A Randomized, Placebo-Controlled Trial of Three Fixed Dosages of Prolonged-Release OROS Methylphenidate in Adults with Attention-Deficit/Hyperactivity Disorder

Medori, Rossella; Ramos-Quiroga, J. Antoni; Casas, Miguel; Kooij, J.J.S.; Niemelä, Asko; Trott, Götz-Erik; Lee, Emma; Buitelaar, Jan K.

doi:10.1016/j.biopsych.2007.11.008

Cited by 186Attention Deficit Hyperactivity DisorderSchizophrenia research and treatmentPharmaceutical studies and practices

A Randomized, Placebo-Controlled Trial of Three Fixed Dosages of Prolonged-Release OROS Methylphenidate in Adults with Attention-Deficit/Hyperactivity Disorder

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Medori, Rossella, Ramos-Quiroga, J. Antoni, Casas, Miguel, Kooij, J.J.S., Niemelä, Asko, Trott, Götz-Erik, Lee, Emma, Buitelaar, Jan K.·2008·Biological Psychiatry

DOI 10.1016/j.biopsych.2007.11.008

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Abstract

Background There is increasing recognition of attention-deficit/hyperactivity disorder (ADHD) in adults and the need to evaluate efficacy and safety of methylphenidate treatment in these patients.Methods In this double-blind trial, 401 adults with ADHD (218 men; 18-63 years) were randomly assigned to receive prolonged-release osmotic release oral system (OROS) methylphenidate (18 mg, 36 mg, or 72 mg/day) or placebo for 5 weeks. Primary outcome was change in total score on Conners' Adult ADHD Rating Scale (CAARS: investigator-rated) at end point compared with baseline. Adverse events, vital signs, and laboratory parameters were assessed.Results Treatment with 18-mg, 36-mg, and 72-mg/day prolonged-release methylphenidate, compared with placebo, was associated with significantly larger improvement in CAARS total symptom score from baseline to end point than placebo: mean change -10.6 (p = .01), -11.5 (p = .01), and -13.7 (p < .001) versus -7.6, respectively. Responders (> or = 30% decrease) were 50.5%, 48.5%, and 59.6% versus 27.4% (p < .001). Other efficacy measures also showed improvements. Incidence of adverse events was 75%, 76%, and 82% in 18-mg, 36-mg, and 72-mg/day groups, respectively, and 66% in placebo; most frequent included decreased appetite (25% methylphenidate; 7% placebo) and headache (21% methylphenidate; 18% placebo). In methylphenidate-treated patients, 4.3% discontinued due to adverse event; one serious adverse event was possibly related to study drug. Blood pressure and pulse increased at week 1 and then remained stable through week 5.Conclusions Prolonged-release methylphenidate is an effective treatment of ADHD in adults, with a safety profile consistent with methylphenidate use in pediatrics.

