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Cited by 183Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major DepressionMental Health Treatment and Access

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

What Clinical and Symptom Features and Comorbid Disorders Characterize Outpatients with Anxious Major Depressive Disorder: A Replication and Extension

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Fava, Maurizio, Rush, A John, Alpert, Jonathan E, Carmin, Cheryl N, Balasubramani, GK, Wisniewski, Stephen R, Trivedi, Madhukar H, Biggs, Melanie M, Shores-Wilson, Kathy·2006·The Canadian Journal of Psychiatry
DOI 10.1177/070674370605101304
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Abstract

OBJECTIVE: We previously found that 46% of the first 1450 outpatients with depression participating in the multicentre Sequenced Treatment Alternatives to Relieve Depression (STAR*D) project qualified for the designation of anxious depression. This study was designed to replicate and extend our initial findings in a subsequent, larger cohort of outpatient STAR*D participants with nonpsychotic major depressive disorder (MDD). METHODS: Baseline clinical and sociodemographic data were collected on 2337 consecutive STAR*D participants. A baseline 17-item Hamilton Depression Rating Scale Anxiety-Somatization factor score of 7 or higher was designated as anxious depression. We identified concurrent Axis I disorders with the Psychiatric Diagnostic Screening Questionnaire (PDSQ), using a 90% specificity threshold. Depressive symptoms were assessed by clinical telephone interview with the 30-item Inventory of Depressive Symptomatology-Clinician-Rated (IDS-C30). RESULTS: The prevalence of anxious depression in this population was 45.1%. Patients with anxious MDD were significantly more likely to be in primary care settings and to be women, nonsingle, unemployed, Hispanic, less educated, and suffering from severe depression, both before and after adjustment for overall depression severity. Patients with anxious depression were significantly more likely to meet PDSQ thresholds for generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, posttraumatic stress disorder, agoraphobia, hypochondriasis, and somatoform disorder, both before and after adjusting for baseline depression severity. Individuals with anxious depression were also significantly less likely to endorse IDS-C30 items concerning atypical features and were significantly more likely to endorse items concerning melancholic-endogenous depression features, both before and after adjusting for baseline depression severity. CONCLUSIONS: This study clearly replicates our previous STAR*D findings and supports the notion that anxious depression may be a valid diagnostic subtype of MDD, with distinct psychiatric comorbidities and clinical and sociodemographic features.

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Research works printed but not linked: 7

  1. Fawcett J, 1983, J Clin Psychiatry, 44, 8
  2. Tollefson GD, 1994, J Clin Psychiatry, 55, 50
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Metadata

Authors
Fava, M., Rush, A. J., Alpert, J. E., Carmin, C. N., Balasubramani, G., Wisniewski, S. R., Trivedi, M. H., Biggs, M. M., & Shores-Wilson, K.
Affiliations
  • Associate Chief of Psychiatry for Clinical Research, Massachusetts General Hospital, Boston, Massachusetts; Director, Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts; Professor of Psychiatry, Harvard Medical School, Boston, Massachussets
  • The University of Texas Southwestern Medical Center (US)
  • Massachusetts General Hospital (US)
  • University of Illinois Chicago (US)
  • Research Associate, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania
  • University of Pittsburgh (US)
  • Associate Professor, The University of Texas Southwestern Medical Center, Department of Psychiatry and Department of Family and Community Medicine, Dallas, Texas
ORCID
Venue
The Canadian Journal of Psychiatry
Publisher
SAGE Publications
Published
2006-11
Volume
51
Issue
13
Pages
823-835
ISSN
  • 0706-7437 (ISSN-L)
  • 1497-0015
DOI
10.1177/070674370605101304
OpenAlex
W1505466667
Cited by
183
References
32
Citations by year
2026: 7 · 2025: 5 · 2024: 11 · 2023: 10 · 2022: 10 · 2021: 7 · 2020: 13 · 2019: 9 · 2018: 15 · 2017: 8 · 2016: 9 · 2015: 5 · 2014: 9 · 2013: 9 · 2012: 7
FWCI
10.51
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • The Canadian Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Health and Human Services (N01MH90003)
  • National Institutes of Health (n01mh90003-26-0-0)
  • National Institute of Mental Health (N01‐MH‐90003)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Keywords
anxious depression, major depressive disorder, psychiatric comorbidity, generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, post-traumatic stress disorder, agoraphobia, health anxiety, somatoform disorders, endogenous depression, atypical depression, depression severity, sociodemographic factors, STAR*D, outpatient depression, diagnostic subtypes
MeSH terms
Adolescent, Adult, Aged, Ambulatory Care, Anxiety Disorders, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Primary Health Care, Prospective Studies, Comorbidity

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