The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring
Open accessAbstract
Over the last decade, there has been a significant increase in average paternal age when the first child is conceived, either due to increased life expectancy, widespread use of contraception, late marriages and other factors. While the effect of maternal ageing on fertilization and reproduction is well known and several studies have shown that women over 35 years have a higher risk of infertility, pregnancy complications, spontaneous abortion, congenital anomalies, and perinatal complications. The effect of paternal age on semen quality and reproductive function is controversial for several reasons. First, there is no universal definition for advanced paternal ageing. Secondly, the literature is full of studies with conflicting results, especially for the most common parameters tested. Advancing paternal age also has been associated with increased risk of genetic disease. Our exhaustive literature review has demonstrated negative effects on sperm quality and testicular functions with increasing paternal age. Epigenetics changes, DNA mutations along with chromosomal aneuploidies have been associated with increasing paternal age. In addition to increased risk of male infertility, paternal age has also been demonstrated to impact reproductive and fertility outcomes including a decrease in IVF/ICSI success rate and increasing rate of preterm birth. Increasing paternal age has shown to increase the incidence of different types of disorders like autism, schizophrenia, bipolar disorders, and childhood leukemia in the progeny. It is thereby essential to educate the infertile couples on the disturbing links between increased paternal age and rising disorders in their offspring, to better counsel them during their reproductive years.
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Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
O’Roak, B. J., Vives, L., Girirajan, S., Karakoc, E., Krumm, N., Coe, B. P., Levy, R., Ko, A., Lee, C., Smith, J. D., et al. (2012) · Nature · doi:10.1038/nature10989 · Cited by 2,165 · cited 1×
“also proposed that age-related de-novo mutations in male germ contribute to increased risk of neurodevelopmental disorders like autism [232,233].”
BackgroundRate of de novo mutations and the importance of father’s age to disease risk
Kong, A., Frigge, M. L., Masson, G., Besenbacher, S., Sulem, P., Magnusson, G., Gudjonsson, S. A., Sigurdsson, A., Jonasdottir, A., Jonasdottir, A., et al. (2012) · Nature · doi:10.1038/nature11396 · Cited by 2,134
De novo mutations revealed by whole-exome sequencing are strongly associated with autism
Sanders, S. J., Murtha, M. T., Gupta, A. R., Murdoch, J. D., Raubeson, M. J., Willsey, A. J., Ercan-Sencicek, A. G., DiLullo, N. M., Parikshak, N. N., Stein, J. L., et al. (2012) · Nature · doi:10.1038/nature10945 · Cited by 2,084
Feldman, H. A., Longcope, C., Derby, C. A., Johannes, C. B., Araujo, A. B., Coviello, A. D., Bremner, W. J., & McKinlay, J. B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8201 · Cited by 1,861
Association between telomere length in blood and mortality in people aged 60 years or older
Cawthon, R. M., Smith, K. R., O'Brien, E., Sivatchenko, A., & Kerber, R. A. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12384-7 · Cited by 1,761
Genomic imprinting in mammalian development: a parental tug-of-war
Moore, T. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90230-n · Cited by 1,281
Aubert, G., & Lansdorp, P. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00026.2007 · Cited by 1,188
EVENSON, D. P., LARSON, K. L., & JOST, L. K. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02599.x · Cited by 1,072 · cited 2×
“sperm chromatin structure assay (SCSA) [74,75], or by the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay [76].”
MethodWu, F. C. W., Tajar, A., Pye, S. R., Silman, A. J., Finn, J. D., O'Neill, T. W., Bartfai, G., Casanueva, F., Forti, G., Giwercman, A., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1972 · Cited by 939
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
Fumagalli, M., Rossiello, F., Clerici, M., Barozzi, S., Cittaro, D., Kaplunov, J. M., Bucci, G., Dobreva, M., Matti, V., Beausejour, C. M., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2466 · Cited by 851
Kirov, G., Pocklington, A. J., Holmans, P., Ivanov, D., Ikeda, M., Ruderfer, D., Moran, J., Chambert, K., Toncheva, D., Georgieva, L., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.154 · Cited by 844 · cited 1×
“Epigenetics might also play role in causing paternal age effect disorders, [209,221].”
