Therapeutic use of serotoninergic hallucinogens: A review of the evidence and of the biological and psychological mechanisms

Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: a randomized double-blind trial

Griffiths, R. R., Johnson, M. W., Carducci, M. A., Umbricht, A., Richards, W. A., Richards, B. D., Cosimano, M. P., & Klinedinst, M. A. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116675513 · Cited by 2,201 · see citing works

Psychedelics

Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762 · see citing works

Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial.

Ross, S., Bossis, A., Guss, J., Agin-Liebes, G., Malone, T., Cohen, B., Mennenga, S. E., Belser, A., Kalliontzi, K., Babb, J., et al. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116675512 · Cited by 1,698 · see citing works

Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance

Griffiths, R. R., Richards, W. A., McCann, U., & Jesse, R. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0457-5 · Cited by 1,684 · see citing works

Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study

Carhart-Harris, R. L., Bolstridge, M., Rucker, J., Day, C. M. J., Erritzoe, D., Kaelen, M., Bloomfield, M., Rickard, J. A., Forbes, B., Feilding, A., et al. (2016) · The Lancet Psychiatry · doi:10.1016/s2215-0366(16)30065-7 · Cited by 1,540 · see citing works

Psychedelics promote structural and functional neural plasticity

Ly, C., Greb, A. C., Cameron, L. P., Wong, J. M., Barragan, E. V., Wilson, P. C., Burbach, K. F., Soltanzadeh Zarandi, S., Sood, A., Paddy, M. R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.022 · Cited by 1,207 · see citing works

Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage Cancer

Grob, C. S., Danforth, A. L., Chopra, G. S., Hagerty, M., McKay, C. R., Halberstadt, A. L., & Greer, G. R. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.116 · Cited by 1,206 · see citing works

Human hallucinogen research: guidelines for safety

Johnson, M., Richards, W., & Griffiths, R. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108093587 · Cited by 1,203 · see citing works

Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin

Carhart-Harris, R. L., Erritzoe, D., Williams, T., Stone, J. M., Reed, L. J., Colasanti, A., Tyacke, R. J., Leech, R., Malizia, A. L., Murphy, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119598109 · Cited by 1,172 · see citing works

Psilocybin-assisted treatment for alcohol dependence: A proof-of-concept study

Bogenschutz, M. P., Forcehimes, A. A., Pommy, J. A., Wilcox, C. E., Barbosa, P., & Strassman, R. J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114565144 · Cited by 1,151 · see citing works

Pilot study of the 5-HT _2A R agonist psilocybin in the treatment of tobacco addiction

Johnson, M. W., Garcia-Romeu, A., Cosimano, M. P., & Griffiths, R. R. (2014) · Journal of Psychopharmacology · doi:10.1177/0269881114548296 · Cited by 914 · see citing works

Mystical experiences occasioned by the hallucinogen psilocybin lead to increases in the personality domain of openness

MacLean, K. A., Johnson, M. W., & Griffiths, R. R. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111420188 · Cited by 895 · see citing works

Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

Palhano-Fontes, F., Barreto, D., Onias, H., Andrade, K. C., Novaes, M. M., Pessoa, J. A., Mota-Rolim, S. A., Osório, F. L., Sanches, R., dos Santos, R. G., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291718001356 · Cited by 852 · see citing works

Safety, tolerability, and efficacy of psilocybin in 9 patients with obsessive-compulsive disorder

Moreno, F. A., Wiegand, C. B., Taitano, E. K., & Delgado, P. L. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1110 · Cited by 789 · see citing works

Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases

Gasser, P., Holstein, D., Michel, Y., Doblin, R., Yazar-Klosinski, B., Passie, T., & Brenneisen, R. (2014) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0000000000000113 · Cited by 750 · see citing works

Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials

Krebs, T. S., & Johansen, P.-Ø. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112439253 · Cited by 583 · see citing works

Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies

Studerus, E., Kometer, M., Hasler, F., & Vollenweider, F. X. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110382466 · Cited by 532 · see citing works

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Osório, F. D. L., Sanches, R. F., Macedo, L. R., dos Santos, R. G., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A., & Hallak, J. E. (2015) · Revista Brasileira de Psiquiatria · doi:10.1590/1516-4446-2014-1496 · Cited by 488 · see citing works

Plants of the Gods: Their Sacred, Healing and Hallucinogenic Powers

Hofmann, A., & Schultes, R. E. (1992) · Medical Entomology and Zoology · Cited by 469 · see citing works

Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression: A SPECT Study

Sanches, R. F., de Lima Osório, F., dos Santos, R. G., Macedo, L. R. H., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000436 · Cited by 466 · see citing works

The Psychedelic State Induced by Ayahuasca Modulates the Activity and Connectivity of the Default Mode Network

Palhano-Fontes, F., Andrade, K. C., Tofoli, L. F., Santos, A. C., Crippa, J. A. S., Hallak, J. E. C., Ribeiro, S., & de Araujo, D. B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118143 · Cited by 454 · see citing works

Dose-response study of N,N-dimethyltryptamine in humans. II. Subjective effects and preliminary results of a new rating scale.

Strassman, R. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020022002 · Cited by 453 · see citing works

Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis

Vollenweider, F. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(96)00246-1 · Cited by 444 · see citing works

The Fabric of Meaning and Subjective Effects in LSD-Induced States Depend on Serotonin 2A Receptor Activation

Preller, K. H., Herdener, M., Pokorny, T., Planzer, A., Kraehenmann, R., Stämpfli, P., Liechti, M. E., Seifritz, E., & Vollenweider, F. X. (2017) · Current Biology · doi:10.1016/j.cub.2016.12.030 · Cited by 402 · see citing works

Monoamine oxidase inhibitors in South American hallucinogenic plants: Tryptamine and β-carboline constituents of ayahuasca

McKenna, D. J., Towers, G. H. N., & Abbott, F. (1984) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(84)90003-5 · Cited by 398 · see citing works

Human pharmacology of ayahuasca: Subjective and cardiovascular effects, monoamine metabolite excretion, and pharmacokinetics

Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., & Barbanoj, M. J. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049882 · Cited by 390 · see citing works

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens

Rickli, A., Moning, O. D., Hoener, M. C., & Liechti, M. E. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.05.001 · Cited by 379 · see citing works

Activation of Serotonin 2A Receptors Underlies the Psilocybin-Induced Effects on Oscillations, N170 Visual-Evoked Potentials, and Visual Hallucinations

Kometer, M., Schmidt, A., Jancke, L., & Vollenweider, F. X. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3007-12.2013 · Cited by 355 · see citing works

Human psychopharmacology of hoasca, a plant hallucinogen used in ritual context in Brazil.

GROB, C. S., McKENNA, D. J., CALLAWAY, J. C., BRITO, G. S., NEVES, E. S., OBERLAENDER, G., SAIDE, O. L., LABIGALINI, E., TACLA, C., MIRANDA, C. T., et al. (1996) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199602000-00004 · Cited by 338 · see citing works

Personality, psychopathology, life attitudes and neuropsychological performance among ritual users of ayahuasca: a longitudinal study.

