Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer’s disease

Neuroinflammation in Alzheimer's disease

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An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

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Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

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LiCl attenuates impaired learning and memory of APP/PS1 mice, which in mechanism involves α7 nAChRs and Wnt/β‐catenin pathway

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Non-alcoholic Fatty Liver Disease: Also a Disease of the Brain? A Systematic Review of the Preclinical Evidence

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Cadherins and the pathogenesis of epilepsy

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Targets and mechanisms of Alpinia oxyphylla Miquel fruits in treating neurodegenerative dementia

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Primary Cilia Structure Is Prolonged in Enteric Neurons of 5xFAD Alzheimer’s Disease Model Mice

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Bridging pathway dysfunction and therapy: novel compounds for neuroprotection

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Chronic Alcohol Exposure Alters Gene Expression and Neurodegeneration Pathways in the Brain of Adult Mice

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Dihydromyricetin ameliorates oxygen‑glucose deprivation and re‑oxygenation‑induced injury in HT22 cells by activating the Wnt/β‑catenin signaling pathway

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Characterizing dysregulations via cell-cell communications in Alzheimer’s brains using single-cell transcriptomes

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Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene

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HLY78 protects blood-brain barrier integrity through Wnt/β-catenin signaling pathway following subarachnoid hemorrhage in rats

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Drosophila melanogaster as a Model Organism to Study Lithium and Boron Bioactivity

Jans, K., Lüersen, K., & Rimbach, G. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111710 · Cited by 19

Posttranslational modifications & lithium’s therapeutic effect—Potential biomarkers for clinical responses in psychiatric & neurodegenerative disorders

Khayachi, A., Schorova, L., Alda, M., Rouleau, G. A., & Milnerwood, A. J. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.05.002 · Cited by 15

Circ-HUWE1 Knockdown Alleviates Amyloid-β-Induced Neuronal Injury in SK-N-SH Cells via miR-433-3p Release-Mediated FGF7 Downregulation

Meng, T., Chen, Y., Wang, P., Yang, L., & Li, C. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00523-5 · Cited by 15

Inhibition of CXXC5 function rescues Alzheimer’s disease phenotypes by restoring Wnt/β-catenin signaling pathway

Yoon, M., Kim, H., Shin, H., Lee, H., Kang, M., Park, S., Han, G., Kim, Y. S., & Choi, K. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106836 · Cited by 15

Expanding germ-organ theory: Understanding non-communicable diseases through enterobacterial translocation

Boopathi, S., Priya, P. S., Haridevamuthu, B., Nayak, S. P. R. R., Chandrasekar, M., Arockiaraj, J., & Jia, A. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106856 · Cited by 17

Association Between Wnt Target Genes and Cortical Volumes in Alzheimer’s Disease

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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The multifaceted role of Wnt canonical signalling in neurogenesis, neuroinflammation, and hyperexcitability in mesial temporal lobe epilepsy

Priya, Yadav, N., Anand, S., Banerjee, J., Tripathi, M., Chandra, P. S., & Dixit, A. B. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109942 · Cited by 15

Unlocking hope: GSK-3 inhibitors and Wnt pathway activation in Alzheimer’s therapy

Varshini, M. S., Reddy, R. A., & Krishnamurthy, P. T. (2024) · Journal of drug targeting · doi:10.1080/1061186x.2024.2365263 · Cited by 15

A RNA-seq approach for exploring the protective effect of ginkgolide B on glutamate-induced astrocytes injury

Wang, J., Zhuang, L., Ding, Y., Wang, Z., Xiao, W., & Zhu, J. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113807 · Cited by 15

ANP32A represses Wnt signaling across tissues thereby protecting against osteoarthritis and heart disease

Monteagudo, S., Cornelis, F. M. F., Wang, X., Roover, A. D., Peeters, T., Quintiens, J., Sermon, A., de Almeida, R. C., Meulenbelt, I., & Lories, R. J. U. (2022) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2022.02.615 · Cited by 15

Single and repeated bisphenol A treatment induces ROS, Aβ and hyperphosphorylated-tau accumulation, and insulin pathways disruption, through HDAC2 and PTP1B overexpression, leading to SN56 cholinergic apoptotic cell death

Flores, A., Moyano, P. M., Solà, E., García, J. M., García, J., Anadón, M. J., Frejo, M. T., Naval, M. V., Fernández, M. D. L. C., & del Pino, J. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.113500 · Cited by 15

The several ways to authentically cure Alzheimer’s dementia

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Attenuation of amyloid‐β‐induced mitochondrial dysfunction by active components of anthocyanins in HT22 neuronal cells

