Energy metabolism and rheumatic diseases: from cell to organism

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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Pleiotropy, natural selection, and the evolution of senescence.

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Upstream and downstream of mTOR

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

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HIF-1α is essential for myeloid cell-mediated inflammation

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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Pleiotropy, natural selection, and the evolution of senescence

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HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638 · see citing works

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

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mTOR regulates memory CD8 T-cell differentiation

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

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Regulation of translation initiation by FRAP/mTOR

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The CD28 Signaling Pathway Regulates Glucose Metabolism

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Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation

Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., et al. (2010) · Blood · doi:10.1182/blood-2009-10-249540 · Cited by 1,246 · see citing works

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

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Corticosteroid insufficiency in acutely ill patients

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Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

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AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

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Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

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Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

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Fuel feeds function: energy metabolism and the T-cell response

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Regulation of Immune Responses by mTOR

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AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

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AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

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Circadian rhythms, sleep, and metabolism

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Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme.

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A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity

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Immunometabolism: an emerging frontier

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Quantitating Protein Synthesis, Degradation, and Endogenous Antigen Processing

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IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival

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Energy regulation and neuroendocrine–immune control in chronic inflammatory diseases

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Regulation of T Lymphocyte Metabolism

Frauwirth, K. A., & Thompson, C. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4661 · Cited by 371 · see citing works

Exercise-induced myokines and their role in chronic diseases

Pedersen, B. K. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.010 · Cited by 358 · see citing works

Revving the Engine: Signal Transduction Fuels T Cell Activation

Jones, R. G., & Thompson, C. B. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.008 · Cited by 349 · see citing works

Oxygen tension in synovial fluids

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Rapamycin reduces disease activity and normalizes T cell activation–induced calcium fluxing in patients with systemic lupus erythematosus

Fernández, D., Bonilla, E., Mirza, N., Niland, B. P., & Perl, A. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22085 · Cited by 321 · see citing works

Metabolism in T cell activation and differentiation

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Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis

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ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

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Bioenergetics of immune functions: fundamental and therapeutic aspects

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Synovial tissue hypoxia and inflammation in vivo

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Hypoxia-Adenosinergic Immunosuppression: Tumor Protection by T Regulatory Cells and Cancerous Tissue Hypoxia

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Respiratory gases of synovial fluids

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Metabolism, migration and memory in cytotoxic T cells

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The AMPK/SNF1/SnRK1 fuel gauge and energy regulator: structure, function and regulation

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Hypoxia prolongs neutrophil survival in vitro

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Rapamycin Prolongs Survival and Arrests Pathophysiologic Changes in Murine Systemic Lupus Erythematosus

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Hypoxic stress up‐regulates the expression of Toll‐like receptor 4 in macrophages via hypoxia‐inducible factor

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Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease

Gatza, E., Wahl, D. R., Opipari, A. W., Sundberg, T. B., Reddy, P., Liu, C., Glick, G. D., & Ferrara, J. L. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001975 · Cited by 168 · see citing works

Hypoxia Prolongs Monocyte/Macrophage Survival and Enhanced Glycolysis Is Associated with Their Maturation under Aerobic Conditions

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TCR Engagement Increases Hypoxia-Inducible Factor-1α Protein Synthesis via Rapamycin-Sensitive Pathway under Hypoxic Conditions in Human Peripheral T Cells

Nakamura, H., Makino, Y., Okamoto, K., Poellinger, L., Ohnuma, K., Morimoto, C., & Tanaka, H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.12.7592 · Cited by 158 · see citing works

Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!

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Low prevalence of antibodies to glucose‐6‐phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders

Matsumoto, I., Lee, D. M., Goldbach‐Mansky, R. T., Sumida, T., Hitchon, C. A., Schur, P. H., Anderson, R. J., Coblyn, J. S., Weinblatt, M. E., Brenner, M. B., et al. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10898 · Cited by 143 · see citing works

Hypoxia. Hypoxia in the pathogenesis of systemic sclerosis

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Treatment with rapamycin prevents fibrosis in tight‐skin and bleomycin‐induced mouse models of systemic sclerosis

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The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice.

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Interaction between oxidative stress and chemokines: Possible pathogenic role in systemic lupus erythematosus and rheumatoid arthritis

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Synovial Hypoxia as a Cause of Tendon Rupture in Rheumatoid Arthritis

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Glycolysis and rheumatoid arthritis

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mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus?

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Evolutionary medicine and chronic inflammatory state—known and new concepts in pathophysiology

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Signaling Pathways Mediating Insulin‐Stimulated Glucose Transport

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Rapamycin versus methotrexate in early diffuse systemic sclerosis: Results from a randomized, single‐blind pilot study

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Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases

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The emerging role of metabolic regulation in the functioning of Toll‐like receptors and the NOD‐like receptor Nlrp3

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Endosomal proteolysis of internalized proteins

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IL-17A Expression Is Localised to Both Mononuclear and Polymorphonuclear Synovial Cell Infiltrates

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Concepts of evolutionary medicine and energy regulation contribute to the etiology of systemic chronic inflammatory diseases

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Macrophage Migration Inhibitory Factor Counterregulates Dexamethasone-Mediated Suppression of Hypoxia-Inducible Factor-1α Function and Differentially Influences Human CD4+ T Cell Proliferation under Hypoxia

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Tumor necrosis factor blocking therapy alters joint inflammation and hypoxia

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Analysis of the thiol status of peripheral blood leukocytes in rheumatoid arthritis patients

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The myosin family: unconventional roles of actin-dependent molecular motors in immune cells

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Intracellular metabolic pathways control immune tolerance

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Glycolytic activity in human synovial lining cells in rheumatoid arthritis.

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Multiple roles for RhoA during T cell transendothelial migration

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Antigen processing and presentation: TAPping into ABC transporters

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Effects of hypoxia and/or lack of glucose on cellular energy metabolism and cytokine production in stimulated human CD4+ T lymphocytes

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ConA induced changes in energy metabolism of rat thymocytes

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<scp>H</scp>uman<scp> CD4</scp>^<scp>+</scp><scp> T </scp>cells maintain specific functions even under conditions of extremely restricted<scp> ATP</scp> production

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Characterization of a series of vacuolar type H+-ATPase inhibitors on CTL-mediated cytotoxicity

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Differential Modulation of ATP-Induced P2X7-Associated Permeabilities to Cations and Anions of Macrophages by Infection with Leishmania amazonensis

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Regulatory T cells expanded by rapamycin in vitro suppress colitis in an experimental mouse model

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ConA induced changes in energy metabolism of rat thymocytes

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A System Out of Breath: How Hypoxia Possibly Contributes to the Pathogenesis of Systemic Sclerosis

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When T Cells Run Out of Breath: The HIF-1α Story

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Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus

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Neuroendokrinimmunologie

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Untitled work

Santiago (2001) · doi:10.1002/1529-0131(200107)44:7

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome – Evidence for an autoimmune disease

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Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?

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Additional file 4 of Plasma metabolomic profiling in patients with rheumatoid arthritis identifies biochemical features predictive of quantitative disease activity

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Additional file 1 of Plasma metabolomic profiling in patients with rheumatoid arthritis identifies biochemical features predictive of quantitative disease activity

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