Bouso, J. C., González, D., Fondevila, S., Cutchet, M., Fernández, X., Ribeiro Barbosa, P. C., Alcázar-Córcoles, M. Á., Araújo, W. S., Barbanoj, M. J., Fábregas, J. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042421 · Cited by 313 · see citing works

Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years

dos Santos, R. G., Osório, F. L., Crippa, J. A. S., Riba, J., Zuardi, A. W., & Hallak, J. E. C. (2016) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316638008 · Cited by 306 · see citing works

Psilocybin Biases Facial Recognition, Goal-Directed Behavior, and Mood State Toward Positive Relative to Negative Emotions Through Different Serotonergic Subreceptors

Kometer, M., Schmidt, A., Bachmann, R., Studerus, E., Seifritz, E., & Vollenweider, F. X. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.04.005 · Cited by 298 · see citing works

The paradoxical psychological effects of lysergic acid diethylamide LSD

Carhart-Harris, R. L., Kaelen, M., Bolstridge, M., Williams, T. M., Williams, L. T., Underwood, R., Feilding, A., & Nutt, D. J. (2016) · Psychological Medicine · doi:10.1017/s0033291715002901 · Cited by 293 · see citing works

Dose-Response Study of N,N-Dimethyltryptamine in Humans

Strassman, R. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020009001 · Cited by 291 · see citing works

Effects of psilocybin therapy on personality structure

Erritzoe, D., Roseman, L., Nour, M. M., MacLean, K., Kaelen, M., Nutt, D. J., & Carhart‐Harris, R. L. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12904 · Cited by 267 · see citing works

P5-HT1A receptors in mood and anxiety: recent insights into autoreceptor versus heteroreceptor function

Garcia‐García, Á. L., Newman‐Tancredi, A., & Leonardo, E. D. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3389-x · Cited by 250 · see citing works

LSD Acutely Impairs Fear Recognition and Enhances Emotional Empathy and Sociality

Dolder, P. C., Schmid, Y., Müller, F., Borgwardt, S., & Liechti, M. E. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.82 · Cited by 247 · see citing works

Increased frontal and paralimbic activation following ayahuasca, the pan-amazonian inebriant

Riba, J., Romero, S., Grasa, E., Mena, E., Carrió, I., & Barbanoj, M. J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0358-7 · Cited by 241 · see citing works

Long-lasting subjective effects of LSD in normal subjects.

Schmid, Y., & Liechti, M. E. (2018) · Psychopharmacology · doi:10.1007/s00213-017-4733-3 · Cited by 232 · see citing works

Efficacy, tolerability, and safety of serotonergic psychedelics for the management of mood, anxiety, and substance-use disorders: a systematic review of systematic reviews

SANTOS, R. G. D., Bouso, J. C., Alcázar‐Córcoles, M. Á., & Hallak, J. E. C. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1511424 · Cited by 228 · see citing works

Long-term use of psychedelic drugs is associated with differences in brain structure and personality in humans.

Bouso, J. C., Palhano-Fontes, F., Rodríguez-Fornells, A., Ribeiro, S., Sanches, R., Crippa, J. A. S., Hallak, J. E. C., de Araujo, D. B., & Riba, J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.008 · Cited by 218 · see citing works

Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution.

Uthaug, M. V., van Oorsouw, K., Kuypers, K. P. C., van Boxtel, M., Broers, N. J., Mason, N. L., Toennes, S. W., Riba, J., & Ramaekers, J. G. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4988-3 · Cited by 212 · see citing works

Exploring the therapeutic potential of Ayahuasca: acute intake increases mindfulness-related capacities

Soler, J., Elices, M., Franquesa, A., Barker, S., Friedlander, P., Feilding, A., Pascual, J. C., & Riba, J. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4162-0 · Cited by 209 · see citing works

Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members

SANTOS, R. G. D., Landeira-Fernández, J., Strassman, R. J., Motta, V., & Cruz, A. P. D. M. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.04.012 · Cited by 205 · see citing works

Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking

Kuypers, K. P. C., Riba, J., de la Fuente Revenga, M., Barker, S., Theunissen, E. L., & Ramaekers, J. G. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4377-8 · Cited by 201 · see citing works

Assessing the psychedelic "after-glow" in ayahuasca users: Post-acute neurometabolic and functional connectivity changes are associated with enhanced mindfulness capacities

Sampedro, F., de la Fuente Revenga, M., Valle, M., Roberto, N., Domínguez-Clavé, E., Elices, M., Luna, L. E., Crippa, J. A. S., Hallak, J. E. C., de Araujo, D. B., et al. (2017) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyx036 · Cited by 200 · see citing works

Psychedelic Drugs Reconsidered

Grinspoon, L., & Bakalar, J. B. (1979) · Medical Entomology and Zoology · Cited by 199 · see citing works

Alterations of consciousness and mystical-type experiences after acute LSD in humans

Liechti, M. E., Dolder, P. C., & Schmid, Y. (2017) · Psychopharmacology · doi:10.1007/s00213-016-4453-0 · Cited by 198 · see citing works

TiHKAL: The Continuation

Shulgin, A. T., & Shulgin, A. (1997) · Cited by 198 · see citing works

Psychedelics in the treatment of unipolar mood disorders: a systematic review

Rucker, J., Jelen, L. A., Flynn, S. K., Frowde, K., & Young, A. H. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116679368 · Cited by 185 · see citing works

Mescaline-induced psychopathological, neuropsychological, and neurometabolic effects in normal subjects: Experimental psychosis as a tool for psychiatric research

Hermle, L., Fünfgeld, M., Oepen, G., Botsch, H., Borchardt, D., Gouzoulis, E., Fehrenbach, R. A., & Spitzer, M. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90059-9 · Cited by 183 · see citing works

Modulation of serum brain-derived neurotrophic factor by a single dose of ayahuasca: observation from a randomized controlled trial

Almeida, R. N. D., Galvão, A. C. D. M., da Silva, F. S., Silva, E. A. D. S., Palhano-Fontes, F., Maia-de-Oliveira, J. P., de Araújo, L.-S. B., Lobão-Soares, B., & Galvão-Coelho, N. L. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01234 · Cited by 177 · see citing works

The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro

Morales-García, J. A., de la Fuente Revenga, M., Alonso-Gil, S., Rodríguez-Franco, M. I., Feilding, A., Perez-Castillo, A., & Riba, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-05407-9 · Cited by 175 · see citing works

Altered network hub connectivity after acute LSD administration

Müller, F., Dolder, P. C., Schmidt, A., Liechti, M. E., & Borgwardt, S. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2018.03.005 · Cited by 174 · see citing works

Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans

Valle, M., Maqueda, A. E., Rabella, M., Rodríguez-Pujadas, A., Antonijoan, R. M., Romero, S., Alonso, J. F., Mañanas, M. À., Barker, S., Friedlander, P., et al. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.03.012 · Cited by 173 · see citing works

Antidepressant-like effect of harmane and other β-carbolines in the mouse forced swim test

Farzin, D., & Mansouri, N. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.08.005 · Cited by 171 · see citing works

Ayahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies

SANTOS, R. G. D., Bouso, J. C., & Hallak, J. E. C. (2017) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316689030 · Cited by 168 · see citing works

Chronic, Intermittent Microdoses of the Psychedelic <i>N</i> , <i>N</i> -Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

Cameron, L. P., Benson, C. J., DeFelice, B. C., Fiehn, O., & Olson, D. E. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00692 · Cited by 168 · see citing works

Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies

SANTOS, R. G. D., Osório, F. D. L., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2015-1701 · Cited by 163 · see citing works

Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus

Fortunato, J. J., Réus, G. Z., Kirsch, T. R., Stringari, R. B., Stertz, L., Kapczinski, F., Pinto, J. P., Hallak, J. E., Zuardi, A. W., Crippa, J. A., et al. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.07.021 · Cited by 150 · see citing works