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DVL/GSK3/ISL1 pathway signaling: unraveling the mechanism of SIRT3 in neurogenesis and AD therapy

Dai, N., Su, X., Li, A., Li, J., Jiang, D., & Wang, Y. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03925-8 · Cited by 14

Exercise training alleviates neuronal apoptosis and re-establishes mitochondrial quality control after cerebral ischemia by increasing SIRT3 expression

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Drugs repurposing in the experimental models of Alzheimer’s disease

Joodi, S. A., Ibrahim, W. W., & Khattab, M. M. (2025) · Inflammopharmacology · doi:10.1007/s10787-024-01608-7 · Cited by 14

Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β‑catenin signaling pathway

Zhao, Y., Yu, J., Ping, F., Xu, L., Li, W., Zhang, H., & Li, Y. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11366 · Cited by 15

Alzheimer’s Disease and Impaired Bone Microarchitecture, Regeneration and Potential Genetic Links

Zhang, M., Hu, S., & Sun, X. (2023) · Life · doi:10.3390/life13020373 · Cited by 15

Aqueous extract of Ceratonia siliqua L. leaves elicits antioxidant, anti‐inflammatory, and AChE inhibiting effects in amyloid‐β42‐induced cognitive deficit mice: Role of α7‐nAChR in modulating Jak2/ PI3K /Akt/ GSK ‐3β/β‐catenin cascade

Sayed, N. S. E., Abidar, S., Nhiri, M., Hriţcu, L., & Ibrahim, W. W. (2023) · Phytotherapy Research · doi:10.1002/ptr.7766 · Cited by 18

Identification of Alzheimer’s Disease Molecular Subtypes Based on Parallel Large-Scale Sequencing

Ma, M., Liao, Y., Huang, X., Zou, C., Chen, L., Liang, L., Meng, Y., Wu, Y., & Zou, D. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.770136 · Cited by 14

MicroRNA Dysregulation in the Hippocampus of Rats with Noise‐Induced Hearing Loss

Ha, S., Kim, K. W., Lee, S. M., Lee, C. H., & Kim, S. Y. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1377195 · Cited by 13

Role of Neddylation in Neurodegenerative Diseases

Govindarajulu, M., Ramesh, S., Shankar, T., Kora, M. K., Moore, T., & Dhanasekaran, M. (2022) · NeuroSci · doi:10.3390/neurosci3040038 · Cited by 13

Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology by restoring canonical Wnt signaling

Suresh, S., & Vellapandian, C. (2024) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2024.116953 · Cited by 13

IGF1 enhances memory function in obese mice and stabilizes the neural structure under insulin resistance via AKT-GSK3β-BDNF signaling

Jo, D., Choi, S. Y., Ahn, S. Y., & Song, J. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117846 · Cited by 14

OGDHL ameliorates cognitive impairment and Alzheimer's disease-like pathology via activating Wnt/β-catenin signaling in Alzheimer's disease mice

Li, Y., Xu, X., Xu, Y., Li, C., Xie, F., Guo, M., Liu, Z., & Liu, X. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113673 · Cited by 13

Role of Nuclear-Receptor-Related 1 in the Synergistic Neuroprotective Effect of Umbilical Cord Blood and Erythropoietin Combination Therapy in Hypoxic Ischemic Encephalopathy

Choi, J.-W., Kang, S. J., Choi, J. I., Kwack, K., & Kim, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052900 · Cited by 13

Age- and Sex-Associated Glucose Metabolism Decline in a Mouse Model of Alzheimer’s Disease

Gherardelli, C., Cisternas, P., Vera-Salazar, R. F., Méndez‐Orellana, C., & Inestrosa, N. C. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215273 · Cited by 13

Alzheimer's disease-associated inflammatory pathways might contribute to osteoporosis through the interaction between PROK2 and CSF3

Zhang, W., Zhang, Y., Hu, N., & Wang, A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.990779 · Cited by 12

Brain–Bone Axis in Physiological and Pathological Conditions

Massaccesi, L., Romanelli, M. M. C., & Galliera, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199822 · Cited by 13

Approaches for Increasing Cerebral Efflux of Amyloid-β in Experimental Systems

Loeffler, D. A. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240212 · Cited by 12

Neurotoxicity of the antineoplastic drugs: “Doxorubicin” as an example

Fouad, G. I., & Rizk, M. Z. (2024) · Journal of Molecular Histology · doi:10.1007/s10735-024-10247-9 · Cited by 12

Wnt/β-catenin Signaling in Central Nervous System Regeneration

Nazli, D., Bora, U., & Özhan, G. (2024) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_830 · Cited by 12

Polyphenols as Wnt/β‐catenin pathway modulators: A promising strategy in clinical neurodegeneration

