Elevated C-reactive protein in depression: a predictor of good long-term outcome with antidepressants and poor outcome with psychotherapy
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Elevated serum C-reactive protein indicates poor response to psychological treatment such as cognitive behavioural therapy or interpersonal therapy but good response to antidepressants such as fluoxetine or nortriptyline.
“Studies have shown that elevated serum CRP indicates poor response to psychological treatment (such as cognitive behavioural therapy (CBT) or interpersonal therapy) but good response to antidepressant, such as fluoxetine or nortriptyline.17–20”
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“17–20 Experiential avoidance (EA) is any attempts made to avoid thoughts, feelings, physical sensations, memories and other internal experiences.”
Background
- Authors
- Harley, J., Luty, S., Carter, J., Mulder, R., & Joyce, P.
- Affiliations
- University of Otago (NZ)
- University of Canterbury (NZ)
- Corresponding author
- Harley, J.
- ORCID
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2009-03-12
- Volume
- 24
- Issue
- 4
- Pages
- 625-626
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2056504548
- Cited by
- 53
- References
- 9
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 7 · 2018: 9 · 2017: 3 · 2016: 6 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- C-reactive protein, depression, antidepressants, psychotherapy, treatment outcome prediction, inflammation, biomarkers
- MeSH terms
- Antidepressive Agents, C-Reactive Protein, Depression, Humans, Psychiatric Status Rating Scales, Psychotherapy, Regression Analysis, Severity of Illness Index, Time Factors, Biomarkers, Up-Regulation, Randomized Controlled Trials as Topic, Treatment Outcome, Inflammation Mediators
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