Autonomic, Neuroendocrine, and Immunological Effects of Ayahuasca

SANTOS, R. G. D., Valle, M., Bouso, J. C., Nomdedeu, J. F., Rodrı́guez-Espinosa, J., McIlhenny, E. H., Barker, S. A., Barbanoj, M. J., & Riba, J. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31823607f6 · Cited by 136 · see citing works

Serotonergic psychedelics and personality: A systematic review of contemporary research

Bouso, J. C., dos Santos, R. G., Alcázar-Córcoles, M. Á., & Hallak, J. E. C. (2018) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.004 · Cited by 134 · see citing works

Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects

Müller, F., Lenz, C., Dolder, P. C., Harder, S., Schmid, Y., Lang, U. E., Liechti, M. E., & Borgwardt, S. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.54 · Cited by 128 · see citing works

Clinical Interpretations of Patient Experience in a Trial of Psilocybin-Assisted Psychotherapy for Alcohol Use Disorder

Bogenschutz, M. P., Podrebarac, S. K., Duane, J. H., Amegadzie, S. S., Malone, T. C., Owens, L. T., Ross, S., & Mennenga, S. E. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00100 · Cited by 128 · see citing works

The current state of research on ayahuasca: a systematic review of human studies assessing psychiatric symptoms, neuropsychological functioning, and neuroimaging

dos Santos, R. G., Balthazar, F. M., Bouso, J. C., & Hallak, J. E. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116652578 · Cited by 125 · see citing works

The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine

Gillin, J. C., Kaplan, J., Stillman, R. C., & Wyatt, R. J. (1976) · American Journal of Psychiatry · doi:10.1176/ajp.133.2.203 · Cited by 123 · see citing works

Serotonergic hallucinogens in the treatment of anxiety and depression in patients suffering from a life-threatening disease: A systematic review

Reiche, S., Hermle, L., Gutwinski, S., Jungaberle, H., Gasser, P., & Majić, T. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.012 · Cited by 122 · see citing works

The endogenous hallucinogen and trace amine N.N-dimethyltryptamine (DMT) displays potent protective effects against hypoxia via sigma-1 receptor activation in human primary iPSC-derived cortical neurons and microglia-like immune cells

Szabo, A., Kovacs, A., Riba, J., Djurovic, S., Rajnavolgyi, E., & Frecska, E. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00423 · Cited by 121 · see citing works

Chemistry and Structure–Activity Relationships of Psychedelics

Nichols, D. E. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_475 · Cited by 114 · see citing works

The Psychedelic Debriefing in Alcohol Dependence Treatment: Illustrating Key Change Phenomena through Qualitative Content Analysis of Clinical Sessions

Nielson, E. M., May, D. G., Forcehimes, A. A., & Bogenschutz, M. P. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00132 · Cited by 113 · see citing works

Cortisol Modulation by Ayahuasca in Patients With Treatment Resistant Depression and Healthy Controls

Galvão, A. C. D. M., de Almeida, R. N., Silva, E. A. D. S., Freire, F. A. D. M., Palhano-Fontes, F., Onias, H., Arcoverde, E., Maia‐de‐Oliveira, J. P., de Araújo, D. B., Soares, B. L., et al. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00185 · Cited by 108 · see citing works

Classical hallucinogens and neuroimaging: A systematic review of human studies

dos Santos, R. G., Osório, F. L., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.026 · Cited by 107 · see citing works

Psychological and neuropsychological assessment of regular hoasca users

Barbosa, P. C. R., Strassman, R. J., da Silveira, D. X., Areco, K., Hoy, R., Pommy, J., Thoma, R., & Bogenschutz, M. (2016) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2016.09.003 · Cited by 105 · see citing works

The mixed serotonin receptor agonist psilocybin reduces threat-induced modulation of amygdala connectivity

Kraehenmann, R., Schmidt, A., Friston, K., Preller, K. H., Seifritz, E., & Vollenweider, F. X. (2016) · NeuroImage: Clinical · doi:10.1016/j.nicl.2015.08.009 · Cited by 104 · see citing works

Psilocybin with psychological support improves emotional face recognition in treatment-resistant depression

Stroud, J., Freeman, T. P., Leech, R., Hindocha, C., Lawn, W., Nutt, D., Curran, H. V., & Carhart-Harris, R. L. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4754-y · Cited by 104 · see citing works

Behavioural and neurotoxic effects of ayahuasca infusion (Banisteriopsis caapi and Psychotria viridis) in female Wistar rat

Pic‐Taylor, A., da Motta, L. G., de Morais, J. A., Melo, W., Santos, A. D. F. A., Campos, L. A., Mortari, M. R., von Zuben, M. V., & Caldas, E. D. (2015) · Behavioural Processes · doi:10.1016/j.beproc.2015.05.004 · Cited by 102 · see citing works

Four weekly ayahuasca sessions lead to increases in “acceptance” capacities: a comparison study with a standard 8-week mindfulness training program

Soler, J., Elices, M., Dominguez-Clavé, E., Pascual, J. C., Feilding, A., Navarro-Gil, M., García-Campayo, J., & Riba, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00224 · Cited by 102 · see citing works

Therapeutic use of classic psychedelics to treat cancer-related psychiatric distress

Ross, S. (2018) · International Review of Psychiatry · doi:10.1080/09540261.2018.1482261 · Cited by 102 · see citing works

Exploring ayahuasca‐assisted therapy for addiction: A qualitative analysis of preliminary findings among an Indigenous community in Canada

Argento, E., Capler, R., Thomas, G., Lucas, P., & Tupper, K. W. (2019) · Drug and Alcohol Review · doi:10.1111/dar.12985 · Cited by 102 · see citing works

Serotonergic psychedelics temporarily modify information transfer in humans.

Alonso, J. F., Romero, S., Mañanas, M. À., & Riba, J. (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv039 · Cited by 101 · see citing works

Effects of β-carboline harmine on behavioral and physiological parameters observed in the chronic mild stress model: Further evidence of antidepressant properties

Fortunato, J. J., Réus, G. Z., Kirsch, T. R., Stringari, R. B., Fries, G. R., Kapczinski, F. P., Hallak, J. E. C., Zuardi, A. W., Crippa, J. A. S., & Quevedo, J. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.09.008 · Cited by 99 · see citing works

Metabolism and urinary disposition of N,N‐dimethyltryptamine after oral and smoked administration: a comparative study

Jordi Riba, A., McIlhenny, E. H., Bouso, J. C., & Barker, S. A. (2014) · Drug Testing and Analysis · doi:10.1002/dta.1685 · Cited by 98 · see citing works

Chronic administration of harmine elicits antidepressant-like effects and increases BDNF levels in rat hippocampus

Fortunato, J. J., Réus, G. Z., Kirsch, T. R., Stringari, R. B., Fries, G. R., Kapczinski, F., Hallak, J. E., Zuardi, A. W., Crippa, J. A., & Quevedo, J. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0451-2 · Cited by 98 · see citing works

Assessment of Alcohol and Tobacco Use Disorders Among Religious Users of Ayahuasca

Barbosa, P. C. R., Tófoli, L. F., Bogenschutz, M. P., Hoy, R. V., Berro, L. F., Marinho, E. A. V., Areco, K. C. N., & Winkelman, M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00136 · Cited by 97 · see citing works

Effects of Ayahuasca and its Alkaloids on Drug Dependence: A Systematic Literature Review of Quantitative Studies in Animals and Humans

Nunes, A. A., SANTOS, R. G. D., Osório, F. D. L., Sanches, R. F., Crippa, J. A. S., & Hallak, J. E. C. (2016) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2016.1188225 · Cited by 91 · see citing works

