Neural circuits mediating stress

López, Juan F; Akil, Huda; Watson, Stanley J

doi:10.1016/s0006-3223(99)00266-8

Cited by 373Stress Responses and CortisolNeuropeptides and Animal PhysiologyMemory and Neural Mechanisms

Neural circuits mediating stress

López, Juan F, Akil, Huda, Watson, Stanley J·1999·Biological Psychiatry

DOI 10.1016/s0006-3223(99)00266-8

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Abstract

Stress has been linked to the pathophysiology and pathogenesis of mood and anxiety disorders. Over the past few years, our understanding of the brain and neuroendocrine circuits that are linked to the stress response have increased dramatically. This article reviews a series of animal and human studies aimed at understanding what are the pathways by which stress is perceived, processed, and transduced into a neuroendocrine response. We focus on the classic stress circuit: the limbic-hypothalamic-pituitary-adrenal (LHPA) axis. These studies indicate that the LHPA stress circuit is a complex system with multiple control mechanisms and that these mechanisms are altered in pathological states, such as chronic stress and depression. These studies also suggest that the interactions between the LHPA and other neurotransmitters, such as serotonin, may provide the neurobiological substrate by which stress may affect mood.

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Acute stress activates the HPA axis, leading to release of glucocorticoids such as cortisol, and the SAM, leading to secretion of catecholamines.
“Acute stress activates the hypothalamic-pituitaryadrenal (HPA) axis, leading to release of glucocorticoids such as cortisol (Lopez et al, 1999;Chrousos et al, 2009), and the sympathetic-adrenomedullary system (SAM), leading to secretion of catecholamines (Lopez et al, 1999;Chrousos et al, 2009).”
From Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans (2012) · cites this paper as Lopez et al, 1999

A Syndrome produced by Diverse Nocuous Agents
Selye, H. (1936) · Nature · doi:10.1038/138032a0 · Cited by 3,967 · see citing works
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614 · see citing works
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580 · see citing works
THE GENERAL ADAPTATION SYNDROME AND THE DISEASES OF ADAPTATION1
Selye, H. (1946) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-6-2-117 · Cited by 2,296 · see citing works
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
Pazos, Á., & Palacios, J. M. (1985) · Brain Research · doi:10.1016/0006-8993(85)90856-x · Cited by 1,855 · see citing works
Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
(1992) · American Journal of Psychiatry · doi:10.1176/ajp.149.8.999 · Cited by 1,848 · see citing works
Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey
KESSLER, R. C., DAVIS, C. G., & KENDLER, K. S. (1997) · Psychological Medicine · doi:10.1017/s0033291797005588 · Cited by 1,298 · see citing works
Corticosteroid inhibition of acth secretion
KELLER-WOOD, M. E., & DALLMAN, M. F. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-1 · Cited by 1,219 · see citing works
Pattern and time course of immediate early gene expression in rat brain following acute stress
Cullinan, W. E., Herman, J. P., Battaglia, D. F., Akil, H., & Watson, S. J. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00355-9 · Cited by 1,056 · see citing works
Self-citation
Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation
HOLSBOER, F., & Barden, N. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-187 · Cited by 851 · see citing works
Fear and the brain: where have we been, and where are we going?
LeDoux, J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00282-0 · Cited by 782 · see citing works
Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression
López, J. F., Chalmers, D. T., Little, K. Y., & Watson, S. J. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00484-8 · Cited by 700 · see citing works
Self-citation
Serotonin receptors in the human brain—III. Autoradiographic mapping of serotonin-1 receptors
Pazos, Á., Probst, A., & Palacios, J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90326-5 · Cited by 684 · see citing works
Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed Patients
Raadsheer, F. C., Hoogendijk, W. J. G., Stam, F. C., Tilders, F. J. H., & Swaab, D. F. (2008) · Neuroendocrinology · doi:10.1159/000126778 · Cited by 667 · see citing works
Regulation of ACTH Secretion: Variations on a Theme of B
DALLMAN, M. F., AKANA, S. F., CASCIO, C. S., DARLINGTON, D. N., JACOBSON, L., & LEVIN, N. (1987) · Proceedings of the 1986 Laurentian Hormone Conference · doi:10.1016/b978-0-12-571143-2.50010-1 · Cited by 655 · see citing works
Textbook of psychopharmacology
Edwards, G. (1975) · Nature · doi:10.1038/258648b0 · Cited by 583 · see citing works
Psychiatric Sequelae of Posttraumatic Stress Disorder in Women
Breslau, N. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830130087016 · Cited by 563 · see citing works
Anatomy of the Serotonergic Systema
Törk, I. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb16870.x · Cited by 557 · see citing works
Stress-restress: Effects on ACTH and fast feedback
Liberzon, I., Krstov, M., & Young, E. A. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00044-9 · Cited by 556 · see citing works
Reduced Corticotropin Releasing Factor Binding Sites in the Frontal Cortex of Suicide Victims
Nemeroff, C. B. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800300075009 · Cited by 555 · see citing works
Untitled work
(1996) · PubMed · Cited by 547 · see citing works
Are different parts of the extended amygdala involved in fear versus anxiety?
