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Comparative miRNAome analysis revealed different miRNA expression profiles in bovine sera and exosomes.

Zhao, Ke, Liang, Guanxiang, Sun, Xu, Guan, Le Luo·2016·BMC Genomics
DOI 10.1186/s12864-016-2962-1PMC PMC4983018
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Fig. 1 Profiling of small RNAs in cattle sera and exosomes samples. a The relative abundance of different classes of small RNAs. b Size and frequency distribution of detected small RNAs (19-40 nt). SE Sera, EX Exosomes
Fig. 1 Profiling of small RNAs in cattle sera and exosomes samples. a The relative abundance of different classes of small RNAs. b Size and frequency distribution of detected small RNAs (19-40 nt). SE Sera, EX ExosomesCC BY · PubMed Central
Fig. 2 Complexity of miRNAs detected in the sera and exosomes. a Average number of miRNAs expressed in sera and exosomes, different letters (a, b) represent significant difference (P < 0.05). b Principle component analysis of the total detected miRNAs in sera and exosomes (blue dots represent sera, red dots represent exosomes). c Venn diagram showing the profile of miRNAs expressed in sera and exosomes. d Correlation analysis of the commonly expressed miRNAs in sera and exosomes
Fig. 2 Complexity of miRNAs detected in the sera and exosomes. a Average number of miRNAs expressed in sera and exosomes, different letters (a, b) represent significant difference (P < 0.05). b Principle component analysis of the total detected miRNAs in sera and exosomes (blue dots represent sera, red dots represent exosomes). c Venn diagram showing the profile of miRNAs expressed in sera and exosomes. d Correlation analysis of the commonly expressed miRNAs in sera and exosomesCC BY · PubMed Central
Fig. 3 The pie chart of ten most abundant miRNAs. a Sera. b Exosomes. MiRNAs differed in two samples were colored in red
Fig. 3 The pie chart of ten most abundant miRNAs. a Sera. b Exosomes. MiRNAs differed in two samples were colored in redCC BY · PubMed Central
Fig. 4 Expression of selected DE miRNAs between sera and exosomes detected by RT-qPCR and miRNA-seq. a Expression of miR-146b; b Expression of miR-24-3p; c Expression of miR-328; d Expression of miR-21-3p. miRNA expression from RT-qPCR represented by lines on the top and values are shown on the right vertical axis as relative abundance. miRNA expression from miRNA-seq represented by bars on the bottom and values are shown on the left vertical axis as log2RPM (normalized reads number). * on the top of lines or bars indicate significant (P < 0.05 or FDR < 0.05) difference between sera and exosomes. Data are presented as Mean ± Standard deviation
Fig. 4 Expression of selected DE miRNAs between sera and exosomes detected by RT-qPCR and miRNA-seq. a Expression of miR-146b; b Expression of miR-24-3p; c Expression of miR-328; d Expression of miR-21-3p. miRNA expression from RT-qPCR represented by lines on the top and values are shown on the right vertical axis as relative abundance. miRNA expression from miRNA-seq represented by bars on the bottom and values are shown on the left vertical axis as log2RPM (normalized reads number). * on the top of lines or bars indicate significant (P < 0.05 or FDR < 0.05) difference between sera and exosomes. Data are presented as Mean ± Standard deviationCC BY · PubMed Central
Fig. 5 Heatmap generated by clustering of the 50 most variable miRNAs in sera (SE) and exosomes (EX) from four cattle. Colors represent different normalized sequencing reads number as indicated by the color bar (Log2RPM)
Fig. 5 Heatmap generated by clustering of the 50 most variable miRNAs in sera (SE) and exosomes (EX) from four cattle. Colors represent different normalized sequencing reads number as indicated by the color bar (Log2RPM)CC BY · PubMed Central

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Metadata

Authors
Zhao, K., Liang, G., Sun, X., & Guan, L. L.
Venue
BMC Genomics
Publisher
Springer Science and Business Media LLC
Published
2016-08-12
Volume
17
Issue
1
ISSN
1471-2164
DOI
10.1186/s12864-016-2962-1
PMC
PMC4983018
Cited by
51
References
3
Language
en
Funders
Alberta Livestock and Meat Agency (CA) (ALMA 2011F129R)

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