Cited by 170Systemic Lupus Erythematosus ResearchBlood Coagulation and Thrombosis MechanismsVasculitis and related conditions

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study

Open access

Galli, Monica, Borrelli, Giovanna, Jacobsen, Eva Marie, Marfisi, Rosa Maria, Finazzi, Guido, Marchioli, Roberto, Wisloff, Finn, Marziali, Stefana, Morboeuf, Olivier, Barbui, Tiziano·2007·Blood

DOI 10.1182/blood-2007-01-066043

Open this paper in CoChat — free account Open PDF

Abstract

To assess the clinical significance of lupus anticoagulants (LAs) and antiphospholipid antibodies (aPLs) toward thrombosis and abortions, we measured them in 112 patients whose samples were available at enrollment in the warfarin in the antiphospholipid syndrome (WAPS) study. Enzyme-linked immunosorbent assay (ELISA) and coagulation test values in the highest and lowest tertiles were compared. When considered separately, IgG antibodies to β2-glycoprotein I (aβ2GPI) and prothrombin (aPT) were associated with anamnestic arterial and venous thrombosis, respectively, and those to annexin AV (aAnAV) with abortions. IgM antibodies to protein S and the lupus ratio of the dilute prothrombin time were associated with prospective thrombosis. No other association for IgM antibodies was seen. LA-positive patients who carried aβ2GPI antibodies were at risk of anamnestic arterial and total thrombosis and aPT antibodies to that of anamnestic venous and total thrombosis. LA-positive patients who carried IgG aβ2GPI and aAnAV antibodies were at risk for both anamnestic abortion and prospective thrombosis. Overall, these data support the inclusion of aβ2GPI antibodies in and suggest the removal of anticardiolipin antibodies from the laboratory criteria of the antiphospholipid syndrome. They also suggest that the measurement of aPT and aAnAV antibodies is useful in some selected situations and that there is little role for IgM antibody detection.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1182/blood-2007-01-066043

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
MIYAKIS, S., LOCKSHIN, M. D., ATSUMI, T., BRANCH, D. W., BREY, R. L., CERVERA, R., DERKSEN, R. H. W. M., DE GROOT, P. G., KOIKE, T., MERONI, P. L., et al. (2006) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2006.01753.x · Cited by 7,203
Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).
McNeil, H. P., Simpson, R. J., Chesterman, C. N., & Krilis, S. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.11.4120 · Cited by 1,595
Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor
Galli, M., Barbui, T., Comfurius, P., Maassen, C., Hemker, H. C., Zwaal, R. F. A., Bevers, E. M., Baets, M. H. D., & Vriesman, P. J. C. V. B. (1990) · The Lancet · doi:10.1016/0140-6736(90)91374-j · Cited by 1,266
Self-citation
Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH.
Brandt, J. T., Triplett, D. A., Alving, B. M., & Scharrer, I. (1995) · PubMed · Cited by 1,164
A Comparison of Three Months of Anticoagulation with Extended Anticoagulation for a First Episode of Idiopathic Venous Thromboembolism
Kearon, C., Gent, M., Hirsh, J., Weitz, J. I., Kovacs, M. J., Anderson, D. R., Turpie, A. G. G., Green, D., Ginsberg, J. S., Wells, P. S., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199903253401201 · Cited by 1,057
Criteria for the Diagnosis of Lupus Anticoagulants: An Update: On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH
Brandt, J. T., Triplett, D. A., Alving, B., & Scharrer, I. (1995) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1649901 · Cited by 993
Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature
Galli, M., Luciani, D., Bertolini, G., & Barbui, T. (2003) · Blood · doi:10.1182/blood-2002-02-0441 · Cited by 972 · cited 2×
“In 2003, two systematic reviews of the literature on LA, aCL, aβ2GPI and aPT antibodies showed that LA are the strongest risk factors for both arterial and venous thrombosis, whereas such a role did not clearly emerge for the other antibodies, unless in some selected clinical scenarios (10, 11).”
BackgroundResultSelf-citation
A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome
Crowther, M. A., Ginsberg, J. S., Julian, J., Denburg, J., Hirsh, J., Douketis, J., Laskin, C., Fortin, P., Anderson, D., Kearon, C., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035241 · Cited by 919
Evaluation of the anti-cardiolipin antibody test: report of an international workshop held 4 April 1986.
Harris, E. N., Gharavi, A. E., Patel, S., & Hughes, G. R. (1987) · PubMed Central · Cited by 724
Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease
Matsuura, E., Igarashi, Y., Fujimoto, M., Ichikawa, K., & Koike, T. (1990) · The Lancet · doi:10.1016/0140-6736(90)91697-9 · Cited by 718

