MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain
Open accessAbstract
Recently, the “glymphatic system” of the brain has been discovered in rodents, which is a paravascular, transparenchymal route for clearance of excess brain metabolites and distribution of compounds in the cerebrospinal fluid. It has already been demonstrated that intrathecally administered gadolinium (Gd) contrast medium distributes along this route in rats, but so far not in humans. A 27-year-old woman underwent magnetic resonance imaging (MRI) with intrathecal administration of gadobutrol, which distributed throughout her entire brain after 1 and 4.5 h. MRI with intrathecal Gd may become a tool to study glymphatic function in the human brain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Literature reporting human in vivo CSF tracer studies is lacking, and observations made in animals have not been translated into humans.
“However, literature reporting human in vivo CSF tracer studies is lacking, and observations made in animals have not been translated into humans.”
From Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. (2018) · cites this paper as [12]
The Introduction (page not provided) says that how rodent tracer observations relate to human brain physiology had not been established, supporting the claim's historical point. But it also describes existing human intrathecal contrast MRI for CSF leaks, and this paper reports a human tracer observation. It therefore does not support an unqualified claim that human in vivo CSF tracer studies are lacking or that the animal observations remain untranslated. (LLM, conf=0.86)
Experimental — accuracy not yet measuredTwo recent human studies demonstrated brain parenchyma enhancement subsequent to intrathecal administration of a MRI contrast agent, but observations were limited to selected ROIs.
“Two recent human studies demonstrated brain parenchyma enhancement subsequent to subarachnoid (intrathecal) administration of a MRI contrast agent, but observations were limited to selected ROIs (12, 13).”
From Brain-wide glymphatic enhancement and clearance in humans assessed with MRI. (2018) · cites this paper as [12]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824 · see citing works
The glymphatic system: a beginner's guide
Jessen, N. A., Munk, A. S. F., Lundgaard, I., & Nedergaard, M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1581-6 · Cited by 2,075 · see citing works
Impairment of paravascular clearance pathways in the aging brain
Kress, B. T., Iliff, J. J., Xia, M., Wang, M., Wei, H. S., Zeppenfeld, D., Xie, L., Kang, H., Xu, Q., Liew, J. A., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24271 · Cited by 1,521 · cited 1× · see citing works
“Glymphatic function has also been shown to decrease dramatically with aging (2) and in the injured brain (3).”
BackgroundProduction of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing
Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X.-D., McKay, D. M., Tintner, R., Frangione, B., et al. (1992) · Science · doi:10.1126/science.1439760 · Cited by 1,447 · see citing works
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury
Iliff, J. J., Chen, M. J., Plog, B. A., Zeppenfeld, D. M., Soltero, M., Yang, L., Singh, I., Deane, R., & Nedergaard, M. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3020-14.2014 · Cited by 1,159 · see citing works
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
Iliff, J. J., Lee, H., Yu, M., Feng, T., Logan, J., Nedergaard, M., & Benveniste, H. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67677 · Cited by 1,148 · see citing works
Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI
Gaberel, T., Gakuba, C., Goulay, R., de Lizarrondo, S. M., Hanouz, J., Emery, É., Touzé, E., Vivien, D., & Gauberti, M. (2014) · Stroke · doi:10.1161/strokeaha.114.006617 · Cited by 434 · see citing works
Akbar, J. J., Luetmer, P. H., Schwartz, K. M., et al. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2815 · Cited by 119 · see citing works
LOCALIZATION OF CEREBROSPINAL FLUID LEAKS BY GADOLINIUM-ENHANCED MAGNETIC RESONANCE CISTERNOGRAPHY
Aydın, K., Terzibaşioğlu, E., Sencer, S., Sencer, A., Süoğlu, Y., Karasu, A., Kiris, T., & Turantan, M. I. (2008) · Neurosurgery · doi:10.1227/01.neu.0000317306.39203.24 · Cited by 68 · see citing works
Adam, G., Neuerburg, J. M., Spüntrup, E., et al. (1994) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910320511 · Cited by 45 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works
The glymphatic pathway in neurological disorders.
