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Cited by 2,248Inflammasome and immune disordersImmune Response and InflammationCytokine Signaling Pathways and Interactions

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Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

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Dinarello, Charles A.·2011·Blood
DOI 10.1182/blood-2010-07-273417PMC PMC3083294
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Abstract

More than any other cytokine family, the IL-1 family of ligands and receptors is primarily associated with acute and chronic inflammation. The cytosolic segment of each IL-1 receptor family member contains the Toll-IL-1-receptor domain. This domain is also present in each Toll-like receptor, the receptors that respond to microbial products and viruses. Since Toll-IL-1-receptor domains are functional for both receptor families, responses to the IL-1 family are fundamental to innate immunity. Of the 11 members of the IL-1 family, IL-1β has emerged as a therapeutic target for an expanding number of systemic and local inflammatory conditions called autoinflammatory diseases. For these, neutralization of IL-1β results in a rapid and sustained reduction in disease severity. Treatment for autoimmune diseases often includes immunosuppressive drugs whereas neutralization of IL-1β is mostly anti-inflammatory. Although some autoinflammatory diseases are due to gain-of-function mutations for caspase-1 activity, common diseases such as gout, type 2 diabetes, heart failure, recurrent pericarditis, rheumatoid arthritis, and smoldering myeloma also are responsive to IL-1β neutralization. This review summarizes acute and chronic inflammatory diseases that are treated by reducing IL-1β activity and proposes that disease severity is affected by the anti-inflammatory members of the IL-1 family of ligands and receptors.

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Research works printed but not linked: 100

  1. Dinarello, 1996, Biological basis for interleukin-1 in disease., Blood, 87, 2095, 10.1182/blood.V87.6.2095.bloodjournal8762095 · DOI · Paper page
  2. Opal, 1997, Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial., Crit Care Med, 25, 1115, 10.1097/00003246-199707000-00010 · DOI
  3. Eichacker, 2002, Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis., Am J Respir Crit Care Med, 166, 1197, 10.1164/rccm.200204-302OC · DOI
  4. Lust, 2009, Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1beta-induced interleukin 6 production and the myeloma proliferative component., Mayo Clin Proc, 84, 114, 10.4065/84.2.114 · DOI
  5. Simon, 2007, Pathogenesis of familial periodic fever syndromes or hereditary autoinflammatory syndromes., Am J Physiol Regul Integr Comp Physiol, 292, R86, 10.1152/ajpregu.00504.2006 · DOI
  6. Masters, 2009, Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease., Annu Rev Immunol, 27, 621, 10.1146/annurev.immunol.25.022106.141627 · DOI
  7. Weber, 2010, Interleukin-1 (IL-1) pathway., Sci Signal, 3, cm1
  8. Werman, 2004, The precursor form of IL-1alpha is an intracrine proinflammatory activator of transcription., Proc Natl Acad Sci U S A, 101, 2434, 10.1073/pnas.0308705101 · DOI
  9. Sharma, 2008, The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines., J Immunol, 180, 5477, 10.4049/jimmunol.180.8.5477 · DOI
  10. Nold, 2010, IL-37 is a fundamental inhibitor of innate immunity., Nat Immunol, 11, 1014, 10.1038/ni.1944 · DOI
  11. O'Neill, 2008, The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress., Immunol Rev, 226, 10, 10.1111/j.1600-065X.2008.00701.x · DOI
  12. Heguy, 1991, Internalization and nuclear localization of interleukin 1 are not sufficient for function., Cell Growth Differ, 2, 311