Davis, M. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00288-1 · Cited by 545 · see citing works
Ventral subicular interaction with the hypothalamic paraventricular nucleus: Evidence for a relay in the bed nucleus of the stria terminalis
Cullinan, W. E., Herman, J. P., & Watson, S. J. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903320102 · Cited by 541 · see citing works
Self-citation
Mapping of Glucocorticoid Receptor Immunoreactive Neurons in the Rat Tel- and Diencephalon Using a Monoclonal Antibody against Rat Liver Glucocorticoid Receptor*
Fuxé, K., Wikström, A., Okret, S., Agnati, L. F., Härfstrand, A., Yu, Z., Granholm, L., Zoli, M., Vale, W., & Gustafsson, J.-Α. (1985) · Endocrinology · doi:10.1210/endo-117-5-1803 · Cited by 507 · see citing works
Evidence for hippocampal regulation of neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical axis
Herman, J. P., Schafer, M., Young, E. A., Thompson, R. C., DOUGLASS, J. O., Akil, H., & Watson, S. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03072.1989 · Cited by 467 · see citing works
Self-citation
Regulatory Changes in Neuroendocrine Stress-Integrative Circuitry Produced by a Variable Stress Paradigm
Herman, J. P., Adams, D. J., & Prewitt, C. M. (2008) · Neuroendocrinology · doi:10.1159/000126839 · Cited by 458 · see citing works
Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims
Arango, V., Underwood, M. D., Gubbi, A., & Mann, J. J. (1995) · Brain Research · doi:10.1016/0006-8993(95)00523-s · Cited by 458 · see citing works
Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression
Raadsheer, F. C., van Heerikhuize, J. J., Lucassen, P. J., Hoogendijk, W. J. G., Tilders, F. J. H., & Swaab, D. F. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.9.1372 · Cited by 411 · see citing works
Corticotrophin-releasing factor receptors: from molecular biology to drug design
Chalmers, D. T., Lovenberg, T. W., Grigoriadis, D. E., Behan, D. P., & Souza, E. B. D. (1996) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(96)81594-x · Cited by 398 · see citing works
Childhood Parental Loss and Adult Psychopathology in Women
Kendler, K. S. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820020029004 · Cited by 394 · see citing works
The Neurobiology of Depression
Nemeroff, C. B. (1998) · Scientific American · doi:10.1038/scientificamerican0698-42 · Cited by 381 · see citing works
Stressful Life Events and Major Depression: Risk Period, Long-Term Contextual Threat, and Diagnostic Specificity
KENDLER, K. S., KARKOWSKI, L. M., & PRESCOTT, C. A. (1998) · The Journal of Nervous & Mental Disease · doi:10.1097/00005053-199811000-00001 · Cited by 380 · see citing works
Neuronal Circuit Regulation of the Hypothalamo-Pituitary-Adrenocortical Stress Axis
Herman, J. P., Prewitt, C. M.-F., & Cullinan, W. E. (1996) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v10.i3-4.50 · Cited by 357 · see citing works
Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors
Pazos, A., Probst, A., & Palacios, J. M. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90327-7 · Cited by 355 · see citing works
What is stress?
Selye, H. (1956) · PubMed · Cited by 341 · see citing works
Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.
Brady, L. S., Whitfield, H. J., Fox, R. J., Gold, P. W., & Herkenham, M. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115086 · Cited by 338 · see citing works
Selective serotonin reuptake inhibitors: a review of efficacy and tolerability in depression
Mace, S., & Taylor, D. M. (2000) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.1.5.917 · Cited by 315 · see citing works
In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation
WEBSTER, E. L., Lewis, D. B., Torpy, D. J., Zachman, E. K., Rice, K. C., & Chrousos, G. P. (1996) · Endocrinology · doi:10.1210/endo.137.12.8940412 · Cited by 312 · see citing works
Differential Regulation of Hippocampal Glucocorticoid Receptors mRNA and Fast Feedback: Relevance to Post‐Traumatic Stress Disorder
Liberzon, López, Flagel, Vázquez, & Young (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00288.x · Cited by 308 · see citing works
Loss of Glucocorticoid Fast Feedback in Depression
Young, E. A. (1991) · Archives of General Psychiatry · doi:10.1001/archpsyc.1991.01810320017003 · Cited by 299 · see citing works
Amygdaloid CRF Pathways: Role in Autonomic, Neuroendocrine, and Behavioral Responses to Stress
Gray, T. S. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb49922.x · Cited by 288 · see citing works
Serotonin receptor binding in a colony model of chronic social stress
McKittrick, C. R., Blanchard, D. C., Blanchard, R. J., McEwen, B. S., & Sakai, R. R. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00152-s · Cited by 281 · see citing works
A Functional Neuroanatomy of Anxiety and Fear: Implications for the Pathophysiology and Treatment of Anxiety Disorders
Deutch, A. Y., & Charney, D. S. (1996) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v10.i3-4.70 · Cited by 260 · see citing works
Distinct mechanisms underlie activation of hypothalamic neurosecretory neurons and their medullary catecholaminergic afferents in categorically different stress paradigms.
Li, H.-Y., Ericsson, A. B., & Sawchenko, P. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2359 · Cited by 235 · see citing works
Involvement of the Bed Nucleus of the Stria Terminalis in Tonic Regulation of Paraventricular Hypothalamic CRH and AVP mRNA Expression
Herman, J. P., Cullinan, W. E., & Watson, S. J. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00604.x · Cited by 235 · see citing works
Self-citation
Neuroendocrine and Behavioral Responses and Brain Pattern of c‐fos Induction Associated with Audiogenic Stress
Campeau, S., & Watson, S. J. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00593.x · Cited by 227 · see citing works
Self-citation
Effects of Corticotropin-Releasing Factor on Brain Serotonergic Activity
M Price, B. A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00197-8 · Cited by 226 · see citing works
Stress: Neurobiology and neuroendocrinology
Wolf, S. (1992) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(92)90218-a · Cited by 222 · see citing works
Chapter 12 Regulation of multiple peptides in CRF parvocellular neurosecretory neurons: implications for the stress response
Swanson, L. W., Sawchenko, P. E., & Lind, R. W. (1986) · Progress in brain research · doi:10.1016/s0079-6123(08)60238-1 · Cited by 220 · see citing works
Brain circuits in panic disorder
Coplan, J. D., & Lydiard, R. B. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00300-x · Cited by 195 · see citing works
Biochemical evidence for glutamate as a transmitter in hippocampal efferents to the basal forebrain and hypothalamus in the rat brain
Walaas, I., & Fonnum, F. (1980) · Neuroscience · doi:10.1016/0306-4522(80)90088-3 · Cited by 190 · see citing works
Serotonergic Stimulation of Pituitary-Adrenocortical Function in Rats
Fuller, R. W. (2008) · Neuroendocrinology · doi:10.1159/000123142 · Cited by 187 · see citing works
Stress: Neurobiology and Neuroendocrinology
Brown, M. R., Koob, G. F., & RIVIER, C. L. (1990) · Medical Entomology and Zoology · Cited by 185 · see citing works
The involvement of serotonin in regulation of pituitary-adrenocortical function.
