity, adaptive immunity, acute respiratory distress syndrome, neutrophil response, functional foods
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