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Cited by 92Posttraumatic Stress Disorder ResearchMemory and Neural MechanismsStress Responses and Cortisol

Post-Traumatic Stress Disorder: The Relationship Between the Fear Response and Chronic Stress

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Maeng, Lisa Y, Milad, Mohammed R·2017·Chronic Stress
DOI 10.1177/2470547017713297PMC PMC7219872
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Abstract

Post-traumatic stress disorder (PTSD) is a disabling psychiatric condition that can develop following a physical, psychological, or sexual trauma. Despite the growing body of literature examining the psychological and biological factors involved in PTSD psychopathology, specific biomarkers that may improve diagnosis and treatment of PTSD have yet to be identified and validated. This challenge may be attributed to the diverse array of symptoms that individuals with the disorder manifest. Examining the interrelated stress and fear systems allows for a more comprehensive study of these symptoms, and through this approach, which aligns with the research domain criteria (RDoC) framework, neural and psychophysiological measures of PTSD have emerged. In this review, we discuss PTSD neurobiology and treatment within the context of fear and stress network interactions and elucidate the advantages of using an RDoC approach to better understand PTSD with fear conditioning and extinction paradigms.

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  • Studies in rodent models have focused on fear conditioning because PTSD in humans is believed to arise from abnormal activation of fear circuitry.

    “Studies in rodent models have focused on fear conditioning because PTSD in humans is believed to arise from abnormal activation of fear circuitry [81].”

    From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [81]

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Authors
Maeng, L. Y., & Milad, M. R.
Affiliations
Harvard University (US)
Corresponding author
Milad, Mohammed R
ORCID
Venue
Chronic Stress
Publisher
SAGE Publications
Published
2017-02
Volume
1
Pages
2470547017713297-2470547017713297
ISSN
2470-5470 (ISSN-L)
DOI
10.1177/2470547017713297
PMC
PMC7219872
OpenAlex
W2732981861
Cited by
92
References
36
Citations by year
2026: 6 · 2025: 21 · 2024: 13 · 2023: 12 · 2022: 10 · 2021: 13 · 2020: 9 · 2019: 4 · 2018: 4
FWCI
0.71
Type
journal article
Language
en
Open access
Licence
Locations
  • Chronic Stress (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
post-traumatic stress disorder, fear response, fear conditioning, fear extinction, PTSD treatment, biomarkers, Research Domain Criteria, psychophysiological measures

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