Cited by 125Psychedelics and Drug StudiesAlkaloids: synthesis and pharmacologySynthesis and bioactivity of alkaloids

The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.

The current state of research on ayahuasca: A systematic review of human studies assessing psychiatric symptoms, neuropsychological functioning, and neuroimaging

dos Santos, Rafael G, Balthazar, Fermanda M, Bouso, José C, Hallak, Jaime EC·2016·Journal of Psychopharmacology

Open this paper in CoChat — free account

Abstract

RATIONALE: In recent decades, the use of ayahuasca (AYA) - a β-carboline- and dimethyltryptamine-rich hallucinogenic botanical preparation traditionally used by Northwestern Amazonian tribes for ritual and therapeutic purposes - has spread from South America to Europe and the USA, raising concerns about its possible toxicity and hopes of its therapeutic potential. Thus, it is important to analyze the acute, subacute, and long-term effects of AYA to assess its safety and toxicity. OBJECTIVES: The purpose of this study was to conduct a systematic review of human studies assessing AYA effects on psychiatric symptoms, neuropsychological functioning, and neuroimaging. METHODS: Papers published until 16 December 2015 were included from PubMed, LILACS and SciELO databases following a comprehensive search strategy and pre-determined set of criteria for article selection. RESULTS: The review included 28 full-text articles. Acute AYA administration was well tolerated, increased introspection and positive mood, altered visual perceptions, activated frontal and paralimbic regions and decreased default mode network activity. It also improved planning and inhibitory control and impaired working memory, and showed antidepressive and antiaddictive potentials. Long-term AYA use was associated with increased cortical thickness of the anterior cingulate cortex and cortical thinning of the posterior cingulate cortex, which was inversely correlated to age of onset, intensity of prior AYA use, and spirituality. Subacute and long-term AYA use was not associated with increased psychopathology or cognitive deficits, being associated with enhanced mood and cognition, increased spirituality, and reduced impulsivity. CONCLUSIONS: Acute, subacute, and long-term AYA use seems to have low toxicity. Preliminary studies about potential therapeutic effects of AYA need replication due to their methodological limitations.

Integrity signals

Registry

Crossref · 10.1177/0269881116652578

Cites

122 of 122 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & The PRISMA Group (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000097 · Cited by 64,042
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,766
Dynamic mapping of human cortical development during childhood through early adulthood
Gogtay, N., Giedd, J. N., Lusk, L., Hayashi, K. M., Greenstein, D., Vaituzis, A. C., Nugent, T. F., Herman, D. H., Clasen, L. S., Toga, A. W., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402680101 · Cited by 5,604
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
Wandering minds: the default network and stimulus-independent thought
Mason, M. F., Norton, M. I., Van Horn, J. D., Wegner, D. M., Grafton, S. T., & Macrae, C. N. (2007) · Science · doi:10.1126/science.1131295 · Cited by 2,792
The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs.
Carhart-Harris, R. L., Leech, R., Hellyer, P. J., Shanahan, M., Feilding, A., Tagliazucchi, E., Chialvo, D. R., & Nutt, D. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00020 · Cited by 1,252
Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer
Grob, C. S., Danforth, A. L., Chopra, G. S., Hagerty, M., McKay, C. R., Halberstadt, A. L., & Greer, G. R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.116 · Cited by 1,206
Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin
Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., Tyacke, R. J., Leech, R., Malizia, A. L., Murphy, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119598109 · Cited by 1,172

Show all 122 references

Research works printed but not linked: 11

Bouso JC, 2011, The Ethnopharmacology of Ayahuasca, 55
Damásio A, 2000, O mistério da consciência – do corpo e das emoções ao conhecimento de si
Dos Santos RG, 2011, The Ethnopharmacology of Ayahuasca, 87
Dos Santos RG, Strassman RJ (2008) Ayahuasca and psychosis. Br J Psychiatry (eLetter), 3 December. Available at: http://bjp.rcpsych.org/content/190/1/81.2.e-letters#ayahuasca-and-psychosis (accessed 13 December 2015).
Frecska E, 2008, Neuropsychopharmacol Hung, 10, 103
Frecska E, 2006, Neuropsychopharmacol Hung, 8, 189
Groisman A, 2000, Santo Daime in the Netherlands: An anthropological study of a new world religion in a European setting
Halpern JH, 2008, Med Sci Monit, 14, SR15
Labate BC, 2009, Ayahuasca Religions: A Comprehensive Bibliography and Critical Essays
Riba J, 2002, Br J Clin Psychol, 53, 613
Smart RG, 1967, Can Med Assoc J, 97, 1214