Rasmussen, M. K., Mestre, H., & Nedergaard, M. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30318-1 · Cited by 1,560 · see citing works
Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways
Greenberg, S. M., Bacskai, B. J., Hernandez-Guillamon, M., Pruzin, J., Sperling, R., & van Veluw, S. J. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-019-0281-2 · Cited by 947 · see citing works
Aquaporin-4-dependent glymphatic solute transport in the rodent brain
Mestre, H., Hablitz, L. M., Xavier, A. L., Feng, W., Zou, W., Pu, T., Monai, H., Murlidharan, G., Castellanos Rivera, R. M., Simon, M. J., et al. (2018) · eLife · doi:10.7554/elife.40070 · Cited by 738 · see citing works
Glymphatic MRI in idiopathic normal pressure hydrocephalus
Ringstad, G., Vatnehol, S. A. S., & Eide, P. K. (2017) · Brain · doi:10.1093/brain/awx191 · Cited by 722 · see citing works
Self-citationRasmussen, M. K., Mestre, H., & Nedergaard, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00031.2020 · Cited by 622 · see citing works
Brain-wide glymphatic enhancement and clearance in humans assessed with MRI.
Ringstad, G., Valnes, L. M., Dale, A. M., Pripp, A. H., Vatnehol, S.-A. S., Emblem, K. E., Mardal, K.-A., & Eide, P. K. (2018) · JCI Insight · doi:10.1172/jci.insight.121537 · Cited by 533 · see citing works
“005 Basal ganglia [11, 12, 13, 50, 51, 52] –3 ± 8 –6 ± 14 1 ± 25 –4 ± 14 4 ± 18 32 –8 ± 18 0.”
Self-citationGlymphatic clearance function in patients with cerebral small vessel disease
Zhang, W., Zhou, Y., Wang, J., Gong, X., Chen, Z., Zhang, X., Cai, J., Chen, S., Fang, L., Sun, J., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118257 · Cited by 493 · see citing works
Perivascular spaces, glymphatic dysfunction, and small vessel disease
Mestre, H., Kostrikov, S., Mehta, R. I., & Nedergaard, M. (2017) · Clinical Science · doi:10.1042/cs20160381 · Cited by 403 · see citing works
Taoka, T., Ito, R., Nakamichi, R., Nakane, T., Kawai, H., & Naganawa, S. (2024) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.rev.2023-0175 · Cited by 416 · see citing works
Impairment of the Glymphatic Pathway and Putative Meningeal Lymphatic Vessels in the Aging Human
Zhou, Y., Cai, J., Zhang, W., Gong, X., Yan, S., Zhang, K., Luo, Z., Sun, J., Jiang, Q., & Lou, M. (2020) · Annals of Neurology · doi:10.1002/ana.25670 · Cited by 305 · see citing works
Impairment of the glymphatic system after diabetes
Jiang, Q., Zhang, L., Ding, G., Davoodi-Bojd, E., Li, Q., Li, L., Sadry, N., Nedergaard, M., Chopp, M., & Zhang, Z. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16654702 · Cited by 308 · see citing works
Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis
Salman, M. M., Kitchen, P., Halsey, A., Wang, M. X., Törnroth-Horsefield, S., Conner, A. C., Badaut, J., Iliff, J. J., & Bill, R. M. (2022) · Brain · doi:10.1093/brain/awab311 · Cited by 303 · see citing works
Glymphatic clearance controls state-dependent changes in brain lactate concentration
Lundgaard, I., Lu, M. L., Yang, E., Peng, W., Mestre, H., Hitomi, E., Deane, R., & Nedergaard, M. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16661202 · Cited by 300 · see citing works
Taoka, T., Ito, R., Nakamichi, R., Kamagata, K., Sakai, M., Kawai, H., Nakane, T., Abe, T., Ichikawa, K., Kikuta, J., et al. (2021) · Japanese Journal of Radiology · doi:10.1007/s11604-021-01187-5 · Cited by 295 · see citing works
Huang, S., Zhang, Y.-R., Guo, Y., Du, J., Ren, P., Wu, B., Feng, J., Initiative, A. D. N., Cheng, W., & Yu, J. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13789 · Cited by 292 · see citing works
Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases
Sun, B., Wang, L.-H., Yang, T., Sun, J., Mao, L., Yang, M., Yuan, H., Colvin, R. A., & Yang, X. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.007 · Cited by 255 · see citing works
