Cited by 197Hematopoietic Stem Cell TransplantationT-cell and B-cell ImmunologyBone Metabolism and Diseases

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Impaired Ability of Bone Marrow Stromal Cells to Support B-Lymphopoiesis With Age

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Stephan, Robert P., Reilly, Colette R., Witte, Pamela L.·1998·Blood

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Abstract

B-lymphopoiesis decreases with age. We studied how aging affects bone marrow stromal cells, because they provide the growth factors and cell contacts required for B-lymphopoiesis. No differences were noted in the cell-surface phenotype of young and old primary-cultured stromal cells. Fluorescence-activated cell sorter-purified stromal cells from old mice were deficient in the ability to support the proliferation of interleukin-7 (IL-7)–specific B-lymphoid cell lines. The kinetics of this response indicated that IL-7 was not immediately available from stromal cells of either age and was further delayed on aged stromal cells. The levels of IL-7 protein within stromal cells were equivalent between young and old animals, suggesting that the production of IL-7 was not altered by aging. Negligible amounts of IL-7 were found either freely secreted or in the extracellular matrix of cultures of young and old marrow. Contact between the lymphoid cells and the primary stromal cells was required for detectable proliferation, suggesting that cell contact was required for the release of IL-7. We propose that stromal cells regulate B-lymphopoiesis by limiting the amount of IL-7 available to the developing precursors. Therefore, we conclude that the age-related decrease in the function of bone marrow stromal cells is related to the impaired release of IL-7.

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Authors: Stephan, R. P., Reilly, C. R., & Witte, P. L.
Affiliations: Loyola University Chicago (US)
ORCID: Stephan, Robert P.
Venue: Blood
Publisher: American Society of Hematology
Published: 1998-01-01
Volume: 91
Issue: 1
Pages: 75-88
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood.v91.1.75
OpenAlex: W2415706144
Cited by: 197
References: 52
Citations by year: 2026: 2 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 10
FWCI: 4.57
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk048663-03, 1r03ag014218-01)
National Institute on Aging (AG14218)
National Institute of Diabetes and Digestive and Kidney Diseases (DK48663)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Keywords: mesenchymal stem cells, B cell development, aging, IL-7, lymphocyte proliferation, cell contact, extracellular matrix, bone marrow microenvironment, immunosenescence
MeSH terms: Aging, Animals, B-Lymphocytes, Bone Marrow Cells, Cell Communication, Extracellular Matrix, Female, Hematopoiesis, Hematopoietic Stem Cells, Mice, Inbred BALB C, Secretory Rate, Interleukin-7, Stromal Cells, Mice, Knockout, Mice

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Impaired Ability of Bone Marrow Stromal Cells to Support B-Lymphopoiesis With Age

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