Sorted by citations

Psychedelics and Psychedelic-Assisted Psychotherapy
Reiff, C. M., Richman, E. E., Nemeroff, C. B., Carpenter, L. L., Widge, A. S., Rodriguez, C. I., Kalin, N. H., McDonald, W. M., & and the Work Group on Biomarkers and Novel Treatments, A. D. O. T. A. P. A. C. O. R. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.19010035 · Cited by 649
Therapeutic effects of classic serotonergic psychedelics: a systematic review of modern-era clinical studies
Andersen, K. A. A., Carhart‐Harris, R., Nutt, D. J., & Erritzoe, D. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13249 · Cited by 347
Efficacy, tolerability, and safety of serotonergic psychedelics for the management of mood, anxiety, and substance-use disorders: a systematic review of systematic reviews
SANTOS, R. G. D., Bouso, J. C., Alcázar‐Córcoles, M. Á., & Hallak, J. E. C. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1511424 · Cited by 244
Adverse events in clinical treatments with serotonergic psychedelics and MDMA: a mixed-methods systematic review.
Breeksema, J. J., Kuin, B. W., Kamphuis, J., van den Brink, W., Vermetten, E., & Schoevers, R. A. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221116926 · Cited by 178
“…physiological AEs described in this review are well known from the literature on healthy subjects: for example, nausea, and vomiting with ayahuasca (Dos Santos et al., 2016; Durante et al., 2021; Guimarães dos Santos, 2013; Hamill et al., 2019), headache after psilocybin use (Johnson et al.,…”
Background
Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness
Hamill, J., Hallak, J. E. C., Dursun, S. M., & Baker, G. B. (2018) · Current Neuropharmacology · doi:10.2174/1570159x16666180125095902 · Cited by 201
N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function
Barker, S. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00536 · Cited by 177
Ayahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies
SANTOS, R. G. D., Bouso, J. C., & Hallak, J. E. C. (2017) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316689030 · Cited by 186
Serotonergic psychedelics and personality: A systematic review of contemporary research
Bouso, J. C., dos Santos, R. G., Alcázar-Córcoles, M. Á., & Hallak, J. E. C. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.004 · Cited by 134
Epidemiology of hallucinogen use in the U.S. results from the National epidemiologic survey on alcohol and related conditions III
Shalit, N., Rehm, J. T., & Lev‐Ran, S. (2018) · Addictive Behaviors · doi:10.1016/j.addbeh.2018.09.020 · Cited by 131
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks
Pasquini, L., Palhano-Fontes, F., & de Araújo, D. B. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120909409 · Cited by 120
Toxicokinetics and Toxicodynamics of Ayahuasca alkaloids N,N-dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: clinical and forensic impact
Brito-da-Costa, A. M., Dias-da-Silva, D., Gomes, N. G. M., Dinis-Oliveira, R. J., & Madureira-Carvalho, Á. (2020) · Pharmaceuticals · doi:10.3390/ph13110334 · Cited by 117
Dark Classics in Chemical Neuroscience:N,N-Dimethyltryptamine (DMT)
Cameron, L. P., & Olson, D. E. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00101 · Cited by 128
Therapeutic use of serotoninergic hallucinogens: A review of the evidence and of the biological and psychological mechanisms
dos Santos, R. G., & Hallak, J. E. C. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.001 · Cited by 111
Self-citation
Ayahuasca Improves Self-perception of Speech Performance in Subjects With Social Anxiety Disorder
SANTOS, R. G. D., Osório, F. D. L., Rocha, J. M., Rossi, G. N., Bouso, J. C., Rodrigues, L. S., Silveira, G. D. O., Yonamine, M., & Hallak, J. E. C. (2021) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001428 · Cited by 97
Well-being, problematic alcohol consumption and acute subjective drug effects in past-year ayahuasca users: a large, international, self-selecting online survey
Lawn, W., Hallak, J. E. C., Crippa, J. A. S., SANTOS, R. G. D., Porffy, L., Barratt, M. J., Ferris, J., WINSTOCK, A. R., & Morgan, C. J. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-14700-6 · Cited by 83
