Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

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A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

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Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

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Autophagy in immunity and inflammation

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

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Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

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The role of autophagy in neurodegenerative disease

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Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

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How neuroinflammation contributes to neurodegeneration

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Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

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State of play in amyotrophic lateral sclerosis genetics

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

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Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

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The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS

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Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

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Aggregation and Motor Neuron Toxicity of an ALS-Linked SOD1 Mutant Independent from Wild-Type SOD1

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Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

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The prevalence of frontotemporal dementia

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Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

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Debris clearance by microglia: an essential link between degeneration and regeneration

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Molecular biology of amyotrophic lateral sclerosis: insights from genetics

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Wild-Type Nonneuronal Cells Extend Survival of SOD1 Mutant Motor Neurons in ALS Mice

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Microglia and neuroinflammation: a pathological perspective

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TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

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Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

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TREMs in the immune system and beyond

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The overlap of amyotrophic lateral sclerosis and frontotemporal dementia

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CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

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<emph type="ital">SQSTM1</emph> Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

Fecto, F. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.250 · Cited by 650 · see citing works

Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease

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Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

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Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

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NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase

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Autophagy and autophagy-related proteins in the immune system

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<i>C9orf72</i> is required for proper macrophage and microglial function in mice

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The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

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Neuron-Specific Expression of Mutant Superoxide Dismutase 1 in Transgenic Mice Does Not Lead to Motor Impairment

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ALS clinical trials review: 20 years of failure. Are we any closer to registering a new treatment?

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The genetics and neuropathology of amyotrophic lateral sclerosis

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Microglia in ALS: The Good, The Bad, and The Resting

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Microglia Function in Central Nervous System Development and Plasticity

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Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

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TBK1: a new player in ALS linking autophagy and neuroinflammation

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Inflammation in ALS/FTD pathogenesis

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Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

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ALS Genes in the Genomic Era and their Implications for FTD

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Optineurin Negatively Regulates TNFα- Induced NF-κB Activation by Competing with NEMO for Ubiquitinated RIP

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Microglia and monocyte-derived macrophages: functionally distinct populations that act in concert in CNS plasticity and repair

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<i>TREM2</i>Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

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Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis

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Mutations in SQSTM1 encoding p62 in amyotrophic lateral sclerosis: genetics and neuropathology

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Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models

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The changing phenotype of microglia from homeostasis to disease

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VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: Review of a unique disorder

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Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: Assessed with [11C]-PBR28

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Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

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Amyotrophic Lateral Sclerosis

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Recent advances in p97/VCP/Cdc48 cellular functions

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Inflammasome-Independent Modulation of Cytokine Response by Autophagy in Human Cells

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The role of autophagy in modulation of neuroinflammation in microglia

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Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia

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Autophagy Dysregulation in Amyotrophic Lateral Sclerosis

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VCP (p97) Regulates NFKB Signaling Pathway, Which Is Important for Metastasis of Osteosarcoma Cell Line

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Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response

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Increased cytotoxic potential of microglia from ALS‐transgenic mice

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Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation

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Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis

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Pathogenesis of FUS-associated ALS and FTD: insights from rodent models

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Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis

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Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS

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Frontotemporal dementia: a bridge between dementia and neuromuscular disease

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Progranulin is a chemoattractant for microglia and stimulates their endocytic activity

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Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death

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Insoluble Mutant SOD1 Is Partly Oligoubiquitinated in Amyotrophic Lateral Sclerosis Mice

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Pathogenesis/genetics of frontotemporal dementia and how it relates to ALS

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Genetics insight into the amyotrophic lateral sclerosis/frontotemporal dementia spectrum

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Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease

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Two Decades-Long Journey from Riluzole to Edaravone: Revisiting the Clinical Pharmacokinetics of the Only Two Amyotrophic Lateral Sclerosis Therapeutics

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A C6orf10/LOC101929163 locus is associated with age of onset in C9orf72 carriers

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Additional file 2 of Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery

Hunter, M., Spiller, K. J., Dominique, M. A., Xu, H., Hunter, F. W., Fang, T., Canter, R. G., Roberts, C. J., Ransohoff, R. M., Trojanowski, J. Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15569184

Additional file 4 of Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery

Hunter, M., Spiller, K. J., Dominique, M. A., Xu, H., Hunter, F. W., Fang, T., Canter, R. G., Roberts, C. J., Ransohoff, R. M., Trojanowski, J. Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15569208

Additional file 2 of Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS

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Additional file 3 of Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery

Hunter, M., Spiller, K. J., Dominique, M. A., Xu, H., Hunter, F. W., Fang, T., Canter, R. G., Roberts, C. J., Ransohoff, R. M., Trojanowski, J. Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15569205

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Additional file 1 of Inhibition of the MEK/ERK pathway suppresses immune overactivation and mitigates TDP-43 toxicity in a Drosophila model of ALS

Yue, W., Deng, X., Wang, Z., Jiang, M., Hu, R., Duan, Y., Wang, Q., Cui, J., & Fang, Y. (2023) · Figshare · doi:10.6084/m9.figshare.23550331

Additional file 1 of Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia

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Additional file 1 of Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery

Hunter, M., Spiller, K. J., Dominique, M. A., Xu, H., Hunter, F. W., Fang, T., Canter, R. G., Roberts, C. J., Ransohoff, R. M., Trojanowski, J. Q., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15569145

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