Sleep is more sensitive to high doses of caffeine in the middle years of life
Abstract
During the middle years of life, sleep becomes more fragile and its sensitivity to psychostimulants may increase. This study evaluated the effects of 200 mg and 400 mg of caffeine on sleep in young and middle-aged adults. The sleep of 22 young (23.5 ± 1.9 years) and 24 middle-aged (51.7 ± 11.5 years) adults was recorded using polysomnography in two conditions (placebo and caffeine) in a double-blind cross-over design. Compared to placebo, caffeine increased sleep latency, shortened total sleep duration and reduced sleep efficiency. At the higher dose, these effects were more pronounced in middle-aged than in young adults. Furthermore, the higher dose of caffeine increased absolute stage 1 sleep in young adults, whereas it decreased absolute stage 2 sleep in middle-aged adults. Caffeine also induced dose-dependent increases in relative stage 1 sleep and reductions in absolute and relative slow wave sleep and absolute rapid eye movement sleep in both age groups. There was no dose- or age-related modulation of the effects of caffeine on quantified electroencephalographic measures. These results indicate that, compared to young adults, middle-aged adults are generally more sensitive to the effects of a high dose of caffeine on sleep quantity and quality.
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Dose-dependent reductions in the duration of N3 sleep and REM sleep were identified, with greater reductions occurring at larger caffeine doses.
“Dosedependent reductions in the duration of N3 sleep [35,41] and REM sleep [41] were identi fi ed, with greater reductions occurring at larger doses.”
From The effect of caffeine on subsequent sleep: A systematic review and meta-analysis (2023) · cites this paper as [41]
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- Authors
- Robillard, R., Bouchard, M., Cartier, A., Nicolau, L., & Carrier, J.
- Affiliations
- Hôpital du Sacré-Cœur de Montréal (CA)
- Institut Universitaire de Gériatrie de Montréal (CA)
- Venue
- Journal of Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2015-03-10
- Volume
- 29
- Issue
- 6
- Pages
- 688-697
- ISSN
- 0269-8811 (ISSN-L)
- 1461-7285
- OpenAlex
- W2089552283
- Cited by
- 53
- References
- 51
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 2
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- caffeine, sleep, middle age (human life stage), age differences, dose-response relationship, sleep latency, sleep duration, sleep efficiency, slow-wave sleep, REM sleep, stage 1 sleep, stage 2 sleep, psychostimulants, sleep quality
- MeSH terms
- Adult, Central Nervous System Stimulants, Caffeine, Double-Blind Method, Electroencephalography, Female, Humans, Male, Middle Aged, Sleep, REM, Wakefulness, Cross-Over Studies, Young Adult
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