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Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer
Open accessAbstract
Despite advancement in cancer treatment, oral cancer has a poor prognosis and is often detected at late stage. To overcome these challenges, investigators should search for early diagnostic and prognostic biomarkers. More than 700 bacterial species reside in the oral cavity. The oral microbiome population varies by saliva and different habitats of oral cavity. Tobacco, alcohol, and betel nut, which are causative factors of oral cancer, may alter the oral microbiome composition. Both pathogenic and commensal strains of bacteria have significantly contributed to oral cancer. Numerous bacterial species in the oral cavity are involved in chronic inflammation that lead to development of oral carcinogenesis. Bacterial products and its metabolic by-products may induce permanent genetic alterations in epithelial cells of the host that drive proliferation and/or survival of epithelial cells. Porphyromonas gingivalis and Fusobacterium nucleatum induce production of inflammatory cytokines, cell proliferation, and inhibition of apoptosis, cellular invasion, and migration thorough host cell genomic alterations. Recent advancement in metagenomic technologies may be useful in identifying oral cancer–related microbiome, their genomes, virulence properties, and their interaction with host immunity. It is very important to address which bacterial species is responsible for driving oral carcinogenesis. Alteration in the oral commensal microbial communities have potential application as a diagnostic tool to predict oral squamous cell carcinoma. Clinicians should be aware that the protective properties of the resident microflora are beneficial to define treatment strategies. To develop highly precise and effective therapeutic approaches, identification of specific oral microbiomes may be required. In this review, we narrate the role of microbiome in the progression of oral cancer and its role as an early diagnostic and prognostic biomarker for oral cancer.
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“Additional changes throughout one's life, including to dietary habits, age, hygiene regimens, and behaviors (such as tobacco and alcohol use), also influence changes to the oral microbiome.132”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [132]
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Concurrent bacterial infections in oral cancer: risk and mitigation strategies
Baby, B. M., Subramaniyan, Y., & Rekha, P. D. (2025) · Future Microbiology · doi:10.1080/17460913.2025.2606754
The potential of antimicrobial peptides to treat oral infections and cancer
de Paula, A. E. C., Siqueira, C. S., & Lorenzón, E. N. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2025.1712514
“Among viruses, human papillomavirus, particularly types 16 and 18, is strongly associated with oropharyngeal squamous cell carcinoma (9), while Epstein–Barr virus plays a key role in the pathogenesis of nasopharyngeal carcinoma (10).”
Mistry, L. N., Mulla, S. A., Patil, A. H., Shah, S., & Pulaskar, S. P. (2026) · Cureus · doi:10.7759/cureus.102131
“Clinically, the microbial composition of a person's oral cavity may be a biomarker for early oral tumor diagnosis or prognostication [6].”
Definition and importance of the human microbiome
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Microbiome based diagnostic approaches
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Un nouveau monde microbien chez l’homme : les candidate phyla radiation (CPR)
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The Role of the Microbiome in Cancer Development
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Comparing saliva collection and DNA extraction methods for saliva-based microbiome profiling
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“…focus on stool microbiome composition, altered oral microbiome has been observed in several diseases such as diabetes (Xiao et al., 2017), cancer (Chattopadhyay et al., 2019), endocarditis (Zhu et al., 2018), bacteremia (Han and Wang, 2013), autoimmune disease (Abe et al., 2020), and autism…”
Research advances in the correlation between oral microbiota and tumors
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“Fusobacterium nucleatum , a key intratumoral bacterium in pancreatic cancer, produces the adhesive FadA protein that binds to E-cadherin, thereby activating b -catenin signaling to drive tumor progression (Chattopadhyay et al., 2019).”
MICROBIOLOGICAL ASPECTS OF THE PATHOGENESIS OF PERIIMPLANTITIS
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Microbiome as prognostic indicator in oral cancer
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“…conditions: Dorea correlates with BV [ 18, 19 ]; Marvinbryantia is detected in urinary incontinence [ 15 ]; Eubacterium siraeum correlates with Group B Streptococcus [ 20 ]; Fastidiosipila is linked to high-risk HPV [ 21 ] and BV [ 22 ]; and Lachnoclostridium correlates with cervical cancer [ 23 ].”
The oral microbiota in oral squamous cell carcinoma: unravelling mechanisms and clinical potential
Kamel, A. H. M., El-Tantawy, N., Ahmed, S., Wadan, A.-H. S., & AbuBakr, N. (2026) · Cancer Cell International · doi:10.1186/s12935-026-04414-z
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Metadata
- Authors
- Chattopadhyay, I., Verma, M., & Panda, M.
- Affiliations
- Central University of Tamil Nadu (IN)
- National Institutes of Health (US)
- Corresponding author
- Chattopadhyay, Indranil
- Venue
- Technology in Cancer Research & Treatment
- Publisher
- SAGE Publications
- Published
- 2019-01-01
- Volume
- 18
- Pages
- 1533033819867354-1533033819867354
- ISSN
- 1533-0338 (ISSN-L)
- 1533-0346
- PMC
- PMC6676258
- OpenAlex
- W2965423269
- Cited by
- 407
- References
- 118
- Citations by year
- 2026: 32 · 2025: 72 · 2024: 76 · 2023: 68 · 2022: 72 · 2021: 63 · 2020: 24
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Technology in Cancer Research & Treatment (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Oral Health Pathology and Treatment
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- oral microbiota, oral cancer, oral squamous cell carcinoma, tumor markers, early diagnosis, prognosis, Porphyromonas gingivalis, Fusobacterium nucleatum, oral carcinogenesis, chronic inflammation, alcohol and tobacco use, areca nut, commensal bacteria, metagenomics, host-microbe interactions
- MeSH terms
- Humans, Inflammation, Mouth Neoplasms, Prognosis, Saliva, Porphyromonas gingivalis, Fusobacterium nucleatum, Cell Proliferation, Carcinogenesis, Microbiota
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