In vivo imaging reveals sigmoidal growth kinetic of β-amyloid plaques
Open accessAbstract
A major neuropathological hallmark of Alzheimer's disease is the deposition of amyloid plaques in the brains of affected individuals. Amyloid plaques mainly consist of fibrillar β-amyloid, which is a cleavage product of the amyloid precursor protein. The amyloid-cascade-hypothesis postulates Aβ accumulation as the central event in initiating a toxic cascade leading to Alzheimer's disease pathology and, ultimately, loss of cognitive function. We studied the kinetics of β-amyloid deposition in Tg2576 mice, which overexpress human amyloid precursor protein with the Swedish mutation. Utilizing long-term two-photon imaging we were able to observe the entire kinetics of plaque growth in vivo. Essentially, we observed that plaque growth follows a sigmoid-shaped curve comprising a cubic growth phase, followed by saturation. In contrast, plaque density kinetics exhibited an asymptotic progression. Taking into account the fact that a critical concentration of Aβ is required to seed new plaques, we can propose the following kinetic model of β-amyloid deposition in vivo. In the early cubic phase, plaque growth is not limited by Aβ concentration and plaque density increases very fast. During the transition phase, plaque density stabilizes whereas plaque volume increases strongly reflecting a robust growth of the plaques. In the late asymptotic phase, Aβ peptide production becomes rate-limiting for plaque growth. In conclusion, the present study offers a direct link between in vitro and in vivo studies facilitating the translation of Aβ-lowering strategies from laboratory models to patients.
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Aβ fibrillation and plaque formation follow sigmoidal growth kinetics.
“Aβ fibrillation and plaque formation follow sigmoidal growth kinetics20,21”
From Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice (2024) · cites this paper as [21]
A threshold level of Aβ accumulation is essential for plaque seeding to occur.
“a threshold level of Aβ accumulation is essential for plaque seeding to occur.”
From Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice (2024) · cites this paper as [21]
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- Authors
- Burgold, S., Filser, S., Dorostkar, M. M., Schmidt, B., & Herms, J.
- Affiliations
- German Center for Neurodegenerative Diseases (DE)
- Technische Universität Darmstadt (DE)
- Corresponding author
- Herms, Jochen
- Venue
- Acta Neuropathologica Communications
- Published
- 2014-03-28
- Volume
- 2
- Issue
- 1
- Pages
- 30-30
- ISSN
- 2051-5960 (ISSN-L)
- PMC
- PMC4050984
- OpenAlex
- W2136953158
- Cited by
- 59
- References
- 52
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 8 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 2 · 2014: 1
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Neuropathologica Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
- DZNE Pub (submittedVersion, other-oa)
- Funders
- European Commission (Neuro.GSK3, 223276)
- Deutsche Forschungsgemeinschaft (SFB 596)
- Bundesministerium für Bildung und Forschung (01GZ0713)
- Bundesministerium für Wirtschaft und Technologie (16IN0675)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid plaques, Alzheimer's disease, sigmoidal growth curve, plaque progression, plaque density, Tg2576 mice, amyloid precursor protein, amyloid hypothesis, in vivo two-photon imaging, kinetic model, amyloid seeding
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Female, Humans, Kinetics, Male, Mice, Transgenic, Mutation, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Mice, Presenilin-1, Plaque, Amyloid, Neuroimaging
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