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Cited by 192

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Current concepts on the neurobiology of Attention-Deficit/Hyperactivity Disorder

Biederman, J., Faraone, S. V.·2002·Journal of Attention Disorders
DOI 10.1177/070674370200601s03
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Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) is an early onset, clinically heterogeneous disorder of inattention, hyperactivity, and impulsivity. In contrast to the widespread acceptance of ADHD as a childhood diagnosis, its prevalence in adults and its implications for clinical practice remain a source of controversy. Throughout the lifecycle, a key clinical feature observed in ADHD patients is comorbidity with Conduct, Depressive, Bipolar, and Anxiety disorders. Family studies consistently support the assertion that ADHD runs in families. Heritabillty data from twin studies of ADHD attribute about 80 percent of the etiology of ADHD to genetic factors. Adoption studies of ADHD also implicate genes in its etiology. Molecular genetic data are bolstered by considerations suggesting that DRD4 and DAT genes may be relevant for ADHD. Independently of genes, prenatal exposure to nicotine and psychosocial adversity have also been identified as risk factors for ADHD. Structural and functional Imaging studies consistently implicate catecholamine-rich fronto-subcortical systems in the pathophysiology of ADHD. The effectiveness of stimulants, along with animal models of hyperactivity, point to catecholamine disruption as at least one source of ADHD brain dysfunction. Although not entirely sufficient, changes in dopaminergic and noradrenergic function appear necessary for the clinical efficacy of pharmacological treatments for ADHD, providing support for the hypothesis that alteration of monoaminergic transmission in critical brain regions may be the basis for therapeutic action in ADHD.

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Metadata

Authors
Biederman, J., & Faraone, S. V.
Venue
Journal of Attention Disorders
Publisher
SAGE Publications
Published
2002-04
Volume
6
Issue
1_suppl
Pages
7-16
ISSN
  • 1087-0547 (ISSN-L)
  • 1557-1246
DOI
10.1177/070674370200601s03
OpenAlex
W1253138564
Cited by
192
References
11
FWCI
6.67
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)

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Biederman, J., & Faraone, S. V. (2002). Current concepts on the neurobiology of Attention-Deficit/Hyperactivity Disorder. Journal of Attention Disorders. https://doi.org/10.1177/070674370200601s03

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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