Serotonin 5‐ HT 7 receptor increases the density of dendritic spines and facilitates synaptogenesis in forebrain neurons

Speranza, L., Labus, J., Volpicelli, F., Guseva, D., Lacivita, E., Leopoldo, M., Bellenchi, G. C., di Porzio, U., Bijata, M., Perrone‐Capano, C., et al. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.13962 · Cited by 91 · see citing works

Pharmacotheon: entheogenic drugs, their plant sources and history

(1994) · Choice Reviews Online · doi:10.5860/choice.31-3245 · Cited by 91 · see citing works

Harmine stimulates proliferation of human neural progenitors

Dakic, V., Maciel, R. D. M., Drummond, H., Nascimento, J. M., Trindade, P., & Rehen, S. K. (2016) · PeerJ · doi:10.7717/peerj.2727 · Cited by 87 · see citing works

Therapeutic Applications of Classic Hallucinogens

Bogenschutz, M. P., & Ross, S. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_464 · Cited by 85 · see citing works

Ayahuasca improves emotion dysregulation in a community sample and in individuals with borderline-like traits

Domínguez‐Clavé, E., Soler, J., Pascual, J. C., Elices, M., Franquesa, A., Valle, M., Álvarez, E., & Riba, J. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5085-3 · Cited by 81 · see citing works

Well-being, problematic alcohol consumption and acute subjective drug effects in past-year ayahuasca users: a large, international, self-selecting online survey

Lawn, W., Hallak, J. E. C., Crippa, J. A. S., SANTOS, R. G. D., Porffy, L., Barratt, M. J., Ferris, J., WINSTOCK, A. R., & Morgan, C. J. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-14700-6 · Cited by 78 · see citing works

An exploratory study of experiences with conventional eating disorder treatment and ceremonial ayahuasca for the healing of eating disorders

Renelli, M., Fletcher, J., Tupper, K. W., Files, N., Loizaga-Velder, A., & Lafrance, A. (2018) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-018-0619-6 · Cited by 78 · see citing works

Harmine produces antidepressant-like effects via restoration of astrocytic functions

Liu, F., Wu, J., Gong, Y. L., Wang, P., Zhu, L., Tong, L., Chen, X., Ling, Y., & Huang, C. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.012 · Cited by 77 · see citing works

Ayahuasca and public health: health status, psychosocial well-being, lifestyle, and coping strategies in a large sample of ritual ayahuasca users

Ona, G., Kohek, M., Massaguer, T., Gomariz, A., Jiménez, D. F., Dos Santos, R. G., Hallak, J. E. C., Alcázar-Córcoles, M. Á., & Bouso, J. C. (2019) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2019.1567961 · Cited by 76 · see citing works

Short-Term Treatment Effects of a Substance Use Disorder Therapy Involving Traditional Amazonian Medicine

Berlowitz, I., Walt, H., Ghasarian, C., Mendive, F., & Martin-Soelch, C. (2019) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2019.1607956 · Cited by 72 · see citing works

The serotonin 5-HT 2C receptor and the non-addictive nature of classic hallucinogens

Canal, C. E., & Murnane, K. S. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116677104 · Cited by 67 · see citing works

Effects of the Naturalβ-Carboline Alkaloid Harmine, a Main Constituent of Ayahuasca, in Memory and in the Hippocampus: A Systematic Literature Review of Preclinical Studies

SANTOS, R. G. D., & Hallak, J. E. C. (2016) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2016.1260189 · Cited by 65 · see citing works

Interactions of Hallucinogens with the Glutamatergic System: Permissive Network Effects Mediated Through Cortical Layer V Pyramidal Neurons

Marek, G. J. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_480 · Cited by 63 · see citing works

Psychological variables implied in the therapeutic effect of ayahuasca: A contextual approach

Franquesa, A., Sainz-Cort, A., Gandy, S., Soler, J., Alcázar-Córcoles, M. Á., & Bouso, J. C. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.04.012 · Cited by 58 · see citing works

Ayahuasca and Its DMT- and β-carbolines – Containing Ingredients Block the Expression of Ethanol-Induced Conditioned Place Preference in Mice: Role of the Treatment Environment

Cata-Preta, E. G., Serra, Y. A., Moreira-Junior, E. D. C., Reis, H. S., Kisaki, N. D., Libarino-Santos, M., Silva, R. R. R., Barros-Santos, T., Santos, L. C., Barbosa, P. C. R., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00561 · Cited by 53 · see citing works

Effects of harmaline on anxiety-related behavior in mice

Hilber, P., & Chapillon, P. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.07.006 · Cited by 51 · see citing works

Lysergic Acid Diethylamide and Psilocybin for the Management of Patients with Persistent Pain: a Potential Role?

Whelan, A., & Johnson, M. I. (2018) · Pain Management · doi:10.2217/pmt-2017-0068 · Cited by 51 · see citing works

Acute effects of ayahuasca in a juvenile non-human primate model of depression

da Silva, F. S., Silva, E. A. D. S., de Sousa, G. M., Maia‐de‐Oliveira, J. P., Soares-Rachetti, V. D. P., de Araújo, D. B., de Sousa, M. B. C., Soares, B. L., Hallak, J. E. C., & Coelho, N. L. G. (2018) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2018-0140 · Cited by 46 · see citing works

Potential use of ayahuasca in grief therapy

González, D., Carvalho, M., Cantillo, J., Aixalá, M., & Farré, M. (2019) · OMEGA - Journal of Death and Dying · doi:10.1177/0030222817710879 · Cited by 44 · see citing works

Serotonergic hallucinogens and recognition of facial emotion expressions: a systematic review of the literature

Rocha, J. M., Osório, F. D. L., Crippa, J. A. S., Bouso, J. C., Rossi, G. N., Hallak, J. E. C., & SANTOS, R. G. D. (2019) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125319845774 · Cited by 43 · see citing works

Psychedelic Drugs Reconsidered

W., D. M., Grinspoon, L., Bakalar, J. B., Winkelman, M., Andritzky, W., & Forte, R. (1999) · Journal for the Scientific Study of Religion · doi:10.2307/1387601 · Cited by 42 · see citing works

Ketamine—A Narrative Review of Its Uses in Medicine

Radvansky, B. M., Puri, S., Sifonios, A. N., Eloy, J. D., & Le, V. (2015) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000257 · Cited by 41 · see citing works

Is Ayahuasca an Option for the Treatment of Crack Cocaine Dependence?

da Cruz, J. I., & Nappo, S. A. (2018) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2018.1447174 · Cited by 36 · see citing works

The renaissance in psychedelic research: What do preclinical models have to offer

Murnane, K. S. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.08.003 · Cited by 31 · see citing works

Les effets de l’ayahuasca sur le système nerveux central: étude comportementale

de Lima, L. M. S., Ferreira, S. M., Ávila, A. A. L., Perazzo, F. F., Schneedorf, J. M., Hinsberger, A., & Carvalho, J. C. T. (2007) · Phytothérapie · doi:10.1007/s10298-007-0266-y · Cited by 27 · see citing works

Ayahuasca Modifies Amphetamine Self Ingestion and ModifiesAnxiety and Locomotor Activity in Adolescent Rats

Af, G., SILVA, M., Jd, K., Horta, D. F., Anselmo, F., & Fraia, D. D. (2017) · Electronic journal of biology · Cited by 15 · see citing works

William Burroughs: Sailor of the Soul

Lees, A. J. (2017) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2017.1357862 · Cited by 5 · see citing works