Show all 37 references

Research works printed but not linked: 2

Harris, 1987, Evaluation of the anticardiolipin antbody test: report of a standardization workshop, held April 4th, 1986., Clin Exp Immunol, 68, 215
Van Heerde, 2004, Localization of annexin A5 in human tissues., Annexins, 1, 56

Sorted by citations

Systemic lupus erythematosus
Kaul, A., Gordon, C., Crow, M. K., Touma, Z., Urowitz, M. B., van Vollenhoven, R., Ruiz‐Irastorza, G., & Hughes, G. R. V. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.39 · Cited by 1,480
Antiphospholipid syndrome
Ruiz‐Irastorza, G., Crowther, M. A., Branch, W. D., & Khamashta, M. A. (2010) · The Lancet · doi:10.1016/s0140-6736(10)60709-x · Cited by 875
Guidelines on the investigation and management of antiphospholipid syndrome
Keeling, D., Mackie, I., Moore, G. W., Greer, I. A., Greaves, M., & British Committee for Standards in Haematology (2012) · British Journal of Haematology · doi:10.1111/j.1365-2141.2012.09037.x · Cited by 740
Pathogenesis of antiphospholipid syndrome: understanding the antibodies
Meroni, P. L., Borghi, M. O., Raschi, E., & Tedesco, F. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.52 · Cited by 620
Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task Force at the 13th International Congress on antiphospholipid antibodies
Ruiz-Irastorza, G., Cuadrado, M., Ruiz-Arruza, I., Brey, R., Crowther, M., Derksen, R., Erkan, D., Krilis, S., Machin, S., Pengo, V, et al. (2011) · Lupus · doi:10.1177/0961203310395803 · Cited by 506
Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study
Pengo, V., Ruffatti, A., Legnani, C., Testa, S., Fierro, T., Marongiu, F., De Micheli, V., Gresele, P., Tonello, M., Ghirarduzzi, A., et al. (2011) · Blood · doi:10.1182/blood-2011-03-340232 · Cited by 468
A Comprehensive Review of Risk Factors for Venous Thromboembolism: From Epidemiology to Pathophysiology
Pastori, D., Cormaci, V. M., Marucci, S., Franchino, G., Sole, F. D., Capozza, A., Fallarino, A., Corso, C., Valeriani, E., Menichelli, D., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043169 · Cited by 376
Laboratory criteria for antiphospholipid syndrome: communication from the SSC of the ISTH
Devreese, K. M. J., Ortel, T. L., Pengo, V., & de Laat, B. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13976 · Cited by 269
Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS
Chaturvedi, S., Braunstein, E. M., Yuan, X., Yu, J. M., Alexander, A. A., Chen, H., Gavriilaki, E., Alluri, R. K., Streiff, M. B., Petri, M., et al. (2019) · Blood · doi:10.1182/blood.2019003863 · Cited by 232
The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 1000 consecutive cases
Alijotas‐Reig, J., Esteve‐Valverde, E., Ferrer‐Oliveras, R., Comet, L. S., Lefkou, E. E., MEKINIAN, A., Belizna, C. C., Ruffatti, A., Tincani, A., Marozio, L., et al. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.12.006 · Cited by 220
The antiphospholipid syndrome in patients with systemic lupus erythematosus
Pons‐Estel, G., Andréoli, L., Scanzi, F., Cervera, R., & Tincani, A. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.10.004 · Cited by 208
Diagnosis and management of the antiphospholipid syndrome
Chaturvedi, S., & McCrae, K. R. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.07.006 · Cited by 195
Antiphospholipid antibodies in patients with COVID‐19: A relevant observation?
Devreese, K. M. J., Linskens, E. A., Benoît, D., & Peperstraete, H. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14994 · Cited by 190
The potential role of heparin in assisted conception
Nelson, S. M., & Greer, I. A. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn031 · Cited by 161
The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): A survey of 247 consecutive cases
Alijotas‐Reig, J., Ferrer‐Oliveras, R., Ruffatti, A., Tincani, A., Lefkou, E. E., Bertero, M. T., Coloma, E., Carolis, S. D., Espinosa, G., Rovere, P. Q., et al. (2014) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.12.010 · Cited by 152
