The effects of treatment with liraglutide on atherothrombotic risk in obese young women with polycystic ovary syndrome and controls
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BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with obesity and increased cardiovascular (CV) risk markers. In this study our aim was to assess the effects of six months treatment with liraglutide 1.8 mg od on obesity, and CV risk markers, particularly platelet function, in young obese women with PCOS compared to controls of similar age and weight. METHODS: Carotid intima-media wall thickness (cIMT) was measured by B-mode ultrasonography, platelet function by flow cytometry, clot structure/lysis by turbidimetric assays and endothelial function by ELISA and post-ischaemic reactive hyperemia (RHI). Data presented as mean change (6-month - baseline) ± standard deviation. RESULTS: Nineteen obese women with PCOS and 17 controls, of similar age and weight, were recruited; baseline atherothrombotic risk markers did not differ between the two groups. Twenty five (69.4%) participants completed the study (13 PCOS, 12 controls). At six months, weight was significantly reduced by 3.0 ± 4.2 and 3.8 ± 3.4 kg in the PCOS and control groups, respectively; with no significant difference between the two groups, P = 0.56. Similarly, HOMA-IR, triglyceride, hsCRP, urinary isoprostanes, serum endothelial adhesion markers (sP-selectin, sICAM and sVCAM), and clot lysis area were equally significantly reduced in both groups compared to baseline. Basal platelet P-selectin expression was significantly reduced at six months in controls -0.17 ± 0.26 but not PCOS -0.12 ± 0.28; between groups difference, 95% confidence interval = -0.14 - 0.26, P = 0.41. No significant changes were noted in cIMT or RHI. CONCLUSIONS: Six months treatment with liraglutide (1.8 mg od) equally affected young obese women with PCOS and controls. In both groups, liraglutide treatment was associated with 3-4% weight loss and significant reduction in atherothrombosis markers including inflammation, endothelial function and clotting. Our data support the use of liraglutide as weight loss medication in simple obesity and suggest a potential beneficial effect on platelet function and atherothrombotic risk at 6 months of treatment. TRIAL REGISTRATION: Clinical trial reg. no. ISRCTN48560305. Date of registration 22/05/2012.
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GLP-1RAs have positive effects in patients with PCOS, decreasing insulin resistance and improving metabolic alterations.
“The GLP-1RAs also have positive effects in patients with PCOS decreasing IR and improving metabolic alterations [80,81,82,83].”
From The Role of Glp-1 Receptor Agonists in Insulin Resistance with Concomitant Obesity Treatment in Polycystic Ovary Syndrome (2022) · cites this paper as [83]
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- Authors
- Kahal, H., Aburima, A., Ungvari, T., Rigby, A. S., Coady, A. M., Vince, R. V., Ajjan, R. A., Kilpatrick, E. S., Naseem, K. M., & Atkin, S. L.
- Affiliations
- York Hospital (GB)
- Hull York Medical School (GB)
- Hull University Teaching Hospitals NHS Trust (GB)
- University of Hull (GB)
- University of Leeds (GB)
- Weill Cornell Medical College in Qatar (QA)
- Corresponding author
- Kahal, Hassan
- ORCID
- Venue
- BMC Endocrine Disorders
- Published
- 2015-04-02
- Volume
- 15
- Issue
- 1
- Pages
- 14-14
- ISSN
- 1472-6823 (ISSN-L)
- PMC
- PMC4389314
- OpenAlex
- W1992338711
- Cited by
- 74
- References
- 51
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 12 · 2023: 5 · 2022: 11 · 2021: 8 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 1
- FWCI
- 5.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Endocrine Disorders (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research (DHCS/04/G121/71)
- British Heart Foundation (PG/12/49/29441, FS/10/020/28242)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- liraglutide, polycystic ovary syndrome, obesity, atherothrombotic risk, weight loss, platelet function, P-selectin, endothelial function, carotid intima-media thickness, inflammation, clot lysis, young women, GLP-1 receptor agonists, cardiovascular risk markers, endothelial adhesion molecules, isoprostanes
- MeSH terms
- Liraglutide, Adolescent, Adult, Blood Platelets, Cardiovascular Diseases, Female, Fibrinolysis, Humans, Hypoglycemic Agents, Insulin Resistance, Middle Aged, Polycystic Ovary Syndrome, Risk Factors, Glucagon-Like Peptide 1, Young Adult, Carotid Intima-Media Thickness
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