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Cited by 33Gestational Diabetes Research and ManagementBirth, Development, and HealthPancreatic function and diabetes

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Biochemical and molecular biomarkers: unraveling their role in gestational diabetes mellitus

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Karami, Masoumeh, Mousavi, Seyyed Hossein, Rafiee, Mohammad, Heidari, Reza, Shahrokhi, Seyedeh Zahra·2023·Diabetology & Metabolic Syndrome
DOI 10.1186/s13098-023-00980-8PMC PMC9832639
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Abstract

Gestational diabetes mellitus (GDM) is the most prevalent metabolic disorder during pregnancy, causing short- and long-term complications for both mother and baby. GDM is a multifactorial disease, and it may be affected by interactions between genetic, epigenetic, and environmental factors. However, the exact etiology is poorly understood. Despite the high prevalence of GDM, there is still debate regarding the optimal time for screening, the diagnostic threshold to apply, and the best strategies for treatment. Identifying effective strategies for therapeutic purposes as well as accurate biomarkers for prognostic and diagnostic purposes will reduce the GDM incidence and improve its management. In recent years, new biochemical and molecular biomarkers such as microRNAs, single-nucleotide polymorphisms, and DNA methylation have received great interest in the diagnosis of GDM. In this review, we discuss current and future diagnostic approaches for the detection of GDM and evaluate lifestyle and pharmacological strategies for GDM prevention.

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Metadata

Authors
Karami, M., Mousavi, S. H., Rafiee, M., Heidari, R., & Shahrokhi, S. Z.
Affiliations
  • Aja University of Medical Sciences (IR)
  • Zanjan University of Medical Sciences (IR)
Corresponding author
Shahrokhi, Seyedeh Zahra
ORCID
Venue
Diabetology & Metabolic Syndrome
Publisher
Springer Science and Business Media LLC
Published
2023-01-11
Volume
15
Issue
1
Pages
5-5
ISSN
1758-5996 (ISSN-L)
DOI
10.1186/s13098-023-00980-8
PMC
PMC9832639
OpenAlex
W4315499089
Cited by
33
References
9
Citations by year
2026: 8 · 2025: 10 · 2024: 10 · 2023: 5
FWCI
2.02
Type
journal article
Language
en
Open access
Licence
Locations
  • Diabetology & Metabolic Syndrome (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
gestational diabetes mellitus, biomarkers, microRNA, single nucleotide polymorphisms, DNA methylation, GDM diagnosis, GDM screening, epigenetics, GDM prevention, lifestyle intervention, pharmacotherapy

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