The Efficacy of 2 Different Dosages of Methylphenidate in Treating Adults with Attention-Deficit Hyperactivity Disorder
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Objective: To evaluate the efficacy of methylphenidate in treating adults with attention-deficit hyperactivity disorder (ADHD), using subjective (self-report) and objective (computerized test) measures. Method: This double-blind crossover trial of placebo vs methylphenidate included subjects with childhood and current ADHD symptoms, IQs above 80, no other psychiatric condition explaining their difficulties or requiring other treatment, and no substance abuse in the previous 6 months. We administered 10 mg 3 times daily of medication (that is, placebo or methylphenidate) for 2 weeks. On the final day, subjects completed self-report measures and were tested on computerized tests. We then increased dosage to 15 mg 3 times daily for 2 weeks and administered a complete reassessment on the final day. Following a 1-week washout, we repeated this process on the second medication (that is, placebo or methylphenidate). Results: Thirty adults with ADHD participated. Self-report measures and computerized tests showed significant improvements in ADHD symptoms on methylphenidate, compared with placebo. Other psychiatric symptoms (notably, anxiety and depression) were alleviated with methylphenidate. There was no significant difference between the 2 dosages of methylphenidate. Conclusion: Methylphenidate is effective in improving ADHD symptoms in adults with ADHD, is well tolerated, and has minimal side effects.
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Side-effects of stimulants are usually mild and transitory, mainly consisting of headache, reduced appetite, palpitations, nervousness, difficulty falling asleep, and dry mouth.
“Side-effects are usually mild and transitory, mainly consisting of headache, reduced appetite, palpitations, nervousness, difficulty falling asleep, and dry mouth [148,269,270].”
From European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD (2010) · cites this paper as [269]
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Buglio, G. L., Iyer, S. N., Husain, M. O., Boldrini, T., Chen, C., Corbeil, O., Curtis, L., de Geus, G., Katyal, S., Lingiardi, V., et al. (2026) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2026.113884
- Authors
- Bouffard, R., Hechtman, L., Minde, K., & Iaboni-Kassab, F.
- Affiliations
- Island Health (CA)
- Montreal Children's Hospital (CA)
- School Psychologist, North Clackamas School District, Portland, Oregon
- ORCID
- Hechtman, Lily
- Venue
- The Canadian Journal of Psychiatry
- Publisher
- SAGE Publications
- Published
- 2003-09
- Volume
- 48
- Issue
- 8
- Pages
- 546-554
- ISSN
- 0706-7437 (ISSN-L)
- 1497-0015
- OpenAlex
- W2137870656
- Cited by
- 81
- References
- 18
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 4 · 2018: 7 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Canadian Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McGill University
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- methylphenidate, adult ADHD, dose comparison, computerized cognitive assessment, anxiety and depression, tolerability
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Methylphenidate, Middle Aged, Surveys and Questionnaires, Treatment Outcome, Cross-Over Studies
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