Efficacy of cognitive behavioural therapy delivered over the Internet for depressive symptoms: A systematic review and meta-analysis
Abstract
Introduction: Cognitive behavioural therapy has been shown to improve depressive symptoms in adults with mild to moderate depression. To overcome many of the barriers associated with delivering this treatment, attempts have been made to deliver cognitive behavioural therapy via the Internet. The objective of this meta-analysis is to assess whether Internet-based cognitive behavioural therapy delivered to adults with depressive symptoms leads to a reduction in these symptoms as compared to those who receive no therapy. Methods: In September 2015, the Cochrane, PubMed and PsycInfo databases were searched; studies were also found through bibliography searches. Studies were included if they were randomized controlled trials published in English between 2005–2015 conducted with adults >18 years of age experiencing mild to moderate depression where study subjects received Internet-based cognitive behavioural therapy, and the control group was placed on a wait-list. The search yielded 257 articles; 14 of these were included in the meta-analysis. Results: Internet delivered cognitive behavioural therapy had a medium effect on reducing depressive symptoms at the end of the study period (standardized mean difference: 0.74, confidence interval: 0.62–0.86, p < 0.001). Internet-delivered cognitive behavioural therapy also has a large sustained effect in maintaining reduction of depressive symptoms in follow-up measures done 3–6 months after the conclusion of the therapy (standardized mean difference: 0.83, confidence interval: 0.69–0.99, p < 0.001). There was no publication bias and low heterogeneity. Discussion: Cognitive behavioural therapy delivered over the Internet leads to immediate and sustained reduction in depressive symptoms; thus, it may be a good treatment modality for individuals unable or unwilling to access traditional face-to-face therapy.
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Interventions fully or partially delivered through the Internet, especially those based on Cognitive Behavioural Therapy, are effective in treating different psychological disorders.
“Well-established evidence shows that interventions fully or partially delivered through the Internet (especially those based on Cognitive Behavioural Therapy (CBT)) are effective in treating different psychological disorders [8,9,10]”
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“They also have a strong evidence base in many therapies including cognitive behavioural therapy (CBT) (Sztein et al., 2018) acceptance and commitment therapy (ACT) (Herbert et al., 2017),and parenting interventions (Comer et al., 2015).”
Update on the UC San Diego Healer Education Assessment and Referral (HEAR) Program
Norcross, W. A., Moutier, C. Y., Tiamson‐Kassab, M., Jong, P., Davidson, J. E., Lee, K. C., Newton, I. G., Downs, N. S., & Zisook, S. (2018) · Journal of Medical Regulation · doi:10.30770/2572-1852-104.2.17 · Cited by 26 · see citing works
Dyadic Behavior Change Interventions
Scholz, U., Berli, C., Lüscher, J., & Knoll, N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.043 · Cited by 23 · see citing works
Developing Behavior Change Interventions
Hankonen, N. E., & Hardeman, W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.021 · Cited by 26 · see citing works
Moghimi, E., Knyahnytska, Y., Omrani, M., Nikjoo, N., Stephenson, C., Layzell, G., Simpson, A. I. F., & Alavi, N. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.921527 · Cited by 25 · see citing works
“Most available evidence-based programs for PSP and CWs utilize CBT since it can be easily adapted for different mental disorders and populations (25, 62).”
BackgroundRothman, A. J., Klein, W. M. P., & Sheeran, P. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.020 · Cited by 25 · see citing works
Imagery, Visualization, and Mental Simulation Interventions
Hagger, M. S., & Conroy, D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.033 · Cited by 22 · see citing works
Changing Behavior Using the Common-Sense Model of Self-Regulation
Cameron, L. D., Fleszar‐Pavlović, S. E., & Khachikian, T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.005 · Cited by 23 · see citing works
Engagement of Stakeholders in the Design, Evaluation, and Implementation of Complex Interventions
Hudson, J. L., Moon, Z., Hughes, L. D., & Moss-Morris, R. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.024 · Cited by 20 · see citing works
Uri Gneezy, B., Kajackaite, A., & Meier, S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.036 · Cited by 20 · see citing works
Jia, E., Macon, J., Doering, M. M., & Abraham, J. (2025) · Journal of Medical Internet Research · doi:10.2196/68054 · Cited by 20 · see citing works
Ruiter, R. A. C., Crutzen, R., de Leeuw, E., & Kok, G. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.018 · Cited by 17 · see citing works
Alavi, N., Stephenson, C., Omrani, M., Gerritsen, C. J., Martin, M. S., Knyahnytskyi, A., Zhu, Y., Kumar, A., Jagayat, J., Shirazi, A., et al. (2021) · JMIR Research Protocols · doi:10.2196/30845 · Cited by 18 · see citing works
“e-CBT has been shown to effectively treat a variety of mental health disorders, supported by several meta-analyses [34-37].”