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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The Prevalence and Correlates of Adult ADHD in the United States: Results From the National Comorbidity Survey Replication
Kessler, R. C., Adler, L., Barkley, R., Biederman, J., Conners, C. K., Demler, O., Faraone, S. V., Greenhill, L. L., Howes, M. J., Secnik, K., et al. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.4.716 · Cited by 3,886 · see citing works
The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies
FARAONE, S. V., BIEDERMAN, J., & MICK, E. (2006) · Psychological Medicine · doi:10.1017/s003329170500471x · Cited by 2,267 · see citing works
Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder
Fayyad, J., De Graaf, R., Kessler, R., Alonso, J., Angermeyer, M., Demyttenaere, K., De Girolamo, G., Haro, J. M., Karam, E. G., Lara, C., et al. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.034389 · Cited by 1,321 · see citing works
Practice Parameter for the Use of Stimulant Medications in the Treatment of Children, Adolescents, and Adults
Greenhill, L. L., Pliszka, S., & Dulcan, M. K. (2002) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200202001-00003 · Cited by 927 · see citing works
Atomoxetine in adults with ADHD: two randomized, placebo-controlled studies
Michelson, D., Adler, L., Spencer, T., Reimherr, F. W., West, S. A., Allen, A. J., Kelsey, D., Wernicke, J., Dietrich, A., & Milton, D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01671-2 · Cited by 790 · see citing works
Patterns and Predictors of Attention-Deficit/Hyperactivity Disorder Persistence into Adulthood: Results from the National Comorbidity Survey Replication
Kessler, R. C., Adler, L. A., Barkley, R., Biederman, J., Conners, C. K., Faraone, S. V., Greenhill, L. L., Jaeger, S., Secnik, K., Spencer, T., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.001 · Cited by 663 · see citing works
Randomized, Controlled Trial of OROS Methylphenidate Once a Day in Children With Attention-Deficit/Hyperactivity Disorder
Wolraich, M. L., Greenhill, L. L., Pelham, W., Swanson, J., Wilens, T., Palumbo, D., Atkins, M., McBurnett, K., Bukstein, O., August, G., et al. (2001) · Pediatrics · doi:10.1542/peds.108.4.883 · Cited by 502 · see citing works
Internal and external validity of Attention-Deficit Hyperactivity Disorder in a population-based sample of adults
SANDRA KOOIJ, J. J., BUITELAAR, J. K., van den OORD, E. J., FURER, J. W., TH. RIJNDERS, C. A., & HODIAMONT, P. P. G. (2005) · Psychological Medicine · doi:10.1017/s003329170400337x · Cited by 468 · see citing works
Self-citation
Meta-analysis of the efficacy of methylphenidate for treating adult attention deficit hyperactivity disorder
Faraone, S. V., Spencer, T., Aleardi, M., Pagano, C., & Biederman, J. (2004) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000108984.11879.95 · Cited by 404 · see citing works
A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorder
Spencer, T., Biederman, J., Wilens, T., Doyle, R., Surman, C., Prince, J., Mick, E., Aleardi, M., Herzig, K., & Faraone, S. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.043 · Cited by 385 · see citing works
Once-a-Day Concerta Methylphenidate Versus Three-Times-Daily Methylphenidate in Laboratory and Natural Settings
Pelham, W. E., Gnagy, E. M., Burrows-Maclean, L., Williams, A., Fabiano, G. A., Morrisey, S. M., Chronis, A. M., Forehand, G. L., Nguyen, C. A., Hoffman, M. T., et al. (2001) · Pediatrics · doi:10.1542/peds.107.6.e105 · Cited by 378 · see citing works
Long-acting medications for the hyperkinetic disorders: A systematic review and European treatment guideline
Banaschewski, T., Coghill, D., Santosh, P., Zuddas, A., Asherson, P., Buitelaar, J., Danckaerts, M., Döpfner, M., Faraone, S. V., Rothenberger, A., et al. (2006) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-006-0549-0 · Cited by 375 · see citing works
Self-citation
ADHD Drugs and Cardiovascular Risk
Nissen, S. E. (2006) · New England Journal of Medicine · doi:10.1056/nejmp068049 · Cited by 331 · see citing works
A Randomized, Placebo-Controlled Trial of OROS Methylphenidate in Adults with Attention-Deficit/Hyperactivity Disorder
Biederman, J., Mick, E., Surman, C., Doyle, R., Hammerness, P., Harpold, T., Dunkel, S., Dougherty, M., Aleardi, M., & Spencer, T. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.09.011 · Cited by 267 · see citing works
Evidence-based guidelines for management of attention-deficit/hyperactivity disorder in adolescents in transition to adult services and in adults: recommendations from the British Association for Psychopharmacology
Nutt, D. J., Fone, K., Asherson, P., Bramble, D., Hill, P., Matthews, K., Morris, K. A., Santosh, P., Sonuga-Barke, E., Taylor, E., et al. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106073219 · Cited by 259 · see citing works
Development of a New Once-a-Day Formulation of Methylphenidate for the Treatment of Attention-deficit/Hyperactivity Disorder: Proof-of-Concept and Proof-of-Product Studies
Swanson, J., Gupta, S., Lam, A., Shoulson, I., Lerner, M., Modi, N., Lindemulder, E., & Wigal, S. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.2.204 · Cited by 248 · see citing works
Clinical assessment and treatment of attention deficit hyperactivity disorder in adults
Asherson, P. (2005) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.5.4.525 · Cited by 195 · see citing works
A Double-Blind, Placebo-Controlled, Crossover Study of Osmotic Release Oral System Methylphenidate in Adults With ADHD With Assessment of Oppositional and Emotional Dimensions of the Disorder
Reimherr, F. W., Williams, E. D., Strong, R. E., Mestas, R., Soni, P., & Marchant, B. K. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0113 · Cited by 180 · see citing works
Psychological Medicine goes monthly
Paykel, E. S., & Kendler, K. S. (2004) · Psychological Medicine · doi:10.1017/s0033291704004052 · Cited by 164 · see citing works
Efficacy and safety of methylphenidate in 45 adults with attention-deficit/hyperactivity disorder. A randomized placebo-controlled double-blind cross-over trial
KOOIJ, J. J. S., BURGER, H., BOONSTRA, A. M., VAN DER LINDEN, P. D., KALMA, L. E., & BUITELAAR, J. K. (2004) · Psychological Medicine · doi:10.1017/s0033291703001776 · Cited by 163 · see citing works
Self-citation
Efficacy and Safety of Dexmethylphenidate Extended-Release Capsules in Adults with Attention-Deficit/Hyperactivity Disorder
Spencer, T. J., Adler, L. A., McGough, J. J., Muniz, R., Jiang, H., & Pestreich, L. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.032 · Cited by 155 · see citing works
ADHD in adults.
Okie, S. (2006) · New England Journal of Medicine · doi:10.1056/nejmp068113 · Cited by 121 · see citing works
Adult attention-deficit hyperactivity disorder: recognition and treatment in general adult psychiatry
Asherson, P., Chen, W., Craddock, B., & Taylor, E. (2007) · British Journal of Psychiatry · doi:10.1192/bjp.bp.106.026484 · Cited by 105 · see citing works
Summary of the Practice Parameter for the Use of Stimulant Medications in the Treatment of Children, Adolescents, and Adults
Greenhill, L. L., Pliszka, S. R., Dulcan, M. K., Bernet, W., Arnold, V., Beitchman, J. H., Benson, R. S., Bukstein, O. G., Kinlan, J., McClellan, J., et al. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200111000-00020 · Cited by 85 · see citing works
The Efficacy of 2 Different Dosages of Methylphenidate in Treating Adults with Attention-Deficit Hyperactivity Disorder
Bouffard, R., Hechtman, L., Minde, K., & Iaboni-Kassab, F. (2003) · The Canadian Journal of Psychiatry · doi:10.1177/070674370304800806 · Cited by 81 · see citing works
Efficacy of a Novel Biphasic Controlled-Release Methylphenidate Formula in Adults With Attention-Deficit/Hyperactivity Disorder
Jain, U., Hechtman, L. T., Weiss, M. D., Ahmed, T. S., Reiz, J. L., Donnelly, G. A. E., Harsanyi, Z., & Darke, A. C. (2007) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v68n0213 · Cited by 56 · see citing works
ADHD Drugs and Cardiovascular Risk
Rappley, M. D., MOORE, J. W., & Dokken, D. L. (2006) · New England Journal of Medicine · doi:10.1056/nejmc061187 · Cited by 29 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

