Cited by 12Lipoproteins and Cardiovascular HealthAcute Ischemic Stroke ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Serum Non-High-Density Lipoprotein Cholesterol Levels and the Incidence of Ischemic Stroke in a Japanese Population: The Jichi Medical School Cohort Study

Kakehi, Eiichi, Kotani, Kazuhiko, Ishikawa, Shizukiyo, Gotoh, Tadao, Kayaba, Kazunori, Nakamura, Yosikazu, Kajii, Eiji·2015·Asia Pacific Journal of Public Health

Abstract

The predictive value of serum non-high-density lipoprotein cholesterol (non-HDL-C) levels for the incidence of ischemic stroke and its subtypes has not yet been established. The present cohort study investigated their relationships in a Japanese population. The first incidence of ischemic stroke and its subtypes was documented as the primary outcome. A total of 249 ischemic stroke patients (men/women = 145/104) were identified during a follow-up period of 10.7 years among 10 760 community-dwelling subjects (men/women = 4212/6548). Cox proportional hazard model analyses revealed that when compared with the lowest tertile of non-HDL-C, multivariate-adjusted hazard ratios for the highest tertile were 0.55 (95% confidence interval = 0.32-0.95, P = .03) on ischemic stroke and 0.29 (95% confidence interval = 0.08-1.05, P = .06) on cardioembolic infarction in women. Men did not show such significant relationships. Low serum non-HDL-C levels may be a predictive marker associated with an increase in the incidence of ischemic stroke and possibly of cardioembolic infarction in Japanese women.

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Crossref · 10.1177/1010539513475649

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Authors
Kakehi, E., Kotani, K., Ishikawa, S., Gotoh, T., Kayaba, K., Nakamura, Y., & Kajii, E.
Affiliations
  • Jichi Medical University (JP)
  • Wara National Health Insurance Clinic, Gifu, Japan
  • Saitama Prefectural University (JP)
Venue
Asia Pacific Journal of Public Health
Published
2013-02-20
Volume
27
Issue
2
Pages
NP535-NP543
ISSN
  • 1010-5395 (ISSN-L)
  • 1941-2479
OpenAlex
W2332474321
Cited by
12
References
33
Citations by year
2025: 1 · 2023: 3 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1
FWCI
0.98
Type
journal article
Language
en
Open access
closed
Locations
  • Asia Pacific Journal of Public Health (publishedVersion)
  • PubMed (publishedVersion)
Funders
H2020 European Research Council
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
non-HDL cholesterol, ischemic stroke, cardioembolic stroke, stroke incidence, serum lipids, sex differences, predictive biomarkers, Japanese population
MeSH terms
Adult, Aged, Aged, 80 and over, Brain Ischemia, Cholesterol, Female, Humans, Japan, Cholesterol, HDL, Male, Middle Aged, Prospective Studies, Risk Factors, Schools, Medical, Sex Factors, Cohort Studies, Biomarkers, Incidence, Proportional Hazards Models, Stroke, Young Adult

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