Recent Guidelines and Recommendations for Laboratory Detection of Lupus Anticoagulants
Moore, G. (2014) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0033-1364185 · Cited by 149
Complement in the Pathophysiology of the Antiphospholipid Syndrome
Chaturvedi, S., Brodsky, R. A., & McCrae, K. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00449 · Cited by 143
Hypercoagulable States in Cardiovascular Disease
Chan, M. Y., Andreotti, F., & Becker, R. C. (2008) · Circulation · doi:10.1161/circulationaha.108.778837 · Cited by 134
IgG/IgM antiphospholipid antibodies present in the classification criteria for the antiphospholipid syndrome: a critical review of their association with thrombosis
Kelchtermans, H., Pelkmans, L., de Laat, B., & Devreese, K. M. J. (2016) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13379 · Cited by 133
Antiphospholipid syndrome: laboratory detection, mechanisms of action and treatment
Tripodi, A., de Groot, P. G., & Pengo, V. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02362.x · Cited by 114
Antiphospholipid Syndrome during pregnancy: the state of the art.
Prima, F. A. F. D., Valenti, O., Hyseni, E., Giorgio, E., Faraci, M., Renda, E., Domenico, R. D., & Monte, S. (2011) · PubMed Central · Cited by 111
Antiphospholipid syndrome: Complement activation, complement gene mutations, and therapeutic implications
Chaturvedi, S., Braunstein, E. M., & Brodsky, R. A. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15082 · Cited by 109
Antiphospholipid syndrome
Lim, W. (2013) · Hematology · doi:10.1182/asheducation-2013.1.675 · Cited by 107
Antiphospholipid antibody testing and standardization
Devreese, K. M. J. (2014) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.12234 · Cited by 98
Thrombotic risk assessment in the antiphospholipid syndrome requires more than the quantification of lupus anticoagulants
Devreese, K., Peerlinck, K., & Hoylaerts, M. F. (2010) · Blood · doi:10.1182/blood-2009-09-244426 · Cited by 93
Impaired Fibrinolysis in the Antiphospholipid Syndrome
Krone, K. A., Allen, K. L., & McCrae, K. R. (2010) · Current Rheumatology Reports · doi:10.1007/s11926-009-0075-4 · Cited by 91
The (non-)sense of detecting anti-cardiolipin and anti-β2glycoprotein I IgM antibodies in the antiphospholipid syndrome
Chayoua, W., Kelchtermans, H., Gris, J., Moore, G. W., Musiał, J., Wahl, D., de Groot, P. G., de Laat, B., & Devreese, K. M. J. (2020) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14633 · Cited by 89
Invitation to a debate on the serological criteria that define the antiphospholipid syndrome
GALLI, M., REBER, G., DE MOERLOOSE, P., & DE GROOT, P. G. (2008) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2008.02862.x · Cited by 85
Self-citation
Challenges in the Diagnosis of the Antiphospholipid Syndrome
Devreese, K. M. J., & Hoylaerts, M. (2010) · Clinical Chemistry · doi:10.1373/clinchem.2009.133678 · Cited by 82
Laboratory diagnosis of the antiphospholipid syndrome: a plethora of obstacles to overcome
Devreese, K., & Hoylaerts, M. F. (2009) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2009.01243.x · Cited by 78
Antiphospholipid Antibody-Associated Chorea
Orzechowski, N. M., Wolanskyj, A. P., Ahlskog, J. E., Kumar, N., & Moder, K. G. (2008) · The Journal of Rheumatology · doi:10.3899/jrheum.080268 · Cited by 78
Anti‐beta 2 glycoprotein I antibodies and the risk of myocardial infarction in young premenopausal women
Meroni, P. L., Peyvandi, F., Foco, L., Bernardinelli, L., Fetiveau, R., Mannucci, P. M., & Tincani, A. (2007) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2007.02763.x · Cited by 77
Current insight into diagnostics and pathophysiology of the antiphospolipid syndrome
Urbanus, R. T., Derksen, R. H. W. M., & de Groot, P. G. (2007) · Blood Reviews · doi:10.1016/j.blre.2007.09.001 · Cited by 76
Pathogenesis of the antiphospholipid syndrome: An additional example of the mosaic of autoimmunity