[6]6. U.S. Food and Drug Administration (2007): FDA Directs ADHD Drug Man- ufacturers to Notify Patients about Cardiovascular Adverse Events and Psychiatric Adverse Events. Rockville, MD: National Press Office. Press P07-26.
[27]27. First M, Spitzer R, Gibbon M, Williams G (1994): Structured Clinical Inter- view for DSM-IV Axis I Disorders, Patient Edition (SCID-P), Version 2. New York: New York State Psychiatric Institute, Biometrics Research.

Sorted by citations

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Solanto, M. V., Marks, D. J., Wasserstein, J., Mitchell, K., Abikoff, H., Alvir, J. M. J., & Kofman, M. D. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09081123 · Cited by 370 · see citing works
Associations of sleep disturbance with ADHD: implications for treatment
Hvolby, A. (2015) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-014-0151-0 · Cited by 339 · see citing works
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Fredriksen, M., Halmøy, A., Faraone, S. V., & Haavik, J. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.07.016 · Cited by 173 · see citing works
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Attention deficit hyperactivity disorder in adults
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Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults.
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Retracted
A Randomized, 3-Phase, 34-Week, Double-Blind, Long-Term Efficacy Study of Osmotic-Release Oral System-Methylphenidate in Adults With Attention-Deficit/Hyperactivity Disorder
Biederman, J., Mick, E., Surman, C., Doyle, R., Hammerness, P., Kotarski, M., & Spencer, T. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181ee84a7 · Cited by 76 · see citing works
Oral health status, salivary flow rate and salivary quality in children, adolescents and young adults with ADHD
Hidas, A., Fux‐Noy, A., Birman, N., Shapira, J., Matot, I., Steinberg, D., & Moskovitz, M. (2011) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2011.03.018 · Cited by 59 · see citing works
Effect of Micronutrients on Behavior and Mood in Adults With ADHD: Evidence From an 8-Week Open Label Trial With Natural Extension
Rucklidge, J. J., Taylor, M. R., & Whitehead, K. (2010) · Journal of Attention Disorders · doi:10.1177/1087054709356173 · Cited by 54 · see citing works
Does Extended Release Methylphenidate Help Adults With Hoarding Disorder?
Rodríguez, C. I., Bender, J., Morrison, S., Mehendru, R., Tolin, D. F., & Simpson, H. B. (2013) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318290115e · Cited by 53 · see citing works
Efficacy, Safety, and Tolerability of Centanafadine Sustained-Release Tablets in Adults With Attention-Deficit/Hyperactivity Disorder
Adler, L. A., Adams, J., Madera‐McDonough, J., Kohegyi, E., Hobart, M., Chang, D., Angelicola, M., McQuade, R. D., & Liebowitz, M. R. (2022) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001575 · Cited by 52 · see citing works
Efficacy and safety of the novel α4β2 neuronal nicotinic receptor partial agonist ABT-089 in adults with attention-deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled crossover study
Apostol, G., Abi‐Saab, W., Kratochvil, C. J., Adler, L. A., Robieson, W., Gault, L. M., Pritchett, Y., Feifel, D., Collins, M. A., & Saltarelli, M. D. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2393-2 · Cited by 52 · see citing works
Attention-Deficit/Hyperactivity Disorder in Adults: Evidence-Based Recommendations for Management
Rostain, A. L. (2008) · Postgraduate Medicine · doi:10.3810/pgm.2008.09.1905 · Cited by 50 · see citing works
Criterion and concurrent validity of Conners Adult ADHD Diagnostic Interview for DSM-IV (CAADID) Spanish version.
Ramos-Quiroga, J., Bosch, R., Richarte, V., Valero, S., Gómez-Barros, N., Nogueira, M., Palomar, G., Corrales, M., Sáez-Francàs, N., Corominas, M., et al. (2012) · Revista de Psiquiatría y Salud Mental · doi:10.1016/j.rpsm.2012.05.004 · Cited by 39 · see citing works
Self-citation
Pharmacotherapy of ADHD in Adults
Wilens, T. E. (2008) · CNS Spectrums · doi:10.1017/s1092852900002960 · Cited by 50 · see citing works
A randomized comparison of long acting methylphenidate and cognitive behavioral therapy in the treatment of binge eating disorder
Quilty, L. C., Allen, T. A., Davis, C. A., Knyahnytska, Y., & Kaplan, A. S. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.01.066 · Cited by 51 · see citing works
Amphetamines for Attention Deficit Hyperactivity Disorder (ADHD) in adults
Castells, X., Ramos-Quiroga, J. A., Bosch, R., Nogueira, M., & Casas, M. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007813.pub2 · Cited by 80 · see citing works
Self-citation
Long-Term Safety of OROS Methylphenidate in Adults With Attention-Deficit/Hyperactivity Disorder