New psychoactive substances: a review and updates

Shafi, A., Berry, A. J., Sumnall, H. R., Wood, D. M., & Tracy, D. K. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320967197 · Cited by 350 · see citing works

Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics

Aleksandrova, L. R., & Phillips, A. G. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.08.003 · Cited by 276 · see citing works

Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis

Ko, K., Kopra, E. I., Cleare, A. J., & Rucker, J. J. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.168 · Cited by 150 · see citing works

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

Morales-Garcia, J. A., Calleja-Conde, J., Lopez-Moreno, J. A., Alonso-Gil, S., Sanz-SanCristobal, M., Riba, J., & Perez-Castillo, A. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01011-0 · Cited by 138 · see citing works

Subacute effects of the psychedelic ayahuasca on the salience and default mode networks

Pasquini, L., Palhano-Fontes, F., & de Araújo, D. B. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120909409 · Cited by 115 · see citing works

Toxicokinetics and Toxicodynamics of Ayahuasca alkaloids N,N-dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: clinical and forensic impact

Brito-da-Costa, A. M., Dias-da-Silva, D., Gomes, N. G. M., Dinis-Oliveira, R. J., & Madureira-Carvalho, Á. (2020) · Pharmaceuticals · doi:10.3390/ph13110334 · Cited by 117 · see citing works

Classic Psychedelic Drugs: Update on Biological Mechanisms

Vollenweider, F. X., & Smallridge, J. W. (2022) · Pharmacopsychiatry · doi:10.1055/a-1721-2914 · Cited by 112 · see citing works

Dose–response relationships of psilocybin-induced subjective experiences in humans

Hirschfeld, T., & Schmidt, T. T. (2021) · Journal of Psychopharmacology · doi:10.1177/0269881121992676 · Cited by 93 · see citing works

Psychedelics and Neural Plasticity: Therapeutic Implications

Grieco, S. F., Castrén, E., Knudsen, G. M., Kwan, A. C., Olson, D. E., Zuo, Y., Holmes, T. C., & Xu, X. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.1121-22.2022 · Cited by 82 · see citing works

Neural Mechanisms and Psychology of Psychedelic Ego Dissolution

Stoliker, D., Egan, G. F., Friston, K. J., & Razi, A. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.121.000508 · Cited by 89 · see citing works

Rapid and sustained decreases in suicidality following a single dose of ayahuasca among individuals with recurrent major depressive disorder: results from an open-label trial

Zeifman, R. J., Singhal, N., SANTOS, R. G. D., Sanches, R. F., Osório, F. D. L., Hallak, J. E. C., & Weissman, C. R. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05692-9 · Cited by 83 · see citing works

Brain serotonin 2A receptor binding predicts subjective temporal and mystical effects of psilocybin in healthy humans

Stenbæk, D. S., Madsen, M. K., Ozenne, B., Kristiansen, S., Burmester, D., Erritzøe, D., Knudsen, G. M., & Fisher, P. M. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120959609 · Cited by 80 · see citing works

Psilocybin and LSD have no long-lasting effects in an animal model of alcohol relapse

Meinhardt, M. W., Güngör, C., Skorodumov, I., Mertens, L. J., & Spanagel, R. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0694-z · Cited by 65 · see citing works

The Canadian Network for Mood and Anxiety Treatments (CANMAT) Task Force Report: Serotonergic Psychedelic Treatments for Major Depressive Disorder

Rosenblat, J. D., Husain, M. I., Lee, Y. L., McIntyre, R. S., Mansur, R. B., Castle, D. J., Offman, H., Parikh, S. V., Frey, B. N., Schaffer, A., et al. (2022) · The Canadian Journal of Psychiatry · doi:10.1177/07067437221111371 · Cited by 68 · see citing works

Sustained effects of single doses of classical psychedelics in humans

Knudsen, G. M. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01361-x · Cited by 60 · see citing works

The Use of Classic Hallucinogens/Psychedelics in a Therapeutic Context: Healthcare Policy Opportunities and Challenges

SANTOS, R. G. D., Bouso, J. C., Rocha, J. M., Rossi, G. N., & Hallak, J. E. C. (2021) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s300656 · Cited by 60 · see citing works

Classic and non‐classic psychedelics for substance use disorder: A review of their historic, past and current research

Mendes, F. R., Costa, C. D. S., Wiltenburg, V. D., Morales-Lima, G., Fernandes, J. A. B., & Filev, R. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100025 · Cited by 59 · see citing works

Hallucinogenic/psychedelic 5HT2A receptor agonists as rapid antidepressant therapeutics: Evidence and mechanisms of action

dos Santos, R. G., Hallak, J. E., Baker, G., & Dursun, S. (2021) · Journal of Psychopharmacology · doi:10.1177/0269881120986422 · Cited by 55 · see citing works

Assessing the effects of methodological differences on outcomes in the use of psychedelics in the treatment of anxiety and depressive disorders: A systematic review and meta-analysis

Leger, R. F., & Unterwald, E. M. (2021) · Journal of Psychopharmacology · doi:10.1177/02698811211044688 · Cited by 55 · see citing works

Extensive Collection of Psychotropic Mushrooms with Determination of Their Tryptamine Alkaloids

Gotvaldová, K., Borovička, J., Hájková, K., Cihlářová, P., Rockefeller, A., & Kuchař, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214068 · Cited by 53 · see citing works

Apical amplification—a cellular mechanism of conscious perception?

Marvan, T., Polák, M., Bachmann, T., & Phillips, W. A. (2021) · Neuroscience of Consciousness · doi:10.1093/nc/niab036 · Cited by 45 · see citing works

Psychedelic therapies reconsidered: compounds, clinical indications, and cautious optimism

Mitchell, J., & Anderson, B. T. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01656-7 · Cited by 49 · see citing works

Toxicology and Analysis of Psychoactive Tryptamines

Malaca, S., Faro, A. F. L., Tamborra, A., Pichini, S., Busardò, F. P., & Huestis, M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239279 · Cited by 47 · see citing works

Effects of Ayahuasca on the Recognition of Facial Expressions of Emotions in Naive Healthy Volunteers

Rocha, J. M., Rossi, G. N., Osório, F. D. L., Bouso, J. C., Silveira, G. D. O., Yonamine, M., Campos, A. C., Bertozi, G., Hallak, J. E. C., & SANTOS, R. G. D. (2021) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001396 · Cited by 47 · see citing works

The adverse events of ibogaine in humans: an updated systematic review of the literature (2015–2020)

Oña, G., Rocha, J. M., Bouso, J. C., Hallak, J. E. C., Cabacés, T. B. I., Colomina, M. T., & SANTOS, R. G. D. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05964-y · Cited by 44 · see citing works

A Single Administration of the Atypical Psychedelic Ibogaine or Its Metabolite Noribogaine Induces an Antidepressant-Like Effect in Rats

Rodríguez, P. M., Urbanavicius, J., Prieto, J. P., Fabius, S., Reyes, A. L., Havel, V., Sameš, D., Scorza, C., & Carrera, I. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00152 · Cited by 43 · see citing works

Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review

Lazur, J., Hnatyk, K., Kała, K., Sułkowska‐Ziaja, K., & Muszyńska, B. (2023) · Antioxidants · doi:10.3390/antiox12030623 · Cited by 44 · see citing works

Rapid antidepressant-like effect of non-hallucinogenic psychedelic analog lisuride, but not hallucinogenic psychedelic DOI, in lipopolysaccharide-treated mice

Qu, Y., Chang, L., Ma, L., Wan, X., & Hashimoto, K. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173500 · Cited by 41 · see citing works

Do psychedelics change beliefs?