Jagayat, J., Kumar, A., Shao, Y., Pannu, A., Patel, C. B., Shirazi, A., Omrani, M., & Alavi, N. (2023) · JMIR Mental Health · doi:10.2196/51704 · Cited by 15 · see citing works
“Many studies have shown the efficacy of i-CBT for depression and anxiety, with results comparable with those of traditional in-person CBT [11,16-20].”
Changing Behavior Using Social Identity Processes
Reynolds, K. J., Branscombe, N. R., Subašić, E., & Willis, L. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.016 · Cited by 17 · see citing works
Clunne, S. J., Ryan, B., Hill, A. J., Brandenburg, C., & Kneebone, I. (2018) · Journal of Medical Internet Research · doi:10.2196/jmir.9864 · Cited by 16 · see citing works
Werntz, A. J., Jasman, M., Simeon, K. M., Gunasekaran, H., Yowell, C. M., & Rhodes, J. E. (2023) · Journal of Technology in Behavioral Science · doi:10.1007/s41347-023-00303-8 · Cited by 14 · see citing works
“…the potential of technology-delivered interventions in improving the depression (i.e. Domhardt et al., 2019; Grist et al., 2019; Heber et al., 2017; Sztein et al., 2018), anxiety (i.e. Grist et al., 2019; Heber et al., 2017; Sherifali et al., 2018), and stress (i.e. Heber et al., 2017; Sherifali…”
BackgroundAndo, M., Kao, Y.-C., Lee, Y.-C., Tai, S.-A., Mendez, S. R., Sasaki, K., Wenze Tang, & Papatheodorou, S. (2023) · Journal of Telemedicine and Telecare · doi:10.1177/1357633x231151788 · Cited by 10 · see citing works
Webb, T. L., & de Bruin, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.037 · Cited by 14 · see citing works
Giallo, R., Fogarty, A., Seymour, M., Skinner, L., Savopoulos, P., Bereznicki, A., Talevski, T., Ruthven, C., Bladon, S., Goldfeld, S. R., et al. (2021) · Journal of Family Studies · doi:10.1080/13229400.2021.2019606 · Cited by 13 · see citing works
“Although evidence for telehealth interventions for some conditions, including depression, existed prior to the pandemic (e.g. Backhaus et al., 2012; Sztein et al., 2018), the rapid transition to telehealth for most services and interventions (including FF) in recent times has been based on the…”
BackgroundCritical and Qualitative Approaches to Behavior Change
Chamberlain, K., & Lyons, A. C. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.030 · Cited by 12 · see citing works
Maximizing User Engagement with Behavior Change Interventions
Yardley, L., Morrison, L. G., Müller, I., & Bradbury, K. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.025 · Cited by 11 · see citing works
Pearson, R., Carl, E., & Creech, S. K. (2021) · Journal of Medical Internet Research · doi:10.2196/30065 · Cited by 11 · see citing works
“Meta-analyses have supported the efficacy of computerized psychological interventions in the treatment of depression [4-6], anxiety [4,7], posttraumatic stress disorder (PTSD; [8]), substance use disorders (SUDs; [9,10]), and insomnia [11], with effect sizes ranging from small [5,7,9] to…”
BackgroundSangalli, L., Fernandez-Vial, D., Moreno‐Hay, I., & Boggero, I. A. (2021) · Pain Medicine · doi:10.1093/pm/pnab295 · Cited by 11 · see citing works
Fogarty, A., Jones, A., Seymour, M., Savopoulos, P., Evans, K., O’Brien, J., O'Dea, L., Clout, P., Auletta, S., & Giallo, R. (2021) · Child & Family Social Work · doi:10.1111/cfs.12890 · Cited by 10 · see citing works
Keller, F. M., Dahmen, A., Derksen, C., Kötting, L., & Lippke, S. (2021) · JMIR Mental Health · doi:10.2196/30610 · Cited by 10 · see citing works
“Several studies have examined the usefulness of electronically delivered cognitive behavioral therapy (eCBT), which has proven to be effective with regard to the treatment of anxiety and depression compared to regular in-person therapy [30,31].”