Adler, L. A., Orman, C., Starr, H. L., Silber, S., Palumbo, J., Cooper, K., Berwaerts, J., & Harrison, D. D. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318203ea0a · Cited by 47 · see citing works
Recognizing ADHD in Adults with Comorbid Mood Disorders: Implications for Identification and Management
Goodman, D. W., & Thase, M. E. (2009) · Postgraduate Medicine · doi:10.3810/pgm.2009.09.2049 · Cited by 46 · see citing works
Predictors and impact of non-adherence in adults with attention-deficit/hyperactivity disorder receiving OROS methylphenidate: results from a randomized, placebo-controlled trial
Kooij, J. J. S., Rösler, M., Philipsen, A., Wächter, S., Dejonckheere, J., van der Kolk, A., van Agthoven, M., & Schäuble, B. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-36 · Cited by 44 · see citing works
Self-citation
Long-acting stimulants for treatment of attention-deficit/hyperactivity disorder: a focus on extended-release formulations and the prodrug lisdexamfetamine dimesylate to address continuing clinical challenges
López, F. A., & Leroux, J. R. (2013) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-013-0106-x · Cited by 43 · see citing works
Driving performance in adults with ADHD: Results from a randomized, waiting list controlled trial with atomoxetine
Sobanski, E., Sabljic, D., Alm, B., Dittmann, R., Wehmeier, P. M., Skopp, G., & Strohbeck-Kühner, P. (2012) · European Psychiatry · doi:10.1016/j.eurpsy.2012.08.001 · Cited by 42 · see citing works
A 9-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Dose-Finding Study to Evaluate the Efficacy and Safety of Modafinil as Treatment for Adults With ADHD
Arnold, V. K., Feifel, D., Earl, C. Q., Yang, R., & Adler, L. A. (2014) · Journal of Attention Disorders · doi:10.1177/1087054712441969 · Cited by 48 · see citing works
Stimulant Drug Effects on Attention Deficit/Hyperactivity Disorder: A Review of the Effects of Age and Sex of Patients
Cornforth, C., Sonuga-Barke, E., & Coghill, D. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210791959827 · Cited by 41 · see citing works
Database analysis of children and adolescents with Bipolar Disorder consuming a micronutrient formula
Rucklidge, J. J., Gately, D., & Kaplan, B. J. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-74 · Cited by 41 · see citing works
Efficacy, Acceptability, and Tolerability of Lisdexamfetamine, Mixed Amphetamine Salts, Methylphenidate, and Modafinil in the Treatment of Attention-Deficit Hyperactivity Disorder in Adults: A Systematic Review and Meta-analysis
Stuhec, M., Lukić, P., & Locatelli, I. (2019) · Annals of Pharmacotherapy · doi:10.1177/1060028018795703 · Cited by 46 · see citing works
A Review of OROS Methylphenidate (Concerta®) in the Treatment of Attention-Deficit/Hyperactivity Disorder
Katzman, M. A., & Sternat, T. (2014) · CNS Drugs · doi:10.1007/s40263-014-0175-1 · Cited by 40 · see citing works
Delivering Evidence-Based Treatments for Child Attention-Deficit/Hyperactivity Disorder (ADHD) in the Context of Parental ADHD
Wang, C. H., Mazursky-Horowitz, H., & Chronis-Tuscano, A. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0474-8 · Cited by 39 · see citing works
Predictors of treatment outcome in adults with ADHD treated with OROS® methylphenidate.
Buitelaar, J., Kooij, J. J. S., Ramos-Quiroga, J., Dejonckheere, J., Casas, M., van Oene, J. V., Schäuble, B., & Trott, G. (2011) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.12.016 · Cited by 43 · see citing works
Self-citation
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Self-citation
OROS-methylphenidate efficacy on specific executive functioning deficits in adults with ADHD: A randomized, placebo-controlled cross-over study
Bron, T. I., Bijlenga, D., Boonstra, A. M., Breuk, M., Pardoen, W. F. H., Beekman, A. T. F., & Kooij, J. J. S. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.01.007 · Cited by 38 · see citing works
Self-citation
Toward Quality Care in ADHD: Defining the Goals of Treatment
Rostain, A., Jensen, P. S., Connor, D. F., Miesle, L. M., & Faraone, S. V. (2015) · Journal of Attention Disorders · doi:10.1177/1087054712473835 · Cited by 33 · see citing works
Nonmedication treatments for adult ADHD: Evaluating impact on daily functioning and well-being.
Ramsay, J. R. (2010) · American Psychological Association eBooks · doi:10.1037/12056-000 · Cited by 33 · see citing works
Dose–Response Characteristics in Adolescents with Attention-Deficit/Hyperactivity Disorder Treated with OROS ® Methylphenidate in a 4-Week, Open-Label, Dose-Titration Study
Newcorn, J. H., Stein, M. A., & Cooper, K. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2009.0102 · Cited by 32 · see citing works