McGovern, H. T., Leptourgos, P., Hutchinson, B. T., & Corlett, P. R. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06153-1 · Cited by 38 · see citing works

Evaluating the risk of psilocybin for the treatment of bipolar depression: A review of the research literature and published case studies

Gard, D. E., Pleet, M. M., Bradley, E., Penn, A., Gallenstein, M. L., Riley, L. S., DellaCrosse, M. A., Garfinkle, E. M., Michalak, E. E., & Woolley, J. D. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100240 · Cited by 36 · see citing works

Psilocybin Efficacy and Mechanisms of Action in Major Depressive Disorder: a Review

Prouzeau, D., Conejero, I., Voyvodic, P. L., Bécamel, C., Abbar, M., & López‐Castromán, J. (2022) · Current Psychiatry Reports · doi:10.1007/s11920-022-01361-0 · Cited by 33 · see citing works

Psychedelic use is associated with reduced daily opioid use among people who use illicit drugs in a Canadian setting

Argento, E., Socias, M. E., Hayashi, K., Choi, J., Mackay, L., Christie, D., Milloy, M., & DeBeck, K. (2021) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2021.103518 · Cited by 33 · see citing works

Within-treatment changes in a novel addiction treatment program using traditional Amazonian medicine

O’Shaughnessy, D. M., Berlowitz, I., Rodd, R., Sarnyai, Z., & Quirk, F. H. (2021) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320986634 · Cited by 33 · see citing works

Psilocybin therapy for mood dysfunction in Parkinson’s disease: an open-label pilot trial

Bradley, E., Sakai, K., Fernandes‐Osterhold, G., Szigeti, B., Ludwig, C., Ostrem, J. L., Tanner, C. M., Bock, M., Llerena, K., Finley, P. R., et al. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02097-0 · Cited by 31 · see citing works

Serotonergic Psychedelics in Neural Plasticity

Łukasiewicz, K., Baker, J. J., Zuo, Y., & Lu, J. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.748359 · Cited by 31 · see citing works

Lysergic Acid Diethylamide, Psilocybin and Dimethyltryptamine in Depression Treatment: A Systematic Review

Więckiewicz, G., Stokłosa, I., Piegza, M. J., Gorczyca, P. W., & Pudło, R. (2021) · Pharmaceuticals · doi:10.3390/ph14080793 · Cited by 34 · see citing works

Acute serotonin 2A receptor activation impairs behavioral flexibility in mice

Amodeo, D. A., Hassan, O., Klein, L. M., Halberstadt, A. L., & Powell, S. B. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112861 · Cited by 27 · see citing works

Phytotherapy of mood disorders in the light of microbiota-gut-brain axis.

Korczak, M., Pilecki, M. W., Granica, S., Gorczynska, A., Pawłowska, K. A., & Piwowarski, J. P. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154642 · Cited by 27 · see citing works

Ayahuasca‐enhanced extinction of fear behaviour: Role of infralimbic cortex 5‐HT2A and 5‐HT1A receptors

Werle, I., Nascimento, L. M. M., dos Santos, A. L. A., Soares, L. A., SANTOS, R. G. D., Hallak, J. E. C., & Bertoglio, L. J. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16315 · Cited by 28 · see citing works

The Missing Piece? A Case for Microglia’s Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics

VanderZwaag, J., Halvorson, T., Dolhan, K., Šimončičová, E., Ben‐Azu, B., & Tremblay, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03772-0 · Cited by 26 · see citing works

New Psychoactive Substances: Major Groups, Laboratory Testing Challenges, Public Health Concerns, and Community-Based Solutions

Awuchi, C. G., Aja, P. M., Mitaki, N. B., Morya, S., Amagwula, I. O., Echeta, C. K., & Igwe, V. S. (2023) · Journal of Chemistry · doi:10.1155/2023/5852315 · Cited by 26 · see citing works

Effects of ayahuasca on the endocannabinoid system of healthy volunteers and in volunteers with social anxiety disorder: Results from two pilot, proof‐of‐concept, randomized, placebo‐controlled trials

SANTOS, R. G. D., Rocha, J. M., Rossi, G. N., Osório, F. D. L., Oña, G., Bouso, J. C., Silveira, G. D. O., Yonamine, M., Marchioni, C., Crevelin, E. J., et al. (2022) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2834 · Cited by 21 · see citing works

Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents

Werle, I., & Bertoglio, L. J. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105899 · Cited by 23 · see citing works

To be or not to be hallucinating: Implications of hypnagogic/hypnopompic experiences and lucid dreaming for brain disorders

Foffani, G. (2023) · PNAS Nexus · doi:10.1093/pnasnexus/pgad442 · Cited by 18 · see citing works

Effects of acute lysergic acid diethylamide on intermittent ethanol and sucrose drinking and intracranial self-stimulation in C57BL/6 mice

Elsilä, L. V., Harkki, J., Enberg, E., Martti, A., Linden, A.-M., & Korpi, E. R. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221104641 · Cited by 19 · see citing works

Prophylactic effects of arketamine, but not hallucinogenic psychedelic DOI nor non-hallucinogenic psychedelic analog lisuride, in lipopolysaccharide-treated mice and mice exposed to chronic restrain stress

Liu, G., Ma, L., Qu, Y., Wan, X., Xu, D., Zhao, M., Murayama, R., & Hashimoto, K. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173659 · Cited by 18 · see citing works

Underground ibogaine use for the treatment of substance use disorders: A qualitative analysis of subjective experiences

Rodríguez‐Cano, B. J., Kohek, M., Oña, G., Alcázar‐Córcoles, M. Á., SANTOS, R. G. D., Hallak, J. E. C., & Bouso, J. C. (2022) · Drug and Alcohol Review · doi:10.1111/dar.13587 · Cited by 17 · see citing works

Essential oil-based dispersive liquid-liquid microextraction for the determination of N,N-dimethyltryptamine and β-carbolines in human plasma: A novel solvent-free alternative

Silveira, G. D. O., Lourenço, F. R., Pego, A. M. F., SANTOS, R. G. D., Rossi, G. N., Hallak, J. E. C., & Yonamine, M. (2020) · Talanta · doi:10.1016/j.talanta.2020.121976 · Cited by 15 · see citing works

The association between naturalistic use of psychedelics and co-occurring substance use disorders

Rabinowitz, J., Lev‐Ran, S., & Gross, R. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1066369 · Cited by 14 · see citing works

DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms

Tae, H., Ortells, M. O., Tekarli, B., Manetti, D., Romanelli, M. N., McIntosh, J. M., Adams, D. J., & Arias, H. R. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00212 · Cited by 14 · see citing works

Hallucinogens/psychedelics resurrected as new tools in psychiatric therapy

SANTOS, R. G. D., Bouso, J. C., & Hallak, J. E. C. (2020) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-1035 · Cited by 14 · see citing works

Content analysis of Reddit posts about coadministration of selective serotonin reuptake inhibitors and psilocybin mushrooms

Sakai, K., Bradley, E., Zamaria, J. A., Agin-Liebes, G., Kelley, D. P., Fish, A., Martini, V., Ferris, M. C., Morton, E. E., Michalak, E. E., et al. (2024) · Psychopharmacology · doi:10.1007/s00213-024-06585-x · Cited by 13 · see citing works

Fast Hollow Fiber Liquid-Phase Microextraction as a Greener Alternative for the Determination of N,N-Dimethyltryptamine and Harmala Alkaloids in Human Urine

Silveira, G. D. O., Lourenço, F. R., Bruno, V., & Yonamine, M. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.558501 · Cited by 12 · see citing works

The psychological processes of classic psychedelics in the treatment of depression: a systematic review protocol

Johansen, L., Liknaitzky, P., Nedeljkovic, M., Mastin-Purcell, L., & Murray, G. (2022) · Systematic Reviews · doi:10.1186/s13643-022-01930-7 · Cited by 11 · see citing works

Phytochemical interventions for post-traumatic stress disorder: A cluster co-occurrence network analysis using CiteSpace.