  13. van der Meer, 1988, A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection., Proc Natl Acad Sci U S A, 85, 1620, 10.1073/pnas.85.5.1620 · DOI
  14. Rosenwasser, 1979, Adherent cell function in murine T-lymphocyte antigen recognition, IV: enhancement of murine T-cell antigen recognition by human leukocytic pyrogen., J Exp Med, 150, 709, 10.1084/jem.150.3.709 · DOI
  15. Garlanda, 2009, TIR8/SIGIRR: an IL-1R/TLR family member with regulatory functions in inflammation and T cell polarization., Trends Immunol, 30, 439, 10.1016/j.it.2009.06.001 · DOI
  16. Smith, 2009, A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1., Immunity, 30, 817, 10.1016/j.immuni.2009.03.020 · DOI
  17. O'Neill, 2009, Therapeutic targeting of toll-like receptors for infectious and inflammatory diseases and cancer., Pharmacol Rev, 61, 177, 10.1124/pr.109.001073 · DOI
  18. Arslan, 2010, Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody., Circulation, 121, 80, 10.1161/CIRCULATIONAHA.109.880187 · DOI
  19. van Asseldonk, 2010, The effect of the interleukin-1 cytokine family members IL-1F6 and IL-1F8 on adipocyte differentiation., Obesity, 18, 2234, 10.1038/oby.2010.55 · DOI
  20. Blumberg, 2007, Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation., J Exp Med, 204, 2603, 10.1084/jem.20070157 · DOI
  21. Colotta, 1993, Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4., Science, 261, 472, 10.1126/science.8332913 · DOI
  22. Smeets, 2005, Soluble interleukin-1 receptor accessory protein ameliorates collagen-induced arthritis by a different mode of action from that of interleukin-1 receptor antagonist., Arthritis Rheum, 52, 2202, 10.1002/art.21108 · DOI
  23. Vambutas, 2009, Alternate splicing of interleukin-1 receptor type II (IL1R2) in vitro correlates with clinical glucocorticoid responsiveness in patients with AIED., PLoS One, 4, e5293, 10.1371/journal.pone.0005293 · DOI
  24. Akoum, 2008, Imbalance in the peritoneal levels of interleukin 1 and its decoy inhibitory receptor type II in endometriosis women with infertility and pelvic pain., Fertil Steril, 89, 1618, 10.1016/j.fertnstert.2007.06.019 · DOI · Paper page
  25. Wald, 2003, SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling., Nat Immunol, 4, 920, 10.1038/ni968 · DOI
  26. Garlanda, 2004, Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family., Proc Natl Acad Sci U S A, 101, 3522, 10.1073/pnas.0308680101 · DOI
  27. Bulek, 2009, The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response., J Immunol, 182, 2601, 10.4049/jimmunol.0802729 · DOI
  28. Lech, 2009, Resident dendritic cells prevent postischemic acute renal failure by help of single Ig IL-1 receptor-related protein., J Immunol, 183, 4109, 10.4049/jimmunol.0900118 · DOI
  29. Melnikov, 2001, Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure., J Clin Invest, 107, 1145, 10.1172/JCI12089 · DOI
  30. Ferretti, 1994, Neutralization of endogenous IL-1 receptor antagonist exacerbates and prolongs inflammation in rabbit immune colitis., J Clin Invest, 94, 449, 10.1172/JCI117345 · DOI
  31. Horai, 2000, Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice., J Exp Med, 191, 313, 10.1084/jem.191.2.313 · DOI
  32. Nicklin, 2000, Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene., J Exp Med, 191, 303, 10.1084/jem.191.2.303 · DOI
  33. Krelin, 2007, Interleukin-1beta-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors., Cancer Res, 67, 1062, 10.1158/0008-5472.CAN-06-2956 · DOI · Paper page
  34. Dinarello, 2010, Why not treat human cancer with interleukin-1 blockade?, Cancer Metastasis Rev, 29, 317, 10.1007/s10555-010-9229-0 · DOI
  35. Aksentijevich, 2009, An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist., N Engl J Med, 360, 2426, 10.1056/NEJMoa0807865 · DOI
  36. Reddy, 2009, An autoinflammatory disease due to homozygous deletion of the IL1RN locus., N Engl J Med, 360, 2438, 10.1056/NEJMoa0809568 · DOI