Utpal, B. K., Roy, S. C., Zehravi, M., Sweilam, S. H., Raja, A. D., Haque, M. A., Nayak, C., Balakrishnan, S., Singh, L. P., Panigrahi, S., et al. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12525 · Cited by 12

Cellular and Molecular Mechanisms of Spinal Cord Vascularization

Vieira, J. R., Shah, B., & de Almodóvar, C. R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.599897 · Cited by 12

Mechanism of the Fibroblast Growth Factor 23/α-Klotho Axis in Peripheral Blood Mononuclear Cell Inflammation in Alzheimer’s Disease

Li, B., Zhou, M., Peng, J. Y., Yang, Q., Chu, J., Li, R., & Jiang, Y. (2021) · Immunological Investigations · doi:10.1080/08820139.2021.1970180 · Cited by 12

Devo-Aging: Intersections Between Development and Aging

Silva-García, C. G. (2023) · GeroScience · doi:10.1007/s11357-023-00809-2 · Cited by 14

Impact of GSK-3β and CK-1δ on Wnt signaling pathway in alzheimer disease: A dual target approach

Sharma, V., Sharma, P. C., Reang, J., Yadav, V., Tonk, R. K., Majeed, J., & Sharma, K. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107378 · Cited by 11

Unravelling the Alzheimer's pathogenesis: Molecular and cellular pathways to neurodegeneration and therapeutic targets

Chauhan, P., Wadhwa, K., & Singh, G. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156109 · Cited by 12

Aging disrupts hepatocyte zonation homeostasis in mice and humans

Sinha, S., Ali, Q., Zhang, T., T-Nguyen, D. H., Hanna, S., Sethiadi, J., Hissong, E. M., & Schwartz, R. E. (2025) · Hepatology · doi:10.1097/hep.0000000000001451 · Cited by 12

Computational Strategies to Identify New Drug Candidates against Neuroinflammation

Pavan, M., Bassani, D., Bolcato, G., Bissaro, M., Sturlese, M., & Moro, S. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220208095122 · Cited by 11

RNAseq Analysis of FABP4 Knockout Mouse Hippocampal Transcriptome Suggests a Role for WNT/β-Catenin in Preventing Obesity-Induced Cognitive Impairment

So, S. W., Nixon, J. P., Bernlohr, D., & Butterick, T. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043381 · Cited by 11

The therapeutic effect of traditional Chinese medicine on breast cancer through modulation of the Wnt/β-catenin signaling pathway

Li, H., Li, J., Zhang, Y., Zhao, C., Ge, J., Sun, Y., Fu, H., & Li, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1401979 · Cited by 12

Nradd Acts as a Negative Feedback Regulator of Wnt/β-Catenin Signaling and Promotes Apoptosis

Özalp, Ö., Çark, Ö., Azbazdar, Y., Haykir, B., Cucun, G., Küçükaylak, I., Yeşilyurt, G. A., Sezgin, E., & Özhan, G. (2021) · Biomolecules · doi:10.3390/biom11010100 · Cited by 12

Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in Alzheimer’s diseasePreprint

Vastrad, B. M., & Vastrad, C. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.06.442918 · Cited by 11

Molecular and cellular signalling pathways for promoting neural tissue growth - A tissue engineering approach

Ramasubbu, K., Venkatraman, G., Ramanathan, G., Dhanasekar, S., & Rajeswari, V. D. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122640 · Cited by 10

Modulation of the central nervous system immune response and neuroinflammation via Wnt signaling in health and neurodegenerative diseases

Fang, K. (2024) · Ibrain · doi:10.1002/ibra.12185 · Cited by 10

Potential therapeutic targets for Alzheimer’s disease: Fibroblast growth factors and their regulation of ferroptosis, pyroptosis and autophagy

Li, Y., Yang, C., Liu, X., Shu, J., Zhao, N., Sun, Z., Tabish, M. S., Hong, Y., Liu, E., Wei, N., et al. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.03.009 · Cited by 10

Precious but convenient means of prevention and treatment: physiological molecular mechanisms of interaction between exercise and motor factors and Alzheimer’s disease

Hao, Z., Liu, K., Zhou, L., & Chen, P. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1193031 · Cited by 10

Investigation of Potential Drug Targets for Cholesterol Regulation to Treat Alzheimer’s Disease

Passero, M., Zhai, T., & Huang, Z. J. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20136217 · Cited by 10

Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD

Chen, Z. S., Ou, M., Taylor, S., Dafinca, R., Peng, S. I., Talbot, K., & Chan, H. Y. E. (2023) · Nature Communications · doi:10.1038/s41467-023-44215-w · Cited by 10