Gao, B., Qu, Y.-C., Cai, M., Zhang, Y., Lu, H.-T., Li, H.-X., Tang, Y.-X., & Shen, H. (2023) · Journal of Integrative Medicine · doi:10.1016/j.joim.2023.06.006 · Cited by 10 · see citing works

Psychedelic-Assisted Psychotherapy After COVID-19: The Therapeutic Uses of Psilocybin and MDMA for Pandemic-Related Mental Health Problems

Argento, E., Christie, D., Mackay, L., Callon, C., & Walsh, Z. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.716593 · Cited by 11 · see citing works

Should Adolescents be Included in Emerging Psychedelic Research?

Rajwani, K. (2022) · Canadian Journal of Bioethics · doi:10.7202/1089784ar · Cited by 10 · see citing works

Effects of serotonergic psychedelics on mitochondria: Transdiagnostic implications for mitochondria-related pathologies

Fissler, P., Vandersmissen, A., Filippi, M., Mavioğlu, R. N., Scholkmann, F., Karabatsiakis, A., & Krähenmann, R. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231164707 · Cited by 10 · see citing works

Toxicity of psychedelic drugs

Călina, D. C., Carvalho, F. D., & Docea, A. O. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85215-9.00022-2 · Cited by 10 · see citing works

Adverse Effects After Ayahuasca Administration in the Clinical Setting

Rocha, J. M., Rossi, G. N., Osório, F. L., Hallak, J. E. C., & SANTOS, R. G. D. (2022) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001536 · Cited by 10 · see citing works

Masking Influences: A Systematic Review of Placebo Control and Masking in Psychedelic Studies

Barstowe, A., & Kajonius, P. (2024) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2024.2424272 · Cited by 9 · see citing works

Participants’ Experience of Psychedelic Integration Groups and Processes: A Qualitative Thematic Analysis

Modlin, N. L., McPhee, T., Zazon, N., Sarang, M., Hignett, R., Pick, S., Cleare, A. J., Williamson, V., & Rucker, J. (2024) · Psychedelic Medicine · doi:10.1089/psymed.2024.0027 · Cited by 9 · see citing works

Hallucinations and Hallucinogens: Psychopathology or Wisdom?

Bouso, J. C., Oña, G., Kohek, M., SANTOS, R. G. D., Hallak, J. E. C., Alcázar‐Córcoles, M. Á., & Obiols‐Llandrich, J. (2023) · Culture Medicine and Psychiatry · doi:10.1007/s11013-022-09814-0 · Cited by 9 · see citing works

Human Hepatocyte 4-Acetoxy-N,N-Diisopropyltryptamine Metabolite Profiling by Reversed-Phase Liquid Chromatography Coupled with High-Resolution Tandem Mass Spectrometry

Malaca, S., Huestis, M. A., Lattanzio, L., Marsella, L. T., Tagliabracci, A., Carlier, J., & Busardò, F. P. (2022) · Metabolites · doi:10.3390/metabo12080705 · Cited by 9 · see citing works

Psychedelics and fNIRS neuroimaging: exploring new opportunities

Scholkmann, F., & Vollenweider, F. X. (2022) · Neurophotonics · doi:10.1117/1.nph.10.1.013506 · Cited by 9 · see citing works

Mystical and Ego-Dissolution Experiences in Ayahuasca and Jurema Holistic Rituals: An Exploratory Study

Savoldi, R., Roazzi, A., & Sales, R. C. D. O. (2023) · International Journal for the Psychology of Religion · doi:10.1080/10508619.2023.2185369 · Cited by 8 · see citing works

Delayed Anxiolytic-Like Effects of Psilocybin in Male Mice Are Supported by Acute Glucocorticoid ReleasePreprint

Jones, N., Zahid, Z., Grady, S. M., Sultan, Z. W., Zheng, Z., Banks, M. I., & Wenthur, C. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.12.248229 · Cited by 8 · see citing works

Potential therapeutic use of ayahuasca: A literature review

Costa, S. P. M., CARVALHO, K. C., GOMES, I. N., Calazans, C. L., Silva, M. T. A., de Miranda, J. A., Barreto, I. C., Matheus Vinícius Guimarães de, M. E. L. O., de Holanda, K. E. R., & Filho, J. M. T. D. A. (2024) · Acta Amazonica · doi:10.1590/1809-4392202301821 · Cited by 8 · see citing works

Hospital-based care for hallucinogens and risk of mania and bipolar disorder: A population-based cohort study

Myran, D. T., MacDonald‐Spracklin, R., Pugliese, M., Gibb, M. A., Fiedorowicz, J. G., Kaster, T. S., & Solmi, M. (2025) · PLoS Medicine · doi:10.1371/journal.pmed.1004805 · Cited by 7 · see citing works

Perspective: Can psychedelic-assisted therapy be a promising aid in compulsive sexual behavior disorder treatment?

Wizła, M., Kraus, S. W., & Lewczuk, K. (2022) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2022.152303 · Cited by 7 · see citing works

Three Cases of Reported Improvement in Microsmia and Anosmia Following Naturalistic Use of Psilocybin and LSD

Kovacevich, A., Weleff, J., Claytor, B., & Barnett, B. S. (2023) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2023.2253538 · Cited by 7 · see citing works

Psilocybin-assisted psychotherapy for the treatment of PTSD in UK Armed Forces Veterans: A feasibility study protocol

Biscoe, N., Bonson, A., Slavin, S. L., Busuttil, W., MacManus, D., Cox, L. C. D. A., & Murphy, D. (2023) · European Journal of Trauma &amp; Dissociation · doi:10.1016/j.ejtd.2023.100359 · Cited by 6 · see citing works

Therapeutic Use of Hallucinogens

Wiltenburg, V. D., Prado, D. D. R., & Mendes, F. R. (2021) · Springer eBooks · doi:10.1007/978-3-030-62855-0_35 · Cited by 8 · see citing works

The zebrafish for preclinical psilocybin research

Syed, O. A., Tsang, B., & Gerlai, R. T. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105381 · Cited by 7 · see citing works

Can psychedelic use benefit meditation practice? Examining individual, psychedelic, and meditation-related factors

Jiwani, Z., Goldberg, S. B., Stroud, J., Young, J., Curtin, J., Dunne, J. D., Simonsson, O., Webb, C. A., Carhart-Harris, R., & Schlosser, M. (2025) · PLOS ONE · doi:10.1371/journal.pone.0310160 · Cited by 6 · see citing works

Effect of Bulky N-Dibenzofuranylmethyl Substitution on the 5-HT2 Receptor Affinity and Efficacy of a Psychedelic Phenethylamine

Soares, B. A., Yempala, T., Martínez-Afani, D., Acevedo-Fuentes, W., Brea, J. M., Loza, M. I., Cimadevila, M., & Cassels, B. K. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00639 · Cited by 4 · see citing works

Ayahuasca modulation of traumatic-like fear memories requires infralimbic cortex BDNF-dependent mechanisms in rats

Werle, I., Guimarães, F. S., SANTOS, R. G. D., Hallak, J. E. C., & Bertoglio, L. J. (2025) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2025.11.009 · Cited by 3 · see citing works