Clinical response and symptomatic remission in short- and long-term trials of lisdexamfetamine dimesylate in adults with attention-deficit/hyperactivity disorder
Mattingly, G. W., Weisler, R. H., Young, J. L., Adeyi, B. A., Dirks, B., Babcock, T., Lasser, R. A., Scheckner, B., & Goodman, D. W. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-39 · Cited by 32 · see citing works
Treatment discontinuation with methylphenidate in adults with attention deficit hyperactivity disorder: a meta-analysis of randomized clinical trials
Castells, X., Cunill, R., & Capellà, D. (2013) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-012-1390-7 · Cited by 41 · see citing works
Maintenance of response after open-label treatment with atomoxetine hydrochloride in international European and non-European adult outpatients with attention-deficit/hyperactivity disorder: a placebo-controlled, randomised withdrawal study
Upadhyaya, H., Ramos-Quiroga, J., Adler, L., Williams, D. R., Tanaka, Y., Lane, J. R., Escobar, R., Trzepacz, P., Camporeale, A., & Allen, A. (2013) · The European Journal of Psychiatry · doi:10.4321/s0213-61632013000300004 · Cited by 28 · see citing works
Self-citation
Assessment and Diagnosis of Adult ADHD: Clinical Challenges and Opportunities for Improving Patient Care
Weisler, R. H., & Goodman, D. W. (2008) · Primary psychiatry · Cited by 31 · see citing works
Further evidence of low adherence to stimulant treatment in adult ADHD: an electronic medical record study examining timely renewal of a stimulant prescription
Biederman, J., Fried, R. S., DiSalvo, M., Woodworth, K. Y., Biederman, I., Driscoll, H., Noyes, E. J., Faraone, S. V., & Perlis, R. H. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05576-y · Cited by 33 · see citing works
A Novel Text Message Intervention to Improve Adherence to Stimulants in Adults With Attention Deficit/Hyperactivity Disorder.
Biederman, J., Fried, R., Disalvo, M., Woodworth, K., Biederman, I., Noyes, E., Faraone, S., & Perlis, R. (2019) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000001055 · Cited by 23 · see citing works
Efficacy and safety of prolonged-release OROS methylphenidate in adults with attention deficit/hyperactivity disorder: A 13-week, randomized, double-blind, placebo-controlled, fixed-dose study
Casas, M., Rösler, M., Sandra Kooij, J. J., Ginsberg, Y., Ramos-Quiroga, J. A., Heger, S., Berwaerts, J., Dejonckheere, J., van der Vorst, E., & Schäuble, B. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.600333 · Cited by 38 · see citing works
Self-citation
Correlation of symptomatic improvements with functional improvements and patient-reported outcomes in adults with attention-deficit/hyperactivity disorder treated with OROS methylphenidate
Rösler, M., Ginsberg, Y., Arngrim, T., Adamou, M., Niemelä, A., Dejonkheere, J., van Oene, J., & Schäuble, B. (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.571283 · Cited by 28 · see citing works
Self-citation
Functional improvement and correlations with symptomatic improvement in adults with attention deficit hyperactivity disorder receiving long-acting methylphenidate
Buitelaar, J. K., Casas, M., Philipsen, A., Kooij, J. J. S., Ramos‐Quiroga, J. A., Dejonckheere, J., van Oene, J. C., & Schäuble, B. (2011) · Psychological Medicine · doi:10.1017/s0033291711000845 · Cited by 28 · see citing works
Self-citation
Methylphenidate normalizes emotional processing in adult patients with attention-deficit/hyperactivity disorder: Preliminary findings
Conzelmann, A., Woidich, E., Mucha, R. F., Weyers, P., Jacob, C. P., Lesch, K.-P., & Pauli, P. (2011) · Brain Research · doi:10.1016/j.brainres.2010.12.085 · Cited by 27 · see citing works
Molecular imaging genetics of methylphenidate response in ADHD and substance use comorbidity
Szobot, C. M., Roman, T., Hutz, M. H., Genro, J. P., Shih, M. C., Hoexter, M. Q., Júnior, N., Pechansky, F., Bressan, R. A., & Rohde, L. A. (2010) · Synapse · doi:10.1002/syn.20829 · Cited by 27 · see citing works
A network meta-analysis of atomoxetine and osmotic release oral system methylphenidate in the treatment of attention-deficit/hyperactivity disorder in adult patients
Bushe, C., Day, K., Reed, V., Karlsdotter, K., Berggren, L., Pitcher, A., Televantou, F., & Haynes, V. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116636105 · Cited by 31 · see citing works
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Brown, T. E., Brams, M., Gao, J., Gasior, M., & Childress, A. (2010) · Postgraduate Medicine · doi:10.3810/pgm.2010.09.2196 · Cited by 29 · see citing works
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Takahashi, N., Koh, T., Tominaga, Y., Saito, Y., Kashimoto, Y., & Matsumura, T. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.868925 · Cited by 25 · see citing works