The glymphatic hypothesis: the theory and the evidence
Hladky, S. B., & Barrand, M. A. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00282-z · Cited by 271 · see citing works
Taoka, T., & Naganawa, S. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26892 · Cited by 243 · see citing works
The glymphatic system: implications for drugs for central nervous system diseases
Lohela, T. J., Lilius, T. O., & Nedergaard, M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00500-9 · Cited by 246 · see citing works
Xiong, Y., Mahmood, A., & Chopp, M. (2018) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2018.02.003 · Cited by 237 · see citing works
Eide, P. K., & Ringstad, G. A. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18760974 · Cited by 235 · see citing works
Self-citationShen, T., Yue, Y., Ba, F., He, T., Tang, X., Hu, X., Pu, J., Huang, C., Lv, W., Zhang, B., et al. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00437-1 · Cited by 214 · see citing works
Gadolinium Deposition in the Brain: Current Updates
Choi, J. W., & Moon, W. (2018) · Korean Journal of Radiology · doi:10.3348/kjr.2018.0356 · Cited by 183 · see citing works
Glymphatic System Function in Relation to Anesthesia and Sleep States
Benveniste, H., Heerdt, P. M., Fontes, M. L., Rothman, D. L., & Volkow, N. D. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004069 · Cited by 178 · see citing works
Steward, C. E., Venkatraman, V. K., LUI, E. H., Malpas, C. B., Ellis, K. A., Cyarto, E., Vivash, L. E., O'Brien, T. J., Velakoulis, D., Ames, D. J., et al. (2021) · Journal of Neuroimaging · doi:10.1111/jon.12837 · Cited by 184 · see citing works
Interaction between blood-brain barrier and glymphatic system in solute clearance
Verheggen, I. C. M., van Boxtel, M. P. J., Verhey, F. R. J., Jansen, J. F. A., & Backes, W. H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.028 · Cited by 170 · see citing works
Boespflug, E. L., & Iliff, J. J. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.11.031 · Cited by 171 · see citing works
Bacyinski, A., Xu, M., Wang, W., & Hu, J. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00101 · Cited by 165 · see citing works
Gouveia-Freitas, K., & de Bastos-Leite, A. J. (2021) · Neuroradiology · doi:10.1007/s00234-021-02718-7 · Cited by 161 · see citing works
Obstructive sleep apnea decreases central nervous system–derived proteins in the cerebrospinal fluid
Ju, Y. S., Finn, M. B., Sutphen, C. L., Herries, E. M., Jerome, G. M., Ladenson, J. H., Crimmins, D. L., Fagan, A. M., & Holtzman, D. M. (2016) · Annals of Neurology · doi:10.1002/ana.24672 · Cited by 160 · see citing works
Gadolinium deposition in the brain
Kanda, T., Nakai, Y., Oba, H., Toyoda, K., Kitajima, K., & Furui, S. (2016) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2016.08.024 · Cited by 161 · see citing works
Sundaram, S., Hughes, R. L., Peterson, E., Müller-Oehring, E. M., Brontë-Stewart, H. M., Poston, K. L., Faerman, A., Bhowmick, C., & Schulte, T. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.05.016 · Cited by 152 · see citing works
Goulay, R., Romo, L. M., Hol, E. M., & Dijkhuizen, R. M. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00755-2 · Cited by 142 · see citing works
Burfeind, K. G., Murchison, C. F., Westaway, S. K., Simon, M. J., Erten‐Lyons, D., Kaye, J. A., Quinn, J. F., & Iliff, J. J. (2017) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.05.001 · Cited by 136 · see citing works
The homeostatic astroglia emerges from evolutionary specialization of neural cells
Verkhratsky, A., & Nedergaard, M. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0428 · Cited by 133 · see citing works
Evaluation of Glymphatic System Using Diffusion MR Technique in T2DM Cases
