Serum Non-High-Density Lipoprotein Cholesterol Levels and the Incidence of Ischemic Stroke in a Japanese Population: The Jichi Medical School Cohort Study
Abstract
The predictive value of serum non-high-density lipoprotein cholesterol (non-HDL-C) levels for the incidence of ischemic stroke and its subtypes has not yet been established. The present cohort study investigated their relationships in a Japanese population. The first incidence of ischemic stroke and its subtypes was documented as the primary outcome. A total of 249 ischemic stroke patients (men/women = 145/104) were identified during a follow-up period of 10.7 years among 10 760 community-dwelling subjects (men/women = 4212/6548). Cox proportional hazard model analyses revealed that when compared with the lowest tertile of non-HDL-C, multivariate-adjusted hazard ratios for the highest tertile were 0.55 (95% confidence interval = 0.32-0.95, P = .03) on ischemic stroke and 0.29 (95% confidence interval = 0.08-1.05, P = .06) on cardioembolic infarction in women. Men did not show such significant relationships. Low serum non-HDL-C levels may be a predictive marker associated with an increase in the incidence of ischemic stroke and possibly of cardioembolic infarction in Japanese women.
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Non-HDL-C is associated with CAD in many Japanese epidemiological surveys.
“The association between non-HDL-C and CAD has been reported in the results of many epidemiological surveys conducted in Japan51, 63–70).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [69]
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- Authors
- Kakehi, E., Kotani, K., Ishikawa, S., Gotoh, T., Kayaba, K., Nakamura, Y., & Kajii, E.
- Affiliations
- Jichi Medical University (JP)
- Wara National Health Insurance Clinic, Gifu, Japan
- Saitama Prefectural University (JP)
- Venue
- Asia Pacific Journal of Public Health
- Publisher
- SAGE Publications
- Published
- 2013-02-20
- Volume
- 27
- Issue
- 2
- Pages
- NP535-NP543
- ISSN
- 1010-5395 (ISSN-L)
- 1941-2479
- OpenAlex
- W2332474321
- Cited by
- 12
- References
- 33
- Citations by year
- 2025: 1 · 2023: 3 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Asia Pacific Journal of Public Health (publishedVersion)
- PubMed (publishedVersion)
- Funders
- H2020 European Research Council
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- non-HDL cholesterol, ischemic stroke, cardioembolic stroke, stroke incidence, serum lipids, sex differences, predictive biomarkers, Japanese population
- MeSH terms
- Adult, Aged, Aged, 80 and over, Brain Ischemia, Cholesterol, Female, Humans, Japan, Cholesterol, HDL, Male, Middle Aged, Prospective Studies, Risk Factors, Schools, Medical, Sex Factors, Cohort Studies, Biomarkers, Incidence, Proportional Hazards Models, Stroke, Young Adult
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