BackgroundGuided Internet-Delivered Treatment for Depression: Scoping Review
Børtveit, L., Dechsling, A., Sütterlin, S., Nordgreen, T., & Nordahl‐Hansen, A. (2022) · JMIR Mental Health · doi:10.2196/37342 · Cited by 11 · see citing works
“We implemented no limitations regarding participant age, which typically has been the case in previous reviews [10,11,16,20,51].”
MethodThe Science of Behavior Change: The Road Ahead
Hagger, M. S., Cameron, L. D., Hamilton, K., Hankonen, N. E., & Lintunen, T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.046 · Cited by 11 · see citing works
Autonomy-Supportive Interventions
Reeve, J., & Cheon, S. H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.035 · Cited by 9 · see citing works
Implementation Science and Translation in Behavior Change
Łuszczyńska, A., Łobczowska, K., & Horodyska, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.023 · Cited by 9 · see citing works
de Ridder, D. T. D., Gillebaart, M., & Friese, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.040 · Cited by 9 · see citing works
Epton, T., & Armitage, C. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.038 · Cited by 8 · see citing works
Quiñonez-Freire, C., Vara, M. D., Herrero, R., Mira, A., García‐Palacios, A., Botella, C., & Baños, R. (2020) · Internet Interventions · doi:10.1016/j.invent.2020.100352 · Cited by 8 · see citing works
Alavi, N., Stephenson, C., Miller, S., Khalafi, P., Sinan, I., Kain, D., McDougall, M., Davies, J., Stark, D., Tompkins, E., et al. (2021) · JMIR Research Protocols · doi:10.2196/30735 · Cited by 7 · see citing works
“More specifically, web-based delivery of cognitive behavioral therapy (e-CBT) has been shown to decrease depressive symptoms and sustain beneficial effects [9-12].”
BackgroundSablone, S., Bellino, M., Lagona, V., Franco, T. P., Groicher, M., Risola, R., Violante, M. G., & Grattagliano, I. (2024) · Forensic Sciences Research · doi:10.1093/fsr/owae008 · Cited by 8 · see citing works
“…efficacious in treating common mental health conditions experienced by veterans [48, 49], such as post-traumatic stress disorders (PTSDs) or other trauma and stressor-related imbalances [50], anxiety [51, 52], depression [53], intermittent explosive disorder [54], and substance use disorders [55].”
BackgroundJoyce, K., Rioux, C., MacKinnon, A., Katz, L. Y., Reynolds, K., Kelly, L. E., Klassen, T., Afifi, T., Mushquash, A. R., Clement, F. M., et al. (2023) · Pilot and Feasibility Studies · doi:10.1186/s40814-023-01260-y · Cited by 5 · see citing works
Evaluation of Behavior Change Interventions
Matthews, L., & Simpson, S. A. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.022 · Cited by 7 · see citing works
Motivational Interviewing Interventions
Berman, A. H., Beckman, M., & Lindqvist, H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.045 · Cited by 7 · see citing works
State of the Mind: Growing up with HIV
Bartlett, A. W., Williams, P. C. M., Jantarabenjakul, W., & Kerr, S. J. (2020) · Pediatric Drugs · doi:10.1007/s40272-020-00415-1 · Cited by 7 · see citing works
Economic and Behavioral Economic Approaches to Behavior Change
Brown, P. M., Cameron, L. D., Wilkinson, M., & Taylor, D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.042 · Cited by 6 · see citing works
„iFightDepression“ im stationären Setting
Schwarz, J., Mauche, N., Oehler, C., Rummel-Kluge, C., Hegerl, U., & Strauss, M. (2021) · Der Nervenarzt · doi:10.1007/s00115-021-01214-w · Cited by 4 · see citing works
Spiess, S., Gardner, E., Turner, C., Galt, A., Fortenberry, K. T., Ho, T. F., Knox, J., & Ose, D. J. (2023) · Journal of Medical Internet Research · doi:10.2196/43877 · Cited by 6 · see citing works
“Before the pandemic, virtual care visits were effective conduits for treating patients with anxiety and depression, increasing patient access to specialists, and providing personalized chronic disease management [5-8].”
