Epigenome-wide association study of DNA methylation in panic disorder
Open accessAbstract
BACKGROUND: Panic disorder (PD) is considered to be a multifactorial disorder emerging from interactions among multiple genetic and environmental factors. To date, although genetic studies reported several susceptibility genes with PD, few of them were replicated and the pathogenesis of PD remains to be clarified. Epigenetics is considered to play an important role in etiology of complex traits and diseases, and DNA methylation is one of the major forms of epigenetic modifications. In this study, we performed an epigenome-wide association study of PD using DNA methylation arrays so as to investigate the possibility that different levels of DNA methylation might be associated with PD. METHODS: values via the logit transformation for epigenome-wide association study. The relationship between each DNA methylation site and PD was assessed by linear regression analysis with adjustments for the effects of leukocyte subsets. RESULTS: Forty CpG sites showed significant association with PD at 5% FDR correction, though the differences of the DNA methylation levels were relatively small. Most of the significant CpG sites (37/40 CpG sites) were located in or around CpG islands. Many of the significant CpG sites (27/40 CpG sites) were located upstream of genes, and all such CpG sites with the exception of two were hypomethylated in PD subjects. A pathway analysis on the genes annotated to the significant CpG sites identified several pathways, including "positive regulation of lymphocyte activation." CONCLUSIONS: Although future studies with larger number of samples are necessary to confirm the small DNA methylation abnormalities associated with PD, there is a possibility that several CpG sites might be associated, together as a group, with PD.
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An EWAS study from patients suffering from panic disorder found enrichment in genes involved in the regulation of lymphocytes.
“Furthermore, an EWAS study from patients suffering from Panic Disorder found enrichment in genes involved in the regulation of lymphocytes (Shimada-Sugimoto et al., 2017).”
From Can epigenetics shine a light on the biological pathways underlying major mental disorders? (2022) · cites this paper as Shimada-Sugimoto et al., 2017
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“Furthermore, an EWAS study from patients suffering from Panic Disorder found enrichment in genes involved in the regulation of lymphocytes (Shimada-Sugimoto et al., 2017).”
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- Authors
- Shimada-Sugimoto, M., Otowa, T., Miyagawa, T., Umekage, T., Kawamura, Y., Bundo, M., Iwamoto, K., Tochigi, M., Kasai, K., Kaiya, H., Tanii, H., Okazaki, Y., Tokunaga, K., & Sasaki, T.
- Affiliations
- Teikyo Heisei University (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- The University of Tokyo (JP)
- Shonan Kamakura General Hospital (JP)
- Kumamoto University (JP)
- Teikyo University (JP)
- Mie University (JP)
- Corresponding author
- Otowa, Takeshi
- ORCID
- Venue
- Clinical Epigenetics
- Published
- 2017-01-21
- Volume
- 9
- Issue
- 1
- Pages
- 6-6
- ISSN
- 1868-7075 (ISSN-L)
- 1868-7083
- PMC
- PMC5270210
- OpenAlex
- W2573769293
- Cited by
- 61
- References
- 72
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 12 · 2019: 6 · 2018: 8 · 2017: 6
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Clinical Epigenetics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (15J04964, 26461712, 25461723)
- Takeda Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- panic disorder, DNA methylation, epigenome-wide association study, CpG sites, CpG islands, hypomethylation, leukocyte subsets, lymphocyte activation, gene expression regulation, mental illness
- MeSH terms
- Female, Humans, Male, Genome, Human, Case-Control Studies, Lymphocyte Subsets, Panic Disorder, CpG Islands, DNA Methylation, Genetic Predisposition to Disease, Epigenesis, Genetic, Gene Regulatory Networks, Genome-Wide Association Study, Epigenomics
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