Backgroundthe GAPPS Review Group, Lawn, J. E., Gravett, M. G., Nunes, T. M., Rubens, C. E., & Stanton, C. (2010) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-10-s1-s1 · Cited by 784
Slattery, M. M., & Morrison, J. J. (2002) · The Lancet · doi:10.1016/s0140-6736(02)11476-0 · Cited by 675
Telomeres shorten at equivalent rates in somatic tissues of adults
Daniali, L., Benetos, A., Susser, E., Kark, J. D., Labat, C., Kimura, M., Desai, K. K., Granick, M., & Aviv, A. (2013) · Nature Communications · doi:10.1038/ncomms2602 · Cited by 601
Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men
NEAVES, W. B., JOHNSON, L., PORTER, J. C., PARKER, C. R., & PETTY, C. S. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-4-756 · Cited by 495
In vivo loss of telomeric repeats with age in humans
Lindsey, J., McGill, N. I., Lindsey, L. A., Green, D. K., & Cooke, H. J. (1991) · Mutation Research/DNAging · doi:10.1016/0921-8734(91)90032-7 · Cited by 463
Broer, L., Codd, V., Nyholt, D. R., Deelen, J., Mangino, M., Willemsen, G., Albrecht, E., Amin, N., Beekman, M., de Geus, E. J. C., et al. (2013) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.303 · Cited by 450
Hultman, C. M., Sandin, S., Levine, S. Z., Lichtenstein, P., & Reichenberg, A. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.121 · Cited by 444
Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men
Orentreich, N., Brind, J. L., Vogelman, J. H., Andres, R., & Baldwin, H. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400863 · Cited by 417
The role of DNA damage and repair in aging through the prism of Koch-like criteria
Moskalev, A. A., Shaposhnikov, M. V., Plyusnina, E. N., Zhavoronkov, A., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.02.001 · Cited by 387
Zhao, J., Zhang, Q., Wang, Y., & Li, Y. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.06.033 · Cited by 361 · cited 1×
“Positive correlations have been reported between an increased sperm DNA fragmentation, reduced motility and ART outcomes leading to lower pregnancy rates and higher miscarriages [103].”
BackgroundReview of neuroimaging in autism spectrum disorders: what have we learned and where we go from here
Anagnostou, E., & Taylor, M. J. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-4 · Cited by 321
Impact of cellular senescence signature on ageing research
Sikora, E., Arendt, T., Bennett, M., & Narita, M. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2010.10.002 · Cited by 264
A Comprehensive Assessment of Parental Age and Psychiatric Disorders
McGrath, J. J., Petersen, L., Agerbo, E., Mors, O., Mortensen, P. B., & Pedersen, C. B. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.4081 · Cited by 253
Analysis of sperm telomere length in men with idiopathic infertility
Thilagavathi, J., Kumar, M., Mishra, S. S., Venkatesh, S., Kumar, R., & Dada, R. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2632-8 · Cited by 101
Cited by
Mollaahmadi, L., Keramat, A., Ghiasi, A., & Hashemzadeh, M. (2019) · Journal of the Turkish-German Gynecological Association · doi:10.4274/jtgga.galenos.2018.2018.0089 · Cited by 13
Does type 1 diabetes affect male infertility: Type 1 diabetes exchange registry-based analysis
Raheem, O. A., Hehemann, M. C., Rogers, M. J., Fustok, J. N., Hirsch, I. B., & Walsh, T. J. (2021) · Société Internationale d’Urologie Journal · doi:10.48083/vvmv5977 · Cited by 3
Metadata
- Authors
- Sharma, R., Agarwal, A., Rohra, V. K., Assidi, M., Abu-Elmagd, M., & Turki, R. F.
- Venue
- Reproductive Biology and Endocrinology
- Published
- 2015-04-19
- Volume
- 13
- Issue
- 1
- Pages
- 35-35
- ISSN
- 1477-7827 (ISSN-L)
- OpenAlex
- W2042220560
- Cited by
- 451
- References
- 27
- FWCI
- 28.83
- Type
- journal article
- Language
- en
- Open access
- gold
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