Meroni, P. L. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.11.014 · Cited by 76
Antiphospholipid antibody testing for the antiphospholipid syndrome: a comprehensive practical review including a synopsis of challenges and recent guidelines
Favaloro, E. J., & Wong, R. C. W. (2014) · Pathology · doi:10.1097/pat.0000000000000142 · Cited by 75
B-cell directed therapies in antiphospholipid antibody syndrome — New directions based on murine and human data
Khattri, S., Zandman‐Goddard, G., & Peeva, E. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.12.011 · Cited by 69
Analytical and clinical performance of a new, automated assay panel for the diagnosis of antiphospholipid syndrome
de Moerloose, P., Reber, G., Musiał, J., & Arnout, J. (2010) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2010.03857.x · Cited by 68
Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study
Amengual, O., Forastiero, R. R., Sugiura‐Ogasawara, M., Otomo, K., Oku, K., Favas, C., Alves, J. D., Žigon, P., Ambrožič, A., Tomšič, M., et al. (2016) · Lupus · doi:10.1177/0961203316660203 · Cited by 63
Correct laboratory approach to APS diagnosis and monitoring
Pengo, V., Banzato, A., Denas, G., Jose, S. P., Bison, E., Hoxha, A., & Ruffatti, A. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.11.008 · Cited by 62
The Clinical Spectrum of Antiphospholipid Syndrome
Baker, W., & Bick, R. L. (2008) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2007.10.007 · Cited by 56
Performance of two new, automated chemiluminescence assay panels for anticardiolipin and anti‐beta2‐glycoprotein I antibodies in the laboratory diagnosis of the antiphospholipid syndrome
Hoecke, F. V., Persijn, L., Decavele, A.-S. C., & Devreese, K. M. J. (2012) · International Journal of Laboratory Hematology · doi:10.1111/j.1751-553x.2012.01448.x · Cited by 56
Evaluation of a new set of automated chemiluminescense assays for anticardiolipin and anti-beta2-glycoprotein I antibodies in the laboratory diagnosis of the antiphospholipid syndrome
Persijn, L., Decavele, A.-S., Schouwers, S., & Devreese, K. (2011) · Thrombosis Research · doi:10.1016/j.thromres.2011.04.004 · Cited by 53
The antiphospholipid syndrome: still an enigma
Chaturvedi, S., & McCrae, K. R. (2015) · Hematology · doi:10.1182/asheducation-2015.1.53 · Cited by 51
Obstetric and vascular APS: Same autoantibodies but different diseases?
Meroni, P. L., Raschi, E., Grossi, C., Pregnolato, F., Trespìdi, L., Acaia, B., & Borghi, M. O. (2012) · Lupus · doi:10.1177/0961203312438116 · Cited by 50
Antiphospholipid antibodies: Paradigm in transition
Horstman, L. L., Jy, W., Bidot, C., Ahn, Y. S., Kelley, R. E., Zivadinov, R., Maghzi, A. H., Etemadifar, M., Mousavi, S. A., & Minagar, A. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-3 · Cited by 46
Detection of Antiphosphatidylserine/Prothrombin Antibodies and Their Potential Diagnostic Value
Žigon, P., Čučnik, S., Ambrožič, A., Kveder, T., Šemrl, S. S., Rozman, B., & Božič, B. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/724592 · Cited by 45
Predictive, protective, orphan autoantibodies: The example of anti-phospholipid antibodies
Meroni, P. L., & Shoenfeld, Y. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.08.001 · Cited by 42
Commonalities and contrasts in recent guidelines for lupus anticoagulant detection
Moore, G. W. (2014) · International Journal of Laboratory Hematology · doi:10.1111/ijlh.12227 · Cited by 41
Managing thromboembolic risk in patients with hereditary and acquired thrombophilias
Moran, J. P., & Bauer, K. A. (2020) · Blood · doi:10.1182/blood.2019000917 · Cited by 42
The association of antiphospholipid antibodies with pregnancy-related first time venous thrombosis – a population-based case-control study
Bergrem, A., Jacobsen, E., Skjeldestad, F. E., Jacobsen, A. F., Skogstad, M., & Sandset, P. M. (2010) · Thrombosis Research · doi:10.1016/j.thromres.2009.12.006 · Cited by 41
Self-citation
Antiphospholipid syndrome and central nervous system