Yang, G., Deng, N., Liu, Y., Gu, Y., & Yao, X. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.00300 · Cited by 128 · see citing works
Lundgaard, I., Wang, W., Eberhardt, A., Vinitsky, H. S., Reeves, B. C., Peng, S., Lou, N., Hussain, R., & Nedergaard, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-20424-y · Cited by 127 · see citing works
Klostranec, J. M., Vucevic, D., Bhatia, K. D., Kortman, H. G. J., Krings, T., Murphy, K., terBrugge, K. G., & Mikulis, D. J. (2021) · Radiology · doi:10.1148/radiol.2021204088 · Cited by 119 · see citing works
Altered Brain Glymphatic Flow at Diffusion-Tensor MRI in Rapid Eye Movement Sleep Behavior Disorder
Bae, Y. J., Kim, J., Choi, B. S., Ryoo, N., Song, Y. S., Nam, Y., Yoon, I., Cho, S. J., & Kim, J. H. (2023) · Radiology · doi:10.1148/radiol.221848 · Cited by 120 · see citing works
Naganawa, S., & Taoka, T. (2020) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.rev.2020-0122 · Cited by 120 · see citing works
Gadolinium Retention and Toxicity—An Update
Ramalho, M., Ramalho, J., Burke, L. M. B., & Semelka, R. C. (2017) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2017.03.004 · Cited by 113 · see citing works
The role of the immune system in Alzheimer’s disease
Wu, K., Zhang, Y.-R., Huang, Y., Dong, Q., Tan, L., & Yu, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101409 · Cited by 116 · see citing works
Quantitative Gd‐DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA‐SPGR at 9.4T
Lee, H., Mortensen, K., Sanggaard, S., Koch, P., Brunner, H., Quistorff, B., Nedergaard, M., & Benveniste, H. (2018) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26779 · Cited by 110 · see citing works
Han, F., Brown, G. L., Zhu, Y., Belkin-Rosen, A., Lewis, M. M., Du, G., Gu, Y., Eslinger, P. J., Mailman, R. B., Huang, X., et al. (2021) · Movement Disorders · doi:10.1002/mds.28643 · Cited by 110 · see citing works
Decreased CSF clearance and increased brain amyloid in Alzheimer’s disease
Li, Y., Rusinek, H., Butler, T., Glodzik, L., Pirraglia, E., Babich, J. W., Mozley, P. D., Nehmeh, S. A., Pahlajani, S. S., Wang, X. H., et al. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-022-00318-y · Cited by 105 · see citing works
Glymphatic Cerebrospinal Fluid and Solute Transport Quantified by MRI and PET Imaging
Benveniste, H., Lee, H., Ozturk, B., Chen, X., Koundal, S., Vaska, P., Tannenbaum, A., & Volkow, N. D. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.014 · Cited by 104 · see citing works
Impaired brain glymphatic flow in experimental hepatic encephalopathy
Hadjihambi, A., Harrison, I. F., Costas‐Rodríguez, M., Vanhaecke, F., Arias, N., Gallego‐Durán, R., Mastitskaya, S., Hosford, P. S., Damink, S. W. M. O., Davies, N. A., et al. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.08.021 · Cited by 105 · see citing works
Christensen, J., Yamakawa, G. R., Shultz, S. R., & Mychasiuk, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101917 · Cited by 105 · see citing works
The glymphatic system and meningeal lymphatics of the brain: new understanding of brain clearance
Yankova, G., Bogomyakova, O. B., & Тулупов, А. А. (2021) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0106 · Cited by 104 · see citing works
Neurofluid Dynamics and the Glymphatic System: A Neuroimaging Perspective
Taoka, T., & Naganawa, S. (2020) · Korean Journal of Radiology · doi:10.3348/kjr.2020.0042 · Cited by 97 · see citing works
Measuring Glymphatic Flow in Man Using Quantitative Contrast-Enhanced MRI
Watts, R., Steinklein, J. M., Waldman, L. E., Zhou, X., & Filippi, C. G. (2019) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5931 · Cited by 95 · see citing works
Patel, M., Atyani, A., Salameh, J., et al. (2020) · Radiology · doi:10.1148/radiol.2020191373 · Cited by 96 · see citing works
