Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer
Open accessAbstract
Background: Non-small-cell lung cancer (NSCLC) is the leading cause of cancer death. Early detection of NSCLC will improve its outcome. The current techniques for NSCLC early detection are either invasive or have low accuracy. Molecular analyses of clinical specimens present promising diagnostic approaches. Non-coding RNAs (ncRNAs) play an important role in tumorigenesis and could be developed as biomarkers for cancer. Here we aimed to develop small nucleolar RNAs (snoRNAs), a common class of ncRNAs, as biomarkers for NSCLC early detection. The study comprised three phases: (1) profiling snoRNA signatures in 22 NSCLC tissues and matched noncancerous lung tissues by GeneChip Array, (2) validating expressions of the signatures by RT-qPCR in the tissues, and (3) evaluating plasma expressions of the snoRNAs in 37 NSCLC patients, 26 patients with chronic obstructive pulmonary disease (COPD), and 22 healthy subjects. Results: In the surgical tissues, six snoRNAs were identified, which were overexpressed in all tumour tissues compared with their normal counterparts. The overexpressions of the genes in tumors were confirmed by RT-qPCR. The snoRNAs were stably present and reliably detectable in plasma. Of the six genes, three (SNORD33, SNORD66 and SNORD76) displayed higher plasma expressions in NSCLC patients compared with the cancer-free individuals (All < 0.01). The use of the three genes produced 81.1% sensitivity and 95.8% specificity in distinguishing NSCLC patients from both normal and COPD subjects. The plasma snoRNA expressions were not associated with stages and histological types of NSCLC (All > 0.05). Conclusions: The identified snoRNAs provide potential markers for NSCLC early detection.
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There is evidence that malignant cells of lung cancer tissue in primary cultures and lung cancer cell lines express members of the SNORD115 cluster, in addition to many other SNORDs and SNORAs.
“Although it has been reiterated in recent publications, (Cavaillé, 2017; Chung et al., 2020; Deogharia and Majumder, 2018), there is evidence that malignant cells of lung cancer tissue in primary cultures and lung cancer cell lines express members of SNORD115 cluster, in addition to many other SNORDs and SNORAs (Gao et al., 2014; Liao et al., 2010; Mourksi et al., 2020).”
From Small nucleolar RNAs in plasma extracellular vesicles and their discriminatory power as diagnostic biomarkers of Alzheimer's disease (2021) · cites this paper as Liao et al., 2010
The Results section reports expression of several SNORDs and SNORA42 in resected NSCLC tissues. It does not report SNORD115-cluster expression or experiments on primary cultures or lung cancer cell lines; the Methods section describes surgical tissue specimens and plasma samples instead. Page numbers are unavailable in our copy. (LLM, conf=0.89)
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- Authors
- Liao, J., Yu, L., Mei, Y., Guarnera, M., Shen, J., Li, R., Liu, Z., & Jiang, F.
- Affiliations
- University of Maryland, Baltimore (US)
- Corresponding author
- Jiang, Feng
- Venue
- Molecular Cancer
- Published
- 2010-07-27
- Volume
- 9
- Issue
- 1
- Pages
- 198-198
- ISSN
- 1476-4598 (ISSN-L)
- PMC
- PMC2919450
- OpenAlex
- W2120920586
- Cited by
- 293
- References
- 51
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 25 · 2023: 15 · 2022: 22 · 2021: 28 · 2020: 14 · 2019: 17 · 2018: 23 · 2017: 24 · 2016: 19 · 2015: 23 · 2014: 20 · 2013: 11 · 2012: 17
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Molecular Cancer (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Flight Attendant Medical Research Institute
- National Institutes of Health (5k12rr023250-05)
- National Cancer Institute (CA137742, R21CA135382, R03CA133956, CA135382, R03CA137742, CA-133956)
- National Center for Research Resources (K12-RR023250)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- non-small cell lung cancer, small nucleolar RNA, tumor markers, early cancer detection, plasma biomarkers, non-coding RNA, chronic obstructive pulmonary disease, gene expression profiling
- MeSH terms
- Carcinoma, Non-Small-Cell Lung, Humans, Lung Neoplasms, RNA, Small Nuclear, Biomarkers, Tumor, Case-Control Studies, Reverse Transcriptase Polymerase Chain Reaction
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