Sublime Microglia: Expanding Roles for the Guardians of the CNS
Open accessAbstract
Recent findings challenge the concept that microglia solely function in disease states in the central nervous system (CNS). Rather than simply reacting to CNS injury, infection, or pathology, emerging lines of evidence indicate that microglia sculpt the structure of the CNS, refine neuronal circuitry and network connectivity, and contribute to plasticity. These physiological functions of microglia in the normal CNS begin during development and persist into maturity. Here, we develop a conceptual framework for functions of microglia beyond neuroinflammation and discuss the rich repertoire of signaling and communication motifs in microglia that are critical both in pathology and for the normal physiology of the CNS.
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From Tubular human brain organoids to model microglia-mediated neuroinflammation (2021) · cites this paper as [2]
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- Authors
- Salter, M. W., & Beggs, S.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Salter, Michael W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 158
- Issue
- 1
- Pages
- 15-24
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2101221908
- Cited by
- 531
- References
- 22
- Citations by year
- 2026: 15 · 2025: 31 · 2024: 34 · 2023: 34 · 2022: 44 · 2021: 52 · 2020: 55 · 2019: 45 · 2018: 56 · 2017: 48 · 2016: 57 · 2015: 49 · 2014: 11
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Canadian Institutes of Health Research (MT-11219)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- microglia, central nervous system development, network connectivity, synaptic pruning, neuroplasticity, neuroinflammation, central nervous system physiology
- MeSH terms
- Animals, Central Nervous System, Humans, Nervous System Diseases, Neurons, Synapses, Microglia
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