Glymphatic system: an emerging therapeutic approach for neurological disorders
Gao, Y., Liu, K., & Zhu, J. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1138769 · Cited by 104 · see citing works
Harnessing cerebrospinal fluid circulation for drug delivery to brain tissues
Naseri Kouzehgarani, G., Feldsien, T., Engelhard, H. H., Mirakhur, K. K., Phipps, C., Nimmrich, V., Clausznitzer, D., & Lefebvre, D. R. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.03.002 · Cited by 95 · see citing works
Taoka, T., & Naganawa, S. (2020) · Japanese Journal of Radiology · doi:10.1007/s11604-020-01017-0 · Cited by 88 · see citing works
Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework
Mentis, A. A., Dardiotis, E., & Chrousos, G. P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0731-7 · Cited by 82 · see citing works
Plog, B. A., Lou, N., Pierre, C. A., Cove, A., Kenney, H. M., Hitomi, E., Kang, H., Iliff, J. J., Zeppenfeld, D. M., Nedergaard, M., et al. (2019) · Journal of neurosurgery · doi:10.3171/2019.2.jns182675 · Cited by 87 · see citing works
Altered Waste Disposal System in Aging and Alzheimer’s Disease: Focus on Astrocytic Aquaporin-4
Valenza, M., Facchinetti, R., Steardo, L., & Scuderi, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01656 · Cited by 84 · see citing works
Achieving brain clearance and preventing neurodegenerative diseases—A glymphatic perspective
Kylkilahti, T. M., Berends, E., Ramos, M., Shanbhag, N. C., Töger, J., Bloch, K. M., & Lundgaard, I. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20982388 · Cited by 89 · see citing works
Simon, M. J., Wang, M. X., Murchison, C. F., Roese, N. E., Boespflug, E. L., Woltjer, R. L., & Iliff, J. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-30779-x · Cited by 71 · see citing works
In vivo assessment of cerebrospinal fluid efflux to nasal mucosa in humans
Melin, E., Eide, P. K., & Ringstad, G. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-72031-5 · Cited by 78 · see citing works
Self-citationCarare, R. O., Aldea, R., Agarwal, N., Bacskai, B. J., Bechman, I., Boche, D., Bu, G., Bulters, D. O., Alt, C., Counts, S., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12053 · Cited by 76 · see citing works
Self-citationCould dexmedetomidine be repurposed as a glymphatic enhancer?
Persson, N. D. Å., Uusalo, P., Nedergaard, M., Lohela, T. J., & Lilius, T. O. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.09.007 · Cited by 75 · see citing works
Intrathecal Contrast-Enhanced Magnetic Resonance Imaging–Related Brain Signal Changes
Öner, A. Y., Asfuroğlu, B. B., Aykol, Ş., & Talı, E. T. (2016) · Investigative Radiology · doi:10.1097/rli.0000000000000327 · Cited by 72 · see citing works
Chachaj, A., Gąsiorowski, K., Szuba, A., Sieradzki, A., & Leszek, J. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220411091332 · Cited by 71 · see citing works
Noninvasive Magnetic Resonance Imaging Measures of Glymphatic System Activity
Kamagata, K., Saito, Y., Andica, C., Uchida, W., Takabayashi, K., Yoshida, S., Hagiwara, A., Fujita, S., Nakaya, M., Akashi, T., et al. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28977 · Cited by 76 · see citing works
Gadolinium as an MRI Contrast Agent
Kim, H.-K., Lee, G. H., & Chang, Y. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2017-0215 · Cited by 72 · see citing works
Bhargava, P., Wicken, C., Smith, M. D., Strowd, R. E., III, Cortese, I. C. M., Reich, D. S., Calabresi, P. A., & Mowry, E. M. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.02.013 · Cited by 66 · see citing works
Naganawa, S., Nakane, T., Kawai, H., & Taoka, T. (2018) · Magnetic Resonance in Medical Sciences · doi:10.2463/mrms.mp.2018-0053 · Cited by 67 · see citing works