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Hammerness, P. G., Surman, C. B. H., & Chilton, A. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0213-3 · Cited by 24 · see citing works
An innovative SMS intervention to improve adherence to stimulants in children with ADHD: Preliminary findings
Fried, R. S., DiSalvo, M., Kelberman, C., Adler, A., McCafferty, D., Woodworth, K. Y., Green, A., Biederman, I., Faraone, S. V., & Biederman, J. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120908014 · Cited by 24 · see citing works
Baseline Severity of Parent-Perceived Inattentiveness Is Predictive of the Difference Between Subjective and Objective Methylphenidate Responses in Children with Attention-Deficit/Hyperactivity Disorder
Park, S., Kim, B.-N., Cho, S.-C., Kim, J.-W., Shin, M., Yoo, H., Han, D. H., & Cheong, J. H. (2013) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2013.0031 · Cited by 24 · see citing works
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Waxmonsky, J. G., Waschbusch, D. A., Babinski, D. E., Humphrey, H. H., Alfonso, A., Crum, K. I., Bernstein, M., Slavec, J., Augustus, J. N., & Pelham, W. E. (2014) · CNS Drugs · doi:10.1007/s40263-014-0165-3 · Cited by 26 · see citing works
Clinical utility of ADHD symptom thresholds to assess normalization of executive function with lisdexamfetamine dimesylate treatment in adults
Brown, T. E., Brams, M., Gasior, M., Adeyi, B., Babcock, T., Dirks, B., Scheckner, B., & Wigal, T. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2011.605441 · Cited by 24 · see citing works
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Cervelló, X. C., Sáez, M., Barcheni, M., Cunill, R., Serrano, D., López, B., & Lissa, C. J. V. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab054 · Cited by 22 · see citing works
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Kim, H., Kim, S., Shon, S., Lee, J., Lee, H., & Choi, J. (2014) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2014.0025 · Cited by 22 · see citing works
Criteria and Concurrent Validity of Adult ADHD Section of the Psychiatry Research Interview for Substance and Mental Disorders
Ramos‐Quiroga, J. A., Díaz-Digón, L., Comín, M., Bosch, R., Gloria Palomar, A., Chalita, J. P., Roncero, C., Nogueira, M., Torrens, M., & Casas, M. (2012) · Journal of Attention Disorders · doi:10.1177/1087054712454191 · Cited by 22 · see citing works
Self-citation
Critical analysis of the concept of adult attention-deficit hyperactivity disorder
Moncrieff, J., & Timimi, S. (2011) · The Psychiatrist · doi:10.1192/pb.bp.110.033423 · Cited by 18 · see citing works
Pharmacotherapy for Parents with Attention-Deficit Hyperactivity Disorder (ADHD)
Chronis-Tuscano, A. M., & Stein, M. A. (2012) · CNS Drugs · doi:10.2165/11633910-000000000-00000 · Cited by 22 · see citing works
Safety of stimulant treatment in attention deficit hyperactivity disorder: part II
Merkel, R. L. (2010) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2010.503238 · Cited by 21 · see citing works
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Biederman, J., Mick, E., Spencer, T., Surman, C., & Faraone, S. V. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00233.x · Cited by 20 · see citing works
Safety of stimulant treatment in attention deficit hyperactivity disorder: part I
Merkel, R. L., & Kuchibhatla, A. (2009) · Expert Opinion on Drug Safety · doi:10.1517/14740330903279956 · Cited by 24 · see citing works
Treatment Outcomes With Licensed and Unlicensed Stimulant Doses for Adults With Attention-Deficit/Hyperactivity Disorder
Farhat, L. C., Flores, J. M., Avila-Quintero, V. J., Polanczyk, G. V., Cipriani, A., Furukawa, T. A., Bloch, M. H., & Cortese, S. (2023) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2023.3985 · Cited by 20 · see citing works
Efficacy and Safety of PRC-063, Extended-Release Multilayer Methylphenidate in Adults with ADHD Including 6-Month Open-Label Extension
Weiss, M. D., Childress, A. C., & Donnelly, G. A. E. (2020) · Journal of Attention Disorders · doi:10.1177/1087054719896853 · Cited by 19 · see citing works
Management of attention-deficit hyperactivity disorder in adults: focus on methylphenidate hydrochloride
Nair, R. J., & Moss, S. (2009) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s4101 · Cited by 18 · see citing works
Long-Term (1 Year) Safety and Efficacy of Methylphenidate Modified-Release Long-Acting Formulation (MPH-LA) in Adults with Attention-Deficit Hyperactivity Disorder: A 26-Week, Flexible-Dose, Open-Label Extension to a 40-Week, Double-Blind, Randomised, Placebo-Controlled Core Study
Ginsberg, Y., Arngrim, T., Philipsen, A., Gandhi, P., Chen, C.-W., Kumar, V., & Huss, M. (2014) · CNS Drugs · doi:10.1007/s40263-014-0180-4 · Cited by 20 · see citing works