Therapeutic potential of ayahuasca in grief: a prospective, observational study
González, D., Cantillo, J., Pérez, I., Farré, M., Feilding, A., Obiols, J. E., & Bouso, J. C. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05446-2 · Cited by 75
Self-citation
Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT
Barker, S. A. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06065-0 · Cited by 58
Chemical composition of traditional and analog Ayahuasca
Kaasik, H., Souza, R. C. Z., Zandonadi, F. S., Tófoli, L. F., & Sussulini, A. (2021) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2020.1815911 · Cited by 59
Psychological variables implied in the therapeutic effect of ayahuasca: A contextual approach
Franquesa, A., Sainz-Cort, A., Gandy, S., Soler, J., Alcázar-Córcoles, M. Á., & Bouso, J. C. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.04.012 · Cited by 58
Modulatory effects of ayahuasca on personality structure in a traditional framework
Netzband, N., Ruffell, S., Linton, S., Tsang, W., & Wolff, T. J. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05601-0 · Cited by 56
Psychedelic drug use in healthy individuals: a review of benefits, costs, and implications for drug policy
Elsey, J. W. B. (2017) · Drug Science Policy and Law · doi:10.1177/2050324517723232 · Cited by 57
Ayahuasca, an ancient substance with traditional and contemporary use in neuropsychiatry and neuroscience
SANTOS, R. G. D., & Hallak, J. E. C. (2019) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2019.04.053 · Cited by 66
Underestimated impact of novel psychoactive substances: laboratory confirmation of recreational drug toxicity in Oslo, Norway
Vallersnes, O. M., Persett, P. S., Øiestad, E. L., Karinen, R., Heyerdahl, F., & Hovda, K. E. (2017) · Clinical Toxicology · doi:10.1080/15563650.2017.1312002 · Cited by 54
Ayahuasca: A review of historical, pharmacological, and therapeutic aspects
Ruffell, S., Crosland‐Wood, M., Palmer, R., Netzband, N., Tsang, W., Weiss, B., Gandy, S., Cowley‐Court, T., Halman, A., McHerron, D., et al. (2023) · Psychiatry and Clinical Neurosciences Reports · doi:10.1002/pcn5.146 · Cited by 61
Effects of ayahuasca and its alkaloids on substance use disorders: an updated (2016–2020) systematic review of preclinical and human studies
Rodrigues, L. S., Rossi, G. N., Rocha, J. M., Osório, F. D. L., Bouso, J. C., Hallak, J. E. C., & SANTOS, R. G. D. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01267-7 · Cited by 47
Ayahuasca's therapeutic potential: What we know – and what not
Maia, L. O., Daldegan‐Bueno, D., Wießner, I., de Araújo, D. B., & Tófoli, L. F. (2022) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2022.10.008 · Cited by 54
N,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine
James, E., Keppler, J., Robertshaw, T. L., & Sessa, B. (2022) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2835 · Cited by 50
Psychoactive Substances of Natural Origin: Toxicological Aspects, Therapeutic Properties and Analysis in Biological Samples
Gonçalves, J., Luís, Â., Gallardo, E., & Duarte, A. P. (2021) · Molecules · doi:10.3390/molecules26051397 · Cited by 45
Toxicological Aspects and Determination of the Main Components of Ayahuasca: A Critical Review
Simão, A. Y., Gonçalves, J., Duarte, A. P., Barroso, M., Cristóvão, A. C., & Gallardo, E. (2019) · Medicines · doi:10.3390/medicines6040106 · Cited by 45
Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up
SANTOS, R. G. D., Sanches, R. F., Osório, F. D. L., & Hallak, J. E. C. (2018) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/0101-60830000000149 · Cited by 37
Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects
Aicher, H. D., Mueller, M. J., Dornbierer, D. A., Suay, D., Elsner, C., Wicki, I., Meling, D., Caflisch, L., Hempe, A., Steinhart, C., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1302559 · Cited by 33
How do serotonergic psychedelics treat depression: The potential role of neuroplasticity
Artin, H., Zisook, S., & Ramanathan, D. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i6.201 · Cited by 33
Dysfunction of the NMDA Receptor in the Pathophysiology of Schizophrenia and/or the Pathomechanisms of Treatment-Resistant Schizophrenia
Okubo, R., Okada, M., & Motomura, E. (2024) · Biomolecules · doi:10.3390/biom14091128 · Cited by 37
