Postbiotics and paraprobiotics: From concepts to applications

Cuevas-González, P.F.; Liceaga, A.M.; Aguilar-Toalá, J.E.

doi:10.1016/j.foodres.2020.109502

Cited by 431Probiotics and Fermented FoodsProtein Hydrolysis and Bioactive PeptidesMicrobial Metabolites in Food Biotechnology

Postbiotics and paraprobiotics: From concepts to applications

Cuevas-González, P.F., Liceaga, A.M., Aguilar-Toalá, J.E.·2020·Food Research International

DOI 10.1016/j.foodres.2020.109502

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Abstract

In recent years, new probiotic-related concepts such as postbiotics and paraprobiotics have been used to describe non-viable microorganisms or bacterial-free extracts that may provide benefits to the host by offering bioactivities additional to probiotics. However, several aspects related to these postbiotics and paraprobiotics bioactivities remain unexplored or are poorly understood. Therefore, the aim of this work is to provide an overview of the general aspects and emerging trends of postbiotics and paraprobiotics, such as conceptualization of terms, production, characterization, bioactivities, health-promoting effects, bioengineering approaches, and applications. In vitro and in vivo studies have demonstrated that some postbiotics and paraprobiotics exhibit bioactivities such as anti-inflammatory, immunomodulatory, anti-proliferative, antioxidant, and antimicrobial. These bioactivities could be involved in health-promoting effects observed in human and clinical trials, but despite the scientific evidence available, the mechanisms of action and the signaling pathways involved have not been fully elucidated. Nevertheless, paraprobiotics and postbiotics possess valuable potential for the development of biotechnological products with functional ingredients for the nutraceutical industry.

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A safer and more practical approach than live probiotics would be to use inactivated microbial cells, cell fractions, or soluble products and metabolites of probiotics, known as postbiotics.
“A safer and more practical approach would be to use inactivated microbial cells, cell fractions, or soluble products and metabolites of probiotics, known as postbiotics [12–14].”
From Coaggregation of oral pathogens by postbiotic lactobacilli (2025) · cites this paper as [14]