The Human Visual Pathway Communicates Directly With the Subarachnoid Space
Jacobsen, H. H., Ringstad, G. A., Jørstad, Ø. K., Moe, M. C., Sandell, T., & Eide, P. K. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-26997 · Cited by 63 · see citing works
Self-citationRasschaert, M., Weller, R. O., Schroeder, J. A., Brochhausen, C., & Idée, J. (2020) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27124 · Cited by 64 · see citing works
Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology
Horsburgh, K. J., Wardlaw, J. M., Agtmael, T. V., Allan, S. M., Ashford, M. L. J., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., et al. (2018) · Clinical Science · doi:10.1042/cs20171620 · Cited by 63 · see citing works
Distribution and chemical forms of gadolinium in the brain: a review
Kanda, T., Nakai, Y., Hagiwara, A., Oba, H., Toyoda, K., & Furui, S. (2017) · British Journal of Radiology · doi:10.1259/bjr.20170115 · Cited by 62 · see citing works
Assessment of the dynamics of human glymphatic system by near‐infrared spectroscopy
Myllylä, T., Harju, M., Korhonen, V. O., Bykov, A. V., Kiviniemi, V. J., & Meglinski, I. V. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201700123 · Cited by 57 · see citing works
In vivo T1 mapping for quantifying glymphatic system transport and cervical lymph node drainage
Xue, Y., Liu, X., Koundal, S., Constantinou, S., Dai, F., Santambrogio, L., Lee, H., & Benveniste, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-71582-x · Cited by 56 · see citing works
The lymphatic drainage systems in the brain: a novel target for ischemic stroke?
Wang, Y.-J., Sun, Y., Pei, Y., Ma, H.-W., Ma, H., Qin, L., & Yan, J.-H. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.346484 · Cited by 58 · see citing works
The glymphatic system and its role in cerebral homeostasis
Benveniste, H., Elkin, R., Heerdt, P. M., Koundal, S., Xue, Y., Lee, H., Wardlaw, J. M., & Tannenbaum, A. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00852.2019 · Cited by 54 · see citing works
Piantino, J. A., Iliff, J. J., & Lim, M. M. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.06.025 · Cited by 55 · see citing works
Glymphatic pathways in the gyrencephalic brain
Bèchet, N. B., Shanbhag, N. C., & Lundgaard, I. (2021) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x21996175 · Cited by 55 · see citing works
van Osch, M. J. P., Wåhlin, A., Scheyhing, P., Mossige, I., Hirschler, L., Eklund, A., Mogensen, K., Gomolka, R. S., Radbruch, A., Qvarlander, S., et al. (2024) · NMR in Biomedicine · doi:10.1002/nbm.5159 · Cited by 55 · see citing works
Self-citationXu, M., Xiao, M., Li, S., & Yang, B. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-94-024-1057-0_5 · Cited by 52 · see citing works
The Glymphatic System in Diabetes-Induced Dementia
Kim, Y., Nam, K. I., & Song, J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00867 · Cited by 52 · see citing works
van Veluw, S. J., Benveniste, H., Bakker, E. N. T. P., Carare, R. O., Greenberg, S. M., Iliff, J. J., Lorthois, S., Nostrand, W. E. V., Petzold, G. C., Shih, A. Y., et al. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05277-1 · Cited by 50 · see citing works
The stress of losing sleep: Sex-specific neurobiological outcomes
Wright, C. J., Milosavljevic, S., & Pocivavsek, A. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100543 · Cited by 45 · see citing works
Gadolinium and Multiple Sclerosis: Vessels, Barriers of the Brain, and Glymphatics
Saade, C., Bou‐Fakhredin, R., Yousem, D. M., Asmar, K., Naffaa, L. N., & El‐Merhi, F. (2018) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5773 · Cited by 41 · see citing works
Hennig, J., Kiviniemi, V. J., Riemenschneider, B., Barghoorn, A., Akın, B., Wang, F., & LeVan, P. (2020) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-020-00891-z · Cited by 41 · see citing works