Rw, F. (1992) · PubMed · Cited by 181 · see citing works
Textbook of Psychopharmacology
(1995) · Nature Medicine · doi:10.1038/nm0895-834 · Cited by 178 · see citing works
Corticotropin-Releasing Hormone
Taylor, A. L., & Fishman, L. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190405 · Cited by 177 · see citing works
Life events and affective disorder: replications and limitations.
Brown, G. W. (1993) · Psychosomatic Medicine · doi:10.1097/00006842-199305000-00003 · Cited by 174 · see citing works
Frontiers in neuroendocrinology
(1986) · General and Comparative Endocrinology · doi:10.1016/0016-6480(86)90174-7 · Cited by 173 · see citing works
Long-Term Intracerebroventricular Infusion of Corticotropin-Releasing Hormone Alters Neuroendocrine, Neurochemical, Autonomic, Behavioral, and Cytokine Responses to a Systemic Inflammatory Challenge
Linthorst, A. C. E., Flachskamm, C., Hopkins, S. J., Hoadley, M. E., Labeur, M. S., Holsboer, F., & Reul, J. M. H. M. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04448.1997 · Cited by 163 · see citing works
Converging GABA‐ and glutamate‐immunoreactive axons make synaptic contact with identified hypothalamic neurosecretory neurons
Decavel, C., & van den Pol, A. N. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903160109 · Cited by 145 · see citing works
Selective forebrain fiber tract lesions implicate ventral hippocampal structures in tonic regulation of paraventricular nucleus corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA expression
Herman, J. P., Cullinan, W. E., Young, E. A., Akil, H., & Watson, S. J. (1992) · Brain Research · doi:10.1016/0006-8993(92)91680-d · Cited by 138 · see citing works
Self-citation
Topographical distribution of dorsal and median raphe neurons projecting to motor, Sensorimotor, and visual cortical Areas in the rat
Waterhouse, B. D., Mihailoff, G. A., Baack, J. C., & Woodward, D. J. (1986) · Journal of Comparative Neurology · doi:10.1002/cne.902490403 · Cited by 136 · see citing works
Life Events and the Research Diagnostic Criteria Endogenous Subtype
Frank, E. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950070011005 · Cited by 135 · see citing works
Development of olfactory glomeruli: Temporal and spatial interactions between olfactory receptor axons and mitral cells in opossums and rats
Malun, D., & Brunjes, P. C. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960422)368:1 · Cited by 133 · see citing works
Effects of monoamine oxidase A inhibition on barrel formation in the mouse somatosensory cortex: Determination of a sensitive developmental period
Vitalis, T., Cases, O., Callebert, J., Launay, J., Price, D. J., Seif, I., & Gaspar, P. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980406)393:2 · Cited by 129 · see citing works
Increased adrenal weight in victims of violent suicide
Dorovini‐Zis, K., & Zis, A. P. (1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.9.1214 · Cited by 127 · see citing works
Corticosterone binding to hippocampus: Immediate and delayed influences of the absence of adrenal secretion
McEwen, B. S., Wallach, G., & Magnus, C. (1974) · Brain Research · doi:10.1016/0006-8993(74)90321-7 · Cited by 115 · see citing works
Selective Serotonin Reuptake Inhibitors
Mozayani, M. (2011) · Humana Press eBooks · doi:10.1007/978-1-61779-222-9_6 · Cited by 113 · see citing works
Neurotransmitter modulation of corticotropin releasing factor secretion into the hypophysial-portal circulation
Plotsky, P. M., Otto, S., & Sutton, S. W. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90211-6 · Cited by 111 · see citing works
Postmortem Findings in Suicide Victims. Implications for in Vivo Imaging Studiesa
ARANGO, V., UNDERWOOD, M. D., & MANN, J. J. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52365.x · Cited by 106 · see citing works
The Hypothalamic-Pituitary-Adrenal System in Depression
Heuser, I. (1998) · Pharmacopsychiatry · doi:10.1055/s-2007-979288 · Cited by 106 · see citing works
Raphe Nuclei and the Serotonergic System
Törk, I., & Hornung, J. (1990) · Elsevier eBooks · doi:10.1016/b978-0-12-547625-6.50035-0 · Cited by 104 · see citing works
Regulation of 5‐HT Receptors and the Hypothalamic‐Pituitary‐Adrenal Axis
López, J. F., Vázquez, D. M., Chalmers, D. T., & Watson, S. J. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52357.x · Cited by 102 · see citing works
Self-citation
Chronic electroconvulsive shock treatment elicits up-regulation of CRF and AVP mRNA in select populations of neuroendocrine neurons
Herman, J. P., Schäfer, M. K.-H., Sladek, C. D., Day, R. W., Young, E. A., Akil, H., & Watson, S. J. (1989) · Brain Research · doi:10.1016/0006-8993(89)90641-0 · Cited by 99 · see citing works
Self-citation
Localization and Quantification of Pro-Opiomelanocortin mRNA and Glucocorticoid Receptor mRNA in Pituitaries of Suicide Victims
López, J. F., Palkovits, M., Arató, M., Mansour, A., Akil, H., & Watson, S. J. (2008) · Neuroendocrinology · doi:10.1159/000126266 · Cited by 97 · see citing works
Self-citation
Social Factors and Comorbidity of Depressive and Anxiety Disorders
Brown, G. W., Harris, T., & Eales, M. J. (1996) · The British Journal of Psychiatry · doi:10.1192/s0007125000298413 · Cited by 95 · see citing works
Central 5,7‐Dihydroxytryptamine Lesions Decrease Hippocampal Glucocorticoid and Mineralocorticoid Receptor Messenger Ribonucleic Acid Expression
Seckl, J. R., Dickson, K. L., & Fink, G. (1990) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1990.tb00659.x · Cited by 95 · see citing works
Effects of adrenalectomy and type I or type II glucocorticoid receptor activation on 5-HT1A and 5-HT2 receptor binding and 5-HT transporter mRNA expression in rat brain
Kuroda, Y., Watanabe, Y., Albeck, D. S., Hastings, N. B., & McEwen, B. S. (1994) · Brain Research · doi:10.1016/0006-8993(94)91916-x · Cited by 93 · see citing works
Serotonin Receptor Subtypes Involved in the Elevation of Serum Corticosterone Concentration in Rats by Direct- and Indirect-Acting Serotonin Agonists
Fuller, R. W., & Snoddy, H. D. (2008) · Neuroendocrinology · doi:10.1159/000125586 · Cited by 91 · see citing works
Biological therapies for posttraumatic stress disorder: an overview.