Efficacy and safety of prolonged-release OROS methylphenidate in adults with attention deficit/hyperactivity disorder: A 13-week, randomized, double-blind, placebo-controlled, fixed-dose study
Casas, M., Rösler, M., Sandra Kooij, J. J., Ginsberg, Y., Ramos-Quiroga, J. A., Heger, S., Berwaerts, J., Dejonckheere, J., van der Vorst, E., & Schäuble, B. (2013) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2011.600333 · Cited by 38 · see citing works
Self-citation
Efficacy and Safety of OROS Methylphenidate in Adults With Attention-Deficit/Hyperactivity Disorder: A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Dose-Escalation Study
Adler, L. A., Zimmerman, B., Starr, H. L., Silber, S., Palumbo, J., Orman, C., & Spencer, T. (2009) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181a390ce · Cited by 106 · see citing works
Randomized, 6-Week, Placebo-Controlled Study of Treatment for Adult Attention-Deficit/Hyperactivity Disorder
Goodman, D. W., Starr, H. L., Ma, Y.-W., Rostain, A. L., Ascher, S., & Armstrong, R. B. (2016) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.15m10348 · Cited by 32 · see citing works
A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of osmotic-controlled release oral delivery system methylphenidate HCl in adults with attention-deficit/hyperactivity disorder in Japan
Takahashi, N., Koh, T., Tominaga, Y., Saito, Y., Kashimoto, Y., & Matsumura, T. (2014) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2013.868925 · Cited by 25 · see citing works
Long-Term Safety of OROS Methylphenidate in Adults With Attention-Deficit/Hyperactivity Disorder
Adler, L. A., Orman, C., Starr, H. L., Silber, S., Palumbo, J., Cooper, K., Berwaerts, J., & Harrison, D. D. (2010) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318203ea0a · Cited by 47 · see citing works