Automated Methods for Detecting and Quantitation of Enlarged Perivascular spaces on MRI
Moses, J., Sinclair, B., Law, M., O'Brien, T. J., & Vivash, L. E. (2022) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28369 · Cited by 44 · see citing works
Neurofluids and the glymphatic system: anatomy, physiology, and imaging
Wang, D. J. J., Hua, J., Cao, D., & Ho, M. (2023) · British Journal of Radiology · doi:10.1259/bjr.20230016 · Cited by 38 · see citing works
Glymphatic system dysfunction and risk of clinical milestones in patients with Parkinson disease
Zhou, C. Y., Jiang, X., Guan, X., Guo, T., Wu, J., Wu, H., Wu, C., Chen, J., Wen, J., Tan, S., et al. (2024) · European Journal of Neurology · doi:10.1111/ene.16521 · Cited by 40 · see citing works
Multimodal Imaging Study of Gadolinium Presence in Rat Cerebellum
Rasschaert, M., Schroeder, J. A., Wu, T., Marco, S., Emerit, A., Siegmund, H. I., Fischer, C., Fretellier, N., Idée, J., Corot, C., et al. (2018) · Investigative Radiology · doi:10.1097/rli.0000000000000490 · Cited by 39 · see citing works
Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system
Bèchet, N. B., Kylkilahti, T. M., Mattsson, B., Petrášová, M., Shanbhag, N. C., & Lundgaard, I. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20924954 · Cited by 40 · see citing works
Assessment of factors influencing glymphatic activity and implications for clinical medicine
Gędek, A., Koziorowski, D., & Szlufik, S. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1232304 · Cited by 38 · see citing works
Yue, Y., Zhang, X., Lv, W., Lai, H., & Shen, T. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.390970 · Cited by 38 · see citing works
Ramaswamy, S., Khasiyev, F., & Gutierrez, J. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.026601 · Cited by 37 · see citing works
An explanation for Terson syndrome at last: the glymphatic reflux theory
Kumaria, A., Gruener, A. M., Dow, G. R., Smith, S. J., Macarthur, D., & Ingale, H. A. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10686-4 · Cited by 34 · see citing works
The glymphatic system and multiple sclerosis: An evolving connection
Alghanimy, A., Work, L. M., & Holmes, W. M. (2024) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2024.105456 · Cited by 38 · see citing works
Abdolizadeh, A., Torres‐Carmona, E., Kambari, Y., Amaev, A., Song, J., Ueno, F., Koizumi, T., Nakajima, S., Agarwal, S. M., Luca, V. D., et al. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae060 · Cited by 33 · see citing works
Novel PET Biomarkers to Disentangle Molecular Pathways across Age-Related Neurodegenerative Diseases
Wilson, H., Politis, M., Rabiner, E. A., & Middleton, L. T. (2020) · Cells · doi:10.3390/cells9122581 · Cited by 34 · see citing works
Richmond, S. B., Rane, S., Hanson, M. R., Albayram, S., Iliff, J. J., Kernagis, D., Rosenberg, J. T., & Seidler, R. D. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15974 · Cited by 31 · see citing works
- Authors
- Eide, P. K., & Ringstad, G.
- Affiliations
- Oslo University Hospital (NO)
- Corresponding author
- Eide, Per Kristian
- Venue
- Acta Radiologica Open
- Publisher
- SAGE Publications
- Published
- 2015-11-01
- Volume
- 4
- Issue
- 11
- Pages
- 205846011560963
- ISSN
- 2047-9816 (ISSN-L)
- 2058-4601
- PMC
- PMC4652208
- OpenAlex
- W2252352100
- Cited by
- 218
- References
- 10
- Citations by year
- 2026: 17 · 2025: 33 · 2024: 22 · 2023: 22 · 2022: 15 · 2021: 22 · 2020: 26 · 2019: 17 · 2018: 22 · 2017: 15 · 2016: 7
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Acta Radiologica Open (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- glymphatic system, gadobutrol, cerebrospinal fluid, human brain imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