Davidson, J. R. T. (1997) · PubMed · Cited by 83 · see citing works
Life events and the 1-year prevalence of major depressive episode, generalized anxiety disorder, and panic disorder in a community sample
Newman, S. C., & Bland, R. C. (1994) · Comprehensive Psychiatry · doi:10.1016/0010-440x(94)90173-2 · Cited by 71 · see citing works
Psychological therapies for post-traumatic stress disorder
Adshead, G. M. J. (2000) · The British Journal of Psychiatry · doi:10.1192/bjp.177.2.144 · Cited by 70 · see citing works
Regulation of corticosteroid receptor gene expression in depression and antidepressant action.
Barden, N. (1999) · PubMed Central · Cited by 66 · see citing works
Pretranslational and Posttranslational Mechanisms for Regulatingβ-Endorphin- Adrenocorticotropin of the Anterior Pituitary Lobe*
Shiomi, H., Watson, S. J., Kelsey, J. E., & Akil, H. (1986) · Endocrinology · doi:10.1210/endo-119-4-1793 · Cited by 63 · see citing works
Self-citation
New developments in the treatment of obsessive-compulsive disorder.
Leonard, H. L. (1997) · PubMed · Cited by 60 · see citing works
Regulation of Hippocampal 5-HT1A Receptor Gene Expression by Dexamethasone
Chalmers, D. T., López, J. F., Vázquez, D. M., Akil, H., & Watson, S. J. (1994) · Neuropsychopharmacology · doi:10.1038/npp.1994.24 · Cited by 56 · see citing works
Self-citation
Distribution of glutamic acid decarboxylase messenger RNA-containing nerve cell populations of the male rat brain.
Ferraguti, F., Zoli, M., Aronsson, M., Agnati, L. F., Goldstein, M., Filer, D., & Fuxé, K. (1990) · PubMed · Cited by 56 · see citing works
Effect of acetylcholine and 5-hydroxytryptamine on the secretion of corticotrophin-releasing factor-41 and arginine vasopressin from the rat hypothalamus in vitro
Hillhouse, E. W., & Milton, N. G. N. (1989) · Journal of Endocrinology · doi:10.1677/joe.0.1220713 · Cited by 54 · see citing works
Clinical Neuropharmacology of Hypothalamic Releasing Factors
Frohman, L. A. (1972) · New England Journal of Medicine · doi:10.1056/nejm197206292862606 · Cited by 48 · see citing works
The regulation of ACTH secretion.
Pg, S. (1969) · PubMed · Cited by 46 · see citing works
Pharmacotherapy of Panic Disorder: Proposed Guidelines for the Family Physician
Roy‐Byrne, P., Stein, M. B., Bystrisky, A., & Katon, W. J. (1998) · The Journal of the American Board of Family Medicine · doi:10.3122/jabfm.11.4.282 · Cited by 44 · see citing works
Hypophysiotropic CRF Neurons Display a Sustained Immediate‐Early Gene Response to Chronic Stress but not to Adrenalectomy
Brown, E. R., & Sawchenko, P. E. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00586.x · Cited by 41 · see citing works
Differential effect of subchronic dexamethasone treatment on serotonin-2 and β-adrenergic receptors in the rat cerebral cortex and hippocampus
Kuroda, Y., Mikuni, M., Nomura, N., & Takahashi, K. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90706-q · Cited by 39 · see citing works
Pharmacotherapy of panic disorder: differential efficacy from a clinical viewpoint.
den Boer, J. A. (1998) · PubMed · Cited by 39 · see citing works
POSSIBLE ROLE OF GAMMA-AMINOBUTYRIC ACID SYNTHESIS IN THE MECHANISM OF DEXAMETHASONE FEEDBACK ACTION
Ács, Z., & Stark, E. (1978) · Journal of Endocrinology · doi:10.1677/joe.0.0770137 · Cited by 34 · see citing works
[Regulation of ACTH secretion].
Ervin, S. (1978) · PubMed · Cited by 30 · see citing works
Pharmacotherapy of Panic Disorder
Judd, F. K., Norman, T. R., & Burrows, G. D. (1990) · International Review of Psychiatry · doi:10.3109/09540269009026609 · Cited by 13 · see citing works
Corticotropin-Releasing Hormone
Amano, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801028-0.00109-4 · Cited by 7 · see citing works
THE HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL (HPA) SYSTEM AND ANTI-DEPRESSIVE DRUG (AD) ACTION
Reul, J. M. H. M., Söder, M., & Holsboer, F. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199201001-00303 · Cited by 3 · see citing works
Corticotropin releasing hormone: clinical endocrinology and implications for Cushing's disease and endogenous depression.
