A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform
Abstract
A multi-throughput multi-organ-on-a-chip system was formed on a pneumatic pressure-driven medium circulation platform as a novel type of microphysiological system.
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Microfluidic systems can link different organs-on-a-chip to potentially simulate the complexity of multiorgan drug metabolism and pharmacokinetics.
“Furthermore, microfluidic systems can link different organs-on-a-chip to potentially simulate the complexity of multiorgan drug metabolism and pharmacokinetics9,47,50,68–71.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [9]
In the Satoh liver-tumor model, proliferation of HCT-116 cancer cells was inhibited by capecitabine and its metabolite 5-fluorouracil.
“In this model, the proliferation of HCT-116 cancer cells was inhibited by capecitabine (CAP) and its metabolite 5-fluorouracil (5-fu).”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [9]
Satoh et al. established a two-organ system model composed of liver and tumor.
“Later, Satoh et al. established a two-organ system model composed of liver and tumor9.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [9]
In a breast cancer/liver microenvironment chip, breast cancer cells cultured in the tumor microenvironment have higher vascular porosity and tumor microenvironment permeability than blood vessels in healthy liver microenvironment.
“Compared with blood vessels in the healthy liver microenvironment, breast cancer cells cultured in the microenvironment of this model have higher vascular porosity and tumor microenvironment permeability.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [9]
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“, 2017), recirculation using pneumatic pressure-driven actuation (Satoh et al., 2017), and peristaltic pumps (Chramiec et al.”
BackgroundBridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies
Bouquerel, C., Dubrova, A., Hofer, I., Phan, D. T. T., Bernheim, M., Ladaigue, S., Cavaniol, C., Maddalo, D., Cabel, L., Mechta-Grigoriou, F., et al. (2023) · Lab on a Chip · doi:10.1039/d3lc00531c · Cited by 58 · see citing works
- Authors
- Satoh, T., Sugiura, S., Shin, K., Onuki-Nagasaki, R., Ishida, S., Kikuchi, K., Kakiki, M., & Kanamori, T.
- Affiliations
- National Institute of Advanced Industrial Science and Technology (JP)
- National Institute of Health Sciences (JP)
- Eisai (Japan) (JP)
- Corresponding author
- Sugiura, S.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 18
- Issue
- 1
- Pages
- 115-125
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2769113543
- Cited by
- 181
- References
- 55
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 27 · 2023: 19 · 2022: 26 · 2021: 29 · 2020: 20 · 2019: 15 · 2018: 8
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lab on a Chip (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Keywords
- multi-organ-on-a-chip, microphysiological systems, liver cancer model, HepaRG cells, capecitabine, 5-fluorouracil, tegafur, anticancer prodrugs, HCT116 cells, live/dead staining, gene expression analysis
- MeSH terms
- Equipment Design, Humans, Models, Biological, Organ Culture Techniques, Pressure, Cell Culture Techniques, Caco-2 Cells, HCT116 Cells, Microfluidic Analytical Techniques, Lab-On-A-Chip Devices
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