Mayer, M., Cerovec, M., Radoš, M., & Čikeš, N. (2010) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2010.03.023 · Cited by 40
Clinical significance of antiphosphatidylethanolamine antibodies in the so-called “seronegative antiphospholipid syndrome”
Sanmarco, M. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.03.007 · Cited by 40
Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus
Demir, S., Li, J., Magder, L. S., & Petri, M. (2021) · Rheumatology · doi:10.1093/rheumatology/keaa857 · Cited by 39
Histone Deacetylation
Al-Janadi, A., Chandana, S. R., & Conley, B. A. (2008) · Drugs in R&D · doi:10.2165/0126839-200809060-00003 · Cited by 38
Moderate versus high-titer persistently anticardiolipin antibody positive patients: Are they clinically different and does high-titer anti-β2-glycoprotein-I antibody positivity offer additional predictive information?
Erkan, D., Barbhaiya, M., George, D., Sammaritano, L. R., & Lockshin, M. (2009) · Lupus · doi:10.1177/0961203309355300 · Cited by 37
Current Controversies in Lupus Anticoagulant Detection
Moore, G. (2016) · Antibodies · doi:10.3390/antib5040022 · Cited by 36
COVID-19, Pre-Eclampsia, and Complement System
Agostinis, C., Mangogna, A., Balduit, A., Aghamajidi, A., Ricci, G., Kishore, U., & Bulla, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.775168 · Cited by 38
How to Interpret Antiphospholipid Laboratory Tests
Devreese, K. M. J. (2020) · Current Rheumatology Reports · doi:10.1007/s11926-020-00916-5 · Cited by 36
Anti-β2-glycoprotein-I and anti-phosphatidylserine antibodies in women with spontaneous pregnancy loss
Alijotas‐Reig, J., Ferrer‐Oliveras, R., Rodrigo-Anoro, M. J., Farrán-Codina, I., Cabero, L., & Vilardell, M. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.01.089 · Cited by 34
Relationship between antiphosphatidylserine/prothrombin and conventional antiphospholipid antibodies in primary antiphospholipid syndrome
Hoxha, A., Ruffatti, A., Mattia, E., Meneghel, L., Tonello, M., Salvan, E., Pengo, V., & Punzi, L. (2015) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2014-1129 · Cited by 33
Insights into the diagnosis and pathogenesis of the antiphospholipid syndrome
Noureldine, M. H. A., Nour‐Eldine, W., Khamashta, M. A., & Uthman, I. W. (2018) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2018.08.004 · Cited by 33
Antiphospholipid syndrome
Espinosa, G., & Cervera, R. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2536 · Cited by 33
Antiphospholipid antibodies predict imminent vascular events independently from other risk factors in a prospective cohort
Kassis, J., Solymoss, S., Joseph, L., Bélisle, P., Levine, J. S., Neville, C., Rauch, J., & Fortin, P. R. (2008) · Thrombosis and Haemostasis · doi:10.1160/th08-06-0384 · Cited by 31
Laboratory methods to detect antiphospholipid antibodies
Krilis, S. A., & Giannakopoulos, B. (2014) · Hematology · doi:10.1182/asheducation-2014.1.321 · Cited by 30
Diagnosis and therapy of antiphospholipid syndrome
Pengo, V., Denas, G., Jose, S. P., Zoppellaro, G., Bison, E., Banzato, A., Hoxha, A., & Ruffatti, A. (2015) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.3051 · Cited by 28
Biomarkers to predict risk of venous thromboembolism in patients with rheumatoid arthritis receiving tofacitinib or tumour necrosis factor inhibitors
Weitz, J. I., Szekanecz, Z., Charles‐Schoeman, C., Vranic, I. I., Şahin, B., Paciga, S. A., Wang, Z., Hyde, C. L., & Martin, D. A. (2022) · RMD Open · doi:10.1136/rmdopen-2022-002571 · Cited by 28
Frequency of vascular and pregnancy morbidity in patients with low vs. moderate-to-high titers of antiphospholipid antibodies
Shiber, S., & Molad, Y. (2014) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0000000000000218 · Cited by 28
Tick-borne diseases and autoimmunity: A comprehensive review
Rodríguez, Y., Rojas, M., Gershwin, M. E., & Anaya, J. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.11.007 · Cited by 26
