Cited by 506Hematopoietic Stem Cell TransplantationErythropoietin and Anemia TreatmentHemoglobinopathies and Related Disorders

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Erythroblastic islands: niches for erythropoiesis

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Chasis, Joel Anne, Mohandas, Narla·2008·Blood

DOI 10.1182/blood-2008-03-077883PMC PMC2481536

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Abstract

Erythroblastic islands, the specialized niches in which erythroid precursors proliferate, differentiate, and enucleate, were first described 50 years ago by analysis of transmission electron micrographs of bone marrow. These hematopoietic subcompartments are composed of erythroblasts surrounding a central macrophage. A hiatus of several decades followed, during which the importance of erythroblastic islands remained unrecognized as erythroid progenitors were shown to possess an autonomous differentiation program with a capacity to complete terminal differentiation in vitro in the presence of erythropoietin but without macrophages. However, as the extent of proliferation, differentiation, and enucleation efficiency documented in vivo could not be recapitulated in vitro, a resurgence of interest in erythroid niches has emerged. We now have an increased molecular understanding of processes operating within erythroid niches, including cell-cell and cell-extracellular matrix adhesion, positive and negative regulatory feedback, and central macrophage function. These features of erythroblast islands represent important contributors to normal erythroid development, as well as altered erythropoiesis found in such diverse diseases as anemia of inflammation and chronic disease, myelodysplasia, thalassemia, and malarial anemia. Coupling of historical, current, and future insights will be essential to understand the tightly regulated production of red cells both in steady state and stress erythropoiesis.

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Effects of an Rb mutation in the mouse
Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755
F4/80, a monoclonal antibody directed specifically against the mouse macrophage
Austyn, J. M., & Gordon, S. (1981) · European Journal of Immunology · doi:10.1002/eji.1830111013 · Cited by 1,596
Identification of a factor that links apoptotic cells to phagocytes
Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., & Nagata, S. (2002) · Nature · doi:10.1038/417182a · Cited by 1,401
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1
Pevny, L., Simon, M. C., Robertson, E., Klein, W. H., Tsai, S.-F., D'Agati, V., Orkin, S. H., & Costantini, F. (1991) · Nature · doi:10.1038/349257a0 · Cited by 1,308
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
Lee, E. Y.-H. P., Chang, C.-Y., Hu, N., Wang, Y.-C. J., Lai, C., Herrup, K., Lee, W., & Bradley, A. (1992) · Nature · doi:10.1038/359288a0 · Cited by 1,264
Requirement for a functional Rb-1 gene in murine development
Clarke, A. R., Maandag, E. R., van ROON, M. A., van der Lugt, N. M. T., van der Valk, M., Hooper, M., Berns, A. J. M., & Rielef, H. T. (1992) · Nature · doi:10.1038/359328a0 · Cited by 1,006
Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells
Koury, M. J., & Bondurant, M. C. (1990) · Science · doi:10.1126/science.2326648 · Cited by 819
Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1.
Fujiwara, Y., Browne, C. P., Cunniff, K., Goff, S. C., & Orkin, S. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12355 · Cited by 778
Regulation of Iron Metabolism by Hepcidin
Nemeth, E., & Ganz, T. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111303 · Cited by 756
Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.
Weiss, M. J., Keller, G., & Orkin, S. H. (1994) · Genes & Development · doi:10.1101/gad.8.10.1184 · Cited by 541

Show all 101 references

Research works printed but not linked: 2

Bessis, 1958, L'ilot erythroblastique. Unite functionelle de la moelle osseuse., Rev Hematol, 13, 8
Porter, 1983, Erythroid burst promoting activity (BPA)., 81

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Authors: Chasis, J. A., & Mohandas, N.
Affiliations: Lawrence Berkeley National Laboratory (US)
New York Blood Center (US)
ORCID: Mohandas, Narla
Venue: Blood
Publisher: American Society of Hematology
Published: 2008-08-01
Volume: 112
Issue: 3
Pages: 470-478
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2008-03-077883
PMC: PMC2481536
OpenAlex: W2048719634
Cited by: 506
References: 101
Citations by year: 2026: 12 · 2025: 18 · 2024: 19 · 2023: 31 · 2022: 29 · 2021: 27 · 2020: 34 · 2019: 32 · 2018: 26 · 2017: 29 · 2016: 20 · 2015: 31 · 2014: 33 · 2013: 43 · 2012: 28
FWCI: 3.95
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Blood (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Yale University
National Institutes of Health
National Heart, Lung, and Blood Institute (T32HL007956, HL7956)
National Institute of Diabetes and Digestive and Kidney Diseases (P01DK032094, DK56267, R01DK056267, DK32094)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Keywords: erythroblastic islands, erythropoiesis, erythroid progenitor cells, erythroblast enucleation, erythroid differentiation, erythropoietin, cell-matrix adhesion, feedback regulation, anemia of chronic disease, myelodysplastic syndrome, thalassemia, malarial anemia, stress erythropoiesis
MeSH terms: Bone Marrow, Cell Adhesion, Erythroblasts, Erythropoiesis, Extracellular Matrix, Humans, Macrophages, Feedback, Physiological

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Erythroblastic islands: niches for erythropoiesis

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