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Cited by 989Extracellular vesicles in diseaseCellular transport and secretionNanoparticle-Based Drug Delivery

Exosomes: secreted vesicles and intercellular communications

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Théry, Clotilde·2011·F1000 Biology Reports
DOI 10.3410/b3-15PMC PMC3155154
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Abstract

Exosomes are small membrane vesicles of endocytic origin secreted by most cell types, and are thought to play important roles in intercellular communications. Although exosomes were originally described in 1983, interest in these vesicles has really increased dramatically in the last 3 years, after the finding that they contain mRNA and microRNA. This discovery sparked renewed interest for the general field of membrane vesicles involved in intercellular communications, and research on these structures has grown exponentially over the last few years, probing their composition and function, as well as their potential value as biomarkers.

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  • Extracellular vesicles can transfer RNAs such as non-coding RNAs from one cell to another and thereby contribute to inter-cellular communication.

    “Recent studies have confirmed that EV can transfer RNAs such as ncRNAs from one cell to another and thereby contribute to important roles in inter-cellular communication (3–9).”

    From Analysis of Extracellular RNA by Digital PCR (2014) · cites this paper as [6]

    The Introduction reports that exosomes contain mRNA and microRNA and that, in vitro, some exosomal mRNA was translated in target cells, suggesting transfer of genetic information. The RNA and miRNA in secreted membrane vesicles section confirms miRNA in vesicle preparations but does not establish its transfer to recipient cells; the claim is therefore stronger than this source supports for non-coding RNA. (LLM, conf=0.84)

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Research works printed but not linked: 33

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Cited by

Sorted by citations

Authors
Théry, C.
Affiliations
Inserm (FR)
Corresponding author
Théry, Clotilde
ORCID
Théry, Clotilde
Venue
F1000 Biology Reports
Publisher
Faculty Opinions Ltd
Published
2011-07-01
Volume
3
Pages
15-15
ISSN
1757-594X (ISSN-L)
DOI
10.3410/b3-15
PMC
PMC3155154
OpenAlex
W2143253053
Cited by
989
References
3
Citations by year
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FWCI
20.15
Type
journal article
Language
en
Open access
Locations
  • F1000 Biology Reports (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Funders
  • Agence Nationale de la Recherche
  • Institut National de la Santé et de la Recherche Médicale
  • Fondation de France
  • Institut National Du Cancer
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
exosomes, membrane vesicles, intercellular communication, microRNA, mRNA, biomarkers, endocytic vesicles

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