Clinical and immunological features of antiphospholipid syndrome in the elderly: a retrospective national multicentre study
Grimaud, F., Yelnik, C., de Chambrun, M. P., Amoura, Z., Arnaud, L., Costedoat-Chalumeau, N., HACHULLA, E., Lambert, M., Roriz, M., Sibilia, J., et al. (2018) · Lara D. Veeken · doi:10.1093/rheumatology/key437 · Cited by 27
Anticoagulating patients with high-risk acquired thrombophilias
Skeith, L. (2018) · Blood · doi:10.1182/blood-2018-05-848697 · Cited by 26
Studies of fibrin formation and fibrinolytic function in patients with the antiphospholipid syndrome
Vikerfors, A., Svenungsson, E., Ågren, A., Mobarrez, F., Bremme, K. A., Holmström, M., Eelde, A., Bruzelius, M., Elgue, G., Wallén, H., et al. (2014) · Thrombosis Research · doi:10.1016/j.thromres.2014.02.023 · Cited by 26
Cardiovascular risk factors are major determinants of thrombotic risk in patients with the lupus anticoagulant
Posch, F., Gebhart, J., Rand, J. H., Koder, S., Quehenberger, P., Pengo, V., Ay, C., & Pabinger, I. (2017) · BMC Medicine · doi:10.1186/s12916-017-0807-7 · Cited by 25
“Further, a considerable proportion of patients with LA will not develop thrombosis despite the presence of aPL-associated autoantibodies at high titers [7].”
Background
Prothrombotic mechanisms based on the impairment of fibrinolysis in the antiphospholipid syndrome
Forastiero, R. R., & Martinuzzo, M. E. (2008) · Lupus · doi:10.1177/0961203308091633 · Cited by 25
The clinical relevance of the IgM isotype of antiphospholipid antibodies in the vascular antiphospholipid syndrome
Del Ross, T., Ruffatti, A., Cuffaro, S., Tonello, M., Calligaro, A., Favaro, M., Facchinetti, M., Hoxha, A., & Punzi, L. (2015) · Thrombosis Research · doi:10.1016/j.thromres.2015.08.019 · Cited by 27
Systemic Lupus Erythematosus and Antiphospholipid Antibody Syndrome
Kokosi, M. A., Lams, B., & Agarwal, S. (2019) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2019.06.001 · Cited by 26
Diagnostic test combinations associated with thrombosis in lupus anticoagulant positive patients
Peerlinck, K., Hoylaerts, M., & Devreese, K. M. J. (2011) · Thrombosis and Haemostasis · doi:10.1160/th10-09-0606 · Cited by 23
B cells in primary antiphospholipid syndrome: Review and remaining challenges
Dieudonné, Y., Guffroy, A., Poindron, V., Soulas-Sprauel, P., Martin, T., Korganow, A., & Gies, V. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102798 · Cited by 23
Recent advances in the antiphospholipid antibody syndrome
Chaturvedi, S., & McCrae, K. R. (2014) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000067 · Cited by 22
Antiphospholipid autoantibody detection is important in all patients with systemic autoimmune diseases
Marziale, A., Bettacchioli, É., Picart, G., Nafai, S., Galinat, H., Meroni, P. L., Frostegård, J., Alarcón-Riquelme, M. E., & Renaudineau, Y. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2020.102524 · Cited by 22
Anti-annexin A5 antibodies in women with spontaneous pregnancy loss
Alijotas‐Reig, J., Ferrer‐Oliveras, R., Rodrigo-Anoro, M. J., Farrán-Codina, I., Llurba, E., Vilardell, M., & Casellas‐Caro, M. (2009) · Medicina Clínica · doi:10.1016/j.medcli.2009.09.040 · Cited by 21
The effect of platelet activation on the hypercoagulability induced by murine monoclonal antiphospholipid antibodies
Membré, A., Wahl, D. G., Latger‐Cannard, V., Max, J., Lacolley, P. J., Lecompte, T., & Regnault, V. (2008) · Haematologica · doi:10.3324/haematol.12364 · Cited by 21
Factor X and factor II activity levels do not always agree in warfarin-treated lupus anticoagulant patients
Rosborough, T. K., Jacobsen, J. M., & Shepherd, M. F. (2010) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e32833581a3 · Cited by 18
Controversies and Unresolved Issues in Antiphospholipid Syndrome Pathogenesis and Management
Baker, W., Bick, R. L., & Fareed, J. (2008) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2007.10.006 · Cited by 18
Antiphospholipid syndrome presenting as cerebral venous sinus thrombosis: a case series and a review
