Cited by 1,039Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsInflammasome and immune disorders

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Microglia and neuroinflammation: a pathological perspective

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Streit·2004·Journal of Neuroinflammation

DOI 10.1186/1742-2094-1-14PMC PMC509427

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Abstract

Microglia make up the innate immune system of the central nervous system and are key cellular mediators of neuroinflammatory processes. Their role in central nervous system diseases, including infections, is discussed in terms of a participation in both acute and chronic neuroinflammatory responses. Specific reference is made also to their involvement in Alzheimer's disease where microglial cell activation is thought to be critically important in the neurodegenerative process.

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Authors: Streit
Venue: Journal of Neuroinflammation
Publisher: Springer Science and Business Media LLC
Published: 2004
Volume: 1
Issue: 1
Pages: 14
ISSN: 1742-2094 (ISSN-L)
DOI: 10.1186/1742-2094-1-14
PMC: PMC509427
OpenAlex: W1563590122
Cited by: 1,039
References: 26
Citations by year: 2026: 25 · 2025: 41 · 2024: 73 · 2023: 71 · 2022: 70 · 2021: 78 · 2020: 82 · 2019: 62 · 2018: 62 · 2017: 54 · 2016: 45 · 2015: 49 · 2014: 51 · 2013: 49 · 2012: 41
FWCI: 16.61
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Journal of Neuroinflammation (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Brain Research Foundation
McKnight Foundation
Evelyn F. McKnight Brain Research Foundation
University of Florida
National Institutes of Health
National Institute on Aging (P30AG019606, P01AG012411)
National Institute of Neurological Disorders and Stroke
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: microglia, neuroinflammation, central nervous system infection, Alzheimer's disease, microglial activation, neurodegeneration

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Microglia and neuroinflammation: a pathological perspective

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