Cited by 42Maternal Mental Health During Pregnancy and PostpartumPregnancy and Medication ImpactFetal and Pediatric Neurological Disorders

The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.

Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems, and brain structure in children

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Abstract

BACKGROUND: Two studies have suggested that severe prolonged nausea and vomiting during pregnancy is associated with emotional and behavioral problems in offspring, with smaller sample size and short-term follow-up. Moreover, little information is available on the role of the brain structure in the associations. METHODS: In a US-based cohort, the association was investigated between severe prolonged nausea and vomiting in pregnancy (extending after the second trimester and termed SNVP), psychiatric and cognitive problems, and brain morphology, from the Adolescent Brain Cognitive Development (ABCD) study, from 10,710 children aged 9-11 years. We validated the emotional including psychiatric findings using the Danish National Cohort Study with 2,092,897 participants. RESULTS: ) in children. SNVP was associated with low cortical area and volume, especially in the cingulate cortex, precuneus, and superior medial prefrontal cortex. These lower cortical areas and volumes significantly mediated the relation between SNVP and the psychiatric and cognitive problems in children. In the Danish National Cohort, severe nausea and vomiting in pregnancy were significantly associated with increased risks of behavioral and emotional disorders in children (hazard ratio, 1.24; 95% confidence interval, 1.16-1.33). CONCLUSIONS: SNVP is strongly associated with psychiatric and cognitive problems in children, with mediation by brain structure. These associations highlight the clinical importance and potential benefits of the treatment of SNVP, which could reduce the risk of psychiatric disorder in the next generation.

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  • Factors associated with these differences are low maternal age, problems in the family, severe nausea and vomiting in pregnancy, and low sleep duration.

    “The factors that are associated with these differences are low maternal age (Du et al., 2020b), problems in the family (Gong et al., 2020), severe nausea and vomiting in pregnancy (Wang et al., 2020) and low sleep duration (Cheng et al., 2020).”

    From The orbitofrontal cortex: reward, emotion and depression (2020) · cites this paper as Wang et al., 2020

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Research works printed but not linked: 2

  1. Dick AS, Garcia NL, Pruden SM, Thompson WK, Hawes SW, Sutherland MT, Riedel MC, Laird AR, Gonzalez R. No evidence for a bilingual executive function advantage in the ABCD study. Nat Hum Behav. 2019;3(7):692–701. · DOI
  2. Rolls ET. The brain, emotion, and depression. Oxford: Oxford University Press; 2018.

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Metadata

Authors
Wang, H., Rolls, E. T., Du, X., Du, J., Yang, D., Li, J., Li, F., Cheng, W., & Feng, J.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • Fudan University (CN)
Corresponding author
  • Li, Fei
  • Cheng, Wei
Venue
BMC Medicine
Published
2020-09-01
Volume
18
Issue
1
Pages
228-228
ISSN
1741-7015 (ISSN-L)
OpenAlex
W3082911626
Cited by
42
References
85
Citations by year
2026: 4 · 2025: 8 · 2024: 12 · 2023: 4 · 2022: 9 · 2021: 3 · 2020: 2
FWCI
3.37
Type
journal article
Language
en
Open access
Locations
  • BMC Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Scopus (Elsevier) (submittedVersion, other-oa)
Funders
  • National Natural Science Foundation of China (No.81701773; No.11771010, No. 81571031, No. 81761128035, No.81701334, No. 81703249)
  • Shanghai Science and Technology Innovation Plan (No. 15JC1400101 and No. 16JC1420402)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
Keywords
hyperemesis gravidarum, behavioral and emotional disorders, child cognitive development, brain structure, cortical volume, cingulate cortex, precuneus, mediation, prenatal exposure, Adolescent Brain Cognitive Development Study
MeSH terms
Mental Disorders, Brain, Child, Female, Humans, Male, Nausea, Pregnancy, Pregnancy Complications, Vomiting, Cohort Studies, Cognitive Dysfunction

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