Shlebak, A. A. (2015) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2015-203077 · Cited by 19
Clinical Application of Revised Laboratory Classification Criteria for Antiphospholipid Antibody Syndrome: Is the Follow-Up Interval of 12 Weeks Instead of 6 Weeks Significantly Useful?
Park, S. H., Jang, S., Park, C.-J., & Chi, H.-S. (2016) · BioMed Research International · doi:10.1155/2016/2641526 · Cited by 18
Lung Disease in Antiphospholipid Syndrome
Maioli, G., Calabrese, G., CAPSONI, F., Gerosa, M., Meroni, P. L., & Chighizola, C. B. (2019) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0039-1683994 · Cited by 18
Aspirin in asymptomatic patients with confirmed positivity of antiphospholipid antibodies? Yes (in some cases)
Gerosa, M., Chighizola, C. B., & Meroni, P. L. (2008) · Internal and Emergency Medicine · doi:10.1007/s11739-008-0170-y · Cited by 18
Laboratory Evaluation of Antiphospholipid Antibodies in Patients With Venous Thromboembolism
Hirmerová, J., Ulcova-Gallova, Z., Seidlerová, J., Filipovský, J., Bibková, K., Mičanová, Z., & Mayer, O. (2009) · Clinical and Applied Thrombosis/Hemostasis · doi:10.1177/1076029608331228 · Cited by 17
Thromboprophylaxis and obstetric management of the antiphospholipid syndrome
Espinosa, G., & Cervera, R. (2009) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656560902772302 · Cited by 16
Clinical Risk Assessment in the Antiphospholipid Syndrome: Current Landscape and Emerging Biomarkers
Chaturvedi, S., & McCrae, K. R. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0668-2 · Cited by 17
Antiphospholipid antibodies correlate with stroke severity and outcome in patients with antiphospholipid syndrome
Rodríguez-Sanz, A., Martínez‐Sánchez, P., Prefasi, D., Fuentes, B., Pascual‐Salcedo, D., Blanco-Bañares, M. J., & Díez‐Tejedor, E. (2014) · Autoimmunity · doi:10.3109/08916934.2014.988329 · Cited by 16
Evaluation of three commercial ELISA kits for anticardiolipin and anti‐beta2‐glycoprotein I antibodies in the laboratory diagnosis of the antiphospholipid syndrome
Decavele, A.-S. C., Schouwers, S., & Devreese, K. M. J. (2010) · International Journal of Laboratory Hematology · doi:10.1111/j.1751-553x.2010.01259.x · Cited by 16
Emerging Therapies in Antiphospholipid Syndrome
Hubben, A. K., & McCrae, K. R. (2022) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2022.09.002 · Cited by 15
Viewpoint: The value of non-criteria antiphospholipid antibodies
de Laat, B., Gehlen, R., & de Groot, P. G. (2024) · Rheumatology · doi:10.1093/rheumatology/kead632 · Cited by 15
Antiphospholipid antibody: laboratory, pathogenesis and clinical manifestations
Tincani, A., Casu, C., Cartella, S., ZIGLIOLI, T., & Cattaneo, R. (2011) · Reumatismo · doi:10.4081/reumatismo.2010.65 · Cited by 13
Aspirin in asymptomatic patients with confirmed positivity of antiphospholipid antibodies? No
Finazzi, G. (2008) · Internal and Emergency Medicine · doi:10.1007/s11739-008-0169-4 · Cited by 13
Self-citation
Phospholipid-binding proteins differ in their capacity to induce autoantibodies and murine systemic lupus erythematosus
Levine, J. S., Subang, R., Setty, S., Cabrera, J., Laplante, P., Fritzler, M. J., & Rauch, J. (2014) · Lupus · doi:10.1177/0961203314525676 · Cited by 13
Complement biomarkers in the antiphospholipid syndrome – Approaches to quantification and implications for clinical management
Cole, M. A., Gerber, G. F., & Chaturvedi, S. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109828 · Cited by 14
Thrombotic Primary Antiphospholipid Syndrome: the profile of antibody positivity in patients from North India
Ahluwalia, J., Sreedharanunni, S., Kumar, N., Masih, J., Bose, S. K., Varma, N., Varma, S., & Singh, S. (2014) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12479 · Cited by 12
Genetics of Hypercoagulable and Hypocoagulable States
Singh, D., Natarajan, A., Nand, S., & Mai, H. P. (2018) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2018.06.002 · Cited by 12