  37. Lachmann, 2009, In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes., J Exp Med, 206, 1029, 10.1084/jem.20082481 · DOI
  38. Pascual, 2005, Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade., J Exp Med, 201, 1479, 10.1084/jem.20050473 · DOI
  39. Goldbach-Mansky, 2006, Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition., N Engl J Med, 355, 581, 10.1056/NEJMoa055137 · DOI
  40. Gattorno, 2007, Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations., Arthritis Rheum, 56, 3138, 10.1002/art.22842 · DOI
  41. Hoffman, 2004, Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist prevents., Lancet, 364, 1779, 10.1016/S0140-6736(04)17401-1 · DOI
  42. Gattorno, 2008, The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis., Arthritis Rheum, 58, 1505, 10.1002/art.23437 · DOI
  43. Eiling, 2007, Schnitzler syndrome: treatment failure to rituximab but response to anakinra., J Am Acad Dermatol, 57, 361, 10.1016/j.jaad.2007.03.036 · DOI
  44. Goldbach-Mansky, 2009, Autoinflammation: the prominent role of IL-1 in monogenic autoinflammatory diseases and implications for common illnesses., J Allergy Clin Immunol, 124, 1141, 10.1016/j.jaci.2009.11.016 · DOI
  45. Hawkins, 2004, Spectrum of clinical features in Muckle-Wells syndrome and response to anakinra., Arthr Rheumat, 50, 607, 10.1002/art.20033 · DOI
  46. Hoffman, 2008, Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies., Arthritis Rheum, 58, 2443, 10.1002/art.23687 · DOI · Paper page
  47. Netea, 2009, Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages., Blood, 113, 2324, 10.1182/blood-2008-03-146720 · DOI
  48. Andrei, 2004, Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes., Proc Natl Acad Sci U S A, 101, 9745, 10.1073/pnas.0308558101 · DOI
  49. Perregaux, 2000, ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood., J Immunol, 165, 4615, 10.4049/jimmunol.165.8.4615 · DOI
  50. Solle, 2001, Altered cytokine production in mice lacking P2X(7) receptors., J Biol Chem, 276, 125, 10.1074/jbc.M006781200 · DOI
  51. Agostini, 2004, NALP3 forms an IL-1β processing inflammasome with increased activity in Muckle-Wells auto-inflammatory disorder., Immunity, 20, 319, 10.1016/S1074-7613(04)00046-9 · DOI · Paper page
  52. Hoffman, 2001, Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome., Nat Genet, 29, 301, 10.1038/ng756 · DOI
  53. Bergsbaken, 2009, Pyroptosis: host cell death and inflammation., Nat Rev Microbiol, 7, 99, 10.1038/nrmicro2070 · DOI
  54. Dinarello, 1987, Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro., J Immunol, 139, 1902, 10.4049/jimmunol.139.6.1902 · DOI
  55. Fantuzzi, 1997, Response to local inflammation of IL-1beta converting enzyme-deficient mice., J Immunol, 158, 1818, 10.4049/jimmunol.158.4.1818 · DOI
  56. Joosten, 2009, Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta., Arthritis Rheum, 60, 3651, 10.1002/art.25006 · DOI
  57. Guma, 2009, Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation., Arthritis Rheum, 60, 3642, 10.1002/art.24959 · DOI
  58. Meissner, 2008, Superoxide dismutase 1 regulates caspase-1 and endotoxic shock., Nat Immunol, 9, 866, 10.1038/ni.1633 · DOI
  59. van de Veerdonk, 2010, Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease., Proc Natl Acad Sci U S A, 107, 3030, 10.1073/pnas.0914795107 · DOI · Paper page
  60. Meissner, 2010, Inflammasome activation in NADPH oxidase defective mononuclear phagocytes from patients with chronic granulomatous disease., Blood, 116, 1570, 10.1182/blood-2010-01-264218 · DOI · Paper page
  61. Tassi, 2010, Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion., Proc Natl Acad Sci U S A, 107, 9789, 10.1073/pnas.1000779107 · DOI
  62. Eigenbrod, 2008, Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells., J Immunol, 181, 8194, 10.4049/jimmunol.181.12.8194 · DOI · Paper page