Authors: Medori, R., Ramos-Quiroga, J. A., Casas, M., Kooij, J. J. S., Niemelä, A., Trott, G.-E., Lee, E., & Buitelaar, J. K.
Affiliations: Janssen (Germany) (DE)
Universitat Autònoma de Barcelona (ES)
Oulu University Hospital (FI)
Janssen (Belgium) (BE)
Radboud University Medical Center (NL)
Corresponding author: Medori, Rossella
ORCID: Casas, Miguel
Kooij, J.J.S.
Lee, Emma
Buitelaar, Jan K.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2008-05
Volume: 63
Issue: 10
Pages: 981-989
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2007.11.008
OpenAlex: W2167875798
Cited by: 186
References: 28
Citations by year: 2025: 3 · 2024: 5 · 2023: 6 · 2022: 9 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 17 · 2013: 13 · 2012: 19
FWCI: 18.15
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Funders: Eli Lilly and Company
Cilag
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
Keywords: adult ADHD, osmotic-release oral system, fixed-dose comparison, treatment efficacy, adverse events, appetite loss, blood pressure, Conners' Adult ADHD Rating Scale, dose-response relationship
MeSH terms: Administration, Oral, Adolescent, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Humans, Male, Methylphenidate, Middle Aged, Psychiatric Status Rating Scales, Severity of Illness Index, Infusion Pumps, Implantable, Treatment Outcome

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A Randomized, Placebo-Controlled Trial of Three Fixed Dosages of Prolonged-Release OROS Methylphenidate in Adults with Attention-Deficit/Hyperactivity Disorder

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