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Heat-killed yogurt-containing lactic acid bacteria prevent cytokine-induced barrier disruption in human intestinal Caco-2 cells
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A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders
Sorboni, S. G., Moghaddam, H. S., Jafarzadeh-Esfehani, R., & Soleimanpour, S. (2022) · Clinical Microbiology Reviews · doi:10.1128/cmr.00338-20 · Cited by 562 · see citing works
Paraprobiotics and Postbiotics of Probiotic Lactobacilli, Their Positive Effects on the Host and Action Mechanisms: A Review
Teame, T., Wang, A., Xie, M., Zhang, Z., Yang, Y., Ding, Q., Gao, C., Olsen, R. E., Ran, C., & Zhou, Z. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.570344 · Cited by 397 · see citing works
Postbiotics: Current Trends in Food and Pharmaceutical Industry
Thorakkattu, P., Khanashyam, A. C., Shah, K., Babu, K. S., Mundanat, A. S., Deliephan, A., Deokar, G. S., Santivarangkna, C., & Nirmal, N. P. (2022) · Foods · doi:10.3390/foods11193094 · Cited by 391 · see citing works
Postbiotics produced by lactic acid bacteria: The next frontier in food safety
Moradi, M., Kousheh, S. A., Almasi, H., Alizadeh, A., Guimarães, J. T., YILMAZ, N., & Javid, A. L. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12613 · Cited by 368 · see citing works
Paraprobiotics: A New Perspective for Functional Foods and Nutraceuticals
Siciliano, R. A., Reale, A., Mazzeo, M. F., Morandi, S., Silvetti, T., & Brasca, M. (2021) · Nutrients · doi:10.3390/nu13041225 · Cited by 244 · see citing works
Prebiotics, Probiotics, Synbiotics, Paraprobiotics and Postbiotic Compounds in IBD
Martyniak, A., Medyńska-Przęczek, A., Wędrychowicz, A., Skoczeń, S., & Tomasik, P. (2021) · Biomolecules · doi:10.3390/biom11121903 · Cited by 249 · see citing works
A review on preparation and chemical analysis of postbiotics from lactic acid bacteria
Moradi, M., Molaei, R., & Guimarães, J. T. (2020) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2020.109722 · Cited by 206 · see citing works
The Current and Future Perspectives of Postbiotics
Liang, B., & Xing, D. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10045-x · Cited by 217 · see citing works
Probiotics in the dairy industry—Advances and opportunities
Gao, J., Li, X., Zhang, G., Sadiq, F. A., Simal‐Gandara, J., Xiao, J., & Sang, Y. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12755 · Cited by 195 · see citing works
Exopolysaccharides of Lactic Acid Bacteria: Production, Purification and Health Benefits towards Functional Food
Sørensen, H. M., Rochfort, K. D., Maye, S., Macleod, G. H. B., Brabazon, D., Loscher, C. E., & Freeland, B. H. (2022) · Nutrients · doi:10.3390/nu14142938 · Cited by 190 · see citing works
Gut Microbiota: A Novel Therapeutic Target for Parkinson’s Disease
Zhu, M., Liu, X., Ye, Y., Yan, X., Cheng, Y., Zhao, L., Chen, F., & Ling, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.937555 · Cited by 177 · see citing works
Eating Fermented: Health Benefits of LAB-Fermented Foods
Castellone, V., Bancalari, E., Rubert, J., Gatti, M., Neviani, E., & Bottari, B. (2021) · Foods · doi:10.3390/foods10112639 · Cited by 178 · see citing works
Postbiotics as potential new therapeutic agents for metabolic disorders management
Bourebaba, Y., Marycz, K., Mularczyk, M., & Bourebaba, L. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113138 · Cited by 185 · see citing works
Probiotics, Prebiotics, Synbiotics, and Fermented Foods as Potential Biotics in Nutrition Improving Health via Microbiome-Gut-Brain Axis
Dahiya, D., & Nigam, P. S. N. (2022) · Fermentation · doi:10.3390/fermentation8070303 · Cited by 156 · see citing works
Health Benefits of Consuming Foods with Bacterial Probiotics, Postbiotics, and Their Metabolites: A Review
Vera-Santander, V. E., Hernández‐Figueroa, R. H., Jiménez‐Munguía, M. T., Mani‐López, E., & López‐Malo, A. (2023) · Molecules · doi:10.3390/molecules28031230 · Cited by 149 · see citing works
Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases
Gurunathan, S., Pratheep, T., & Kim, J. (2023) · Foods · doi:10.3390/foods13010089 · Cited by 139 · see citing works
Listeria monocytogenes biofilm inhibition on food contact surfaces by application of postbiotics from Lactobacillus curvatus B.67 and Lactobacillus plantarum M.2
Hossain, M. I., Mizan, M. F. R., Roy, P. K., Nahar, S., Toushik, S. H., Ashrafudoulla, M., Jahid, I. K., Lee, J., & Ha, S. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110595 · Cited by 132 · see citing works
Effect of Lactobacillus plantarum and Lactobacillus acidophilus fermentation on antioxidant activity and metabolomic profiles of loquat juice
Meng, F., Lei, Y., Li, Q., Li, Y., Deng, Y., & Liu, D. (2022) · LWT · doi:10.1016/j.lwt.2022.114104 · Cited by 118 · see citing works
Heat-Treated Bifidobacterium longum CECT-7347: A Whole-Cell Postbiotic with Antioxidant, Anti-Inflammatory, and Gut-Barrier Protection Properties
Martorell, P., Alvarez, B., Llopis, S., Navarro, V., Ortiz, P., González, N., Balaguer, F., Rojas, A., Chenoll, E., Ramón, D., et al. (2021) · Antioxidants · doi:10.3390/antiox10040536 · Cited by 116 · see citing works
Protective and ameliorating effects of probiotics against diet-induced obesity: A review
Tang, C., Kong, L., Shan, M., Lu, Z., & Lu, Y. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110490 · Cited by 112 · see citing works
The biological activities of postbiotics in gastrointestinal disorders
Abbasi, A., Rad, A. H., Ghasempour, Z., Sabahi, S., Kafil, H. S., Hasannezhad, P., Saadat, Y. R., & Shahbazi, N. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1895061 · Cited by 114 · see citing works
Saccharomyces cerevisiae as probiotic, prebiotic, synbiotic, postbiotics and parabiotics in aquaculture: An overview
del Valle, J. C., Bonadero, M. C., & Fernández-Giménez, A. V. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.739342 · Cited by 111 · see citing works
Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model
Zhang, T., Zhang, W., Feng, C., Kwok, L., He, Q., & Sun, Z. (2022) · npj Science of Food · doi:10.1038/s41538-022-00169-9 · Cited by 116 · see citing works
Health effects and probiotic and prebiotic potential of Kombucha: A bibliometric and systematic review
Vargas, B. K., Fabricio, M. F., & Ayub, M. A. Z. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101332 · Cited by 113 · see citing works
Characterization of Pediococcus acidilactici postbiotic and impact of postbiotic-fortified chitosan coating on the microbial and chemical quality of chicken breast fillets
İnci̇li̇, G. K., Karatepe, P., Akgöl, M., Kaya, B., Kanmaz, H., & Hayaloğlu, A. A. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.06.106 · Cited by 102 · see citing works
Harnessing the potentialities of probiotics, prebiotics, synbiotics, paraprobiotics, and postbiotics for shrimp farming
Goh, J. X. H., Tan, L. T., Law, J. W., Ser, H., Khaw, K. Y., Letchumanan, V., Lee, L., & Goh, B. H. (2022) · Reviews in Aquaculture · doi:10.1111/raq.12659 · Cited by 101 · see citing works
Influence of lactic acid bacteria metabolites on physical and chemical food properties
de Souza, E. L., de Oliveira, K. Á. R., & de Oliveira, M. E. (2022) · Current Opinion in Food Science · doi:10.1016/j.cofs.2022.100981 · Cited by 100 · see citing works
Probiotics and paraprobiotics in aquaculture: a sustainable strategy for enhancing fish growth, health and disease prevention-a review
Fachri, M. F., Amoah, K., Huang, Y., Cai, J. X., Alfatat, A., Ndandala, C. B., Shija, V. M., Jin, X., Fred, B., & Chen, H. (2024) · Frontiers in Marine Science · doi:10.3389/fmars.2024.1499228 · Cited by 92 · see citing works
Postbiotics: An overview of concepts, inactivation technologies, health effects, and driver trends
Pimentel, T. C., da Cruz, A. G., Pereira, E. P. R., da Costa, W. K. A., Rocha, R. S., Pedrosa, G. T. D. S., Rocha, C. D. S., Alves, J. M., Alvarenga, V. O., Sant’Ana, A. S., et al. (2023) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2023.06.009 · Cited by 87 · see citing works
Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal Mucositis
Batista, V. L., da Silva, T. F., de Jesus, L. C. L., Coelho-Rocha, N. D., Barroso, F. A. L., Tavares, L. M., Azevedo, V., Mancha-Agresti, P. D. C., & Drumond, M. M. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.544490 · Cited by 85 · see citing works
Journey of the Probiotic Bacteria: Survival of the Fittest
Mendonça, A. A., Pinto-Neto, W. D. P., da Paixão, G. A., Santos, D. D. S., De Morais, M. A., & De Souza, R. B. (2022) · Microorganisms · doi:10.3390/microorganisms11010095 · Cited by 82 · see citing works
The potential of postbiotics as a novel approach in food packaging and biopreservation: a systematic review of the latest developments
Sharafi, H., Divsalar, E., Rezaei, Z. B., Liu, S., & Moradi, M. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2253909 · Cited by 82 · see citing works
Antibacterial, Antiviral, Antioxidant, and Anticancer Activities of Postbiotics: A review of Mechanisms and Therapeutic Perspectives
(2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac122.26292645 · Cited by 82 · see citing works
Production, Formulation, and Application of Postbiotics in the Treatment of Skin Conditions
Vale, A. D. S., Pereira, G. V. D. M., de Oliveira, A. C., Neto, D. P. D. C., Herrmann, L. W., Karp, S. G., Thomaz‐Soccol, V., & Soccol, C. R. (2023) · Fermentation · doi:10.3390/fermentation9030264 · Cited by 85 · see citing works
Exploring the Potential of Postbiotics for Food Safety and Human Health Improvement
Isaac-Bamgboye, F. J., Mgbechidinma, C. L., Onyeaka, H. N., Isaac-Bamgboye, I. T., & Chukwugozie, D. C. (2024) · Journal of Nutrition and Metabolism · doi:10.1155/2024/1868161 · Cited by 72 · see citing works
Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches
Štofilová, J., Kvaková, M., Kamlárová, A., Hijová, E., Bertková, I., & Guľašová, Z. (2022) · Biomedicines · doi:10.3390/biomedicines10092236 · Cited by 74 · see citing works
Novel Horizons in Postbiotics: Lactobacillaceae Extracellular Vesicles and Their Applications in Health and Disease
González-Lozano, E., García-García, J., Gálvez, J., Hidalgo‐Garcia, L., Rodríguez‐Nogales, A., Rodríguez‐Cabezas, M. E., & Sánchez, M. (2022) · Nutrients · doi:10.3390/nu14245296 · Cited by 69 · see citing works
Fabrication of anti-Listeria film based on bacterial cellulose and Lactobacillus sakei-derived bioactive metabolites; application in meat packaging
Rasouli, Y., Moradi, M., Tajik, H., & Molaei, R. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101218 · Cited by 68 · see citing works
Optimizing postbiotic production through solid-state fermentation with Bacillus amyloliquefaciens J and Lactiplantibacillus plantarum SN4 enhances antibacterial, antioxidant, and anti-inflammatory activities
Tong, Y., Guo, H., Abbas, Z., Zhang, J., Wang, J., Cheng, Q., Peng, S., Yang, T., Bai, T., Zhou, Y., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1229952 · Cited by 70 · see citing works
Probiotics, Photobiomodulation, and Disease Management: Controversies and Challenges
Ailioaie, L. M., & Litscher, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094942 · Cited by 68 · see citing works
Untargeted LC-QTOF-MS/MS based metabolomics approach for revealing bioactive components in probiotic fermented coffee brews
Chan, M. Z. A., Lau, H., Lim, S. Y., Li, S. F. Y., & Liu, S. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110656 · Cited by 66 · see citing works
Intestinal pharmacokinetics of resveratrol and regulatory effects of resveratrol metabolites on gut barrier and gut microbiota
Zhang, B., Xu, Y., Lv, H., Pang, W., Wang, J., Ma, H., & Wang, S. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.129532 · Cited by 64 · see citing works
Functional meat products: Trends in pro-, pre-, syn-, para- and post-biotic use
Manassi, C. F., de Souza, S. S., Hassemer, G. D. S., Sartor, S., Lima, C. M. G., Miotto, M., Lindner, J. D. D., Rezzadori, K., Pimentel, T. C., Ramos, G. L. D. P. A., et al. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111035 · Cited by 63 · see citing works
Recent advances in the probiotic application of the Bacillus as a potential candidate in the sustainable development of aquaculture
Ghosh, T. (2024) · Aquaculture · doi:10.1016/j.aquaculture.2024.741432 · Cited by 63 · see citing works
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Self-citation