  63. Cohen, 2010, Differential release of chromatin-bound IL-1alpha discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation., Proc Natl Acad Sci U S A, 107, 2574, 10.1073/pnas.0915018107 · DOI
  64. Pollock, 2003, The prodomain of interleukin 1alpha interacts with elements of the RNA processing apparatus and induces apoptosis in malignant cells., FASEB J, 17, 203, 10.1096/fj.02-0602com · DOI
  65. Abbate, 2008, Anakinra, a recombinant human interleukin-1 receptor antagonist, inhibits apoptosis in experimental acute myocardial infarction., Circulation, 117, 2670, 10.1161/CIRCULATIONAHA.107.740233 · DOI
  66. Di Paolo, 2009, Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo., Immunity, 31, 110, 10.1016/j.immuni.2009.04.015 · DOI
  67. Kelk, 2008, IL-1beta secretion induced by Aggregatibacter (Actinobacillus) actinomycetemcomitans is mainly caused by the leukotoxin., Int J Med Microbiol, 298, 529, 10.1016/j.ijmm.2007.06.005 · DOI
  68. Ben-Sasson, 2009, IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation., Proc Natl Acad Sci U S A, 106, 7119, 10.1073/pnas.0902745106 · DOI · Paper page
  69. van de Veerdonk, 2010, Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1., J Leukoc Biol, 88, 227, 10.1189/jlb.0809550 · DOI
  70. Joosten, 2010, Excessive interleukin-1 signaling determines the development of Th1 and Th17 responses in chronic inflammation., Arthritis Rheum, 62, 320, 10.1002/art.27242 · DOI
  71. Chung, 2009, Critical regulation of early Th17 cell differentiation by interleukin-1 signaling., Immunity, 30, 576, 10.1016/j.immuni.2009.02.007 · DOI
  72. Koenders, 2008, Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice., Arthritis Rheum, 58, 3461, 10.1002/art.23957 · DOI
  73. Nakae, 2003, IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist., Proc Natl Acad Sci U S A, 100, 5986, 10.1073/pnas.1035999100 · DOI
  74. Lamacchia, 2010, Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cell-specific interleukin-1 receptor antagonist., Arthritis Rheum, 62, 452, 10.1002/art.27235 · DOI
  75. van de Veerdonk, The anti-CD20 antibody rituximab reduces the T helper response., Arthr Rheumat
  76. Sutton, 2006, A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis., J Exp Med, 203, 1685, 10.1084/jem.20060285 · DOI
  77. Chizzolini, 2008, Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion., Blood, 112, 3696, 10.1182/blood-2008-05-155408 · DOI
  78. Donath, 2009, XOMA 052, a potential disease modifying anti-1L–1beta antibody, shows sustained HbA1c reductions 3 months after a single injection with no increases in safety parameters in subjects with Type 2 diabetes., Diabetes, 58, A30
  79. Carmi, 2009, The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis., J Immunol, 183, 4705, 10.4049/jimmunol.0901511 · DOI · Paper page
  80. Coxon, 2002, Inhibition of interleukin-1 but not tumor necrosis factor suppresses neovascularization in rat models of corneal angiogenesis and adjuvant arthritis., Arthritis Rheum, 46, 2604, 10.1002/art.10546 · DOI
  81. Voronov, 2003, IL-1 is required for tumor invasiveness and angiogenesis., Proc Natl Acad Sci U S A, 100, 2645, 10.1073/pnas.0437939100 · DOI
  82. Olson, 2009, Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model., Ocul Immunol Inflamm, 17, 195, 10.1080/09273940802710705 · DOI
  83. Antin, 2002, Interleukin-1 blockade does not prevent acute graft-versus-host disease: results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantation., Blood, 100, 3479, 10.1182/blood-2002-03-0985 · DOI
  84. Antin, 1994, Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease., Blood, 84, 1342, 10.1182/blood.V84.4.1342.1342 · DOI
  85. Wood, 1983, Isolation of an interleukin-1-like factor from human joint effusions., Arthritis Rheum, 26, 975, 10.1002/art.1780260806 · DOI