Within-treatment changes in a novel addiction treatment program using traditional Amazonian medicine
O’Shaughnessy, D. M., Berlowitz, I., Rodd, R., Sarnyai, Z., & Quirk, F. H. (2021) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320986634 · Cited by 32
Psychedelic Cognition—The Unreached Frontier of Psychedelic Science
Bălăeţ, M. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.832375 · Cited by 34
The felt-presence experience: from cognition to the clinic
Barnby, J. M., Park, S., Baxter, T., Rosen, C., Brugger, P., & Alderson‐Day, B. (2023) · The Lancet Psychiatry · doi:10.1016/s2215-0366(23)00034-2 · Cited by 31
Psychotherapeutic and neurobiological processes associated with ayahuasca: A proposed model and implications for therapeutic use
Perkins, D., Ruffell, S., Day, K., Rubiano, D. P., & Sarris, J. J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.879221 · Cited by 33
How does ayahuasca work from a psychiatric perspective? Pros and cons of the entheogenic therapy
Orsolini, L., Chiappini, S., Papanti, D., Latini, R., Volpe, U., Fornaro, M., Tomasetti, C., Vellante, F., & Berardis, D. D. (2020) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2728 · Cited by 33
Ayahuasca Beverages: Phytochemical Analysis and Biological Properties
Gonçalves, J., Luís, Â., Gradillas, A., Garcı́a, A., Restolho, J., Fernández, N., Domingues, F., Gallardo, E., & Duarte, A. P. (2020) · Antibiotics · doi:10.3390/antibiotics9110731 · Cited by 29
Beyond serotonin: newer antidepressants in the future
Rakesh, G., Pae, C., & Masand, P. S. (2017) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2017.1341310 · Cited by 26
Antidepressant and anxiolytic-like effects of ayahuasca in rats subjected to LPS-induced neuroinflammation
da Silva, M. G., Daros, G. C., Santos, F. P., Yonamine, M., & de Bitencourt, R. M. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114007 · Cited by 25
Amazonian Medicine and the Psychedelic Revival: Considering the “Dieta”
O’Shaughnessy, D. M., & Berlowitz, I. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.639124 · Cited by 22
Psychedelics and Psychedelic-Assisted Psychotherapy
Reiff, C. M., Richman, E. E., Nemeroff, C. B., Carpenter, L. L., Widge, A. S., Rodríguez, C. I., Kalin, N. H., & McDonald, W. M. (2021) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.19104 · Cited by 28
Reproductive effects of the psychoactive beverage ayahuasca in male Wistar rats after chronic exposure
Santos, A. D. F. A., Vieira, A. L. S., Pic‐Taylor, A., & Caldas, E. D. (2017) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2017.01.006 · Cited by 21
Ayahuasca and the traveller: A scoping review of risks and possible benefits
Houle, S. K. D., Evans, D., Carter, C. A., & Schlagenhauf, P. (2021) · Travel Medicine and Infectious Disease · doi:10.1016/j.tmaid.2021.102206 · Cited by 20
Ayahuasca, a potentially rapid acting antidepressant: focus on safety and tolerability
Rossi, G. N., Dias, I. C. D. S., Baker, G. B., Bouso, J. C., Dursun, S. M., Hallak, J. E. C., & SANTOS, R. G. D. (2022) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2054988 · Cited by 23
A Systematic Review on the Therapeutic Effects of Ayahuasca
Gonçalves, J., Luís, Â., Gallardo, E., & Duarte, A. P. (2023) · Plants · doi:10.3390/plants12132573 · Cited by 27
Ayahuasca and Dimethyltryptamine Adverse Events and Toxicity Analysis: A Systematic Thematic Review
White, E., Kennedy, T., Ruffell, S., Perkins, D., & Sarris, J. J. (2024) · International Journal of Toxicology · doi:10.1177/10915818241230916 · Cited by 21
Overcoming epistemic injustices in the biomedical study of ayahuasca: Towards ethical and sustainable regulation
Schenberg, E. E., & Gerber, K. (2022) · Transcultural Psychiatry · doi:10.1177/13634615211062962 · Cited by 21
The current state of ayahuasca research in animal models: A systematic review
Daldegan‐Bueno, D., Simionato, N. M., Favaro, V. M., & Maia, L. O. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110738 · Cited by 21
Who are you after psychedelics? A systematic review and a meta-analysis of the magnitude of long-term effects of serotonergic psychedelics on cognition/creativity, emotional processing and personality
