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Cited by 107

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Human Protein and Amino Acid Requirements

Hoffer, L. John·2016·Journal of Parenteral and Enteral Nutrition
DOI 10.1177/0148607115624084
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Abstract

Human protein and amino acid nutrition encompasses a wide, complex, frequently misunderstood, and often contentious area of clinical research and practice. This tutorial explains the basic biochemical and physiologic principles that underlie our current understanding of protein and amino acid nutrition. The following topics are discussed: (1) the identity, measurement, and essentiality of nutritional proteins; (2) the definition and determination of minimum requirements; (3) nutrition adaptation; (4) obligatory nitrogen excretion and the minimum protein requirement; (5) minimum versus optimum protein intakes; (6) metabolic responses to surfeit and deficient protein intakes; (7) body composition and protein requirements; (8) labile protein; (9) N balance; (10) the principles of protein and amino acid turnover, including an analysis of the controversial indicator amino acid oxidation technique; (11) general guidelines for evaluating protein turnover articles; (12) amino acid turnover versus clearance; (13) the protein content of hydrated amino acid solutions; (14) protein requirements in special situations, including protein‐catabolic critical illness; (15) amino acid supplements and additives, including monosodium glutamate and glutamine; and (16) a perspective on the future of protein and amino acid nutrition research. In addition to providing practical information, this tutorial aims to demonstrate the importance of rigorous physiologic reasoning, stimulate intellectual curiosity, and encourage fresh ideas in this dynamic area of human nutrition. In general, references are provided only for topics that are not well covered in modern textbooks.

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Cited by

Metadata

Authors
Hoffer, L. J.
Venue
Journal of Parenteral and Enteral Nutrition
Publisher
Wiley
Published
2016-01-21
Volume
40
Issue
4
Pages
460-474
ISSN
  • 0148-6071
  • 1941-2444
DOI
10.1177/0148607115624084
Cited by
107
References
10
Language
en
Licence

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