Wnt Signaling Rescues Amyloid Beta-Induced Gut Stem Cell Loss

Kaur, P., Chua, E. H. Z., Lim, W. K., Liu, J., Harmston, N., & Tolwinski, N. S. (2022) · Cells · doi:10.3390/cells11020281 · Cited by 10

Neurogenesis Is Increased in Human Neural Stem Cells by Aβ40 Peptide

Bernabeu-Zornoza, A., Coronel, R., Palmer, C., Martín, A., López-Alonso, V., & Liste, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105820 · Cited by 11

Deciphering the enigmatic crosstalk between prostate cancer and Alzheimer's disease: A current update on molecular mechanisms and combination therapy

Poddar, N. K., Agarwal, D., Agrawal, Y., Wijayasinghe, Y. S., Mukherjee, A., & Khan, S. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166524 · Cited by 10

The Possible Neuroprotective Effect of Caffeic Acid on Cognitive Changes and Anxiety-Like Behavior Occurring in Young Rats Fed on High-Fat Diet and Exposed to Chronic Stress: Role of β-Catenin/GSK-3B Pathway

El-Sayed, N. S., Khalil, N. A., Saleh, S. R., Aly, R. G. M., & Basta, M. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02232-4 · Cited by 9

REMOVED: Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude. Neuroprotective effects of nanodelivery of a potent antioxidant compound H-290/51

Sharma, H. S., Lafuente, J. V., Feng, L., Muresanu, D. F., Menon, P. K., Nozari, A., Sahib, S., Tian, Z. R., Buzoianu, A. D., Sjöquist, P.-O. B., et al. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.06.008 · Cited by 9

The relationship between long non-coding RNAs and Wnt/β-catenin signaling pathway in the pathogenesis of Alzheimer’s disease

Ghasemi, A., Qaffaripour, Z., Tourani, M., Saleki, K., Rahmani-Kukia, N., Khatami, S. H., & Taheri‐Anganeh, M. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114434 · Cited by 9

Repositioning of antidiabetic drugs for Alzheimer’s disease: possibility of Wnt signaling modulation by targeting LRP6 an in silico based study

Manandhar, S., Priya, K., Mehta, C. H., Nayak, U. Y., Kabekkodu, S. P., & Pai, K. S. R. (2021) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2021.1930583 · Cited by 9

Amisulpride attenuates 5-fluorouracil-induced cognitive deficits via modulating hippocampal Wnt/GSK-3β/β-catenin signaling in Wistar rats

Raafat, R. S., Habib, M. Z., AbdElfattah, A. A., Olama, N. K., Abdelraouf, S. M., Hendawy, N., Kamal, K. A., Nawishy, S., & Aboul‐Fotouh, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110945 · Cited by 8

Disparities in the Diagnosis and Treatment of Osteoporosis in Persons with Cognitive Impairment and Dementia

Shrestha, P., Basida, B., Elam, R. E., Hajj, J. E., Le, B. K., Fink, H. A., Bethel, M., Tharrington, S. G., & Carbone, L. D. (2025) · Current Osteoporosis Reports · doi:10.1007/s11914-025-00924-3 · Cited by 8

Beyond epilepsy: The expanding role of valproic acid in Alzheimer disease therapy – a review

Markowicz-Piasecka, M., Miłkowska, Z., Adla, S. K., Huttunen, K. M., & Pietrzak, B. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103658 · Cited by 9

Glycogen synthase kinase-3: the master switch driving neurodegeneration in Alzheimer’s disease and Parkinson’s disease

Liu, Y., Zhang, J., Tang, L., Yang, J., Hao, L., Lou, F., & Su, J. (2025) · Archives of Toxicology · doi:10.1007/s00204-025-04174-1 · Cited by 8

Combined use of hair follicle stem cells and CEPO (carbamylated erythropoietin)-Fc in a rat model of chronic cerebral hypoperfusion: A behavioral, electrophysiological, and molecular study

Hooshmandi, E., Akbari, S., Pandamooz, S., Ghobadi, M., Ghasemi, R., Maghsoudi, N., Nand, S., Borhani‐Haghighi, A., Salehi, M. S., Azarpira, N., et al. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114655 · Cited by 8

Common neurodegenerative pathways in brain aging, cognitive decline, type 2 diabetes & metabolic syndrome

Abbatecola, A. M., Arosio, B., Cerasuolo, M., Auriemma, M. C., Meo, I. D., Langiano, E., & Rizzo, M. R. (2024) · Journal of Gerontology and Geriatrics · doi:10.36150/2499-6564-n691 · Cited by 8

Unearthing nature's remedy: An exploration into Lycopodium's medicinal and therapeutic potential

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