Solaja, I., Haldane, K., Mason, N. L., Weiss, B., Xu, X., Xu, M., Nikolin, S., Jayasena, T., Millard, M., Brett, J., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105570 · Cited by 22
fMRI Evidence for Default Mode Network Deactivation Associated with Rapid Eye Movements in Sleep
Hong, C. C.-H., Fallon, J., & Friston, K. J. (2021) · Brain Sciences · doi:10.3390/brainsci11111528 · Cited by 20
Meditating on psychedelics. A randomized placebo-controlled study of DMT and harmine in a mindfulness retreat
Meling, D., Egger, K., Aicher, H., Redondo, J. J., Mueller, J., Dornbierer, J., Temperli, E., Vasella, E. A., Caflisch, L., Pfeiffer, D., et al. (2024) · Journal of Psychopharmacology · doi:10.1177/02698811241282637 · Cited by 20
Psychosocial and Drug Use Assessment of Regular vs. Non-Regular Ayahuasca Users in a Brazilian Sample: a Web-Based Survey
Daldegan‐Bueno, D., Révész, D., Morais, P. R., Barbosa, P. C. R., & Maia, L. O. (2022) · Substance Use & Misuse · doi:10.1080/10826084.2022.2063896 · Cited by 20
Therapeutic Potential Ascribed to Ayahuasca by Users in the Czech Republic
Horák, M., Hasíková, L., & Verter, N. (2018) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2018.1511878 · Cited by 17
Ayahuasca: what mental health professionals need to know
dos Santos, R. D., Bouso, J., & Hallak, J. (2017) · Archives of Clinical Psychiatry (São Paulo) · doi:10.1590/0101-60830000000130 · Cited by 12
Sub-acute and long-term effects of ayahuasca on mental health and well-being in healthy ceremony attendants: A replication study
van Oorsouw, K. I. M., Uthaug, M. V., Mason, N. L., Broers, N. J., & Ramaekers, J. G. (2021) · Journal of Psychedelic Studies · doi:10.1556/2054.2021.00174 · Cited by 17
Altered State of Consciousness and Mental Imagery as a Function of N, N-dimethyltryptamine Concentration in Ritualistic Ayahuasca Users
Ramaekers, J. G., Mallaroni, P., Kloft, L., Reckweg, J. T., Toennes, S. W., van Oorsouw, K. I. M., & Mason, N. L. (2023) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_02003 · Cited by 16
Effect of Ritualistic Consumption of Ayahuasca on Hepatic Function in Chronic Users
Mello, S. M., Soubhia, P. C., Silveira, G. D. O., Correa-Netto, N. F., Lanaro, R., Costa, J. L., & Linardi, A. (2018) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2018.1557355 · Cited by 19
Ayahuasca-induced personal death experiences: prevalence, characteristics, and impact on attitudes toward death, life, and the environment
David, J., Bouso, J. C., Kohek, M., Oña, G., Tadmor, N., Arnon, T., Dor‐Ziderman, Y., & Berkovich‐Ohana, A. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1287961 · Cited by 12
Long-term ayahuasca use is associated with preserved global cognitive function and improved memory: a cross-sectional study with ritual users
Fonseca, A. M., SANTOS, R. G. D., de Medeiros, L. S., Veiga, T. A. M., Cassas, F., Bruniera, C. P., Rossi, G. N., Bouso, J. C., Hallak, J. E. C., Santos, F. P., et al. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01817-9 · Cited by 13
Ayahuasca and Childhood Trauma: Potential Therapeutic Applications
Perkins, D., & Sarris, J. J. (2021) · Springer eBooks · doi:10.1007/978-3-030-55688-4_6 · Cited by 13
Ayahuasca and its major component harmine promote antinociceptive effects in mouse models of acute and chronic pain
Lauria, P. S. S., Gomes, J. D. M., Abreu, L. S., Santana, R. C., Nunes, V. L. C., Couto, R. D., Colavolpe, P. O., da Silva, M. S., Soares, M. B. P., & Villarreal, C. F. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117710 · Cited by 14
Ayahuasca as a Decoction Applied to Human: Analytical Methods, Pharmacology and Potential Toxic Effects
Nižňanský, Ľ., Nižnanská, Ž., Kuruc, R., Szórádová, A., Šikuta, J., & Zummerová, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11041147 · Cited by 13
Psychosis induced by abuse of ayahuasca: a case report
Palma-Álvarez, R. F., Grau‐López, L., Ros‐Cucurull, E., Abad, A. C., Dualde, J., Robles-Martínez, M., & Roncero, C. (2020) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2019.10.005 · Cited by 12
Ayahuasca-induced psychosis: A case report
Tapia, H. R. C., Guzmán, M. A. G., & Ortiz, S. A. C. (2022) · Revista Colombiana de Psiquiatría (English ed ) · doi:10.1016/j.rcpeng.2022.08.008 · Cited by 12
