The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
Open accessAbstract
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids, RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential intercellular communication regulators in multiple physiological and pathological processes. Previous studies revealed that mesenchymal stem cells (MSCs) could either support or suppress tumor progression in different cancers by paracrine signaling via MSC-derived EVs. Evidence suggested that MSC-derived EVs could mimic their parental cells, possessing pro-tumor and anti-tumor effects, and inherent tumor tropism. Therefore, MSC-derived EVs can be a cell-free cancer treatment alternative. This review discusses different insights regarding MSC-derived EVs' roles in cancer treatment and summarizes bioengineered MSC-derived EVs’ applications as safe and versatile anti-tumor agent delivery platforms. Meanwhile, current hurdles of moving MSC-derived EVs from bench to bedside are also discussed.
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Cited by
Exosome engineering in cell therapy and drug delivery
Sadeghi, S., Tehrani, F. R., Tahmasebi, S., Shafiee, A., & Hashemi, S. M. (2023) · Inflammopharmacology · doi:10.1007/s10787-022-01115-7 · Cited by 351
Targeting the tumor stroma for cancer therapy
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Metadata
- Authors
- Weng, Z., Zhang, B., Wu, C., Yu, F., Han, B., Li, B., & Li, L.
- Venue
- Journal of Hematology & Oncology
- Published
- 2021-09-03
- Volume
- 14
- Issue
- 1
- Pages
- 136-136
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W3198812529
- Cited by
- 405
- References
- 18
- FWCI
- 16.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Weng, Z., Zhang, B., Wu, C., Yu, F., Han, B., Li, B., & Li, L. (2021). Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-021-01141-y
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