Authors: Galli, M., Borrelli, G., Jacobsen, E. M., Marfisi, R. M., Finazzi, G., Marchioli, R., Wisloff, F., Marziali, S., Morboeuf, O., & Barbui, T.
Affiliations: Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy;
Mario Negri Sud Foundation (IT)
Ulleval Hospital, Oslo, Norway;
Stago (France) (FR)
ORCID: Galli, Monica
Jacobsen, Eva Marie
Finazzi, Guido
Barbui, Tiziano
Venue: Blood
Publisher: American Society of Hematology
Published: 2007-08-15
Volume: 110
Issue: 4
Pages: 1178-1183
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2007-01-066043
OpenAlex: W2084234423
Cited by: 170
References: 37
Citations by year: 2025: 5 · 2024: 2 · 2023: 6 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 14 · 2013: 7 · 2012: 8
FWCI: 13.30
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
Keywords: antiphospholipid syndrome, antiphospholipid antibodies, lupus anticoagulant, anti-beta2-glycoprotein I antibodies, anticardiolipin antibodies, arterial thrombosis, venous thrombosis, miscarriage, thrombosis risk
MeSH terms: Abortion, Habitual, Adult, Aged, Aged, 80 and over, Female, Humans, Immunoglobulin G, Immunoglobulin M, Male, Middle Aged, Pregnancy, Pregnancy Complications, Hematologic, Prospective Studies, Risk Factors, Thromboembolism, Lupus Coagulation Inhibitor, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin, beta 2-Glycoprotein I

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinical significance of different antiphospholipid antibodies in the WAPS (warfarin in the antiphospholipid syndrome) study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks