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Osteogenesis and aging: lessons from mesenchymal stem cells
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Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures. At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesis at the cost of osteogenesis. This differentiation shift leads to decreased bone formation, contributing to the etiology of osteoporosis. This review will focus on the most recent/relevant molecular findings driving this functional impairment of mesenchymal stem cells in the aging process.
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Bone ageing is a major risk factor for primary osteoporosis, an age-related disease characterised by altered bone metabolism that suppresses bone formation and promotes bone resorption, impairing bone homoeostasis.
“Bone ageing is major risk factor for primary osteoporosis, an age-related disease characterised by altered bone metabolism that suppresses bone formation and promotes bone resorption, 91 impairing bone homoeostasis.92”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [92]
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Human Fibroblasts as a Model for the Study of Bone Disorders
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FGFR2 accommodates osteogenic cell fate determination in human mesenchymal stem cells
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Metadata
- Authors
- Infante, A., & Rodríguez, C. I.
- Affiliations
- BioCruces Health research Institute (ES)
- Venue
- Stem Cell Research & Therapy
- Published
- 2018-09-26
- Volume
- 9
- Issue
- 1
- Pages
- 244-244
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC6158877
- OpenAlex
- W2893485895
- Cited by
- 334
- References
- 59
- Citations by year
- 2026: 28 · 2025: 45 · 2024: 54 · 2023: 54 · 2022: 53 · 2021: 49 · 2020: 35 · 2019: 15
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Instituto de Salud Carlos III (PI15/00820)
- Basque Country Government (KK-2018/00031)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- bone formation, aging, mesenchymal stem cells, osteoporosis, bone marrow microenvironment, adipogenesis, osteogenic differentiation, molecular mechanisms of aging
- MeSH terms
- Aging, Bone Marrow Cells, Cell Differentiation, Humans, Osteogenesis, Adipogenesis, Stem Cell Niche, Mesenchymal Stem Cells
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