Rs, J., & Lopez, J. F. (1985) · PubMed · Cited by 3 · see citing works

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Neurobiology of emotion perception I: the neural basis of normal emotion perception
Phillips, M. L., Drevets, W. C., Rauch, S. L., & Lane, R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00168-9 · Cited by 2,173 · see citing works
Salivary cortisol as a biomarker in stress research
Hellhammer, D. H., Wüst, S., & Kudielka, B. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.026 · Cited by 1,925 · see citing works
The cortisol awakening response (CAR): Facts and future directions
Fries, E., Dettenborn, L., & Kirschbaum, C. (2009) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2008.03.014 · Cited by 1,188 · see citing works
Investigating emotion with music: An fMRI study
Koelsch, S., Fritz, T., v. Cramon, D. Y., Müller, K., & Friederici, A. D. (2006) · Human Brain Mapping · doi:10.1002/hbm.20180 · Cited by 1,037 · see citing works
Restricted and disrupted sleep: Effects on autonomic function, neuroendocrine stress systems and stress responsivity
Meerlo, P., Sgoifo, A., & Suchecki, D. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.07.007 · Cited by 948 · see citing works
The biology of fear- and anxiety-related behaviors
Steimer, T. J. (2002) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2002.4.3/tsteimer · Cited by 796 · see citing works
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822 · see citing works
Local Brain Functional Activity Following Early Deprivation: A Study of Postinstitutionalized Romanian Orphans
Chugani, H. T., Behen, M. E., Muzik, O., Juhász, C., Nagy, F. T., & Chugani, D. C. (2001) · NeuroImage · doi:10.1006/nimg.2001.0917 · Cited by 577 · see citing works
Role of GABA in anxiety and depression
Kalueff, A. V., & Nutt, D. (2006) · Depression and Anxiety · doi:10.1002/da.20262 · Cited by 536 · see citing works
Psychological determinants of the cortisol stress response: the role of anticipatory cognitive appraisal
Gaab, J., Rohleder, N., Nater, U. M., & Ehlert, U. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.02.001 · Cited by 525 · see citing works
Psychiatric genetics: progress amid controversy
Burmeister, M., McInnis, M. G., & Zöllner, S. K. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2381 · Cited by 522 · see citing works
Effects of early adverse experiences on brain structure and function: clinical implications
Kaufman, J., Plotsky, P. M., Nemeroff, C. B., & Charney, D. S. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00998-7 · Cited by 508 · see citing works
Paroxetine Controlled Release in the Treatment of Menopausal Hot Flashes: A Randomized Controlled Trial
Stearns, V., Beebe, K. L., Iyengar, M., & Dube, E. (2003) · JAMA · doi:10.1001/jama.289.21.2827 · Cited by 496 · see citing works
An Ecological‐Transactional Perspective on Child Maltreatment: Failure of the Average Expectable Environment and Its Influence on Child Development
Cicchetti, D., & Valentino, K. (2015) · Wiley eBooks · doi:10.1002/9780470939406.ch4 · Cited by 469 · see citing works
Abnormal brain connectivity in children after early severe socioemotional deprivation: A diffusion tensor imaging study
Eluvathingal, T. J., Chugani, H. T., Behen, M. E., Juhász, C., Muzik, O., Maqbool, M., Chugani, D. C., & Makki, M. (2006) · Pediatrics · doi:10.1542/peds.2005-1727 · Cited by 451 · see citing works
Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress
Müller, M. B., Zimmermann, S., Sillaber, I., Hagemeyer, T. P., Deussing, J. M., Timpl, P., Kormann, M., Droste, S. K., Kühn, R., Reul, J. M. H. M., et al. (2003) · Nature Neuroscience · doi:10.1038/nn1123 · Cited by 446 · see citing works
The hippocampal–prefrontal pathway: The weak link in psychiatric disorders?
Godsil, B. P., Kiss, J., Spedding, M., & Jay, T. M. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.10.018 · Cited by 434 · see citing works
Catechol-O-Methyltransferaseval158metGenotype Affects Processing of Emotional Stimuli in the Amygdala and Prefrontal Cortex
Smolka, M. N., Schumann, G., Wrase, J., Grüsser, S. M., Flor, H., Mann, K. F., Braus, D. F., Goldman, D. A., Büchel, C., & Heinz, A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1792-04.2005 · Cited by 416 · see citing works
The Links Between Stress and Depression: Psychoneuroendocrinological, Genetic, and Environmental Interactions
Tafet, G. E., & Nemeroff, C. B. (2016) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/appi.neuropsych.15030053 · Cited by 393 · see citing works
Serotonergic vulnerability and depression: assumptions, experimental evidence and implications
Jans, L. A. W., Riedel, W. J., Markus, C. R., & Blokland, A. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001920 · Cited by 372 · see citing works
Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states
Sinha, R., Talih, M., Malison, R. T., Cooney, N. L., Anderson, G. M., & Kreek, M. J. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1525-8 · Cited by 366 · see citing works
Hot flushes
Stearns, V., Ullmer, L., López, J. F., Smith, Y. R., Isaacs, C. J., & Hayes, D. F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11774-0 · Cited by 355 · see citing works
Self-citation
Anxiety and Poor Glycemic Control: A Meta-Analytic Review of the Literature
Anderson, R. J., Grigsby, A. B., Freedland, K. E., De Groot, M., McGill, J. B., Clouse, R. E., & Lustman, P. J. (2002) · The International Journal of Psychiatry in Medicine · doi:10.2190/klgd-4h8d-4ryl-twq8 · Cited by 328 · see citing works
Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible
Heine, V. M., Maslam, S., Zareno, J., Joëls, M., & Lucassen, P. J. (2004) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.03100.x · Cited by 317 · see citing works
Inflammation in Anxiety
Salim, S., Chugh, G., & Asghar, M. (2012) · Advances in protein chemistry and structural biology · doi:10.1016/b978-0-12-398314-5.00001-5 · Cited by 315 · see citing works
Depression, Antidepressants, and Neurogenesis: A Critical Reappraisal
Hanson, N. D., Owens, M. J., & Nemeroff, C. B. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.220 · Cited by 302 · see citing works
Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia
López-Figueroa, A. L., Norton, C. S., López-Figueroa, M. O., Armellini-Dodel, D., Burke, S., Akil, H., López, J. F., & Watson, S. J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.09.017 · Cited by 296 · see citing works
Self-citation
Stress Neurobiology and Developmental Psychopathology
Gunnar, M., & Vázquez, D. (2015) · Wiley eBooks · doi:10.1002/9780470939390.ch13 · Cited by 219 · see citing works
A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications
Holman, A. J., & Myers, R. R. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21191 · Cited by 289 · see citing works
Parental Depression: Animal Models of an Adverse Life Event
Newport, D. J., Stowe, Z. N., & Nemeroff, C. B. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.8.1265 · Cited by 265 · see citing works
Gap Junction Dysfunction in the Prefrontal Cortex Induces Depressive-Like Behaviors in Rats
Sun, J.-D., Liu, Y., Yuan, Y.-H., Li, J., & Chen, N.-H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.319 · Cited by 258 · see citing works
Raphe serotonin neurons are not homogenous: Electrophysiological, morphological and neurochemical evidence
Calizo, L. H., Akanwa, A., Ma, X., Pan, Y.-Z., Lemos, J. C., Craige, C., Heemstra, L. A., & Beck, S. G. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.008 · Cited by 252 · see citing works
The impact of early adverse care on HPA axis development: Nonhuman primate models
Sánchez, M. M. (2006) · Hormones and Behavior · doi:10.1016/j.yhbeh.2006.06.012 · Cited by 247 · see citing works
Regular exercise is associated with emotional resilience to acute stress in healthy adults
Childs, E., & de Wit, H. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00161 · Cited by 250 · see citing works
Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans
Dlugos, A., Childs, E., Stuhr, K. L., Hillard, C. J., & de Wit, H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.100 · Cited by 248 · see citing works
Effects of psychological stress on male fertility
Nargund, V. H. (2015) · Nature Reviews Urology · doi:10.1038/nrurol.2015.112 · Cited by 248 · see citing works
Covariance between psychological and endocrine responses to pharmacological challenge and psychosocial stress: a question of timing
Schlotz, W., Kumsta, R., Layes, I., Entringer, S., Jones, A., & Wüst, S. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181810658 · Cited by 237 · see citing works
Stress, the Hippocampus and the Hypothalamic-Pituitary-Adrenal Axis: Implications for the Development of Psychotic Disorders
Phillips, L., McGorry, P. D., Garner, B., Thompson, K. N., Pantelis, C., Wood, S. J., & Berger, G. E. (2006) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2006.01877.x · Cited by 230 · see citing works
Functional Coupling of the Amygdala in Depressed Patients Treated with Antidepressant Medication
Chen, C.-H., Suckling, J., Ooi, C., Fu, C. H. Y., Williams, S. C. R., Walsh, N. D., Mitterschiffthaler, M. T., Pich, E. M., & Bullmore, E. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301593 · Cited by 224 · see citing works
Epigenetics of stress adaptations in the brain
Stankiewicz, A. M., Swiergiel, A. H., & Lisowski, P. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.07.003 · Cited by 220 · see citing works
Pharmacological Treatment of Anxiety Disorders: The Role of the HPA Axis
Tafet, G. E., & Nemeroff, C. B. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00443 · Cited by 216 · see citing works
Effects of Early and Recent Adverse Experiences on Adrenal Response to Psychosocial Stress in Depressed Adolescents
Rao, U., Hammen, C. L., Ortiz, L. R., Chen, L.-A., & Poland, R. E. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.05.012 · Cited by 210 · see citing works
Circuits and systems in stress. I. Preclinical studies
Vermetten, E. H. G. J. M., & Bremner, J. D. (2002) · Depression and Anxiety · doi:10.1002/da.10016 · Cited by 211 · see citing works
Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms
Vollert, C., Zagaar, M., Hovatta, I., Taneja, M., Vu, A., Dao, A., Levine, A., Alkadhi, K., & Salim, S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.010 · Cited by 207 · see citing works
Sex differences in neural responses to stress and alcohol context cues
Seo, D., Jia, Z., Lacadie, C., Tsou, K. A., Bergquist, K. L., & Sinha, R. (2010) · Human Brain Mapping · doi:10.1002/hbm.21165 · Cited by 199 · see citing works
Chronically restricted sleep leads to depression-like changes in neurotransmitter receptor sensitivity and neuroendocrine stress reactivity in rats
Novati, A., Roman, V., Cetin, T., Hagewoud, R., den Boer, J. A., Luiten, P. G. M., & Meerlo, P. (2008) · SLEEP · doi:10.1093/sleep/31.11.1579 · Cited by 204 · see citing works
Cell pathology in bipolar disorder
Rajkowska, G. (2002) · Bipolar Disorders · doi:10.1034/j.1399-5618.2002.01149.x · Cited by 202 · see citing works
The Use of Auricular Acupuncture to Reduce Preoperative Anxiety
Wang, S.-M., Peloquin, C., & Kain, Z. N. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200111000-00024 · Cited by 189 · see citing works
Auricular Acupuncture: A Potential Treatment for Anxiety
Wang, S., & Kain, Z. N. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200102000-00049 · Cited by 182 · see citing works
INVITED REVIEW: The usefulness of measuring glucocorticoids for assessing animal welfare
Ralph, C. R., & Tilbrook, A. J. (2016) · Journal of Animal Science · doi:10.2527/jas.2015-9645 · Cited by 179 · see citing works
Attenuated Response to Stress and Novelty and Hypersensitivity to Seizures in 5-HT 4 Receptor Knock-Out Mice
Compan, V., Zhou, M., Grailhe, R., Gazzara, R. A., Martin, R., Gingrich, J. A., Dumuis, A., Brunner, D., Bockaert, J., & Hen, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2806-03.2004 · Cited by 177 · see citing works
Chronic social stress: effects on limbic brain structures
Fuchs, E., & Flügge, G. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00161-6 · Cited by 171 · see citing works