  86. Duff, 1983, The fever of gout: urate crystals activate endogenous pyrogen production from human and rabbit mononuclear phagocytes., Trans Assoc Am Physicians, 96, 234
  87. So, 2007, A pilot study of IL-1 inhibition by anakinra in acute gout., Arthritis Res Ther, 9, R28, 10.1186/ar2143 · DOI · Paper page
  88. Terkeltaub, 2010, Update on gout: new therapeutic strategies and options., Nat Rev Rheumatol, 6, 30, 10.1038/nrrheum.2009.236 · DOI
  89. So, 2010, Canakinumab for the treatment of acute flares in difficult-to-treat gouty arthritis: Results of a multicenter, phase II, dose-ranging study., Arthritis Rheum, 62, 3064, 10.1002/art.27600 · DOI
  90. Joosten, 2010, Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1beta production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis., Arthritis Rheum, 62, 3237, 10.1002/art.27667 · DOI
  91. Dinarello, 2010, How interleukin-1beta induces gouty arthritis., Arthritis Rheum, 62, 3140, 10.1002/art.27663 · DOI
  92. Ghezzi, 1991, Hypoxia increases production of interleukin-1 and tumor necrosis factor by human mononuclear cells., Cytokine, 3, 189, 10.1016/1043-4666(91)90015-6 · DOI
  93. Emsley, 2005, A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients., J Neurol Neurosurg Psychiatry, 76, 1366, 10.1136/jnnp.2004.054882 · DOI
  94. Mandrup-Poulsen, 2010, Blockade of interleukin 1 in type 1 diabetes mellitus., Nat Rev Endocrinol, 6, 158, 10.1038/nrendo.2009.271 · DOI
  95. Maedler, 2002, Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets., J Clin Invest, 110, 851, 10.1172/JCI200215318 · DOI
  96. Dinarello, 2010, Role of IL-1beta in type 2 diabetes., Curr Opin Endocrinol Diabetes Obes, 17, 314, 10.1097/MED.0b013e32833bf6dc · DOI
  97. Stienstra, 2010, The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity., Cell Metab, 12, 593, 10.1016/j.cmet.2010.11.011 · DOI
  98. Joosten, 2004, Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction., Am J Pathol, 165, 959, 10.1016/S0002-9440(10)63357-3 · DOI
  99. Chevalier, 2009, Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study., Arthritis Rheum, 61, 344, 10.1002/art.24096 · DOI
  100. Abbate, 2010, Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction., Am J Cardiol, 105, 1371, 10.1016/j.amjcard.2009.12.059 · DOI

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Metadata

Authors
Dinarello, C. A.
Affiliations
Radboud University Nijmegen (NL)
Corresponding author
Dinarello, Charles A.
ORCID
Dinarello, Charles A.
Venue
Blood
Publisher
American Society of Hematology
Published
2011-04-07
Volume
117
Issue
14
Pages
3720-3732
ISSN
  • 0006-4971 (ISSN-L)
  • 1528-0020
DOI
10.1182/blood-2010-07-273417
PMC
PMC3083294
OpenAlex
W2150107812
Cited by
2,248
References
118
Citations by year
2026: 138 · 2025: 173 · 2024: 151 · 2023: 150 · 2022: 161 · 2021: 160 · 2020: 159 · 2019: 164 · 2018: 151 · 2017: 145 · 2016: 123 · 2015: 154 · 2014: 139 · 2013: 124 · 2012: 110
FWCI
12.05
Type
journal article
Language
en
Open access
Locations
  • Blood (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Funders
  • National Cancer Institute (CA 046934, P30CA046934)
  • National Institute of Allergy and Infectious Diseases (AI‑15614, R56AI015614, R01AI015614)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Keywords
interleukin-1, IL-1 receptor family, innate immunity, autoinflammatory disease, autoimmune disease, caspase-1, gout, type 2 diabetes, rheumatoid arthritis, recurrent pericarditis, smoldering multiple myeloma, heart failure, anti-inflammatory therapy
MeSH terms
Animals, Autoimmune Diseases, Disease, Multigene Family, Humans, Inflammation, Interleukin-1, Models, Biological, Receptors, Interleukin-1, Toll-Like Receptors, Molecular Targeted Therapy

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