Authors: Cuevas-González, P. F., Liceaga, A. M., & Aguilar-Toalá, J. E.
Affiliations: Universidad Tecnologica de Tijuana (MX)
Purdue University West Lafayette (US)
Corresponding author: Liceaga, A.M.
Aguilar-Toalá, J.E.
ORCID: Cuevas-González, P.F.
Liceaga, A.M.
Aguilar-Toalá, J.E.
Venue: Food Research International
Publisher: Elsevier BV
Published: 2020-10
Volume: 136
Pages: 109502
ISSN: 0963-9969 (ISSN-L)
DOI: 10.1016/j.foodres.2020.109502
OpenAlex: W3038698648
Cited by: 431
References: 109
Citations by year: 2026: 70 · 2025: 90 · 2024: 84 · 2023: 73 · 2022: 54 · 2021: 53 · 2020: 6
FWCI: 3.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Food Research International (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: postbiotics, paraprobiotics, bacterial extracts, bioactive compounds, anti-inflammatory activity, immunomodulation, antioxidant activity, antimicrobial activity, health-promoting properties, nutraceuticals, functional food ingredients
MeSH terms: Anti-Bacterial Agents, Bacteria, Humans, Dietary Supplements, Probiotics

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Postbiotics and paraprobiotics: From concepts to applications

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