Bisphenol A exposure and symptoms of anxiety and depression among inner city children at 10–12 years of age
Perera, F. P., Nolte, E. L. R., Wang, Y., Margolis, A. E., Calafat, A. M., Wang, S., Garcia, W. E., Hoepner, L., Peterson, B. S., Rauh, V., et al. (2016) · Environmental Research · doi:10.1016/j.envres.2016.07.028 · Cited by 171 · see citing works
Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer
Sephton, S. E., Dhabhar, F. S., Keuroghlian, A. S., Giese-Davis, J., McEwen, B. S., Ionan, A. C., & Spiegel, D. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.07.007 · Cited by 170 · see citing works
Primary parental preoccupation: circuits, genes, and the crucial role of the environment
Leckman, J. F., Feldman, R., Swain, J. E., Eicher, V. W., Thompson, N., & Mayes, L. C. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-003-0067-x · Cited by 168 · see citing works
Gene–gene effects on central processing of aversive stimuli
Smolka, M. N., Fauth‐Bühler, M., Schumann, G., Vollstädt‐Klein, S., Hu, X.-Z., Moayer, M., Zimmer, A., Wrase, J., Flor, H., Mann, K. F., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001946 · Cited by 167 · see citing works
Mapping Brain Response to Social Stress in Rodents With c-fos Expression: A Review
Martı́nez, M., Calvo-Torrent, A., & Herbert, J. (2002) · Stress · doi:10.1080/102538902900012369 · Cited by 167 · see citing works
The influence of perceived control and locus of control on the cortisol and subjective responses to stress
Bollini, A. M., Walker, E. F., Hamann, S. B., & Kestler, L. P. (2004) · Biological Psychology · doi:10.1016/j.biopsycho.2003.11.002 · Cited by 164 · see citing works
A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients
Rockliff, H., Lightman, S. L., Rhidian, E., Buchanan, H., Gordon, U. D., & Vedhara, K. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu010 · Cited by 155 · see citing works
Psychosocial stress, glucocorticoids, and structural alterations in the tree shrew hippocampus
Fuchs, E., Flügge, G., Ohl, F., Lucassen, P. J., Vollmann-Honsdorf, G. K., & Michaelis, T. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00497-8 · Cited by 150 · see citing works
Cardiovascular, hormonal, and emotional responses to the TSST in relation to sex and menstrual cycle phase
Childs, E., Dlugos, A. M., & de Wit, H. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00961.x · Cited by 151 · see citing works
The Effects of Catechol O-methyltransferase Genotype on Brain Activation Elicited by Affective Stimuli and Cognitive Tasks
Heinz, A., & Smolka, M. N. (2006) · Reviews in the Neurosciences · doi:10.1515/revneuro.2006.17.3.359 · Cited by 148 · see citing works
Amygdala and Hippocampus Enlargement During Adolescence in Autism
Groen, W. B., Teluij, M., Buitelaar, J. K., & Tendolkar, I. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2009.12.023 · Cited by 147 · see citing works
Interface of physical and emotional stress regulation through the endogenous opioid system and μ-opioid receptors
Ribeiro, S. C. M., Kennedy, S. E., Smith, Y. R., Stohler, C. S., & Zubieta, J. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.08.011 · Cited by 147 · see citing works
The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes
Zhao, Q., Wu, X., Yan, S., Xie, X., Fan, Y., Zhang, J., Peng, C. Y., & You, Z. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0728-y · Cited by 142 · see citing works
Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats
Morley‐Fletcher, S., Mairesse, J., Soumier, A., Banasr, M., Fagioli, F., Gabriel, C., Mocaër, E., Daszuta, A., McEwen, B. S., Nicoletti, F., et al. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2280-x · Cited by 141 · see citing works
The European Prediction of Psychosis Study (EPOS): integrating early recognition and intervention in Europe.
Klosterkötter, J., Ruhrmann, S., Schultze‐Lutter, F., Salokangas, R. K. R., LINSZEN, D. H., Birchwood, M. J., Juckel, G., Morrison, A. P., Vázquez‐Barquero, J. L., Hambrecht, M., et al. (2005) · PubMed Central · Cited by 142 · see citing works
Maternal behavior and developmental psychopathology
Leckman, J. F., & Herman, A. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01277-x · Cited by 139 · see citing works
Modulation of stress consequences by hippocampal monoaminergic, glutamatergic and nitrergic neurotransmitter systems
Joca, S. R. L., Ferreira, F. R., & Guimarães, F. S. (2007) · Stress · doi:10.1080/10253890701223130 · Cited by 137 · see citing works
The relation between early life adversity, cortisol awakening response and diurnal salivary cortisol levels in postpartum women
González, A., Jenkins, J. M., Steiner, M. S., & Fleming, A. S. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.08.012 · Cited by 136 · see citing works
Investigating Emotion with Music
Koelsch, S. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1360.034 · Cited by 138 · see citing works
Tuning synaptic transmission in the hippocampus by stress: the CRH system
Chen, Y., Andres, A. L., Frotscher, M., & Baram, T. Z. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00013 · Cited by 133 · see citing works
The effects of allostatic load on neural systems subserving motivation, mood regulation, and social affiliation
Beauchaine, T. P., Neuhaus, E., Zalewski, M., Crowell, S. E., & Potapova, N. V. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000459 · Cited by 129 · see citing works
Behavioral and neuroendocrine correlates of displaced aggression in trout
Øyvind Øverli, A., Korzan, W. J., Larson, E. T., Winberg, S., Lepage, O., Pottinger, T. G., Renner, K. J., & Summers, C. H. (2004) · Hormones and Behavior · doi:10.1016/j.yhbeh.2004.01.001 · Cited by 126 · see citing works
The Effects of Child Maltreatment on the Hypothalamic-Pituitary-Adrenal Axis
Voorhees, E. E. V., & Scarpa, A. (2004) · Trauma Violence & Abuse · doi:10.1177/1524838004269486 · Cited by 125 · see citing works
Subcortical Gray Matter Volume Abnormalities in Healthy Bipolar Offspring: Potential Neuroanatomical Risk Marker for Bipolar Disorder?
