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Signaling and regulation of G protein-coupled receptors in airway smooth muscle

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Billington, Charlotte K, Penn, Raymond B·2003·Respiratory Research
DOI 10.1186/1465-9921-4-2
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Abstract

Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state.

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Metadata

Authors
Billington, C. K., & Penn, R. B.
Venue
Respiratory Research
Publisher
Springer Science and Business Media LLC
Published
2003-03-14
Volume
4
Issue
1
Pages
2-2
ISSN
  • 1465-9921 (ISSN-L)
  • 1465-993X
DOI
10.1186/1465-9921-4-2
OpenAlex
W2121774438
Cited by
284
References
4
FWCI
3.54
Type
journal article
Language
en
Open access
gold

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