Changing Behavior Using Integrative Self-Control Theory
Hofmann, W., Dohle, S., & Diel, K. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.011 · Cited by 6 · see citing works
Conner, M. T., Williams, D. M., & Rhodes, R. E. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.034 · Cited by 6 · see citing works
Addressing Underserved Populations and Disparities in Behavior Change
Schüz, B., & Hooper, M. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.027 · Cited by 5 · see citing works
Stephenson, C., Jagayat, J., Kumar, A., Khamooshi, P., Eadie, J., Pannu, A., Meartsi, D., Danaee, E., Gutiérrez, G., Khan, F., et al. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1220607 · Cited by 4 · see citing works
“…e-CBT content can make mental health care more scalable and affordable and address the general concerns of most individuals with mild to moderate symptoms (8, 9, 21, 22), individuals with severe symptoms may require further intensive clinical interventions and clinician involvement (22, 23).”
BackgroundChanging Behavior in the Digital Age
Kavanagh, D. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.029 · Cited by 4 · see citing works
Fernández-Regueras, D., Elvira, A. C., & Guerrero-Escagedo, M. C. (2023) · Behavioral Psychology/Psicología Conductual · doi:10.51668/bp.8323306n · Cited by 4 · see citing works
“There is substantial research evidence supporting the effectiveness of telepsychological interventions using cognitive-behavioral therapies (CBT) for various conditions, as evidenced by systematic reviews and meta-analyses (e.g., Grist & Cavanagh, 2013; Sztein et al., 2018).”
BackgroundThielecke, J., Kuper, P. R., Lehr, D., Schuurmans, L., Harrer, M., Ebert, D. D., Cuijpers, P. J., Behrendt, D., Brückner, H., Horvath, H., et al. (2024) · Psychological Medicine · doi:10.1017/s0033291724000527 · Cited by 4 · see citing works
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“…such option, since it has been shown to have treatment effects comparable to face-to-face CBT (Andersson et al., 2019; P ˘ as ˘ arelu et al., 2017; Sztein et al., 2018), while allowing the therapist to treat four times as many patients in the same amount of time (Andersson et al., 2014), and is…”
Nur auf Einladung? Wie die Rekrutierungsstrategie beeinflusst, wer online behandelt wird
Zagorscak, P., Bohn, J., Heinrich, M., Kampisiou, C., & Knaevelsrud, C. (2019) · Verhaltenstherapie · doi:10.1159/000502018 · Cited by 3 · see citing works
Charron, C., & Gorey, K. M. (2022) · Depression Research and Treatment · doi:10.1155/2022/2972219 · Cited by 3 · see citing works
Terapia cognitiva con entrega virtual en trastorno depresivo persistente: estudio de caso
García, N. B. (2019) · Clínica Contemporánea · doi:10.5093/cc2019a21 · Cited by 3 · see citing works
Changing Behavior Using Control Theory
Mansell, W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108677318.009 · Cited by 2 · see citing works
Tavares, I., Pieta, M. A. M., Pedroso, M. E., & Dias, A. C. G. (2021) · Revista Brasileira de Terapias Cognitivas · doi:10.5935/1808-5687.20210018 · Cited by 2 · see citing works
- Authors
- Sztein, D. M., Koransky, C. E., Fegan, L., & Himelhoch, S.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Sztein, Dina M
- ORCID
- Himelhoch, Seth
- Venue
- Journal of Telemedicine and Telecare
- Publisher
- SAGE Publications
- Published
- 2017-07-11
- Volume
- 24
- Issue
- 8
- Pages
- 527-539
- ISSN
- 1357-633X (ISSN-L)
- 1758-1109
- OpenAlex
- W2776959657
- Semantic Scholar
- 7e2fbea7bc194e627a1c6fce6a9a8acc65d3e710
- Cited by
- 135
- References
- 51
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 6 · 2023: 19 · 2022: 14 · 2021: 17 · 2020: 55 · 2019: 6 · 2018: 5
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Telemedicine and Telecare (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Telemedicine and Telehealth Implementation
- Keywords
- internet-based cognitive behavioral therapy, depressive symptoms, mild to moderate depression, online therapy, treatment efficacy, sustained treatment effects, access to mental health care
- MeSH terms
- Adult, Depression, Depressive Disorder, Female, Humans, Male, Middle Aged, Waiting Lists, Cognitive Behavioral Therapy, Internet, PubMed
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