Ladouceur, C. D., Almeida, J., Birmaher, B. B., Axelson, D., Nau, S., Kalas, C., Monk, K., Kupfer, D. J., & Phillips, M. L. (2008) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e318167656e · Cited by 121 · see citing works
Depression and Stress Reactivity in Metastatic Breast Cancer
Giese‐Davis, J., Wilhelm, F. H., Conrad, A., Abercrombie, H. C., Sephton, S. E., Yutsis, M. V., Neri, E., Taylor, C. B., KRAEMER, H. C., & Spiegel, D. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000238216.88515.e5 · Cited by 118 · see citing works
Identification of genes regulated by chronic psychosocial stress and antidepressant treatment in the hippocampus
Alfonso, J., Pollevick, G. D., Hart, M. G. V. D., Flügge, G., Fuchs, E., & Frasch, A. C. C. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03178.x · Cited by 117 · see citing works
Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling
Chen, Y., Kramár, E. A., Chen, L. Y., Babayan, A. H., Andres, A. L., Gall, C. M., Lynch, G., & Baram, T. Z. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.17 · Cited by 115 · see citing works
Toxoplasmosis: A pathway to neuropsychiatric disorders
Tyebji, S., Seizova, S., Hannan, A. J., & Tonkin, C. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.11.012 · Cited by 111 · see citing works
Prolonged and site-specific over-expression of corticotropin-releasing factor reveals differential roles for extended amygdala nuclei in emotional regulation
Regev, L., Neufeld-Cohen, A., Tsoory, M., Kuperman, Y., Getselter, D., Gil, S., & Chen, A. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.64 · Cited by 110 · see citing works
Age-Dependent and Gender-Dependent Regulation of Hypothalamic-Adrenocorticotropic-Adrenal Axis
Veldhuis, J. D., Sharma, A., & Roelfsema, F. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.002 · Cited by 110 · see citing works
Activation of post-synaptic 5-HT1A receptors in the dorsal hippocampus prevents learned helplessness development
Joca, S. R. L., Padovan, C. M., & Guimarães, F. S. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02943-3 · Cited by 108 · see citing works
Chronic Cold Stress Alters Prefrontal Cortical Modulation of Amygdala Neuronal Activity in Rats
Correll, C. M., Rosenkranz, J. A., & Grace, A. A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.009 · Cited by 106 · see citing works
Potential contribution of oxidative stress and inflammation to anxiety and hypertension
Salim, S., Asghar, M., Taneja, M., Hovatta, I., Chugh, G., Vollert, C. T., & Vu, A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.06.024 · Cited by 104 · see citing works
Links Between Depression and Substance Abuse in Adolescents
Rao, U. (2006) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2006.07.002 · Cited by 101 · see citing works
RESEARCH FOCUS ON COMPULSIVE BEHAVIOUR IN ANIMALS: Compulsive alcohol drinking in rodents
Vengeliene, V., Célèrier, E., Chaskiel, L., Penzo, F., & Spanagel, R. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00177.x · Cited by 103 · see citing works
Gender-specific effects of social housing in rats after chronic mild stress exposure
Westenbroek, C. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00310-x · Cited by 102 · see citing works
Modeling depression: social dominance–submission gene expression patterns in rat neocortex
Kroes, R. A., Panksepp, J., Burgdorf, J. S., Otto, N. J., & Moskal, J. R. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.076 · Cited by 101 · see citing works
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Noseda, R., Kainz, V., Borsook, D., & Burstein, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103929 · Cited by 101 · see citing works
The role of brain reward pathways in stress resilience and health
Dutcher, J. M., & Creswell, J. D. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.10.014 · Cited by 100 · see citing works
Androgens Alter Corticotropin Releasing Hormone and Arginine Vasopressin mRNA Within Forebrain Sites Known to Regulate Activity in the Hypothalamic‐Pituitary‐Adrenal Axis
Viau, V., Soriano, L., & Dallman, M. F. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00653.x · Cited by 97 · see citing works
Trait anxiety moderates the impact of performance pressure on salivary cortisol in everyday life
Schlotz, W., Schulz, P. J., Hellhammer, J., Stone, A. A., & Hellhammer, D. H. (2005) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.11.003 · Cited by 96 · see citing works
How can the study of biological processes help design new interventions for children with severe antisocial behavior?
van Goozen, S. H. M., & Fairchild, G. F. (2008) · Development and Psychopathology · doi:10.1017/s095457940800045x · Cited by 94 · see citing works
Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: selective supersensitivity of α2A-adrenoceptors
González‐Maeso, J., Rodríguez‐Puertas, R., Meana, J. J., Garcı́a-Sevilla, J. A., & Guimón, J. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001067 · Cited by 94 · see citing works
Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge
Regev, L., Tsoory, M., Gil, S., & Chen, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.036 · Cited by 93 · see citing works
Oestrogen‐deficient female aromatase knockout (ArKO) mice exhibit ‘depressive‐like’ symptomatology
Dalla, C., Antoniou, K., Papadopoulou‐Daifoti, Z., Balthazart, J., & Bakker, J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03443.x · Cited by 93 · see citing works
Post-Traumatic Stress Disorder: The Relationship Between the Fear Response and Chronic Stress
Maeng, L. Y., & Milad, M. R. (2017) · Chronic Stress · doi:10.1177/2470547017713297 · Cited by 92 · see citing works
Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study
Mason, N. L., Szabó, A., Kuypers, K. P. C., Mallaroni, P., de la Torre, R., Reckweg, J. T., Tse, D. H. Y., Hutten, N. R. P. W., Feilding, A., & Ramaekers, J. G. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.09.004 · Cited by 89 · see citing works
PTSD and the HPA axis: Differences in response to the cold pressor task among individuals with child vs. adult trauma
Ana, E. J. S., Saladin, M. E., Back, S. E., Waldrop, A. E., Spratt, E. G., McRae‐Clark, A. L., LaRowe, S. D., Timmerman, M. A., Upadhyaya, H. P., & Brady, K. T. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2005.11.009 · Cited by 88 · see citing works

The Interacting Neuroendocrine Network in Stress-Inducing Mood Disorders
Leff, P., Hernández, M. E., Becerril‐Villanueva, E., Martinez, C. B. D. R., Téllez-Santillán, C., Pérez-Tapia, M., Salazar, A., Antón, B., Berlanga, C., & Pavón, L. (2010) · The Open Neuroendocrinology Journal · doi:10.2174/1876528901003010180 · Cited by 5 · see citing works
스트레스의 신경생물학적 이해
유범희, & Woo, J. (2001) · 精神身體醫學 = Korean journal of psychosomatic medicine
Circuits and systems in stress. I. Preclinical studies
Vermetten, E. H. G. J. M., & Bremner, J. D. (2002) · Depression and Anxiety · doi:10.1002/da.10016 · Cited by 211 · see citing works
Haunted by Stress: A New Circuit-Level Perspective on Anhedonia and Depression
Purewal, R. A. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.04.024
Psychoneuroendocrinological links between chronic stress and depression
Tafet, G. E., & Bernardini, R. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00162-3 · Cited by 241 · see citing works

Authors: López, J. F., Akil, H., & Watson, S. J.
Affiliations: University of Michigan (US)
Corresponding author: López, Juan F
ORCID: Akil, Huda
Watson, Stanley J
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 1999-12
Volume: 46
Issue: 11
Pages: 1461-1471
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/s0006-3223(99)00266-8
OpenAlex: W2092002730
Cited by: 373
References: 107
Citations by year: 2026: 1 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 6 · 2019: 3 · 2018: 10 · 2017: 7 · 2016: 8 · 2015: 9 · 2014: 14 · 2013: 22 · 2012: 10
FWCI: 1.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k21mh001164-05)
National Institute of Mental Health (MH 42251, P01MH042251, MH-01164)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: stress, neuroendocrine stress response, chronic stress, depression, mood disorders, anxiety disorders, serotonin, perceived stress, neural circuits
MeSH terms: Brain, Child, Child Development, Humans, Nerve Net, Stress, Psychological

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