The Genesis of a New Open-Access Journal Focused on the Latest Scientific Advances in Psychoactive Substances

Dinis‐Oliveira, R. J. (2022) · Psychoactives · doi:10.3390/psychoactives1010001 · Cited by 3 · see citing works

Classical Hallucinogens As Antidepressant Drugs: A Cautionary Approach

SANTOS, R. G. D., Rossi, G. N., Hallak, J. E. C., Öngür, D., & Dursun, S. M. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220425133824 · Cited by 3 · see citing works

A scoping review of variations in psychedelic interventions for psychological suffering associated with the end of life

Kratina, S., Strıke, C., Schwartz, R. D., Nayfeh, A., Jopling, S. A., Lo, C., & Rush, B. R. (2025) · Social Science & Medicine · doi:10.1016/j.socscimed.2025.118536 · Cited by 2 · see citing works

The Structural Organization and Construct Validity Evidence of the Brazilian Versions of the Mysticism Scale and the Ego-Dissolution Inventory in a Major Religion of the Ayahuasca

Savoldi, R., Roazzi, A., Escobar, J. A. C., Nour, M. M., & Carhart-Harris, R. L. (2023) · International Journal of Latin American Religions · doi:10.1007/s41603-023-00203-y · Cited by 2 · see citing works

Unique biological and physiological properties of endogenous N, N-dimethyltryptamine from the perspective of functioning of the nervous system

Schimmelpfennig, J., & Jankowiak-Siuda, K. (2023) · Neuropsychiatria i Neuropsychologia · doi:10.5114/nan.2023.129068 · Cited by 2 · see citing works

Terapia antidepresiboaren azken pausoak: oraina eta geroa

Erkizia-Santamaría, I., Ortega, J. E., & Horrillo, I. (2020) · Osagaiz osasun-zientzien aldizkaria · doi:10.26876/osagaiz.2.2020.311 · Cited by 2 · see citing works

O PAPEL DOS ALUCINÓGENOS NO TRATAMENTO DE TRANSTORNOS MENTAIS E SUA RELEVÂNCIA NA PSIQUIATRIA: UMA REVISÃO INTEGRATIVA

da Silva, J. R. M. Q., & Mendonça, M. A. (2023) · Revista Ibero-Americana de Humanidades, Ciências e Educação · doi:10.51891/rease.v9i8.11098 · Cited by 2 · see citing works

Can the revival of serotonergic psychedelic drugs as treatments for mental disorders help to characterize their risks and benefits?

Husain, M. I., Umer, M., & Mulsant, B. H. (2022) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.2063274 · Cited by 2 · see citing works

A protocol for a scoping review of variations among psychedelic interventions for psychological suffering associated with the end-of-life

Kratina, S., Strıke, C., Schwartz, R. D., Nayfeh, A., Jopling, S. A., Lo, C., & Rush, B. R. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318343 · Cited by 1 · see citing works

Should People With a History of Psychosis Be Included in Psychedelic Research?

Rajwani, K. (2026) · Canadian Journal of Bioethics · doi:10.7202/1124213ar · Cited by 1 · see citing works

Possível uso da Psilocibina no tratamento psiquiátrico, incluindo sequelas da COVID-19

Bonifácio, M. C. A. C., Bento, P. B. B., Trevisan, K., Cristina-Pereira, R., Magri, M. P. D. F., & Aversi‐Ferreira, T. A. (2021) · Research Society and Development · doi:10.33448/rsd-v10i11.19259 · Cited by 1 · see citing works

Perioperative considerations for patients exposed to hallucinogens

Emerick, T. D., Marshall, T., Martin, T. J., & Ririe, D. (2024) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2023-104851 · Cited by 1 · see citing works

The role of psilocybin in depressive disorders

Najib, J. (2024) · Current Medical Research and Opinion · doi:10.1080/03007995.2024.2396536 · Cited by 1 · see citing works

The unpaved road of ayahuasca, a psychoactive brew, as a treatment for neuropathic pain: A review of mechanistic insights and clinical prospects

Santos, B. C. D., dos Reis, A. L. G., Nucci, R., Campos, A., Martins, D. D. O., Daldegan-Bueno, D., & Pagano, R. (2024) · Brain Behavior and Immunity Integrative · doi:10.1016/j.bbii.2024.100087 · Cited by 1 · see citing works

Psychedelic therapy for body dysmorphic disorder

Johnson, S., & Letheby, C. (2022) · Journal of Psychedelic Studies · doi:10.1556/2054.2022.00200 · Cited by 1 · see citing works

Psilocybin Therapy for Major Depressive Disorder: A Systematic Review

Venugopal, K. (2023) · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal · doi:10.26685/urncst.489 · Cited by 1 · see citing works

Psilocybin Therapy for Depression and Anxiety in Parkinson's Disease: An Open-Label Pilot TrialPreprint

Bradley, E., Sakai, K., Fernandes‐Osterhold, G., Szigeti, B., Ludwig, C., Ostrem, J. L., Tanner, C. M., Bock, M., Llerena, K., Finley, P. R., et al. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4871260 · Cited by 1 · see citing works

Avaliação das possíveis interações entre o canabidiol e a ayahuasca em voluntários saudáveis: um estudo randomizado, duplo-cego e controlado com placebo

Rossi, G. N. (2020) · doi:10.11606/d.17.2020.tde-08022021-150020

Ayahuasca and its interaction with the sigma-1 receptor: a potential treatment for COVID-19

Cornejo, G. S. E., Escobar-Cornejo, D. M., & Vargas, L. F. R. (2022) · Brazilian Journal of Psychiatry · doi:10.47626/1516-4446-2022-2541 · Cited by 1 · see citing works

Desenvolvimento de métodos analíticos para determinação dos alcaloides da ayahuasca em diferentes matrizes aplicando estratégias de química analítica verde

Silveira, G. D. O. (2020) · doi:10.11606/t.9.2020.tde-25082022-101857

Natural Hallucinogens in Mental Health

SANTOS, R. G. D., & Hallak, J. E. C. (2022) · Psychoactives · doi:10.3390/psychoactives1020009

Aplicações terapêuticas e benéficas do LSD: uma revisão sistemática

Marson, M. A. G., Neto, J. V. D. P., Zaniratto, J., & Borges, K. K. (2023) · Peer Review · doi:10.53660/516.prw1503b

A protocol for a scoping review of psychedelic interventions to alleviate psychological suffering in populations coping with end-of-life issuesPreprint

Kratina, S., Lo, C., Schwartz, R. D., Strıke, C., Jopling, S. A., Nayfeh, A., & Rush, B. R. (2023) · doi:10.31234/osf.io/4gfyd

Psychedelics in psychiatry

SANTOS, R. G. D., & Hallak, J. E. C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18496-3.00015-x

Serotonergic hallucinogenes and their therapeutic use

Bouberl, D. (2021) · Digital Repository (National Repository of Grey Literature)

Recent advances in the neuropsychopharmacology of serotonergic hallucinogens

Halberstadt, A. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.016 · Cited by 312 · see citing works

Psychedelics and Personality

Aixalà, M., SANTOS, R. G. D., Hallak, J. E. C., & Bouso, J. C. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00237 · Cited by 14 · see citing works

The therapeutical role of psychedelic drugs in treatment of mental disorders

Oprea, D. C., Epure, L., Chiriță, V., & Cantemir, A. (2021) · Bulletin of Integrative Psychiatry · doi:10.36219/bpi.2021.3.09