Polypharmacology or “Pharmacological Promiscuity” In Psychedelic Research: What Are We Missing?
Oña, G., SANTOS, R. G. D., Hallak, J. E. C., & Bouso, J. C. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00614 · Cited by 12
Psicosis inducida por ayahuasca: reporte de un caso.
Neyra-Ontaneda, D. (2017) · Revista de Neuro-Psiquiatría · doi:10.20453/rnp.v80i4.3241 · Cited by 11
Should Australian Psychology Consider Enhancing Psychotherapeutic Interventions with Psychedelic Drugs? A Call for Research
Bright, S. J., & Williams, M. L. (2018) · Australian Psychologist · doi:10.1111/ap.12345 · Cited by 12
Ayahuasca in the Czech Republic: Extended Version
Horák, M., & Verter, N. (2019) · doi:10.11118/978-80-7509-657-9 · Cited by 10
Harmaline potentiates morphine-induced antinociception via affecting the ventral hippocampal GABA-A receptors in mice
Alijanpour, S., Jafaripour, S., Ghasemzadeh, Z., Khakpai, F., & Zarrindast, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173806 · Cited by 9
The Pharmacology and Clinical Applications of Psychedelic Medicines Within Midwifery Practice
Stein, C. A., Penn, A., Hope, S., Dorsen, C. G., & Mangini, M. (2022) · Journal of Midwifery & Women s Health · doi:10.1111/jmwh.13371 · Cited by 9
Episodios psicóticos inducidos por ayahuasca: revisión sistemática a partir de un caso.
Alcantarilla, L., García-Alcarria, E., & Almonacid, C. (2022) · Revista de Neuro-Psiquiatría · doi:10.20453/rnp.v85i3.4331 · Cited by 9
Associations Between Ayahuasca Use in Naturalistic Settings and Mental Health and Wellbeing Outcomes: Analysis of a Large Global Dataset
Perkins, D., Sarris, J. J., Cowley‐Court, T., Aicher, H., Tófoli, L. F., Bouso, J. C., Opaleye, E. S., Halman, A., Coelho, N. L. G., & Schubert, V. (2024) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2024.2424288 · Cited by 7
Ayahuasca ceremony leaders’ perspectives on special considerations for eating disorders
Williams, M., Miller, A. K., & Lafrance, A. (2023) · Eating Disorders · doi:10.1080/10640266.2023.2271201 · Cited by 7
Treatment and outcomes at Takiwasi Center, a Peruvian therapeutic community: identifying patient-related indicators
Defelippe, V. M., Schlütter, A., Meriaan, A., Winkens, B., Kavenská, V., Rojas, G. S., & Politi, M. (2019) · Therapeutic Communities The International Journal of Therapeutic Communities · doi:10.1108/tc-07-2018-0016 · Cited by 7
Anxiety, panic, and hopelessness during and after ritual ayahuasca intake in a woman with generalized anxiety disorder: A case report
SANTOS, R. G. D., Osório, F. D. L., Crippa, J. A. S., & Hallak, J. E. C. (2017) · Journal of Psychedelic Studies · doi:10.1556/2054.01.2017.004 · Cited by 9
Psychedelics and Hallucinogens in Psychiatry: Finding New Pharmacological Targets
de Sousa, T. R., Rema, J., Machado, S. E. D. C., & Novais, F. (2021) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026621666211201145800 · Cited by 7
Psicosis por consumo de ayahuasca: un reporte de caso
Tapia, H. R. C., Guzmán, M. A. G., & Ortiz, S. A. C. (2021) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2020.11.014 · Cited by 6
Neural Network Modulation of Ayahuasca: A Systematic Review of Human Studies
Santos, G. H. D. M., Rodrigues, L. S., Rocha, J. M., Rossi, G. N., Oña, G., Bouso, J. C., Hallak, J. E. C., & SANTOS, R. G. D. (2023) · Psychoactives · doi:10.3390/psychoactives2010006 · Cited by 7
Ayahuasca Ethno-tourism and its Impact on the Indigenous Shuar Community (Ecuador) and Western Participants
Salibová, D. (2020) · Český lid · doi:10.21104/cl.2020.4.05 · Cited by 6
AYAHUASCA V ČESKÉ REPUBLICE
Horák, M. (2017) · Mendelova univerzita v Brně eBooks · doi:10.11118/978-80-7509-510-7 · Cited by 6
Subjective Effects of a Single Dose of Ayahuasca among College Students with Harmful Alcohol Use: Qualitative Analysis of Participant Accounts
Vicentini, A. B., Rodrigues, L. S., Rossi, G. N., Rocha, J. M., Guerra, L. T. L., Reis, J. A. S., Maekawa, R. M., Osório, F. D. L., Bouso, J. C., Santos, F. P., et al. (2023) · Psychoactives · doi:10.3390/psychoactives2040022 · Cited by 4
Treatment and therapy of mental health conditions in the Global South using psychedelics: A scoping review and narrative synthesis
Griffin, C., & Knight, A. (2024) · Journal of Psychedelic Studies · doi:10.1556/2054.2024.00333 · Cited by 4
A prospective ecological momentary assessment study of an ayahuasca retreat: exploring the salutary impact of acute psychedelic experiences on subacute affect and mindfulness skills in daily life
Sznitman, S. R., Behar, Y. A., Dicker‐Oren, S. D., Shochat, T., Meiri, D., Butto, N., Roe, D., & Bernstein, A. (2025) · Psychopharmacology · doi:10.1007/s00213-024-06704-8 · Cited by 4
The Novelty of Ayahuasca Scale and the prediction of intentions to use
Altman, B. R., Mian, M. N., & Earleywine, M. (2020) · Journal of Psychedelic Studies · doi:10.1556/2054.2020.00117 · Cited by 3
Potential Anti-Depressive Treatment Maneuvers from Bench to Bedside
Cai, M., Wang, H., & Zhang, X. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-32-9271-0_15 · Cited by 4
The current state of ayahuasca research in animal models: A systematic reviewPreprint
Daldegan‐Bueno, D., Simionato, N. M., Favaro, V. M., & Maia, L. O. (2022) · doi:10.31234/osf.io/7s3b8 · Cited by 4
How to set up a psychedelic study: Unique considerations for research involving human participants
Glennon, M. J., Bird, C., Yadav, P., Kleine, P., Suseelan, S., Boman-Markaki, C., Kotoula, V., Butler, M., Leech, R., Roseman, L., et al. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106657 · Cited by 5
Beyond prohibition: A public health analysis of naturalistic psychedelic use
Haden, M., Paschall, S. A., & Woods, B. (2025) · Journal of Psychedelic Studies · doi:10.1556/2054.2025.00450 · Cited by 3
Psychosis induced by abuse of ayahuasca: a case report
Palma-Álvarez, R. F., Grau‐López, L., Ros‐Cucurull, E., Abad, A. C., Dualde, J., Robles-Martínez, M., & Roncero, C. (2021) · Revista Colombiana de Psiquiatría (English ed ) · doi:10.1016/j.rcpeng.2019.10.003 · Cited by 3
Ayahuasca – Religion, Life-style oder Droge?
Neu, P. (2020) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-1149-9187 · Cited by 2
Assessment of environmental condition and drying process of the plants on the concentration of alkaloids and cytotoxicity of traditional Ayahuasca Tea
de, M. O. F., de, A. M., de Oliveira, S. I. M., Ruiz, A. L. T. G., da, C. J. L., da Silva, M. R., & Foglio, M. A. (2021) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2021.10.2.0209 · Cited by 2
Could Psychedelics Treat Neuropathic Chronic Pain?
(2023) · Neurological Sciences and Neurosurgery · doi:10.47275/2692-093x-130 · Cited by 1
Ayahuasca enhances functional connectivity in the third visual pathway and mirror neuron networks: a crossover, multiple-dose functional MRI study
Soares, C., Lima, G., Teixeira, M., André, R., Rijo, P. M., Cabral, C., & Castelo-Branco, M. S. (2026) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsag004 · Cited by 1
The DEA report on ayahuasca risks: “Science” in service of prohibition?
Labate, B. C., Ermakova, A. O., Sloshower, J., Coelho, N. L. G., Palhano-Fontes, F., Antunes, H. F., de Assis, G. L., Cavnar, C., de Araújo, D. B., & Ribeiro, S. T. G. (2023) · Journal of Psychedelic Studies · doi:10.1556/2054.2023.00279 · Cited by 1
Special Subsection Afterword: ESP Research and Cognitive Neuroscience: Possibly Incompatible - But Methodologically Complementary
Acunzo, D. J. (2023) · Journal of Scientific Exploration · doi:10.31275/20233195 · Cited by 2
Ayahuasca and personality. A systematic review and meta-analysis of cross-sectional studies with long-term participants ( Ayahuasca y personalidad. Revisión sistemática y metaanálisis de estudios transversales con participantes de larga trayectoria )
Apud, I. (2023) · Studies in Psychology Estudios de Psicología · doi:10.1080/02109395.2022.2163776 · Cited by 1
Psychotherapeutic and neurobiological processes associated with ayahuasca’s mental health and wellbeing outcomes: a proposed model and implications for therapeutic usePreprint
Perkins, D., Ruffell, S., Day, K., Pinzon, D., & Sarris, J. J. (2022) · doi:10.31219/osf.io/e5tjc · Cited by 1
The Felt Presence experience: From cognition to the clinicPreprint
Barnby, J. M., Park, S., Baxter, T., Rosen, C., Brugger, P., & Alderson‐Day, B. (2022) · doi:10.31234/osf.io/qykhd · Cited by 1

Authors: dos Santos, R. G., Balthazar, F. M., Bouso, J. C., & Hallak, J. E.
Affiliations: Department of Neurosciences and Behavior, University of São Paulo, Ribeirão Preto, Brazil
Federal Institute of São Paulo (BR)
International Center for Ethnobotanical Education, Research, and Service (ES)
Universidade de São Paulo (BR)
ORCID: Bouso, José C
Hallak, Jaime EC
Venue: Journal of Psychopharmacology
Publisher: SAGE Publications
Published: 2016-07-10
Volume: 30
Issue: 12
Pages: 1230-1247
ISSN: 0269-8811 (ISSN-L)
1461-7285
DOI: 10.1177/0269881116652578
OpenAlex: W2413873059
Cited by: 125
References: 122
Citations by year: 2026: 5 · 2025: 6 · 2024: 15 · 2023: 17 · 2022: 17 · 2021: 16 · 2020: 18 · 2019: 8 · 2018: 13 · 2017: 10
FWCI: 1.53
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
Physical Sciences › Chemistry › Organic Chemistry › Synthesis and bioactivity of alkaloids
Keywords: ayahuasca, dimethyltryptamine, β-carbolines, hallucinogens, psychiatric symptoms, neuropsychological performance, neuroimaging, default mode network, anterior cingulate cortex, posterior cingulate cortex, cortical thickness, impulsivity, spirituality, antidepressant effects, drug safety and toxicity
MeSH terms: Animals, Antidepressive Agents, Mental Disorders, Hallucinogens, Humans, Banisteriopsis, Neuroimaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The current state of research on ayahuasca: A systematic review of human studies assessing psychiatric symptoms, neuropsychological functioning, and neuroimaging

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks